AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 11,510,320 $20.1M <0.01% +4,599,083 13F-HR/A Timeline Group B Group, Inc. More: the full row for B Group, Inc. 11,414,285 $20M 14.81% +6,914,285 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 10,689,452 $18.8M 0.01% +149,118 13F-HR/A Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 10,276,317 $18M 1.99% +708,419 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 8,928,149 $15.6M 0.31% -3,121,851 13F-HR/A Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 7,181,062 $12.6M 0.73% -4,263,938 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 7,124,116 $12.5M 0.13% 0 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 5,785,189 $10.1M <0.01% +692,627 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 5,373,951 $9.4M <0.01% +4,816,386 13F-HR Timeline Group Eversept Partners, LP More: the full row for Eversept Partners, LP 4,987,499 $8.73M 0.58% -404,049 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 4,799,875 $8.4M 1.1% 0 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 4,551,533 $7.97M <0.01% +409,087 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 4,500,000 $7.88M 0.01% 0 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 3,405,757 $5.96M 1.46% new 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 3,270,845 $5.72M 0.01% +2,945,478 13F-HR Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 3,136,607 $5.49M 0.01% new 13F-HR Timeline Group Squadron Capital Management LLC More: the full row for Squadron Capital Management LLC 3,000,000 $5.25M 2.1% -1,500,000 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 2,904,911 $5.08M <0.01% new 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 2,754,403 $4.82M 0.01% new 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 2,500,000 $4.38M 0.12% new 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 2,333,000 $4.08M 0.09% +461,580 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 2,264,845 $3.96M 0.24% +260,000 13F-HR Timeline Group VANGUARD GROUP INC group of 3 filers holding More: the full row for VANGUARD GROUP INC 2,140,889 $3.75M new Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 2,103,353 $3.68M <0.01% +1,808,867 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 2,019,326 $3.53M 0.98% +719,295 13F-HR Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 1,992,367 $3.49M 0.79% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,876,340 $3.28M <0.01% -2,979 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 1,733,471 $3.03M 0.52% +1,549,371 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,546,240 $2.71M <0.01% -19,212 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 1,454,400 $2.55M <0.01% -928,100 13F-HR Timeline PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 1,231,414 $2.15M 0.54% +567,327 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 1,166,951 $2.04M <0.01% +919,197 13F-HR Timeline Group Propel Bio Management, LLC More: the full row for Propel Bio Management, LLC 1,115,000 $2M 1.26% new 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 662,900 $1.16M <0.01% new 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 636,197 $1.11M <0.01% -7,800 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 600,000 $1.05M 0.62% -158,203 13F-HR Timeline Creek Drive Management Group LLC More: the full row for Creek Drive Management Group LLC 540,000 $945K 0.59% +232,500 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 411,772 $721K <0.01% -10,083,480 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 410,761 $719K <0.01% +67,075 13F-HR Timeline Group Simplify Asset Management Inc. More: the full row for Simplify Asset Management Inc. 350,000 $612K 0.01% new 13F-HR Timeline LANDSCAPE CAPITAL MANAGEMENT, L.L.C. in group LANDSCAPE CAPITAL MANAGEMENT,… More: the full row for LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 325,019 $569K 0.04% new 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 280,650 $491K <0.01% -2,497 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 274,978 $481K 0.07% 0 13F-HR Timeline Group ACT CAPITAL MANAGEMENT, LLC More: the full row for ACT CAPITAL MANAGEMENT, LLC 257,500 $451K 0.35% +107,500 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 236,348 $414K 0.16% -179,687 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 214,821 $376K <0.01% new 13F-HR Timeline Group Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 213,100 $373K 0.12% -114,400 13F-HR/A Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 211,882 $370K <0.01% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 204,590 $358K 0.01% +182,921 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 197,074 $345K <0.01% +126,977 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 196,939 $345K <0.01% -125,151 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 189,261 $331K <0.01% new 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 169,648 $297K 0.01% +37,000 13F-HR Timeline BIT Capital GmbH More: the full row for BIT Capital GmbH 155,000 $271K 0.02% -150,000 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 148,970 $261K <0.01% new 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 133,131 $233K 0.02% new 13F-HR Timeline Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 111,410 $195K 0.02% +40,700 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 110,154 $193K <0.01% +95,000 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 105,832 $185K 0.01% new 13F-HR Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 88,000 $172K 0.14% new 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 89,386 $156K <0.01% -567,074 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 87,704 $153K <0.01% +35,423 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 83,300 $146K <0.01% -24,700 13F-HR Timeline EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 79,495 $139K 0.04% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 76,000 $133K <0.01% new 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 53,842 $94.2K <0.01% +52,817 13F-HR Timeline Group Diametric Capital, LP More: the full row for Diametric Capital, LP 51,874 $90.8K 0.02% new 13F-HR Timeline Vontobel Holding Ltd. in group Vontobel Holding Ltd. More: the full row for Vontobel Holding Ltd. 45,000 $78.8K <0.01% +25,000 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 43,730 $77K <0.01% new 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 34,875 $61K <0.01% -11,886 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 33,146 $58K <0.01% +21,915 13F-HR Timeline Catalyst Funds Management Pty Ltd More: the full row for Catalyst Funds Management Pty Ltd 31,400 $55K 0.01% new 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 27,640 $48.4K <0.01% 0 13F-HR Timeline Group Total Clarity Wealth Management, Inc. More: the full row for Total Clarity Wealth Management, Inc. 27,000 $47.2K 0.01% -2,935 13F-HR Timeline CTC Alternative Strategies, Ltd. More: the full row for CTC Alternative Strategies, Ltd. 17,441 $30.5K 0.07% new 13F-HR Timeline NFSG Corp More: the full row for NFSG Corp 17,000 $29.8K <0.01% +2,000 13F-HR Timeline COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 16,500 $28.9K <0.01% -150 13F-HR Timeline VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 16,454 $28.8K <0.01% +382 13F-HR Timeline CHOREO, LLC More: the full row for CHOREO, LLC 15,743 $27.6K <0.01% new 13F-HR Timeline LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 15,400 $26.9K <0.01% new 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 15,346 $26.9K <0.01% new 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 14,272 $25K <0.01% -1,687,139 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 13,125 $23K <0.01% new 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 12,912 $22.6K <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 12,177 $21.3K <0.01% -22,327 13F-HR Timeline RFG Advisory, LLC More: the full row for RFG Advisory, LLC 11,750 $20.6K <0.01% new 13F-HR Timeline WINTON GROUP Ltd in group WINTON GROUP Ltd More: the full row for WINTON GROUP Ltd 11,500 $20.1K <0.01% -3,391 13F-HR Timeline Group Cetera Investment Advisers More: the full row for Cetera Investment Advisers 10,506 $18.4K <0.01% -6 13F-HR Timeline FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 9,951 $17K 0.01% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 2,230 $3.9K <0.01% -12,550 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 2,066 $3.62K <0.01% +2,000 13F-HR Timeline Group Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 500 $875 <0.01% 0 13F-HR Timeline Group Quantbot Technologies LP More: the full row for Quantbot Technologies LP 381 $667 <0.01% new 13F-HR Timeline Avion Wealth More: the full row for Avion Wealth 500 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios.