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Sio Capital Management, LLC

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13F filer, CIK 1482416, NEW YORK, NY

Sio Capital Management, LLC reported $395,154,620 across 51 holdings for the quarter ended 2025-09-30, in a 13F-HR filed 2025-11-13. Its ten largest share positions make up 59.5% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001214659-25-016415

Period
2025-09-30
Reported value
$395M
Holdings
51
Top 10 weight
59.5%
New
15
Sold out
16

Largest buys vs the previous quarter

SecurityShares changeApprox. value
CELCnew+786,526$38.9M
ALKSnew+674,840$20.2M
SNYadded+375,203$17.7M
HSICnew+219,207$14.5M
KVUEnew+844,000$13.7M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
DRUGreduced-321,574-$19.5M
GMEDexited-245,570-$14.5M
NBIXexited-100,725-$12.7M
ANNXexited-4,095,764-$9.83M
SEPNreduced-395,236-$7.43M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q3 2025

Share positions as resolved from 13F-HR 0001214659-25-016415, largest first. % of portfolio is the value over $395,154,620, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
MMSMAXIMUS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 155,142 shares; 2024Q4: 381,423 shares; 2025Q1: 468,352 shares; 2025Q2: 548,086 shares; 2025Q3: 557,615 shares 557,615$50.9M12.89%+9,529Timeline
CELCCELCUITY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 786,526 shares 786,526$38.9M9.83%newTimeline
SNYSANOFI SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 387,000 shares; 2025Q1: not reported; 2025Q2: 187,500 shares; 2025Q3: 562,703 shares 562,703$26.6M6.72%+375,203Timeline
DNTHDIANTHUS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 116,997 shares; 2025Q2: 236,070 shares; 2025Q3: 577,750 shares 577,750$22.7M5.75%+341,680Timeline
ALKSALKERMES PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 674,840 shares 674,840$20.2M5.12%newTimeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 187,941 shares; 2024Q4: 73,511 shares; 2025Q1: 73,511 shares; 2025Q2: 284,787 shares; 2025Q3: 284,787 shares 284,787$18.8M4.76%0Timeline
MRKMERCK & CO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 270,596 shares; 2025Q2: 173,951 shares; 2025Q3: 177,300 shares 177,300$14.9M3.77%+3,349Timeline
HSICSCHEIN HENRY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 219,207 shares 219,207$14.5M3.68%newTimeline
CNCCENTENE CORP DELQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 262,500 shares; 2025Q3: 387,600 shares 387,600$13.8M3.5%+125,100Timeline
KVUEKENVUE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 474,741 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 844,000 shares 844,000$13.7M3.47%newTimeline
BMRNBIOMARIN PHARMACEUTICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 141,134 shares; 2025Q2: 225,114 shares; 2025Q3: 225,114 shares 225,114$12.2M3.09%0Timeline
GSKGSK PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 268,873 shares 268,873$11.6M2.94%newTimeline
DRUGBRIGHT MINDS BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 451,793 shares; 2025Q1: 507,562 shares; 2025Q2: 512,338 shares; 2025Q3: 190,764 shares 190,764$11.6M2.93%-321,574Timeline
HAEHAEMONETICS CORP MASSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 133,966 shares; 2025Q2: not reported; 2025Q3: 198,035 shares 198,035$9.65M2.44%newTimeline
AQSTAQUESTIVE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 391,629 shares; 2025Q2: 947,489 shares; 2025Q3: 1,498,095 shares 1,498,095$8.37M2.12%+550,606Timeline
KALVKALVISTA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 683,819 shares 683,819$8.33M2.11%newTimeline
AVRANTERIS TECHNOLOGIES GLOBALQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,370,000 shares; 2025Q1: 2,369,960 shares; 2025Q2: 1,839,022 shares; 2025Q3: 1,772,601 shares 1,772,601$7.98M2.02%-66,421Timeline
CRNXCRINETICS PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 174,841 shares 174,841$7.28M1.84%newTimeline
TYRATYRA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 400,870 shares; 2024Q4: 240,870 shares; 2025Q1: 416,617 shares; 2025Q2: 810,274 shares; 2025Q3: 514,947 shares 514,947$7.2M1.82%-295,327Timeline
RAPPRAPPORT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 185,265 shares 185,265$5.5M1.39%newTimeline
NVCRNOVOCURE LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 413,829 shares 413,829$5.35M1.35%newTimeline
ANIPANI PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 160,051 shares; 2025Q1: 87,298 shares; 2025Q2: 112,923 shares; 2025Q3: 55,723 shares 55,723$5.1M1.29%-57,200Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 539,730 shares; 2025Q3: 307,181 shares 307,181$4.98M1.26%-232,549Timeline
TFXTELEFLEX INCORPORATEDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 39,272 shares; 2024Q4: 66,772 shares; 2025Q1: 107,780 shares; 2025Q2: not reported; 2025Q3: 40,057 shares 40,057$4.9M1.24%newTimeline
SLPSIMULATIONS PLUS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 320,307 shares 320,307$4.83M1.22%newTimeline
PRQRPROQR THRAPEUTICS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,054,593 shares; 2025Q1: 2,054,593 shares; 2025Q2: 2,075,139 shares; 2025Q3: 2,075,139 shares 2,075,139$4.42M1.12%0Timeline
SISHOULDER INNOVATIONS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 350,000 shares 350,000$4.39M1.11%newTimeline
PMVPPMV PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,214,239 shares; 2024Q4: 3,572,167 shares; 2025Q1: 3,735,396 shares; 2025Q2: 3,735,396 shares; 2025Q3: 2,636,548 shares 2,636,548$3.69M0.93%-1,098,848Timeline
SEPNSEPTERNA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 271,687 shares; 2025Q1: 788,670 shares; 2025Q2: 584,435 shares; 2025Q3: 189,199 shares 189,199$3.56M0.9%-395,236Timeline
IDYAIDEAYA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 123,000 shares; 2024Q4: 123,000 shares; 2025Q1: 123,000 shares; 2025Q2: 124,230 shares; 2025Q3: 124,230 shares 124,230$3.38M0.86%0Timeline
ALGSALIGOS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 180,720 shares; 2025Q2: 335,937 shares; 2025Q3: 335,937 shares 335,937$3.29M0.83%0Timeline
ERASERASCA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,219,186 shares; 2024Q4: 1,356,186 shares; 2025Q1: 1,356,186 shares; 2025Q2: 1,369,748 shares; 2025Q3: 1,369,748 shares 1,369,748$2.99M0.76%0Timeline
VIRVIR BIOTECHNOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,054,651 shares; 2025Q1: 473,607 shares; 2025Q2: 478,343 shares; 2025Q3: 478,343 shares 478,343$2.73M0.69%0Timeline
SVRASAVARA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 3,747 shares; 2025Q1: 719,654 shares; 2025Q2: 726,851 shares; 2025Q3: 726,851 shares 726,851$2.59M0.66%0Timeline
VTYXVENTYX BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,971,948 shares; 2024Q4: 4,046,797 shares; 2025Q1: 2,582,655 shares; 2025Q2: 1,307,964 shares; 2025Q3: 829,178 shares 829,178$2.58M0.65%-478,786Timeline
NMTCNEUROONE MED TECHNOLOGIES COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 3,523,663 shares; 2025Q3: 2,360,635 shares 2,360,635$2.1M0.53%-1,163,028Timeline
OVIDOVID THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 1,000,000 shares; 2025Q1: 2,232,000 shares; 2025Q2: 2,232,000 shares; 2025Q3: 1,427,495 shares 1,427,495$1.86M0.47%-804,505Timeline
BBOTBRIDGEBIO ONCOLOGY THERAPEUTQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 130,628 shares 130,628$1.51M0.38%newTimeline
CNTXCONTEXT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,328,352 shares; 2024Q4: 1,328,352 shares; 2025Q1: 1,328,352 shares; 2025Q2: 1,341,636 shares; 2025Q3: 1,341,636 shares 1,341,636$1.3M0.33%0Timeline
SENSEONICS HLDGS INCSENSEONICS HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 4,852,298 shares; 2025Q3: 2,315,749 shares 2,315,749$1.01M0.26%-2,536,549
TELATELA BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 630,000 shares; 2025Q1: 630,000 shares; 2025Q2: 636,300 shares; 2025Q3: 636,300 shares 636,300$948K0.24%0Timeline
AVTXAVALO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 71,458 shares; 2024Q4: 71,458 shares; 2025Q1: 71,458 shares; 2025Q2: 72,173 shares; 2025Q3: 72,173 shares 72,173$917K0.23%0Timeline
FHTXFOGHORN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 121,672 shares; 2024Q4: 121,672 shares; 2025Q1: 121,672 shares; 2025Q2: 122,889 shares; 2025Q3: 122,889 shares 122,889$601K0.15%0Timeline
MODDMODULAR MED INC COM NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 120,772 shares; 2024Q4: 251,990 shares; 2025Q1: 251,990 shares; 2025Q2: 785,824 shares; 2025Q3: 785,824 shares 785,824$550K0.14%0Timeline
NYXHNYXOAH S AQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 50,839 shares; 2024Q4: 50,839 shares; 2025Q1: 50,839 shares; 2025Q2: 50,839 shares; 2025Q3: 50,839 shares 50,839$234K0.06%0Timeline
BOLDBOUNDLESS BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 162,058 shares; 2024Q4: 162,058 shares; 2025Q1: 162,058 shares; 2025Q2: 163,679 shares; 2025Q3: 163,679 shares 163,679$201K0.05%0Timeline
APREAPREA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 276,603 shares; 2024Q4: 276,603 shares; 2025Q1: 276,603 shares; 2025Q2: 279,369 shares; 2025Q3: 112,223 shares 112,223$166K0.04%-167,146Timeline
TERNTERNS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 10,000 shares; 2024Q4: 10,000 shares; 2025Q1: 10,000 shares; 2025Q2: 10,100 shares; 2025Q3: 10,100 shares 10,100$75.9K0.02%0Timeline
NXTCNEXTCURE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 10,940 shares 10,940$64.1K0.02%newTimeline
RCKTWROCKET PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 400,000 shares; 2024Q4: 400,000 shares; 2025Q1: 400,000 shares; 2025Q2: 400,000 shares; 2025Q3: 400,000 shares 400,000$14.4K<0.01%0Timeline
HUMAWHUMACYTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 49,998 shares; 2024Q4: 49,998 shares; 2025Q1: 49,998 shares; 2025Q2: 49,998 shares; 2025Q3: 49,998 shares 49,998$12.2K<0.01%0Timeline

Sold out in Q3 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
GMEDGLOBUS MED INC245,570$14.5Mshares
NBIXNEUROCRINE BIOSCIENCES INC100,725$12.7Mshares
ANNXANNEXON INC4,095,764$9.83Mshares
IDXXIDEXX LABS INC18,000$9.65Mput
AORTARTIVION INC158,736$4.94Mshares
AVNSAVANOS MED INC288,849$3.54Mshares
MERUS N VMERUS N V62,719$3.3Mshares
INMBINMUNE BIO INC1,299,300$3Mput
MBXMBX BIOSCIENCES INC241,000$2.75Mshares
TVTXTRAVERE THERAPEUTICS INC122,210$1.81Mshares
ASTRIA THERAPEUTICS INCASTRIA THERAPEUTICS INC318,256$1.71Mshares
ENTAENANTA PHARMACEUTICALS INC178,774$1.35Mshares
ALECALECTOR INC845,531$1.18Mshares
EMBCEMBECTA CORP31,169$302Kshares
NEXTCURE INCNEXTCURE INC131,300$60.4Kshares
ATYRATYR PHARMA INC1,100$5.58Kput

How Q3 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001214659-25-016415 base2025-11-13acceptance time not in the bulk data set