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Disclosery

UPB UPSTREAM BIO INC

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COMMON STOCK (common), issuer CIK 2022626

95 managers (95 13F filers) reported a position in UPB shares at 2025-09-30, 44,461,816 shares in all. 22 filers opened a position and 10 filers sold out during the quarter.

Managers
95
13F filers
95
New
22
Added
38
Reduced
22
Sold out
10
Shares held by filers
44,461,816

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC8,086,413$152M0.01%+149,53313F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC5,693,589$107M2.57%013F-HRTimelineGroup
Decheng Capital LLC3,285,293$61.8M10.78%013F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.2,603,706$49M<0.01%+507,20013F-HRTimelineGroup
ENAVATE SCIENCES GP, LLC2,459,703$46.3M14.13%013F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC2,442,551$45.9M<0.01%+271,71813F-HRTimelineGroup
Bain Capital Life Sciences Investors, L…in group Bain Capital Life Sciences In…2,439,538$45.9M3.05%013F-HRTimelineGroup
TCG Crossover Management, LLC2,117,103$39.8M1.96%-684,66013F-HRTimeline
Altshuler Shaham Ltd1,416,822$26.7M0.44%-1,977,61913F-HRTimeline
Omega Fund Management, LLC1,356,293$25.5M11.47%-680,00013F-HRTimeline
Venrock Adviser, LLC1,169,298$22M1.24%-1,126,02113F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…1,125,395$21.2M<0.01%-99,90013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,114,581$21M<0.01%+633,20613F-HRTimelineGroup
SAMSARA BIOCAPITAL, LLC962,154$18.1M2.36%-481,07713F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP867,999$16.3M0.02%+577,47313F-HRTimelineGroup
Parkman Healthcare Partners LLC843,502$15.9M1.74%+127,99813F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC817,109$15.4M<0.01%+170,47413F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.788,450$14.8M0.58%013F-HRTimelineGroup
Woodline Partners LP602,252$11.3M0.05%+44,00013F-HRTimeline
Nantahala Capital Management, LLCin group Nantahala Capital Management,…594,971$11.2M0.69%013F-HRTimelineGroup
Integral Health Asset Management, LLC575,000$10.8M0.79%new13F-HRTimeline
GREAT POINT PARTNERS LLC300,000$5.64M2.36%013F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co284,828$5.36M<0.01%+106,57513F-HRTimelineGroup
UBS Group AGin group UBS Group AG272,271$5.12M<0.01%+39,38413F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP254,719$4.79M<0.01%+25,41613F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC223,214$4.2M<0.01%new13F-HRTimelineGroup
Schonfeld Strategic Advisors LLC190,244$3.58M0.02%-175,54613F-HRTimeline
Ikarian Capital, LLCin group Ikarian Capital, LLC161,113$3.03M0.61%new13F-HRTimelineGroup
SummitTX Capital, L.P.112,404$2.11M0.09%new13F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp91,521$1.72M<0.01%+11,75513F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY87,535$1.65M<0.01%-11,77313F-HR/ATimelineGroup
BARCLAYS PLCin group BARCLAYS PLC85,315$1.6M<0.01%-11,67513F-HR/ATimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management73,131$1.38M<0.01%new13F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC71,540$1.35M<0.01%+49,17813F-HRTimelineGroup
Nuveen, LLCin group TIAA69,882$1.31M<0.01%-4,05413F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC61,299$1.15M0.03%new13F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/55,473$1.04M<0.01%+37,44213F-HR/ATimelineGroup
Exome Asset Management LLC51,960$977K0.65%new13F-HRTimeline
RHUMBLINE ADVISERS49,406$929K<0.01%+1,34013F-HRTimeline
Verition Fund Management LLC47,001$884K0.01%+13,49613F-HRTimeline
CITIGROUP INCin group CITIGROUP INC42,037$791K<0.01%+30,34213F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC40,113$755K<0.01%new13F-HRTimelineGroup
Rafferty Asset Management, LLC34,521$649K<0.01%new13F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC29,954$563K<0.01%+20213F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO29,947$563K<0.01%+13,47813F-HR/ATimelineGroup
NOMURA HOLDINGS INCin group NOMURA ASSET MANAGEMENT CO LTD28,290$532K<0.01%new13F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\26,737$503K<0.01%+3,33413F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC25,962$488K<0.01%-3,01413F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN25,160$473K<0.01%+2,79613F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…21,691$408K<0.01%013F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.19,850$373K<0.01%-4,71013F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/18,501$349K<0.01%+1,05313F-HRTimeline
Caption Management, LLC18,196$342K0.02%new13F-HRTimeline
Invesco Ltd.in group Invesco Ltd.17,190$323K<0.01%+89013F-HRTimelineGroup
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.in group Mirae Asset Global Investment…16,863$315K<0.01%-2,22113F-HRTimelineGroup
PRELUDE CAPITAL MANAGEMENT, LLC15,735$296K0.02%new13F-HRTimeline
COMMONWEALTH EQUITY SERVICES, LLC15,503$292K<0.01%-2313F-HRTimeline
Quantinno Capital Management LP14,889$280K<0.01%+4,27513F-HRTimeline
Creative Planningin group Creative Planning14,266$268K<0.01%+23613F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …12,092$227K<0.01%-1,09813F-HRTimelineGroup
Mariner, LLCin group Mariner, LLC10,933$206K<0.01%new13F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP10,500$198K<0.01%new13F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC10,396$196K<0.01%-10,89413F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…9,843$185K0.05%+1,70913F-HRTimelineGroup
Police & Firemen's Retirement System of…9,447$178K<0.01%+1,61413F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS6,527$123K<0.01%+3,43013F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND6,300$119K<0.01%+1,60013F-HRTimeline
CWM, LLCin group CWM, LLC3,341$63K<0.01%+2913F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…3,034$57.1K<0.01%+2,88713F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc2,924$55K<0.01%-25013F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…2,741$51.6K<0.01%-81713F-HRTimelineGroup
Sterling Capital Management LLC2,264$42.6K<0.01%+1,32313F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…2,176$40.9K<0.01%+213F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…1,868$35.1K<0.01%-1,18313F-HRTimelineGroup
GROUP ONE TRADING LLC1,305$24.5K<0.01%new13F-HRTimeline
Aster Capital Management (DIFC) Ltd1,141$21.5K0.01%new13F-HRTimeline
GAMMA Investing LLC890$16.7K<0.01%+19713F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA832$16K<0.01%-2,25813F-HRTimelineGroup
AMALGAMATED BANK594$11K<0.01%013F-HRTimeline
Versant Capital Management, Inc548$10.3K<0.01%-1013F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\531$9.99K<0.01%-12813F-HRTimelineGroup
Global Retirement Partners, LLC332$6.25K<0.01%new13F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…310$5.83K<0.01%+113F-HRTimelineGroup
Clearstead Advisors, LLC163$3.07K<0.01%013F-HRTimeline
Arax Advisory Partners149$2.8K<0.01%new13F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…130$2.45K<0.01%new13F-HRTimelineGroup
J.Safra Asset Management Corp128$2.41K<0.01%new13F-HRTimeline
Essential Partners LLC97$1.82K<0.01%013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC96$1.81K<0.01%013F-HRTimeline
Allworth Financial LP67$1.26K<0.01%+113F-HRTimeline
N.E.W. Advisory Services LLC60$1.13K<0.01%new13F-HRTimeline
SIGNATUREFD, LLC51$959<0.01%+213F-HRTimeline
Sunbelt Securities, Inc.19$357<0.01%new13F-HRTimeline
IFP Advisors, Inc2$38<0.01%+113F-HR/ATimeline
Parallel Advisors, LLC2$38<0.01%013F-HRTimeline