TRV GP V, LLC More: the full row for TRV GP V, LLC 7,135,233 $127M 43.06% 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 5,486,468 $97.3M 0.01% 0 13F-HR Timeline Group ARCH Venture Management, LLC More: the full row for ARCH Venture Management, LLC 3,728,738 $66.1M 28.73% 0 13F-HR Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 2,940,921 $52.2M 2.87% 0 13F-HR Timeline Capital International Investors in group Capital International Investo… More: the full row for Capital International Investors 2,602,529 $46.2M 0.01% 0 13F-HR Timeline Group JOHNSON & JOHNSON in group JOHNSON & JOHNSON More: the full row for JOHNSON & JOHNSON 2,498,051 $44.3M 11.48% 0 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 1,995,594 $35.4M 2.59% 0 13F-HR Timeline T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 1,636,931 $29M 0.02% -90,180 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,252,136 $22.2M <0.01% +4,965 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,143,384 $20.3M <0.01% +95,976 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 1,098,415 $19.5M 0.01% +9,494 13F-HR Timeline TRV GP VI, LLC More: the full row for TRV GP VI, LLC 969,218 $17.2M 14.71% 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 756,543 $13.4M <0.01% +180,425 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 555,473 $9.85M <0.01% +48,706 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 487,458 $8.65M 0.01% 0 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 384,197 $6.82M 0.3% 0 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 311,551 $5.53M 0.15% -436,632 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 210,676 $3.74M <0.01% +8,928 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 208,910 $3.71M 0.43% 0 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 181,530 $3.22M 0.02% -5,030 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 177,906 $3.16M <0.01% +115,708 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 167,538 $2.97M <0.01% +109,492 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 77,275 $1.37M <0.01% -69 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 73,509 $1.3M <0.01% +363 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 72,826 $1.29M <0.01% +614 13F-HR Timeline Group JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 62,287 $1.1M <0.01% new 13F-HR Timeline NORGES BANK More: the full row for NORGES BANK 48,452 $860K <0.01% -21,548 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 29,580 $525K <0.01% new 13F-HR Timeline Group Crestline Management, L.P. More: the full row for Crestline Management, L.P. 27,496 $488K 0.02% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 22,636 $402K <0.01% -1,592 13F-HR/A Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 21,328 $378K <0.01% +15,771 13F-HR Timeline Group LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 20,000 $355K 0.01% 0 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 19,968 $354K <0.01% -2 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 18,497 $328K <0.01% +5,634 13F-HR/A Timeline Group Swiss National Bank More: the full row for Swiss National Bank 18,000 $319K <0.01% new 13F-HR Timeline ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 16,400 $291K 0.29% -1,200 13F-HR Timeline Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 12,068 $214K <0.01% 0 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 10,249 $182K <0.01% -5,594 13F-HR/A Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 9,577 $170K <0.01% -3,197 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 9,523 $169K <0.01% +8,614 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 8,571 $152K <0.01% +7,886 13F-HR/A Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 7,756 $138K 0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 7,170 $127K <0.01% +3,137 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 6,524 $117K +1,447 Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 6,578 $117K <0.01% -12,532 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 5,710 $101K <0.01% 0 13F-HR Timeline Group Sandia Investment Management LP More: the full row for Sandia Investment Management LP 5,000 $88.7K 0.17% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 4,824 $85.6K <0.01% +1,352 13F-HR Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 4,618 $81.9K <0.01% -349 13F-HR Timeline Group VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 3,740 $66.3K 0.03% new 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 3,500 $62.1K <0.01% new 13F-HR/A Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 2,317 $41.1K <0.01% new 13F-HR/A Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 2,003 $35.5K <0.01% 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 1,900 $33.7K <0.01% 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 1,700 $30.2K <0.01% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,412 $25K <0.01% -272 13F-HR Timeline Group Tidemark, LLC More: the full row for Tidemark, LLC 1,088 $19.3K 0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 992 $18K <0.01% -480 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 941 $16.7K <0.01% 0 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 768 $13.6K <0.01% 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 741 $13.1K <0.01% +484 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 317 $6K <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 143 $2.54K <0.01% +124 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 121 $2K <0.01% new 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 18 $319 <0.01% new 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 10 $177 <0.01% new 13F-HR Timeline Aster Capital Management (DIFC) Ltd More: the full row for Aster Capital Management (DIFC) Ltd 5 $89 <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 1 $18 <0.01% new 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 11 $0 0% new 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.