FMR LLC in group FMR LLC More: the full row for FMR LLC 7,168,939 $224M 0.01% +57,074 13F-HR Timeline Group TRV GP V, LLC More: the full row for TRV GP V, LLC 7,135,233 $223M 55.68% 0 13F-HR Timeline ARCH Venture Management, LLC More: the full row for ARCH Venture Management, LLC 3,728,738 $117M 17.23% 0 13F-HR Timeline Capital International Investors in group Capital International Investo… More: the full row for Capital International Investors 3,097,973 $96.9M 0.02% -304,556 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 2,957,521 $92.5M 4.67% -70,000 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 2,942,251 $92.1M 0.01% -59,628 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,505,955 $78.4M <0.01% +74,093 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 1,904,408 $59.6M 2.99% 0 13F-HR Timeline VANGUARD GROUP INC group of 6 filers holding More: the full row for VANGUARD GROUP INC 1,878,275 $58.8M new Timeline VANGUARD CAPITAL MANAGEMENT LLC : 1,325,082 (<0.01%) 13F-HR/A VANGUARD PORTFOLIO MANAGEMENT LLC : 320,909 (<0.01%) 13F-HR VANGUARD FIDUCIARY TRUST CO : 189,253 (<0.01%) 13F-HR VANGUARD ASSET MANAGEMENT, Ltd : 18,532 (<0.01%) 13F-HR Vanguard Global Advisers, LLC : 17,240 (<0.01%) 13F-HR Vanguard Investments Australia, L… : 7,259 (<0.01%) 13F-HR JOHNSON & JOHNSON in group JOHNSON & JOHNSON More: the full row for JOHNSON & JOHNSON 1,784,517 $55.8M 8.56% 0 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 1,642,461 $51.4M 0.22% +637,733 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 1,547,090 $48.4M 0.28% 0 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 1,436,229 $44.9M 1.26% +326,229 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 1,070,624 $33.5M -108,107 Timeline TRV GP VI, LLC More: the full row for TRV GP VI, LLC 969,218 $30.3M 22.37% 0 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 866,456 $27.1M <0.01% -15,153 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 759,552 $23.8M <0.01% +44,731 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 721,622 $22.6M <0.01% +26,888 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 727,843 $22.1M 0.01% -60,568 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 673,923 $21.1M 0.42% 0 13F-HR/A Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 641,469 $20.1M 0.56% -67,000 13F-HR Timeline Group T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 620,600 $19.4M 0.01% +1,571 13F-HR Timeline Capital World Investors More: the full row for Capital World Investors 536,607 $16.8M <0.01% new 13F-HR Timeline Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 366,809 $11.5M 1.65% +181,544 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 319,552 $10M 0.01% +117,727 13F-HR Timeline Group KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 257,431 $8.06M 0.17% +78,694 13F-HR Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 250,000 $7.82M 0.39% 0 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 239,917 $7.51M <0.01% -4,474 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 237,992 $7.45M <0.01% +17,177 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 224,498 $7.02M <0.01% +141,011 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 194,200 $6.08M 0.01% 0 13F-HR/A Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 185,925 $5.82M 0.03% new 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 175,449 $5.49M <0.01% -71,866 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 171,757 $5.37M <0.01% -95,363 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 165,954 $5.19M <0.01% -44,377 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 150,000 $4.69M 0.01% 0 13F-HR Timeline Group Artia Global Partners LP More: the full row for Artia Global Partners LP 138,508 $4.33M 0.98% 0 13F-HR Timeline Freestone Grove Partners LP More: the full row for Freestone Grove Partners LP 127,783 $4M 0.03% new 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 114,815 $3.59M <0.01% -140,152 13F-HR Timeline Group Swedbank AB in group Swedbank AB More: the full row for Swedbank AB 113,200 $3.54M <0.01% 0 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 110,826 $3.47M <0.01% +76,273 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 99,078 $3.1M <0.01% -16,112 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 78,799 $2.47M <0.01% +22,315 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 78,231 $2.45M <0.01% +21,774 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 75,359 $2.36M <0.01% -3,300 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 75,000 $2.35M 0.53% 0 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 72,948 $2.28M <0.01% +6,799 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 72,319 $2.26M <0.01% -1,762 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 71,508 $2.24M <0.01% +562 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 56,500 $1.77M <0.01% +1,900 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 56,292 $1.76M <0.01% +9,443 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 47,903 $1.5M 0.03% +34,841 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 38,907 $1.22M 0.01% -232 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 38,456 $1.2M +21,217 Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 35,952 $1.12M <0.01% +23,599 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 35,825 $1.12M 0.02% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 34,533 $1.08M <0.01% +3,807 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 33,426 $1.05M <0.01% +6,736 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 32,918 $1.03M <0.01% +30,636 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 30,819 $964K <0.01% +12,551 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 28,103 $879K <0.01% -22,516 13F-HR Timeline Group SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 25,421 $835K 0.69% -13,504 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 25,510 $798K <0.01% +4,632 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 24,169 $756K <0.01% +2,634 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 23,914 $748K <0.01% +15,617 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 20,984 $657K <0.01% -41,995 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 17,154 $537K <0.01% -5,230 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 16,104 $504K +539 Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 15,996 $501K <0.01% 0 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 15,519 $486K <0.01% +3,307 13F-HR Timeline Group VARCOV Co. More: the full row for VARCOV Co. 15,473 $484K 0.18% new 13F-HR Timeline OPTIMIZE FINANCIAL INC. More: the full row for OPTIMIZE FINANCIAL INC. 14,656 $459K 0.23% new 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 14,585 $456K <0.01% -209 13F-HR/A Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 15,846 $439K <0.01% +717 13F-HR/A Timeline Group PSP Research LLC More: the full row for PSP Research LLC 14,000 $438K 0.31% -3,506 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 13,800 $433K <0.01% 0 13F-HR/A Timeline Group Allianz Asset Management GmbH in group Allianz SE More: the full row for Allianz Asset Management GmbH 13,200 $413K <0.01% 0 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 12,058 $377K 0.03% +1,292 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 11,789 $367K <0.01% -32,502 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 11,148 $349K <0.01% new 13F-HR/A Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 11,116 $348K <0.01% -20,993 13F-HR/A Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 11,000 $344K <0.01% +3,700 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 10,000 $313K 0.01% new 13F-HR Timeline CATALYST PRIVATE WEALTH, LLC More: the full row for CATALYST PRIVATE WEALTH, LLC 10,000 $313K 0.17% 0 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 9,928 $311K 0.02% -2,805 13F-HR Timeline State of New Jersey Common Pension Fund… in group State of New Jersey Common Pe… More: the full row for State of New Jersey Common Pension Fund D 9,773 $306K <0.01% new 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 9,700 $304K <0.01% -109,114 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 9,611 $301K <0.01% -42,869 13F-HR Timeline Group CLEAR WAVE WEALTH MANAGEMENT LLC More: the full row for CLEAR WAVE WEALTH MANAGEMENT LLC 9,500 $297K 0.08% 13F-HR Timeline STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 9,023 $282K <0.01% +2,200 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 9,007 $282K 0.08% +218 13F-HR Timeline Group ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 7,854 $246K <0.01% +128 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 7,531 $236K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 7,471 $234K <0.01% 0 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 7,035 $220K <0.01% -991 13F-HR Timeline Allspring Global Investments Holdings, … in group Allspring Global Investments … More: the full row for Allspring Global Investments Holdings, LLC 6,868 $215K <0.01% new 13F-HR Timeline Group MANGROVE PARTNERS IM, LLC More: the full row for MANGROVE PARTNERS IM, LLC 6,753 $211K 0.02% new 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 6,612 $207K <0.01% new 13F-HR Timeline Quantbot Technologies LP More: the full row for Quantbot Technologies LP 6,493 $203K 0.01% new 13F-HR Timeline AlphaCentric Advisors LLC More: the full row for AlphaCentric Advisors LLC 6,438 $201K 0.2% +408 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 6,394 $200K <0.01% -914 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 5,900 $185K <0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 3,792 $119K <0.01% +3,362 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 3,776 $118K <0.01% -5,897 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,310 $72.3K <0.01% 0 13F-HR Timeline Group STRS OHIO More: the full row for STRS OHIO 2,100 $65.7K <0.01% 0 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 1,475 $46.2K <0.01% +7 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 1,353 $42.3K <0.01% 0 13F-HR Timeline Tidemark, LLC More: the full row for Tidemark, LLC 1,088 $34K 0.01% 0 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,070 $33.5K <0.01% +135 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 975 $30.5K <0.01% -665 13F-HR Timeline KBC Group NV in group KBC Group NV More: the full row for KBC Group NV 962 $30K <0.01% new 13F-HR Timeline Group BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 582 $18.2K <0.01% +162 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 513 $16.1K <0.01% new 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 378 $11.8K <0.01% +36 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 344 $10.8K <0.01% +317 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 225 $7K <0.01% -875 13F-HR Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 205 $6.41K <0.01% -20 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 204 $6.38K <0.01% +132 13F-HR/A Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 197 $6.16K <0.01% new 13F-HR Timeline MassMutual Private Wealth & Trust, FSB More: the full row for MassMutual Private Wealth & Trust, FSB 163 $5.1K <0.01% +2 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 147 $4.6K <0.01% +32 13F-HR/A Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 143 $4.47K <0.01% +88 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 116 $3.63K <0.01% +107 13F-HR Timeline Group Larson Financial Group LLC More: the full row for Larson Financial Group LLC 102 $3.19K <0.01% +19 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 63 $1.97K <0.01% 0 13F-HR Timeline QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 57 $1.78K <0.01% 0 13F-HR/A Timeline Cornerstone Financial Management LLC More: the full row for Cornerstone Financial Management LLC 49 $1.53K <0.01% 0 13F-HR/A Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 48 $1.5K <0.01% +1 13F-HR Timeline Group True Wealth Design, LLC More: the full row for True Wealth Design, LLC 44 $1.38K <0.01% 0 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 40 $1.25K <0.01% 0 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 27 $845 <0.01% new 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 20 $626 <0.01% new 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 11 $344 <0.01% 0 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 6 $188 <0.01% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 5 $156 <0.01% new 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 4 $126 <0.01% new 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 3 $94 <0.01% 0 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 5 $0 0% new 13F-HR Timeline Value filed as zero, left out of ratios.