FMR LLC in group FMR LLC More: the full row for FMR LLC 13,834,875 $490M 0.03% +40,385 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 9,250,005 $328M 16.95% 0 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 8,761,650 $310M 0.04% -132,236 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 6,695,880 $237M <0.01% -611,389 13F-HR Timeline Group SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 5,612,896 $199M 40.66% 0 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 4,861,594 $172M <0.01% +16,389 13F-HR Timeline Group Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 3,929,039 $139M 14.81% -469,242 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 3,074,296 $109M <0.01% -59,844 13F-HR Timeline Group Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 2,947,295 $104M 2.3% +440,405 13F-HR Timeline Group EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 2,913,246 $103M 1.81% +251,638 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 2,450,286 $86.7M 0.04% +780,099 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 2,024,865 $71.7M 0.01% +179,868 13F-HR Timeline Group Hood River Capital Management LLC More: the full row for Hood River Capital Management LLC 1,974,964 $70M 0.98% +30,806 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,887,410 $66.9M <0.01% +39,961 13F-HR Timeline Group Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 1,824,031 $64.6M 8.37% +450,000 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 1,640,437 $58.1M 0.07% +5,137 13F-HR Timeline Group Paradigm Biocapital Advisors LP in group Paradigm Biocapital Advisors … More: the full row for Paradigm Biocapital Advisors LP 1,600,554 $56.7M 2.42% new 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 1,500,000 $53.1M 0.28% -1,083,371 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 1,500,000 $53.1M 2.8% +200,000 13F-HR Timeline Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 1,450,000 $51.4M 3.63% -295,000 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,289,973 $45.7M 0.01% -114,450 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 1,215,000 $43M 0.07% -803,000 13F-HR Timeline Group Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 1,177,515 $41.7M 0.33% +663,423 13F-HR Timeline NORGES BANK More: the full row for NORGES BANK 1,175,278 $41.6M 0.01% -458,144 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 1,136,453 $40.3M 0.68% 0 13F-HR Timeline Group Capital World Investors More: the full row for Capital World Investors 1,128,752 $40M 0.01% 0 13F-HR Timeline Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 987,464 $35M 0.04% +898,437 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 976,625 $34.6M 0.03% +9,076 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 944,432 $33.5M 0.18% +84,125 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 933,432 $33.1M 0.08% new 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 904,387 $32M <0.01% +50,950 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 794,133 $28.1M 1.75% +32,592 13F-HR Timeline Nationale-Nederlanden Powszechne Towarz… More: the full row for Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. 769,442 $27.3M 3.22% +455,753 13F-HR Timeline LOOMIS SAYLES & CO L P in group LOOMIS SAYLES & CO L P More: the full row for LOOMIS SAYLES & CO L P 742,939 $26.3M 0.03% -17,706 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 736,786 $26.1M <0.01% -28,494 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 692,676 $24.5M 0.01% +28,749 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 644,232 $22.8M <0.01% +317,847 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 635,891 $22.5M <0.01% +18,784 13F-HR Timeline Group Man Group plc in group Man Group plc More: the full row for Man Group plc 601,153 $21.3M 0.05% -386,557 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 600,639 $21.3M 0.04% +264,693 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 544,112 $19.3M +197,022 Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 528,115 $18.7M 6.02% -38,097 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 496,553 $17.6M <0.01% +99,211 13F-HR Timeline Group LORD, ABBETT & CO. LLC More: the full row for LORD, ABBETT & CO. LLC 474,144 $16.8M 0.05% -403,230 13F-HR Timeline Fisher Asset Management, LLC More: the full row for Fisher Asset Management, LLC 412,411 $14.6M 0.01% -44,460 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 407,686 $14.4M <0.01% +407,581 13F-HR/A Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 375,316 $13.3M 0.01% +241,134 13F-HR Timeline Group JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 365,946 $13M 0.01% new 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 341,010 $12.1M 2.47% new 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 339,333 $12M 0.07% -157,423 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 333,626 $11.8M 0.01% -5,390 13F-HR Timeline Franklin Resources group of 2 filers holding More: the full row for Franklin Resources 322,549 $11.4M -32,493 Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 291,200 $10.3M 0.01% -26,200 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 285,320 $10.1M <0.01% +128,949 13F-HR/A Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 273,587 $9.69M <0.01% +198,440 13F-HR Timeline Group Eagle Health Investments LP More: the full row for Eagle Health Investments LP 269,400 $9.54M 2.36% new 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 241,000 $8.54M 0.02% +238,791 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 225,897 $8M -268,440 Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 222,430 $7.88M <0.01% +6,207 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 209,206 $7.41M 0.01% -6,199 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 191,998 $6.8M 0.01% +131,458 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 171,948 $6.09M <0.01% -7,975 13F-HR Timeline Group Patient Square Capital LP More: the full row for Patient Square Capital LP 154,000 $5.45M 1.97% 0 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 153,886 $5.45M 0.01% -29,046 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 136,283 $4.83M <0.01% -181,362 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 132,348 $4.69M 0.01% new 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 127,000 $4.5M <0.01% 0 13F-HR Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 126,285 $4.47M 1.15% -45,900 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 125,477 $4.44M <0.01% +64,098 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 125,381 $4.44M <0.01% +4,629 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 125,000 $4.43M 0.31% -160,000 13F-HR Timeline Tetragon Partners GP Ltd in group Tetragon Partners GP Ltd More: the full row for Tetragon Partners GP Ltd 103,482 $3.67M 0.66% new 13F-HR Timeline Group Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 100,000 $3.54M 0.33% -25,000 13F-HR Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 99,855 $3.54M 0.01% -11,816 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 97,334 $3.45M -83,925 Timeline AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 92,992 $3.29M 0.01% -12,968 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 89,145 $3.16M <0.01% +7,913 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 84,339 $2.99M 2.46% 0 13F-HR/A Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 82,110 $2.91M <0.01% 0 13F-HR Timeline Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 76,738 $2.72M <0.01% +60,796 13F-HR Timeline Group VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 73,902 $2.62M <0.01% +21,274 13F-HR Timeline Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 73,375 $2.6M 0.11% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 71,795 $2.54M <0.01% +5,076 13F-HR Timeline Group Moody Aldrich Partners LLC More: the full row for Moody Aldrich Partners LLC 66,261 $2.35M 0.45% +38,895 13F-HR Timeline E. Ohman J:or Asset Management AB More: the full row for E. Ohman J:or Asset Management AB 64,568 $2.29M 0.06% +7,383 13F-HR Timeline Jasper Ridge Partners, L.P. More: the full row for Jasper Ridge Partners, L.P. 64,169 $2.27M 0.06% 0 13F-HR Timeline DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 62,926 $2.23M 1.39% +5,003 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 62,372 $2.21M <0.01% +577 13F-HR Timeline Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 62,347 $2.21M 0.33% -29,691 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 61,964 $2.19M <0.01% +7,027 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 61,607 $2.18M 1.42% new 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 57,497 $2.04M 0.53% -20,696 13F-HR Timeline Group RICE HALL JAMES & ASSOCIATES, LLC More: the full row for RICE HALL JAMES & ASSOCIATES, LLC 56,716 $2.01M 0.11% +3,153 13F-HR Timeline KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 54,556 $1.93M 0.05% +46,722 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 53,043 $1.88M -3,171 Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 51,668 $1.83M <0.01% -97,016 13F-HR Timeline Group EFG Asset Management (North America) Co… More: the full row for EFG Asset Management (North America) Corp. 51,478 $1.82M 0.26% new 13F-HR Timeline MASTERS CAPITAL MANAGEMENT LLC More: the full row for MASTERS CAPITAL MANAGEMENT LLC 50,000 $1.77M 0.34% new 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 49,964 $1.77M <0.01% -24,927 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 49,179 $1.74M 0.58% -195,000 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 48,363 $1.71M 0.01% +2,314 13F-HR Timeline Group Cinctive Capital Management LP More: the full row for Cinctive Capital Management LP 45,422 $1.61M 0.09% new 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 45,291 $1.6M 0.02% -11,493 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 43,302 $1.53M <0.01% +2,558 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 43,000 $1.52M 0.03% +33,000 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 39,677 $1.41M 0.23% -117,402 13F-HR Timeline Group DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 38,000 $1.36M <0.01% 0 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 36,103 $1.28M 0.03% new 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 35,300 $1.25M <0.01% -317 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 31,230 $1.11M 0.41% 0 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 30,104 $1.07M 0.01% +14,402 13F-HR Timeline AMI ASSET MANAGEMENT CORP More: the full row for AMI ASSET MANAGEMENT CORP 29,601 $1.05M 0.06% new 13F-HR Timeline Skandinaviska Enskilda Banken AB (publ) More: the full row for Skandinaviska Enskilda Banken AB (publ) 28,599 $1.01M <0.01% 0 13F-HR Timeline Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 26,440 $937K 0.06% -89,677 13F-HR Timeline DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. in group DYMON ASIA CAPITAL (SINGAPORE… More: the full row for DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. 26,000 $921K 0.65% new 13F-HR Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 25,426 $901K 0.02% -2,191 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 25,286 $896K <0.01% 0 13F-HR/A Timeline TEACHERS RETIREMENT SYSTEM OF THE STATE… More: the full row for TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 24,019 $851K 0.01% 0 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 23,944 $848K 0.08% -4,900 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 23,737 $841K <0.01% +5,180 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 23,503 $832K <0.01% -33,791 13F-HR Timeline Group Polar Asset Management Partners Inc. More: the full row for Polar Asset Management Partners Inc. 21,400 $758K 0.02% +13,226 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 21,346 $756K 0.03% -2,252 13F-HR Timeline FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 21,100 $747K <0.01% new 13F-HR Timeline Group Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 21,000 $744K <0.01% -800 13F-HR Timeline EXCHANGE TRADED CONCEPTS, LLC More: the full row for EXCHANGE TRADED CONCEPTS, LLC 20,770 $736K 0.01% +2,589 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 20,767 $736K <0.01% +1,045 13F-HR Timeline Group ProShare Advisors LLC More: the full row for ProShare Advisors LLC 20,194 $715K <0.01% -1,502 13F-HR Timeline Values First Advisors, Inc. More: the full row for Values First Advisors, Inc. 20,125 $713K 0.39% +1,917 13F-HR Timeline CANADA LIFE ASSURANCE Co in group CANADA LIFE ASSURANCE Co More: the full row for CANADA LIFE ASSURANCE Co 19,567 $693K <0.01% 0 13F-HR Timeline Group ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 19,360 $686K <0.01% +593 13F-HR Timeline DNB Asset Management AS in group DNB Asset Management AS More: the full row for DNB Asset Management AS 19,211 $680K <0.01% +1,485 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 19,069 $675K 0.06% +78 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 18,150 $643K 0.01% +978 13F-HR Timeline Thrivent Financial for Lutherans in group Thrivent Financial for Luther… More: the full row for Thrivent Financial for Lutherans 18,037 $639K <0.01% new 13F-HR/A Timeline Group TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 17,849 $632K <0.01% +275 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 16,000 $567K 0.56% 0 13F-HR Timeline Allianz Asset Management GmbH in group Allianz SE More: the full row for Allianz Asset Management GmbH 15,400 $545K <0.01% -9,600 13F-HR Timeline Group STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 15,210 $539K <0.01% 0 13F-HR Timeline NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 15,153 $537K 0.01% new 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 15,153 $537K 0.14% new 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 14,314 $507K 0.44% +1,211 13F-HR Timeline LPL Financial LLC More: the full row for LPL Financial LLC 14,286 $506K <0.01% +993 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 14,100 $499K <0.01% +1,700 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 13,532 $479K <0.01% +244 13F-HR Timeline Group Clarius Group, LLC More: the full row for Clarius Group, LLC 13,422 $475K 0.03% 0 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 12,891 $457K <0.01% +4,379 13F-HR Timeline Group LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 11,575 $410K <0.01% -220 13F-HR Timeline E Fund Management Co., Ltd. More: the full row for E Fund Management Co., Ltd. 11,146 $395K 0.02% +710 13F-HR Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 10,380 $368K 0.24% new 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 10,280 $364K <0.01% new 13F-HR Timeline Group CIBC WORLD MARKETS CORP More: the full row for CIBC WORLD MARKETS CORP 10,003 $354K <0.01% -7,837 13F-HR Timeline SYON CAPITAL LLC More: the full row for SYON CAPITAL LLC 9,524 $337K 0.02% -38 13F-HR Timeline Spire Wealth Management in group Spire Wealth Management More: the full row for Spire Wealth Management 9,455 $335K 0.01% 0 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 9,319 $330K 0.01% -61,355 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 9,318 $330K <0.01% -190,937 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 9,115 $323K 0.01% +6,768 13F-HR Timeline Group Glenmede Investment Management, LP More: the full row for Glenmede Investment Management, LP 8,781 $311K <0.01% 13F-HR Timeline J. Goldman & Co LP More: the full row for J. Goldman & Co LP 8,688 $308K 0.01% -31,402 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 8,109 $287K 0.01% 0 13F-HR Timeline Group Mill Creek Capital Advisors, LLC More: the full row for Mill Creek Capital Advisors, LLC 7,500 $266K 0.01% new 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 7,128 $252K <0.01% +289 13F-HR Timeline Group GUGGENHEIM CAPITAL LLC in group GUGGENHEIM CAPITAL LLC More: the full row for GUGGENHEIM CAPITAL LLC 7,052 $250K <0.01% -319 13F-HR Timeline Group FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 7,000 $248K <0.01% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. OP Asset Management Ltd More: the full row for OP Asset Management Ltd 6,990 $248K <0.01% new 13F-HR/A Timeline M&T Bank Corp in group M&T Bank Corp More: the full row for M&T Bank Corp 6,966 $247K <0.01% +288 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 6,526 $231K 0.01% -6,601 13F-HR Timeline Group SIG BROKERAGE, LP More: the full row for SIG BROKERAGE, LP 6,392 $226K 0.06% -586 13F-HR Timeline XPONANCE LLC More: the full row for XPONANCE LLC 6,346 $225K <0.01% new 13F-HR Timeline INCEPTIONR LLC More: the full row for INCEPTIONR LLC 5,793 $205K 0.05% new 13F-HR Timeline PRINCIPAL FINANCIAL GROUP INC group of 2 filers holding More: the full row for PRINCIPAL FINANCIAL GROUP INC 5,767 $204K -539 Timeline PUBLIC EMPLOYEES RETIREMENT ASSOCIATION… More: the full row for PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 5,738 $203K <0.01% 0 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 4,472 $158K <0.01% -2,640 13F-HR Timeline BIT Capital GmbH More: the full row for BIT Capital GmbH 4,278 $152K 0.01% -38,416 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 3,900 $138K <0.01% +1,500 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 3,000 $106K 0.01% -4,591 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 2,822 $100K 0.03% -1,117 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 2,771 $98K <0.01% 0 13F-HR Timeline ELEVATION POINT WEALTH PARTNERS, LLC More: the full row for ELEVATION POINT WEALTH PARTNERS, LLC 2,665 $94.4K 0.01% new 13F-HR/A Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 2,624 $92.9K 0.01% -2,793 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 2,396 $84.9K <0.01% 0 13F-HR Timeline Brooklyn Investment Group More: the full row for Brooklyn Investment Group 2,261 $80.1K 0.01% new 13F-HR/A Timeline KBC Group NV in group KBC Group NV More: the full row for KBC Group NV 2,055 $73K <0.01% -965 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 1,922 $68.1K <0.01% +141 13F-HR/A Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 1,836 $65K <0.01% +75 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,554 $55K <0.01% +706 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 1,050 $37.2K <0.01% -66 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 794 $28.1K <0.01% -168 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 653 $23K <0.01% -343 13F-HR Timeline Group BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 617 $22K <0.01% new 13F-HR Timeline Group Accent Capital Management, LLC More: the full row for Accent Capital Management, LLC 607 $21.5K 0.01% +207 13F-HR Timeline Compagnie Lombard Odier SCmA More: the full row for Compagnie Lombard Odier SCmA 550 $19.5K <0.01% new 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 510 $18.1K <0.01% +283 13F-HR Timeline Group Essential Partners LLC More: the full row for Essential Partners LLC 508 $18K 0.01% 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 424 $15K <0.01% +357 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 372 $13.2K <0.01% +49 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 358 $12.7K <0.01% +142 13F-HR/A Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 341 $12K <0.01% +32 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $11.5K <0.01% -152 13F-HR Timeline Amount filed as zero, left out of ratios. Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 276 $9.78K <0.01% 0 13F-HR Timeline