TRV GP V, LLC More: the full row for TRV GP V, LLC 7,135,233 $71.6M 57.21% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 5,486,468 $55M <0.01% 0 13F-HR Timeline Group ARCH Venture Management, LLC More: the full row for ARCH Venture Management, LLC 3,728,738 $37.5M 18.21% 0 13F-HR Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 2,940,921 $29.5M 2.23% 0 13F-HR Timeline Capital International Investors in group Capital International Investo… More: the full row for Capital International Investors 2,602,529 $26.1M 0.01% 0 13F-HR Timeline Group JOHNSON & JOHNSON in group JOHNSON & JOHNSON More: the full row for JOHNSON & JOHNSON 2,498,051 $25.1M 7.33% 0 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 1,995,594 $20M 1.51% 0 13F-HR Timeline T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 1,551,925 $15.6M 0.01% -85,006 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,244,310 $12.5M <0.01% -7,826 13F-HR/A Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,167,251 $11.7M <0.01% +410,708 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,115,424 $11.2M <0.01% +559,951 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 1,109,625 $11.1M <0.01% +11,210 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,073,208 $10.8M <0.01% -70,176 13F-HR Timeline TRV GP VI, LLC More: the full row for TRV GP VI, LLC 969,218 $9.72M 23.16% 0 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 457,556 $4.59M 0.15% new 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 378,469 $3.8M 0.21% -5,728 13F-HR/A Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 315,663 $3.17M <0.01% +104,987 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 267,989 $2.69M +246,661 Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 249,414 $2.5M <0.01% -238,044 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 208,910 $2.1M 0.37% 0 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 194,200 $1.95M <0.01% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 191,122 $1.92M <0.01% +23,584 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 182,028 $1.83M 0.01% +498 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 162,818 $1.63M <0.01% -15,088 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 128,083 $1.28M <0.01% +55,257 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 90,968 $912K <0.01% +17,459 13F-HR/A Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 78,931 $792K <0.01% +1,656 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 76,604 $768K <0.01% +53,968 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 62,696 $629K <0.01% +44,199 13F-HR/A Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 45,757 $459K new Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 35,482 $356K <0.01% +15,514 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 31,900 $320K <0.01% +13,900 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 29,939 $300K <0.01% +21,368 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 26,830 $269K 0.01% 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 26,128 $262K <0.01% -3,452 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 24,471 $245K <0.01% new 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 21,873 $219K <0.01% 13F-HR Timeline Group ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 16,400 $164K 0.19% 0 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 15,442 $155K 0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 15,085 $151K <0.01% +5,508 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 14,358 $144K <0.01% +4,109 13F-HR/A Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 13,760 $138K <0.01% new 13F-HR/A Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 11,153 $112K +4,629 Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 10,863 $109K <0.01% +5,153 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 10,554 $106K <0.01% +3,384 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 10,296 $103K <0.01% +773 13F-HR Timeline Group CATALYST PRIVATE WEALTH, LLC More: the full row for CATALYST PRIVATE WEALTH, LLC 10,000 $100K 0.05% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 8,967 $89.9K <0.01% +4,143 13F-HR Timeline Group Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 8,637 $86.6K +4,897 Timeline Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 8,271 $83K <0.01% +3,653 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 7,461 $74.8K <0.01% +883 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 7,337 $73.6K 0.01% -419 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 6,502 $65.2K <0.01% +4,185 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 4,532 $45.5K <0.01% +2,529 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 3,500 $35.1K <0.01% 0 13F-HR/A Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 1,900 $19.1K <0.01% 0 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 1,700 $17.1K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,311 $13K <0.01% +319 13F-HR/A Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,209 $12.1K <0.01% -203 13F-HR Timeline Group Tidemark, LLC More: the full row for Tidemark, LLC 1,088 $10.9K <0.01% 0 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 998 $10K <0.01% +987 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 941 $9.44K <0.01% 0 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 936 $9.39K <0.01% +168 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 922 $9.25K <0.01% +181 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 918 $9.21K <0.01% +908 13F-HR/A Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 582 $6K <0.01% +265 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 145 $1.45K <0.01% +2 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 144 $1.44K <0.01% new 13F-HR Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 137 $1.37K <0.01% new 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 121 $1K <0.01% 0 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 59 $592 <0.01% +58 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 15 $167 <0.01% new 13F-HR Timeline Lindbrook Capital, LLC More: the full row for Lindbrook Capital, LLC 15 $150 <0.01% new 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 3 $31 <0.01% new 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.