VIKING GLOBAL INVESTORS LP in group VIKING GLOBAL INVESTORS LP More: the full row for VIKING GLOBAL INVESTORS LP 6,572,700 $36.7M 0.12% +2,141,692 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 5,435,087 $30.3M <0.01% +322,053 13F-HR Timeline Group Pfizer Inc More: the full row for Pfizer Inc 5,376,344 $30M 5.99% 0 13F-HR Timeline Nextech Invest Ltd. More: the full row for Nextech Invest Ltd. 5,285,714 $29.5M 6.85% 13F-HR Timeline ALKEON CAPITAL MANAGEMENT LLC More: the full row for ALKEON CAPITAL MANAGEMENT LLC 4,004,096 $22.3M 0.13% +100,000 13F-HR Timeline Column Group LLC More: the full row for Column Group LLC 3,540,777 $19.8M 44.67% 0 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 3,418,068 $19.1M 1.13% 0 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 3,215,887 $17.9M <0.01% +12,098 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 3,182,527 $17.8M 1.51% -1,212,000 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 2,480,420 $13.8M <0.01% +12,611 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 2,196,549 $12.3M <0.01% +350,287 13F-HR Timeline Group NEA Management Company, LLC More: the full row for NEA Management Company, LLC 2,195,545 $12.3M 0.94% +629,464 13F-HR Timeline Vivo Capital, LLC More: the full row for Vivo Capital, LLC 2,080,450 $11.6M 1.54% +802,632 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 2,060,240 $11.5M 2.4% +881,940 13F-HR Timeline Group First Turn Management, LLC More: the full row for First Turn Management, LLC 2,027,430 $11.3M 2.28% +576,393 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 2,007,272 $11.2M 0.03% +452,012 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 2,000,000 $11.2M 0.82% 0 13F-HR Timeline Group Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 1,732,571 $9.67M 2.91% 0 13F-HR/A Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 1,410,193 $7.87M 0.36% -2,478,045 13F-HR Timeline MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 1,399,514 $7.81M 1.34% new 13F-HR Timeline ArrowMark Colorado Holdings LLC More: the full row for ArrowMark Colorado Holdings LLC 1,346,189 $7.51M 0.12% -49,163 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,332,860 $7.44M <0.01% +37,835 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,305,991 $7.29M <0.01% +27,278 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 1,022,790 $5.71M <0.01% +72,268 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 1,007,575 $5.62M 0.32% 0 13F-HR/A Timeline Group Euclidean Capital LLC More: the full row for Euclidean Capital LLC 989,410 $5.52M 2.07% 0 13F-HR Timeline SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 819,194 $4.57M 5.45% -761,551 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 727,830 $4.06M <0.01% +10,642 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 700,000 $3.91M 0.09% new 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 588,717 $3.29M +478,209 Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 546,746 $3.05M <0.01% -7,247 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 511,889 $2.86M <0.01% +475,463 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 426,902 $2.38M 0.02% -297,417 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 408,505 $2.28M <0.01% -9,450 13F-HR/A Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 294,784 $1.64M <0.01% +24,778 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 259,801 $1.45M <0.01% +147,281 13F-HR Timeline Group MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 255,000 $1.42M 0.06% new 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 242,000 $1.35M 0.38% new 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 234,834 $1.31M 0.32% -38,379 13F-HR Timeline Group Atom Investors LP More: the full row for Atom Investors LP 210,706 $1.18M 0.14% +134,064 13F-HR Timeline Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 203,006 $1.13M 0.13% new 13F-HR Timeline CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 200,000 $1.12M 0.04% +177,296 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 195,717 $1.09M +144,380 Timeline FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 178,722 $997K 0.01% -40,554 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 178,217 $994K <0.01% -8,213 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 168,671 $941K <0.01% -178,684 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 167,502 $935K <0.01% 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 166,154 $927K <0.01% -1,145 13F-HR Timeline Group Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 156,643 $874K 0.04% -6,266 13F-HR Timeline Nicholas Investment Partners, LP More: the full row for Nicholas Investment Partners, LP 154,379 $861K 0.09% new 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 152,700 $852K <0.01% +4,900 13F-HR Timeline VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 150,260 $838K <0.01% +52,760 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 129,657 $723K <0.01% -531 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 112,628 $628K <0.01% +4,766 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 107,432 $599K <0.01% +53,562 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 104,106 $581K <0.01% +32,312 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 101,790 $568K <0.01% -12,902 13F-HR/A Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 88,753 $495K <0.01% -4,566 13F-HR/A Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 88,190 $492K -117,993 Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 77,424 $432K <0.01% +26,032 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 76,093 $425K <0.01% new 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 68,400 $382K <0.01% +6,000 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 53,983 $301K <0.01% +26,349 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 51,976 $290K <0.01% -5,461 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 49,530 $276K <0.01% new 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 47,695 $266K <0.01% new 13F-HR Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 47,642 $266K 0.01% -127,204 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 42,578 $241K +3,156 Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 42,677 $238K 0.03% +14,242 13F-HR Timeline NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 40,934 $228K <0.01% -4,542 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 40,934 $228K 0.07% -4,542 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 40,856 $228K <0.01% -752 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 40,782 $228K <0.01% +28,570 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 40,766 $227K <0.01% +12,053 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 40,419 $226K <0.01% +16,461 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 38,988 $218K <0.01% +3,131 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 38,486 $215K <0.01% +22,257 13F-HR/A Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 36,158 $202K <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 35,649 $199K <0.01% +1,913 13F-HR Timeline Group LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 35,300 $197K <0.01% new 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 35,285 $197K <0.01% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 32,458 $181K <0.01% -470 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 31,833 $178K <0.01% 0 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 31,198 $174K <0.01% new 13F-HR/A Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 30,163 $168K <0.01% -447 13F-HR Timeline Group Jasper Ridge Partners, L.P. More: the full row for Jasper Ridge Partners, L.P. 20,870 $116K <0.01% 0 13F-HR Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 20,000 $112K 0.09% new 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 19,915 $111K <0.01% -46,449 13F-HR Timeline Legato Capital Management LLC More: the full row for Legato Capital Management LLC 19,523 $109K 0.01% new 13F-HR Timeline Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 19,473 $109K +11,039 Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 19,077 $106K 0.01% -6,889 13F-HR Timeline Group HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 17,983 $102K <0.01% new 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 16,885 $94.2K <0.01% -1,904 13F-HR/A Timeline Group ProShare Advisors LLC More: the full row for ProShare Advisors LLC 16,531 $92.2K <0.01% -4,152 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 16,469 $91.9K <0.01% +5,651 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 14,600 $89.7K <0.01% 0 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 15,844 $88K 0.01% new 13F-HR Timeline Baird Financial Group, Inc. in group Baird Financial Group, Inc. More: the full row for Baird Financial Group, Inc. 15,691 $87.6K <0.01% 0 13F-HR Timeline Group Clear Harbor Asset Management, LLC More: the full row for Clear Harbor Asset Management, LLC 15,119 $84.4K 0.01% +1,375 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 14,247 $79.5K 0.01% -716 13F-HR Timeline CIBC WORLD MARKETS CORP More: the full row for CIBC WORLD MARKETS CORP 13,662 $76.2K <0.01% new 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 12,626 $70.5K <0.01% -1,550 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 12,378 $69.1K <0.01% 0 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 11,590 $64.7K <0.01% -1,927 13F-HR Timeline Group STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 11,310 $63.1K <0.01% 0 13F-HR Timeline ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 10,088 $56.3K <0.01% new 13F-HR Timeline AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 10,061 $56.1K 0.02% new 13F-HR Timeline SHELL ASSET MANAGEMENT CO More: the full row for SHELL ASSET MANAGEMENT CO 8,472 $47K <0.01% -352 13F-HR Timeline CANADA LIFE ASSURANCE Co in group CANADA LIFE ASSURANCE Co More: the full row for CANADA LIFE ASSURANCE Co 8,324 $46K <0.01% 0 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 7,215 $40.3K <0.01% -1,586 13F-HR Timeline Group KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 6,200 $34.6K <0.01% 0 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 6,032 $33.7K <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 4,834 $27K <0.01% -2,913 13F-HR/A Timeline Group ANTIPODES PARTNERS Ltd More: the full row for ANTIPODES PARTNERS Ltd 3,822 $21.3K <0.01% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 3,091 $17K <0.01% +2,969 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 2,130 $12K <0.01% 0 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 2,000 $11.2K <0.01% 0 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,807 $10.1K <0.01% +325 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 844 $4.71K <0.01% -13,817 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 834 $4.65K <0.01% -702 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 707 $3.94K <0.01% +558 13F-HR/A Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 607 $3.39K <0.01% +33 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 549 $3.06K <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 350 $1.95K <0.01% new 13F-HR Timeline Lindbrook Capital, LLC More: the full row for Lindbrook Capital, LLC 319 $1.78K <0.01% +105 13F-HR Timeline COMERICA BANK More: the full row for COMERICA BANK 294 $1.64K <0.01% new 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 236 $1.32K <0.01% 0 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 180 $1K <0.01% +85 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 249 $1K <0.01% 0 13F-HR Timeline Group Amundi in group Amundi More: the full row for Amundi 178 $936 <0.01% new 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 109 $608 <0.01% new 13F-HR Timeline Group Parkside Financial Bank & Trust More: the full row for Parkside Financial Bank & Trust 50 $279 <0.01% new 13F-HR Timeline COLDSTREAM CAPITAL MANAGEMENT INC More: the full row for COLDSTREAM CAPITAL MANAGEMENT INC 45 $252 <0.01% new 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 26 $146 <0.01% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 22 $123 <0.01% -5 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 14 $78 <0.01% -198 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 12 $67 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 2 $11 <0.01% 0 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 146 $0 0% new 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.