TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 3,033,560 $8.55M 1.17% 0 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 2,789,833 $7.87M 0.44% -41,937 13F-HR/A Timeline Group Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 2,214,947 $6.25M 0.59% -184,370 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 2,000,105 $5.64M <0.01% +337,037 13F-HR Timeline Group Lombard Odier Asset Management (USA) Co… More: the full row for Lombard Odier Asset Management (USA) Corp 1,849,734 $4.04M 1.36% -6,289 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 1,148,591 $3.24M 0.15% 0 13F-HR Timeline Vivo Capital, LLC More: the full row for Vivo Capital, LLC 1,105,454 $3.12M 0.41% 0 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,042,427 $2.94M 0.24% -7,249 13F-HR Timeline Group Nextech Invest Ltd. More: the full row for Nextech Invest Ltd. 952,400 $2.69M 0.62% 13F-HR Timeline CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 773,845 $2.18M 0.08% +234,119 13F-HR Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 732,463 $2.07M 1.04% +337,439 13F-HR Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 476,200 $1.34M 0.51% 0 13F-HR Timeline Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 401,746 $1.13M 0.13% -89,334 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 396,862 $1.12M <0.01% -76,690 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 319,514 $901K <0.01% -36,557 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 308,289 $869K <0.01% -9,339 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 250,012 $705K 0.02% -101,515 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 228,418 $644K <0.01% -260,471 13F-HR Timeline Group M28 Capital Management LP More: the full row for M28 Capital Management LP 185,100 $522K 0.72% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 180,435 $509K <0.01% -31,072 13F-HR Timeline Group HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 172,834 $499K <0.01% 0 13F-HR Timeline Group BANK OF MONTREAL /CAN/ in group BANK OF MONTREAL /CAN/ More: the full row for BANK OF MONTREAL /CAN/ 158,593 $447K <0.01% +93,586 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 149,996 $423K <0.01% +26,796 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 136,150 $384K <0.01% +99,753 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 134,492 $379K <0.01% -364,240 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 125,208 $353K -115,644 Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 71,497 $201K <0.01% +30,630 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 64,886 $183K <0.01% -434,180 13F-HR Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 62,639 $177K <0.01% -66,351 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 62,441 $176K <0.01% -220,296 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 61,071 $172K <0.01% +569 13F-HR Timeline Group Shay Capital LLC More: the full row for Shay Capital LLC 47,728 $135K 0.04% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 35,414 $99.9K <0.01% +31,621 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 29,417 $83K <0.01% 0 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 26,351 $74.3K <0.01% new 13F-HR/A Timeline Group Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 24,872 $70.1K +14,100 Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 24,375 $68.7K <0.01% -12,510 13F-HR/A Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 18,913 $53.3K <0.01% -35,833 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 18,643 $52.6K 0.01% +643 13F-HR Timeline Group Rathbones Group PLC More: the full row for Rathbones Group PLC 18,421 $51.9K <0.01% 0 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 16,032 $45.2K <0.01% -617,068 13F-HR/A Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 12,153 $34K <0.01% -7,314 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 9,432 $26.6K <0.01% -531 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 7,364 $20.8K <0.01% -98,956 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 6,854 $19.3K <0.01% +728 13F-HR/A Timeline Group FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 7,000 $19K 0.01% -10,515 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 4,788 $13.5K <0.01% +3,004 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 4,263 $12K <0.01% +2,748 13F-HR/A Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 3,560 $10K <0.01% -2,532 13F-HR/A Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 2,500 $8.6K <0.01% new 13F-HR/A Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,367 $6.67K <0.01% +1,735 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 1,573 $5.41K <0.01% +7 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 1,875 $5.28K <0.01% +1,034 13F-HR/A Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 1,300 $3.67K <0.01% new 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,165 $3.29K <0.01% +178 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 100 $282 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 28 $79 <0.01% 0 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 251 $0 0% +200 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.