Nextech Invest Ltd. More: the full row for Nextech Invest Ltd. 7,162,637 $72.7M 13.76% +1,876,923 13F-HR Timeline Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 6,596,885 $67M 5.02% +3,414,358 13F-HR Timeline VIKING GLOBAL INVESTORS LP in group VIKING GLOBAL INVESTORS LP More: the full row for VIKING GLOBAL INVESTORS LP 6,572,700 $66.7M 0.19% 0 13F-HR Timeline Group Pfizer Inc More: the full row for Pfizer Inc 5,376,344 $54.6M 9.47% 0 13F-HR Timeline SR One Capital Management, LP More: the full row for SR One Capital Management, LP 4,514,929 $45.8M 9.93% new 13F-HR Timeline ALKEON CAPITAL MANAGEMENT LLC More: the full row for ALKEON CAPITAL MANAGEMENT LLC 4,504,096 $45.7M 0.22% +500,000 13F-HR Timeline NEA Management Company, LLC More: the full row for NEA Management Company, LLC 4,118,621 $41.8M 3.15% +1,923,076 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 4,077,985 $41.4M <0.01% -1,357,102 13F-HR Timeline Group Column Group LLC More: the full row for Column Group LLC 3,540,777 $35.9M 54.68% 0 13F-HR Timeline Vivo Capital, LLC More: the full row for Vivo Capital, LLC 3,126,604 $31.7M 3.25% +1,046,154 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 3,124,693 $31.7M <0.01% -91,194 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 2,850,641 $28.9M 0.07% new 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 2,762,915 $28M <0.01% +1,430,055 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 2,470,057 $25.1M <0.01% -10,363 13F-HR Timeline Group First Turn Management, LLC More: the full row for First Turn Management, LLC 2,009,923 $20.4M 3.81% -17,507 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 1,800,829 $18.3M 3.74% -259,411 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 1,777,744 $18M 0.04% -229,528 13F-HR Timeline Group MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 1,729,378 $17.6M 3.04% +329,864 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,632,116 $16.6M <0.01% -564,433 13F-HR Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 1,618,068 $16.4M 0.97% -1,800,000 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,402,768 $14.2M 0.01% +890,879 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 1,335,448 $13.6M <0.01% +1,299,799 13F-HR Timeline Group ArrowMark Colorado Holdings LLC More: the full row for ArrowMark Colorado Holdings LLC 1,278,454 $13M 0.23% -67,735 13F-HR Timeline Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 1,250,000 $12.7M 1.19% new 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,108,460 $11.3M <0.01% -197,531 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 1,065,334 $10.8M 0.43% -344,859 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 1,042,558 $10.6M <0.01% +19,768 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 1,007,575 $10.2M 0.53% 0 13F-HR Timeline Group Euclidean Capital LLC More: the full row for Euclidean Capital LLC 989,410 $10M 3.28% 0 13F-HR Timeline EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 951,433 $9.66M 0.17% new 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 899,281 $9.13M 0.23% +199,281 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 714,866 $7.26M <0.01% -12,964 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 489,637 $4.97M <0.01% +194,853 13F-HR Timeline Group Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 485,629 $4.93M 4.1% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 400,954 $4.07M <0.01% -145,792 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 394,785 $4.01M <0.01% +226,114 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 394,693 $4.01M 1.05% +159,859 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 382,389 $3.88M <0.01% -26,116 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 365,400 $3.71M 0.01% new 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 350,535 $3.56M <0.01% +296,552 13F-HR Timeline Group SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 344,922 $3.5M 4.36% -474,272 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 298,442 $3.03M <0.01% +38,641 13F-HR Timeline Group Atom Investors LP More: the full row for Atom Investors LP 252,653 $2.56M 0.23% +41,947 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 244,368 $2.48M 0.01% new 13F-HR Timeline ROYCE & ASSOCIATES LP More: the full row for ROYCE & ASSOCIATES LP 234,774 $2.38M 0.02% new 13F-HR Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 231,485 $2.35M 1.55% +211,485 13F-HR Timeline Resolute Capital Asset Partners LLC More: the full row for Resolute Capital Asset Partners LLC 227,515 $2.31M 1.21% new 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 223,302 $2.27M <0.01% +45,085 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 200,785 $2.04M 0.66% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 184,393 $1.87M -11,324 Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 177,700 $1.8M <0.01% +25,000 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 171,433 $1.74M <0.01% +121,903 13F-HR Timeline Group Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 149,726 $1.52M 0.06% -6,917 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 142,681 $1.45M <0.01% +40,891 13F-HR/A Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 135,271 $1.37M 0.38% -106,729 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 135,034 $1.37M <0.01% -31,120 13F-HR Timeline Group VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 132,630 $1.35M <0.01% -17,630 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 124,108 $1.26M <0.01% -5,549 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 122,686 $1.25M <0.01% -44,816 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 106,767 $1.08M <0.01% new 13F-HR/A Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 102,583 $1.04M <0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 99,899 $1.01M <0.01% +95,065 13F-HR/A Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 99,006 $1M -489,711 Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 91,210 $926K <0.01% -21,418 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 86,755 $881K <0.01% +79,540 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 76,447 $776K <0.01% new 13F-HR Timeline FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 76,286 $774K <0.01% -102,436 13F-HR Timeline Group Nicholas Investment Partners, LP More: the full row for Nicholas Investment Partners, LP 74,242 $754K 0.07% -80,137 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 71,431 $725K <0.01% -17,322 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 63,810 $648K <0.01% -43,622 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 61,563 $625K <0.01% +21,144 13F-HR Timeline Group OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 49,000 $497K 0.01% +1,358 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Palumbo Wealth Management LLC More: the full row for Palumbo Wealth Management LLC 46,783 $475K 0.15% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 46,711 $474K <0.01% +15,513 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 42,644 $433K <0.01% -34,780 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 38,864 $394K <0.01% +2,706 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 38,577 $392K <0.01% -13,399 13F-HR Timeline Group LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 35,267 $358K 0.01% -33 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 34,725 $352K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 33,603 $341K <0.01% -5,385 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 33,530 $340K <0.01% -1,755 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 32,549 $330K <0.01% -71,557 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 29,404 $299K -13,174 Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 27,072 $275K <0.01% -13,784 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 25,875 $263K <0.01% -14,907 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 25,447 $258K <0.01% -15,319 13F-HR Timeline IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 22,987 $233K <0.01% new 13F-HR Timeline Brooklyn Investment Group More: the full row for Brooklyn Investment Group 20,903 $212K 0.03% new 13F-HR/A Timeline Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 20,892 $212K 0.04% new 13F-HR Timeline Jasper Ridge Partners, L.P. More: the full row for Jasper Ridge Partners, L.P. 20,870 $212K 0.01% 0 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 20,157 $205K 0.02% -22,520 13F-HR Timeline Monaco Asset Management SAM More: the full row for Monaco Asset Management SAM 20,000 $203K 0.08% new 13F-HR Timeline Campbell & CO Investment Adviser LLC More: the full row for Campbell & CO Investment Adviser LLC 19,668 $200K 0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 17,792 $181K <0.01% -20,694 13F-HR/A Timeline Clear Harbor Asset Management, LLC More: the full row for Clear Harbor Asset Management, LLC 15,119 $153K 0.01% 0 13F-HR Timeline TWO SIGMA SECURITIES, LLC More: the full row for TWO SIGMA SECURITIES, LLC 14,332 $145K 0.02% new 13F-HR Timeline Sanctuary Advisors, LLC More: the full row for Sanctuary Advisors, LLC 14,286 $145K <0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 14,278 $145K 0.01% +31 13F-HR Timeline AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 12,950 $131K 0.04% +2,889 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 12,728 $129K <0.01% -4,157 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 12,487 $127K <0.01% +897 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 12,457 $126K <0.01% +9,366 13F-HR Timeline Group Quantessence Capital LLC More: the full row for Quantessence Capital LLC 11,868 $120K 0.04% new 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 11,856 $120K <0.01% -4,675 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 11,757 $119K <0.01% +10,913 13F-HR Timeline Group STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 11,310 $115K <0.01% 0 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 11,095 $113K <0.01% new 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 10,684 $108K <0.01% -1,694 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 10,200 $104K <0.01% new 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 9,724 $98.7K 0.03% -9,749 13F-HR Timeline Group ANTIPODES PARTNERS Ltd More: the full row for ANTIPODES PARTNERS Ltd 5,194 $52.7K <0.01% +1,372 13F-HR Timeline SHELL ASSET MANAGEMENT CO More: the full row for SHELL ASSET MANAGEMENT CO 4,836 $49K <0.01% -3,636 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 4,581 $46.5K <0.01% -1,451 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 4,339 $44K <0.01% -28,119 13F-HR Timeline Group Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 3,980 $40.4K <0.01% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,800 $28.4K <0.01% -29,033 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 2,436 $24.7K <0.01% +2,422 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 2,130 $22K <0.01% 0 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 2,000 $20.3K <0.01% 0 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,807 $18.3K <0.01% 0 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1,267 $12.9K 0.01% +917 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 984 $9.99K <0.01% new 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 922 $9.36K <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 901 $9.14K <0.01% +67 13F-HR/A Timeline Quarry LP More: the full row for Quarry LP 892 $9.05K <0.01% new 13F-HR Timeline Versant Capital Management, Inc More: the full row for Versant Capital Management, Inc 720 $7.31K <0.01% new 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 552 $5.6K <0.01% 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 400 $4.06K <0.01% -149 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 336 $3.41K <0.01% -371 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 297 $3.02K <0.01% +285 13F-HR Timeline Daiwa Securities Group Inc. in group Daiwa Securities Group Inc. More: the full row for Daiwa Securities Group Inc. 249 $3K <0.01% 0 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 292 $2.96K <0.01% +183 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 90 $914 <0.01% -90 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 83 $842 <0.01% -153 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 83 $842 <0.01% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 28 $284 <0.01% +6 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 20 $203 <0.01% new 13F-HR/A Timeline Group Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 4 $41 <0.01% new 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 2 $21 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 2 $20 <0.01% 0 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.