BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 16,001,284 $298M 9.5% -3,750,000 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 6,408,863 $119M 2.47% +1,798,792 13F-HR Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 4,480,433 $83.5M 4.21% +125,000 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 3,451,628 $64.3M 0.03% +1,355,640 13F-HR/A Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 2,390,661 $44.6M 0.04% -90,106 13F-HR Timeline Group MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 1,811,082 $33.8M 2.61% new 13F-HR Timeline Weiss Asset Management LP in group Weiss Asset Management LP More: the full row for Weiss Asset Management LP 1,708,328 $31.8M 0.58% +1,375,367 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. Logos Global Management LP More: the full row for Logos Global Management LP 1,500,000 $28M 1.44% -250,000 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,368,518 $25.5M 0.04% +596,018 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,323,728 $24.7M 0.02% +942,838 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,294,861 $24.1M <0.01% +335,308 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,130,233 $21.1M <0.01% +859,568 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 1,122,312 $20.9M 0.02% +337,501 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 1,065,610 $19.9M 0.04% -505,461 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,021,851 $19M <0.01% +735,258 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 1,000,000 $18.6M 1.55% 0 13F-HR/A Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 1,088,514 $18.4M <0.01% +250,775 13F-HR/A Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 818,126 $15.2M 0.08% +683,797 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 724,794 $13.5M <0.01% +711,261 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 614,482 $11.5M <0.01% -430,099 13F-HR Timeline Group Holocene Advisors, LP More: the full row for Holocene Advisors, LP 600,000 $11.2M 0.03% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 595,398 $11.1M -207,812 Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 576,092 $10.7M 0.01% -226,630 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 500,000 $9.32M 0.11% 0 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 500,000 $9.32M 2.28% new 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 495,336 $9.23M 0.07% +311,017 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 487,583 $9.09M 0.02% -148,318 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 457,137 $8.52M 0.51% new 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 453,625 $8.46M 0.01% -1,228,523 13F-HR Timeline Group Casdin Capital, LLC More: the full row for Casdin Capital, LLC 450,000 $8.39M 0.64% new 13F-HR Timeline Longaeva Partners L.P. More: the full row for Longaeva Partners L.P. 410,000 $7.64M 0.37% new 13F-HR Timeline Voleon Capital Management LP More: the full row for Voleon Capital Management LP 373,021 $6.95M 0.15% -126,078 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 325,968 $6.08M 0.09% -99,591 13F-HR Timeline Group Walleye Capital LLC group of 2 filers holding More: the full row for Walleye Capital LLC 320,472 $5.97M +157,330 Timeline First Turn Management, LLC More: the full row for First Turn Management, LLC 315,563 $5.88M 0.66% +52,920 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 276,772 $5.16M 0.01% +142,300 13F-HR Timeline Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 275,000 $5.13M 0.67% 0 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 239,838 $4.47M <0.01% +228,528 13F-HR Timeline Group Rhenman & Partners Asset Management AB More: the full row for Rhenman & Partners Asset Management AB 239,500 $4.46M 0.55% -124,500 13F-HR Timeline Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 220,600 $4.11M 0.2% +22,293 13F-HR Timeline Exome Asset Management LLC More: the full row for Exome Asset Management LLC 215,376 $4.01M 2.36% new 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 193,955 $3.62M 1% new 13F-HR Timeline ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 191,760 $3.57M 2.54% +132,480 13F-HR Timeline CONGRESS ASSET MANAGEMENT CO More: the full row for CONGRESS ASSET MANAGEMENT CO 178,555 $3.33M 0.02% +107,459 13F-HR Timeline Kalehua Capital Management LLC More: the full row for Kalehua Capital Management LLC 175,734 $3.28M 2.32% 0 13F-HR/A Timeline Ishara Investments LP More: the full row for Ishara Investments LP 174,250 $3.25M 3.28% new 13F-HR Timeline RICE HALL JAMES & ASSOCIATES, LLC More: the full row for RICE HALL JAMES & ASSOCIATES, LLC 167,766 $3.13M 0.17% +40,301 13F-HR Timeline ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 151,256 $2.82M 0.04% -70,360 13F-HR/A Timeline READYSTATE ASSET MANAGEMENT LP More: the full row for READYSTATE ASSET MANAGEMENT LP 144,238 $2.69M 0.16% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 143,559 $2.68M <0.01% -12,717 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 142,706 $2.66M <0.01% +15,962 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 139,574 $2.6M <0.01% new 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 136,900 $2.55M 0.12% +35,433 13F-HR Timeline VANGUARD GROUP INC group of 3 filers holding More: the full row for VANGUARD GROUP INC 128,102 $2.39M new Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 127,087 $2.37M 0.04% +31,115 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 120,310 $2.24M 0.02% -92,686 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 118,961 $2.22M <0.01% +33,391 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 112,044 $2.09M 0.04% +89,071 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 111,331 $2.08M <0.01% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 110,217 $2.05M <0.01% -11,423 13F-HR Timeline Group Headlands Technologies LLC More: the full row for Headlands Technologies LLC 97,133 $1.81M 0.21% new 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 80,233 $1.5M 0.09% -9,003 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 78,041 $1.45M -160,979 Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 72,269 $1.35M <0.01% -337 13F-HR Timeline Group ARROWSTREET CAPITAL, LIMITED PARTNERSHIP in group ARROWSTREET CAPITAL, LIMITED … More: the full row for ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 70,140 $1.31M <0.01% new 13F-HR Timeline Group Lion Point Capital, LP More: the full row for Lion Point Capital, LP 67,500 $1.26M 7.52% 0 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 61,700 $1.15M 0.07% 0 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 61,577 $1.15M 0.01% -41,939 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 61,500 $1.15M <0.01% 0 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 58,395 $1.09M 0.01% +226 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 56,490 $1.05M <0.01% +5,517 13F-HR Timeline Group Avidity Partners Management LP More: the full row for Avidity Partners Management LP 50,000 $932K 0.19% new 13F-HR/A Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 48,883 $911K 0.07% new 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 46,185 $861K <0.01% +13,299 13F-HR Timeline Group Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 44,950 $838K <0.01% +24,791 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 42,917 $800K <0.01% new 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 33,417 $623K <0.01% -604,017 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 32,507 $606K 0.01% -46,131 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 29,296 $546K <0.01% 0 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 28,682 $535K <0.01% -293,579 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 27,602 $515K <0.01% -22,649 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 26,307 $490K <0.01% -157,245 13F-HR Timeline Group OPTIMIZE FINANCIAL INC. More: the full row for OPTIMIZE FINANCIAL INC. 24,419 $455K 0.22% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 21,563 $402K 0.01% -8,913 13F-HR Timeline Quarry LP More: the full row for Quarry LP 21,250 $396K 0.08% new 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 21,089 $393K 0.01% -3,203 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 20,559 $383K <0.01% +4,481 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 19,477 $363K <0.01% +998 13F-HR Timeline Group AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 19,241 $359K 0.05% new 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 19,229 $358K <0.01% +5,637 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 18,436 $344K 0.09% +449 13F-HR Timeline Group Vident Advisory, LLC in group Vident Advisory, LLC More: the full row for Vident Advisory, LLC 18,208 $339K <0.01% +2,764 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 16,527 $305K <0.01% new 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 15,905 $296K <0.01% +6,920 13F-HR Timeline Group WINTON GROUP Ltd in group WINTON GROUP Ltd More: the full row for WINTON GROUP Ltd 15,670 $292K 0.01% new 13F-HR Timeline Group Jain Global LLC More: the full row for Jain Global LLC 15,362 $286K <0.01% -55,249 13F-HR Timeline FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 16,518 $280K 0.05% -55,444 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 13,691 $255K <0.01% +12,781 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 12,598 $235K <0.01% +160 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 12,520 $233K <0.01% +2,520 13F-HR/A Timeline Group Entropy Technologies, LP More: the full row for Entropy Technologies, LP 11,854 $221K 0.01% -18,446 13F-HR Timeline CAPTRUST FINANCIAL ADVISORS More: the full row for CAPTRUST FINANCIAL ADVISORS 11,446 $213K <0.01% new 13F-HR Timeline IMC-Chicago, LLC More: the full row for IMC-Chicago, LLC 11,352 $212K <0.01% -25,116 13F-HR Timeline CAPITAL FUND MANAGEMENT S.A. More: the full row for CAPITAL FUND MANAGEMENT S.A. 11,260 $210K <0.01% new 13F-HR Timeline State of New Jersey Common Pension Fund… in group State of New Jersey Common Pe… More: the full row for State of New Jersey Common Pension Fund D 10,864 $203K <0.01% new 13F-HR Timeline Group Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 10,526 $196K 0.01% -2,056 13F-HR Timeline Group Crystal Cove Asset Management, LLC More: the full row for Crystal Cove Asset Management, LLC 10,000 $186K 0.25% 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 9,350 $174K <0.01% -12,538 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 6,800 $127K <0.01% 0 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 4,489 $83.7K <0.01% 0 13F-HR/A Timeline Advisors Asset Management, Inc. More: the full row for Advisors Asset Management, Inc. 3,942 $73.5K <0.01% -50 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 3,426 $63.9K <0.01% 0 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 3,075 $57.3K <0.01% -25,897 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 3,065 $57.1K 0.01% -3,885 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 2,867 $53.4K <0.01% +1,974 13F-HR/A Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 2,323 $43.3K <0.01% +995 13F-HR Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 2,267 $42.3K <0.01% +853 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 2,052 $38.2K <0.01% 0 13F-HR Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 1,664 $31K <0.01% +180 13F-HR/A Timeline DecisionPoint Financial, LLC More: the full row for DecisionPoint Financial, LLC 1,219 $22.7K <0.01% 0 13F-HR Timeline Delos Wealth Advisors, LLC More: the full row for Delos Wealth Advisors, LLC 1,000 $18.6K 0.01% -5,000 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 923 $17.2K <0.01% -61,025 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 669 $12.5K <0.01% +288 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 733 $12.1K <0.01% -38 13F-HR Timeline SUMMIT SECURITIES GROUP LLC More: the full row for SUMMIT SECURITIES GROUP LLC 516 $9.62K <0.01% new 13F-HR Timeline Avion Wealth More: the full row for Avion Wealth 500 $9K <0.01% new 13F-HR Timeline QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 383 $7.14K <0.01% +173 13F-HR/A Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 304 $5.67K <0.01% +244 13F-HR Timeline Group Basecamp Wealth Advisors LLC More: the full row for Basecamp Wealth Advisors LLC 250 $4.66K <0.01% -22 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 244 $4.55K <0.01% +149 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 213 $3.97K <0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 84 $2K <0.01% -19 13F-HR Timeline Group Quantbot Technologies LP More: the full row for Quantbot Technologies LP 99 $1.84K <0.01% -6,167 13F-HR Timeline CVA Family Office, LLC More: the full row for CVA Family Office, LLC 60 $1.12K <0.01% new 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 52 $901 <0.01% new 13F-HR Timeline Group Cornerstone Financial Management LLC More: the full row for Cornerstone Financial Management LLC 28 $522 <0.01% new 13F-HR/A Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 12 $224 <0.01% -35 13F-HR Timeline Group Essential Partners LLC More: the full row for Essential Partners LLC 8 $149 <0.01% new 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 7 $131 <0.01% new 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 6 $112 <0.01% new 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 6 $112 <0.01% +5 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 5 $93 <0.01% new 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 1 $19 <0.01% new 13F-HR Timeline