Pfizer Inc More: the full row for Pfizer Inc 5,376,344 $43.4M 1.67% 13F-HR Timeline Nextech Invest Ltd. More: the full row for Nextech Invest Ltd. 5,285,714 $42.7M 6.92% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 5,113,034 $41.3M <0.01% +11,217 13F-HR Timeline Group VIKING GLOBAL INVESTORS LP in group VIKING GLOBAL INVESTORS LP More: the full row for VIKING GLOBAL INVESTORS LP 4,431,008 $35.8M 0.12% +431,008 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 4,394,527 $35.5M 2.43% 0 13F-HR Timeline ALKEON CAPITAL MANAGEMENT LLC More: the full row for ALKEON CAPITAL MANAGEMENT LLC 3,904,096 $31.5M 0.18% 0 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 3,888,238 $31.4M 1.3% -254,617 13F-HR Timeline Column Group LLC More: the full row for Column Group LLC 3,540,777 $28.6M 51.26% 0 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 3,418,068 $27.6M 1.1% 0 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 3,203,789 $25.9M <0.01% +36,478 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 2,467,809 $19.9M <0.01% -1,911,010 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 2,000,000 $16.1M 1.18% 0 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,846,262 $14.9M <0.01% -91,907 13F-HR Timeline Group Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 1,732,571 $14M 1.19% 13F-HR Timeline Group SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 1,580,745 $12.8M 11.2% +631,223 13F-HR Timeline NEA Management Company, LLC More: the full row for NEA Management Company, LLC 1,566,081 $12.6M 0.71% +66,081 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 1,555,260 $12.6M 0.03% +424,194 13F-HR Timeline Group First Turn Management, LLC More: the full row for First Turn Management, LLC 1,451,037 $11.7M 2.1% 0 13F-HR Timeline ArrowMark Colorado Holdings LLC More: the full row for ArrowMark Colorado Holdings LLC 1,395,352 $11.3M 0.15% +40,844 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,295,025 $10.5M <0.01% +180,140 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,278,713 $10.3M <0.01% +5,200 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 1,277,818 $10.3M 1.16% 0 13F-HR Timeline Avidity Partners Management LP More: the full row for Avidity Partners Management LP 1,265,200 $10.2M 1.02% -181,919 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 1,178,300 $9.51M 2.13% +78,810 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 1,007,575 $8.13M 0.36% 0 13F-HR Timeline Group Euclidean Capital LLC More: the full row for Euclidean Capital LLC 989,410 $7.98M 1.08% 0 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 950,522 $7.67M <0.01% +63 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 724,319 $5.85M 0.04% new 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 717,188 $5.79M <0.01% +103,237 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 553,993 $4.47M <0.01% +28,079 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 500,000 $4.04M 0.01% -75,000 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 417,955 $3.37M <0.01% +7,726 13F-HR Timeline Group Altium Capital Management LLC More: the full row for Altium Capital Management LLC 355,000 $2.86M 0.89% 0 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 347,355 $2.8M <0.01% -24,372 13F-HR/A Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 273,213 $2.2M 0.41% +144,817 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 270,006 $2.18M <0.01% -52,619 13F-HR Timeline Group FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 219,276 $1.77M 0.01% -171 13F-HR Timeline Group DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 214,291 $1.73M 1.95% 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 206,183 $1.66M -36,092 Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 186,430 $1.5M <0.01% +12,042 13F-HR Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 174,846 $1.41M 0.04% +31,526 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 167,502 $1.35M <0.01% 0 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 167,299 $1.35M <0.01% +129 13F-HR Timeline Group Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 162,909 $1.31M 0.06% +24,947 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 147,800 $1.19M <0.01% +8,400 13F-HR Timeline Monaco Asset Management SAM More: the full row for Monaco Asset Management SAM 135,561 $1.09M 0.49% -15,000 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 130,188 $1.05M <0.01% -452 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 120,000 $968K 0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 114,692 $926K <0.01% +7,431 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 112,520 $908K <0.01% +28,570 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 110,508 $892K +15,919 Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 107,862 $870K <0.01% +8,359 13F-HR Timeline Group M&T Bank Corp in group M&T Bank Corp More: the full row for M&T Bank Corp 99,234 $801K <0.01% +14,097 13F-HR Timeline Group VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 97,500 $787K <0.01% -2,250 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 93,319 $753K <0.01% +4,072 13F-HR/A Timeline NATIXIS in group Natixis Investment Managers More: the full row for NATIXIS 79,900 $645K <0.01% new 13F-HR Timeline Group Atom Investors LP More: the full row for Atom Investors LP 76,642 $619K 0.08% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 71,794 $579K <0.01% +25,794 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 66,364 $536K <0.01% -3,256 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 62,400 $504K <0.01% +3,200 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 57,437 $464K <0.01% +18,745 13F-HR/A Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 53,870 $435K <0.01% -8,000 13F-HR Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 51,392 $415K <0.01% -13,193 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 51,337 $414K +25,802 Timeline NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 45,476 $367K 0.01% new 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 45,476 $367K 0.15% 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 41,608 $336K <0.01% +5,530 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 39,422 $319K +505 Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 36,426 $294K <0.01% +30,659 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 35,857 $289K <0.01% +8,311 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 34,205 $276K <0.01% -8,775 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 33,736 $272K <0.01% -1,515 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 32,928 $266K <0.01% 0 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 31,833 $257K <0.01% +891 13F-HR/A Timeline Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 30,610 $247K <0.01% -2,311 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 28,713 $232K <0.01% +9,245 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 28,435 $229K 0.03% +27,381 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 27,634 $223K <0.01% -265,889 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 25,966 $210K 0.02% +14,209 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 23,958 $193K <0.01% +1,876 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 23,417 $189K <0.01% new 13F-HR Timeline CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 22,704 $183K 0.01% new 13F-HR Timeline Group Jasper Ridge Partners, L.P. More: the full row for Jasper Ridge Partners, L.P. 20,870 $168K 0.01% 0 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 20,683 $167K <0.01% +4,881 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 18,789 $152K <0.01% -1,806 13F-HR/A Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 16,554 $134K <0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 16,229 $131K <0.01% 0 13F-HR/A Timeline Baird Financial Group, Inc. in group Baird Financial Group, Inc. More: the full row for Baird Financial Group, Inc. 15,691 $127K <0.01% 0 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 14,963 $121K 0.01% +1,395 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 14,661 $118K <0.01% +13,384 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 14,600 $118K <0.01% new 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 14,176 $114K <0.01% +9,059 13F-HR Timeline Clear Harbor Asset Management, LLC More: the full row for Clear Harbor Asset Management, LLC 13,744 $111K 0.01% 0 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 13,517 $109K <0.01% +2,520 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 12,378 $99.9K <0.01% 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 12,212 $98.6K <0.01% new 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 11,310 $91.3K <0.01% 0 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 10,818 $87.3K <0.01% -2,684 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 7,373 $76.8K 0.07% 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 8,801 $71K <0.01% new 13F-HR Timeline Group SHELL ASSET MANAGEMENT CO More: the full row for SHELL ASSET MANAGEMENT CO 8,824 $71K <0.01% 0 13F-HR Timeline VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 8,434 $68.1K 0.03% -3,563 13F-HR Timeline Group CANADA LIFE ASSURANCE Co in group CANADA LIFE ASSURANCE Co More: the full row for CANADA LIFE ASSURANCE Co 8,324 $67K <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 7,747 $63K <0.01% +823 13F-HR Timeline Group KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 6,200 $50K <0.01% 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 6,032 $48.7K <0.01% 0 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 2,130 $17K <0.01% 0 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 2,000 $16.1K <0.01% 0 13F-HR Timeline R Squared Ltd More: the full row for R Squared Ltd 1,800 $14.5K 0.01% 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 1,536 $12.4K <0.01% +1,354 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,482 $12K <0.01% 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 574 $4.63K <0.01% 0 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 478 $3.86K <0.01% new 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 249 $2K <0.01% 0 13F-HR Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 236 $1.91K <0.01% -39 13F-HR Timeline Lindbrook Capital, LLC More: the full row for Lindbrook Capital, LLC 214 $1.73K <0.01% -48 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 212 $1.71K <0.01% +71 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 149 $1.2K <0.01% +106 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 122 $1K <0.01% +78 13F-HR Timeline Group Brooklyn Investment Group More: the full row for Brooklyn Investment Group 105 $848 <0.01% new 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 95 $767 <0.01% -20 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 68 $549 <0.01% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 27 $218 <0.01% new 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 12 $97 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 2 $16 <0.01% 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.