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Disclosery

SLN SILENCE THERAPEUTICS PLC

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ADS (ADR), issuer CIK 1479615

57 managers (58 13F filers) reported a position in SLN shares at 2025-12-31, 18,090,067 shares in all. 12 filers opened a position and 10 filers sold out during the quarter.

Managers
57
13F filers
58
New
12
Added
15
Reduced
17
Sold out
10
Shares held by filers
18,090,067

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
TCG Crossover Management, LLC3,033,560$18.4M0.61%013F-HRTimeline
Siren, L.L.C.in group Siren, L.L.C.2,911,438$17.7M0.53%013F-HRTimelineGroup
Redmile Group, LLCin group Redmile Group, LLC2,164,777$13.2M0.97%013F-HRTimelineGroup
Nantahala Capital Management, LLCin group Nantahala Capital Management,…1,542,427$9.38M0.56%+500,00013F-HRTimelineGroup
Vivo Capital, LLC1,105,454$6.72M0.43%013F-HRTimeline
Nextech Invest Ltd.952,400$5.79M0.56%013F-HRTimeline
GREAT POINT PARTNERS LLC808,032$4.91M1.59%new13F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC659,592$4.01M<0.01%+361,08013F-HRTimelineGroup
5AM Venture Management, LLC476,200$2.9M0.91%013F-HRTimeline
Tetragon Partners GP Ltdin group Tetragon Partners GP Ltd365,369$2.22M0.47%new13F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY324,630$1.97M<0.01%-883,09413F-HR/ATimelineGroup
Ikarian Capital, LLCin group Ikarian Capital, LLC865,784$1.73M0.22%-35,00013F-HRTimelineGroup
SG Americas Securities, LLC256,340$1.56M<0.01%-51,94913F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC244,061$1.48M<0.01%+222,55613F-HRTimelineGroup
Ishara Investments LP240,000$1.46M1.7%13F-HRTimeline
BOOTHBAY FUND MANAGEMENT, LLC209,088$1.27M0.03%-70,54913F-HRTimeline
UBS Group AGin group UBS Group AG207,513$1.26M<0.01%-99,85013F-HRTimelineGroup
Lombard Odier Asset Management (USA) Co…255,901$1.15M0.47%-1,589,04713F-HRTimeline
M28 Capital Management LP185,100$1.13M0.82%013F-HRTimeline
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC172,834$1.07M<0.01%-3913F-HR/ATimelineGroup
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/160,474$976K<0.01%+6,69213F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP155,680$947K<0.01%+72,46113F-HRTimelineGroup
Seven Fleet Capital Management LP147,600$897K0.61%13F-HR/ATimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.114,070$694K<0.01%new13F-HRTimelineGroup
Opaleye Management Inc.78,926$480K0.06%new13F-HR/ATimeline
BlackRock, Inc.in group BlackRock, Inc.73,153$445K<0.01%+11,32113F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding55,244$336K-50,603Timeline
Quadrature Capital Ltdin group Quadrature Capital Ltd54,380$331K<0.01%new13F-HRTimelineGroup
Qube Research & Technologies Ltd34,962$213K<0.01%new13F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC29,538$180K<0.01%013F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC29,168$177K<0.01%new13F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC25,000$152K<0.01%new13F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC23,643$144K0.01%+5,00013F-HR/ATimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC18,114$110K<0.01%-4,53013F-HR/ATimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…16,866$103K<0.01%new13F-HRTimelineGroup
China Universal Asset Management Co., L…13,653$83K0.01%+5,42113F-HRTimeline
RHUMBLINE ADVISERS12,999$79K<0.01%+7,13413F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS12,027$73.1K<0.01%+11,42713F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd11,718$71.2K<0.01%new13F-HRTimelineGroup
GAMMA Investing LLC10,112$61.5K<0.01%+19713F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO7,942$48.3K<0.01%+17613F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC5,065$30.8K<0.01%-2,07113F-HRTimelineGroup
SIMPLEX TRADING, LLC3,991$24.3K<0.01%+3,34013F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/2,966$18K<0.01%-56513F-HRTimelineGroup
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP2,500$15.2K<0.01%013F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…2,448$14.9K<0.01%+113F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.in group Mirae Asset Global Investment…2,282$13.9K<0.01%+46613F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC1,621$9.86K<0.01%-15213F-HRTimelineGroup
Parallel Advisors, LLC1,300$7.9K<0.01%013F-HRTimeline
Global Retirement Partners, LLC1,000$6.08K<0.01%new13F-HRTimeline
GF FUND MANAGEMENT CO. LTD.922$5.61K<0.01%-5613F-HRTimeline
Steward Partners Investment Advisory, L…100$608<0.01%013F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…45$274<0.01%013F-HR/ATimelineGroup
SBI Securities Co., Ltd.28$170<0.01%-113F-HRTimeline
SageView Advisory Group, LLC11$67<0.01%new13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.3$18<0.01%-62,16813F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA16$00%-1,12013F-HRTimelineGroupValue filed as zero, left out of ratios.