TRV GP V, LLC More: the full row for TRV GP V, LLC 7,135,233 $216M 50.44% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 7,111,865 $216M 0.01% +194,870 13F-HR Timeline Group ARCH Venture Management, LLC More: the full row for ARCH Venture Management, LLC 3,728,738 $113M 17.36% 0 13F-HR Timeline Capital International Investors in group Capital International Investo… More: the full row for Capital International Investors 3,402,529 $103M 0.02% 0 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 3,027,521 $91.9M 5.21% -165,000 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 3,001,879 $91.1M 0.01% +579,903 13F-HR/A Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,431,862 $73.8M <0.01% +863,781 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 1,904,408 $57.8M 2.49% -43,171 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,817,757 $55.2M <0.01% +191,219 13F-HR Timeline Group JOHNSON & JOHNSON in group JOHNSON & JOHNSON More: the full row for JOHNSON & JOHNSON 1,784,517 $54.1M 9.75% 0 13F-HR/A Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 1,547,090 $46.9M 0.27% 0 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 1,178,731 $35.8M -271,600 Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 1,110,000 $33.7M 1.24% +160,000 13F-HR Timeline Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 1,004,728 $30.5M 0.14% +65,776 13F-HR Timeline Group TRV GP VI, LLC More: the full row for TRV GP VI, LLC 969,218 $29.4M 19.8% 0 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 881,609 $26.7M <0.01% -220,782 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 788,411 $23.9M 0.01% -67,209 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 714,821 $21.7M <0.01% +343,195 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 708,469 $21.5M 0.64% -345,000 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 694,734 $21.1M <0.01% +161,331 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 673,923 $20.4M 0.37% +270,000 13F-HR Timeline Group T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 619,029 $18.8M 0.01% -88,479 13F-HR/A Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 267,120 $8.1M <0.01% +109,136 13F-HR Timeline Group PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 254,967 $7.74M 0.01% new 13F-HR Timeline Group Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 250,000 $7.58M 0.5% 0 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 247,315 $7.5M 0.01% new 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 244,391 $7.41M <0.01% +41,942 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 220,815 $6.7M <0.01% +66,958 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 210,331 $6.38M <0.01% -64,237 13F-HR/A Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 201,825 $6.12M <0.01% +47,651 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 194,200 $5.89M 0.01% 0 13F-HR/A Timeline Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 185,265 $5.62M 0.93% 0 13F-HR Timeline KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 178,737 $5.42M 0.11% new 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 150,000 $4.55M 0.01% -300,000 13F-HR Timeline Group Artia Global Partners LP More: the full row for Artia Global Partners LP 138,508 $4.2M 0.68% +73,900 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 118,814 $3.6M 0.01% +83,514 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 115,190 $3.49M <0.01% -21,824 13F-HR Timeline Swedbank AB in group Swedbank AB More: the full row for Swedbank AB 113,200 $3.43M <0.01% new 13F-HR/A Timeline Group Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 85,555 $2.6M 0.29% -1,717 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 83,487 $2.53M <0.01% +72,157 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 78,659 $2.41M <0.01% -3,672 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 75,000 $2.28M 0.53% 0 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 74,081 $2.25M <0.01% +26,659 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 70,946 $2.15M <0.01% +49,073 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 66,149 $2.01M <0.01% +52,808 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 62,979 $1.91M 0.02% +42,460 13F-HR Timeline Eversept Partners, LP More: the full row for Eversept Partners, LP 59,233 $1.8M 0.1% -84,332 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 56,484 $1.71M <0.01% +54,714 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 56,457 $1.71M <0.01% -6,365 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 54,600 $1.66M <0.01% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 52,480 $1.59M <0.01% +25,767 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 50,619 $1.54M <0.01% +29,119 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 46,849 $1.42M <0.01% +28,599 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 44,291 $1.34M <0.01% +42,813 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 39,139 $1.19M 0.01% +22,037 13F-HR Timeline Group SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 38,925 $1.18M 0.95% -4,555 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 34,651 $1.05M 0.01% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 34,553 $1.05M <0.01% -23,508 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 32,109 $974K <0.01% +18,647 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 30,726 $932K <0.01% +6,440 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 26,690 $810K <0.01% +25,594 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 22,384 $679K <0.01% -11,509 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 21,535 $653K <0.01% +15,286 13F-HR Timeline Group DARK FOREST CAPITAL MANAGEMENT LP More: the full row for DARK FOREST CAPITAL MANAGEMENT LP 21,074 $639K 0.03% new 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 20,878 $633K <0.01% +256 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 18,268 $554K <0.01% +10,115 13F-HR Timeline Group PSP Research LLC More: the full row for PSP Research LLC 17,506 $531K 0.46% 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 17,239 $523K -11,435 Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 16,783 $509K 0.01% new 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 15,996 $485K <0.01% +5,133 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 15,565 $472K +6,101 Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 15,129 $459K <0.01% +5,145 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 14,794 $449K <0.01% -110,009 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 13,800 $419K <0.01% new 13F-HR Timeline Group Allianz Asset Management GmbH in group Allianz SE More: the full row for Allianz Asset Management GmbH 13,200 $400K <0.01% new 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 13,062 $396K 0.01% new 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 12,733 $386K 0.03% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 12,353 $375K <0.01% +5,133 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 12,212 $371K <0.01% +253 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 10,766 $327K 0.03% +3,368 13F-HR Timeline CATALYST PRIVATE WEALTH, LLC More: the full row for CATALYST PRIVATE WEALTH, LLC 10,000 $303K 0.13% 0 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 9,659 $293K 0.04% -194,287 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 9,673 $293K <0.01% +3,408 13F-HR Timeline CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 9,100 $276K <0.01% new 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 8,880 $269K 0.01% new 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 8,837 $268K <0.01% new 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 8,789 $267K 0.07% -1,425 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 8,297 $252K <0.01% new 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 8,099 $246K <0.01% -96,779 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 8,026 $244K <0.01% new 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 7,859 $238K <0.01% new 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 7,801 $237K <0.01% new 13F-HR Timeline ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 7,726 $234K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 7,471 $227K <0.01% +2,219 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 7,308 $222K <0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 7,300 $221K <0.01% 0 13F-HR Timeline STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 6,823 $207K <0.01% new 13F-HR Timeline Group LANDSCAPE CAPITAL MANAGEMENT, L.L.C. in group LANDSCAPE CAPITAL MANAGEMENT,… More: the full row for LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 6,594 $200K 0.01% new 13F-HR Timeline Group AlphaCentric Advisors LLC More: the full row for AlphaCentric Advisors LLC 6,030 $183K 0.18% 13F-HR Timeline Sandia Investment Management LP More: the full row for Sandia Investment Management LP 6,000 $182K 0.45% 0 13F-HR Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 6,690 $180K <0.01% new 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 5,900 $179K <0.01% new 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 3,754 $114K 0.01% new 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,310 $70.1K <0.01% +827 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 2,282 $69.2K <0.01% +828 13F-HR Timeline Group STRS OHIO More: the full row for STRS OHIO 2,100 $63.7K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 1,640 $49.8K <0.01% +429 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 1,468 $45K <0.01% +10 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 1,353 $41K <0.01% 0 13F-HR Timeline MEEDER ASSET MANAGEMENT INC in group Meeder Advisory Services, Inc. More: the full row for MEEDER ASSET MANAGEMENT INC 1,208 $36.7K <0.01% new 13F-HR Timeline Group Tidemark, LLC More: the full row for Tidemark, LLC 1,088 $33K 0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,100 $33K <0.01% +8 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 935 $28.4K <0.01% +146 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 894 $27K <0.01% +312 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 500 $15.2K <0.01% -64 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 430 $13K <0.01% -626 13F-HR Timeline Group BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 420 $13K <0.01% new 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 342 $10.4K <0.01% -12 13F-HR Timeline Cygnus Capital Advisors, LLC More: the full row for Cygnus Capital Advisors, LLC 341 $10K 0.01% 13F-HR Timeline Aster Capital Management (DIFC) Ltd More: the full row for Aster Capital Management (DIFC) Ltd 300 $9.1K <0.01% new 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 225 $6.83K <0.01% +20 13F-HR Timeline MassMutual Private Wealth & Trust, FSB More: the full row for MassMutual Private Wealth & Trust, FSB 161 $4.88K <0.01% new 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 121 $4K <0.01% 0 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 115 $3.49K <0.01% 0 13F-HR Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 83 $2.52K <0.01% new 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 72 $2.18K <0.01% -34 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 63 $1.91K <0.01% +10 13F-HR Timeline QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 57 $1.73K <0.01% 0 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 55 $1.67K <0.01% new 13F-HR Timeline Group Cornerstone Financial Management LLC More: the full row for Cornerstone Financial Management LLC 49 $1.49K <0.01% 13F-HR/A Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 47 $1.43K <0.01% -5 13F-HR Timeline Group True Wealth Design, LLC More: the full row for True Wealth Design, LLC 44 $1.33K <0.01% 0 13F-HR Timeline Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 40 $1.21K <0.01% -5 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 40 $1.21K <0.01% 0 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 27 $819 <0.01% -16,703 13F-HR Timeline SageView Advisory Group, LLC More: the full row for SageView Advisory Group, LLC 16 $486 <0.01% new 13F-HR Timeline Bare Financial Services, Inc More: the full row for Bare Financial Services, Inc 16 $485 <0.01% new 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 11 $334 <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 9 $273 <0.01% new 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 3 $91 <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 1 $30 <0.01% new 13F-HR Timeline