TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 3,033,560 $20.9M 2.04% 0 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 2,831,770 $19.5M 0.86% 0 13F-HR Timeline Group Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 2,399,317 $16.5M 1.15% +500,000 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,663,068 $11.4M <0.01% +941,651 13F-HR/A Timeline Group Lombard Odier Asset Management (USA) Co… More: the full row for Lombard Odier Asset Management (USA) Corp 1,856,023 $10.2M 3.92% -808,054 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 1,148,591 $7.9M 0.33% 0 13F-HR Timeline Vivo Capital, LLC More: the full row for Vivo Capital, LLC 1,105,454 $7.61M 0.85% 0 13F-HR Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,049,676 $7.22M 0.51% +849,676 13F-HR Timeline Group Nextech Invest Ltd. More: the full row for Nextech Invest Ltd. 952,400 $6.55M 1.06% 0 13F-HR Timeline EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 640,000 $4.4M 0.08% 0 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 633,100 $4.36M 0.01% +165,300 13F-HR Timeline Group CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 539,726 $3.71M 0.14% +205,534 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 499,066 $3.43M <0.01% +498,032 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 498,732 $3.43M 0.02% +91,829 13F-HR Timeline Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 491,080 $3.38M 0.45% -6,790 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 488,889 $3.36M <0.01% +320,472 13F-HR Timeline Group 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 476,200 $3.28M 0.78% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 473,552 $3.26M <0.01% -636,678 13F-HR Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 395,024 $2.72M 1.06% -86,103 13F-HR Timeline Aquilo Capital Management, LLC More: the full row for Aquilo Capital Management, LLC 367,214 $2.53M 4.33% +50,000 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 356,071 $2.45M <0.01% +285,410 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 351,527 $2.42M 0.07% +180,372 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 317,628 $2.19M 0.01% -25,562 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 282,737 $1.95M <0.01% -153,960 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 240,852 $1.66M -11,840 Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 211,507 $1.46M <0.01% new 13F-HR Timeline Group Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 200,000 $1.38M 0.12% new 13F-HR Timeline M28 Capital Management LP More: the full row for M28 Capital Management LP 185,100 $1.27M 1.25% 0 13F-HR Timeline HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 172,834 $1.19M <0.01% -5,000 13F-HR Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 128,990 $887K 0.02% +43,289 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 123,200 $848K 0.01% -42,800 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 106,320 $731K 0.01% +60,015 13F-HR Timeline BANK OF MONTREAL /CAN/ in group BANK OF MONTREAL /CAN/ More: the full row for BANK OF MONTREAL /CAN/ 65,007 $447K <0.01% -252 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 63,663 $438K 0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 60,502 $416K <0.01% +2,169 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 54,746 $377K <0.01% +35,550 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 40,867 $281K <0.01% +27,708 13F-HR/A Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 36,885 $254K <0.01% +6,253 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 36,397 $250K <0.01% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 29,417 $202K <0.01% 0 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 24,123 $166K <0.01% +12,733 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 21,217 $146K 0.01% +139 13F-HR Timeline COMMONWEALTH OF PENNSYLVANIA PUBLIC SCH… More: the full row for COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS 19,467 $134K <0.01% new 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 19,467 $133K <0.01% new 13F-HR Timeline Group Rathbones Group PLC More: the full row for Rathbones Group PLC 18,421 $127K <0.01% 0 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 18,000 $124K 0.03% -22,290 13F-HR Timeline Group FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 17,515 $120K 0.06% new 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 16,360 $113K <0.01% new 13F-HR Timeline Group Quantum Portfolio Management LLC More: the full row for Quantum Portfolio Management LLC 11,861 $81.6K 0.04% -2,554 13F-HR Timeline VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 10,772 $74.1K 0.03% +6,098 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 9,963 $68.5K 0.01% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 6,126 $42.1K <0.01% +2,793 13F-HR/A Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 6,092 $41.9K <0.01% +5,233 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 3,793 $26.1K <0.01% new 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,784 $12.3K <0.01% new 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 1,566 $11.1K <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,515 $10K <0.01% -426 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 987 $6.79K <0.01% 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 841 $5.78K <0.01% +87 13F-HR/A Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 632 $4.35K <0.01% new 13F-HR Timeline Group Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 100 $688 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 28 $193 <0.01% 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 19 $131 <0.01% 0 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 51 $0 0% new 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.