BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 19,751,284 $142M 5.74% 0 13F-HR Timeline Group Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 2,000,000 $14.3M 0.19% -2,150,000 13F-HR Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 1,994,173 $14.3M 0.99% -6,499,978 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 1,699,235 $12.2M 0.02% +1,276,065 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 1,500,000 $10.8M 0.02% new 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 965,405 $6.92M 0.05% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 822,957 $5.9M <0.01% -1,790,276 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 726,932 $5.21M <0.01% -5,003,617 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 635,699 $4.56M <0.01% -155,856 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 493,592 $3.54M new Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 435,839 $3.12M 0.63% new 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 362,871 $2.6M <0.01% -912,698 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 321,109 $2.3M <0.01% -208,102 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 272,768 $1.96M 0.01% +249,241 13F-HR Timeline First Turn Management, LLC More: the full row for First Turn Management, LLC 262,643 $1.88M 0.28% new 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 258,779 $1.86M 0.05% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 256,655 $1.84M <0.01% +213,416 13F-HR/A Timeline Group Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 250,000 $1.79M 0.57% new 13F-HR/A Timeline Group Rhenman & Partners Asset Management AB More: the full row for Rhenman & Partners Asset Management AB 207,000 $1.48M 0.16% +162,000 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 194,741 $1.4M <0.01% new 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 178,084 $1.28M 0.84% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 174,161 $1.25M <0.01% +134,764 13F-HR/A Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 195,490 $1.22M <0.01% +176,100 13F-HR Timeline Franklin Resources group of 2 filers holding More: the full row for Franklin Resources 169,073 $1.21M +140,646 Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 151,495 $1.09M 0.11% +117,181 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 143,275 $1.03M <0.01% new 13F-HR Timeline RICE HALL JAMES & ASSOCIATES, LLC More: the full row for RICE HALL JAMES & ASSOCIATES, LLC 134,835 $967K 0.05% -7,485 13F-HR Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 133,642 $958K 0.01% -11,188 13F-HR Timeline Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 133,131 $955K 0.18% -29,465 13F-HR Timeline Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 131,991 $946K <0.01% -15,730 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 125,381 $899K <0.01% -201,961 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 120,243 $862K <0.01% -626 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 106,610 $764K <0.01% -79,542 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 90,800 $651K 0.04% +84,831 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 89,172 $639K <0.01% new 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 84,553 $606K 0.42% +84,177 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 84,347 $605K -15,167 Timeline CONGRESS ASSET MANAGEMENT CO More: the full row for CONGRESS ASSET MANAGEMENT CO 73,365 $526K <0.01% +514 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 71,010 $509K 0.12% new 13F-HR Timeline Group PRINCIPAL FINANCIAL GROUP INC group of 2 filers holding More: the full row for PRINCIPAL FINANCIAL GROUP INC 70,997 $509K +70,989 Timeline Lion Point Capital, LP More: the full row for Lion Point Capital, LP 67,500 $484K 2.75% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 65,256 $468K <0.01% -44,713 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 62,385 $447K <0.01% +2,832 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 60,854 $436K <0.01% -249,748 13F-HR Timeline AXA Investment Managers S.A. More: the full row for AXA Investment Managers S.A. 60,755 $436K <0.01% 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 58,810 $422K <0.01% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 58,229 $417K 0.01% new 13F-HR Timeline Walleye Trading LLC in group Walleye Capital LLC More: the full row for Walleye Trading LLC 53,700 $385K 0.01% new 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 52,886 $379K <0.01% -11,678 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 49,334 $354K <0.01% -1,624,707 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 48,298 $346K <0.01% +26,441 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 45,015 $323K <0.01% +30,701 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 44,779 $321K 0.03% new 13F-HR Timeline TWINBEECH CAPITAL LP More: the full row for TWINBEECH CAPITAL LP 43,735 $314K 0.01% new 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 43,000 $308K <0.01% +700 13F-HR Timeline Voleon Capital Management LP More: the full row for Voleon Capital Management LP 40,273 $289K 0.01% new 13F-HR Timeline TWO SIGMA SECURITIES, LLC More: the full row for TWO SIGMA SECURITIES, LLC 36,405 $261K 0.04% new 13F-HR Timeline Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 35,052 $251K 0.01% +32,052 13F-HR Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 33,878 $243K <0.01% -4,326 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 32,245 $231K 0.01% new 13F-HR Timeline Group HAP Trading, LLC More: the full row for HAP Trading, LLC 31,073 $223K 0.06% 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 30,756 $221K <0.01% -3,534 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 30,690 $220K <0.01% +13,119 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 30,000 $215K 0.03% -52,023 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 28,200 $202K 0.01% new 13F-HR Timeline AXIOM INVESTORS LLC /DE More: the full row for AXIOM INVESTORS LLC /DE 25,180 $181K <0.01% new 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 25,000 $179K <0.01% +19,811 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 21,978 $158K <0.01% new 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 20,905 $150K <0.01% 0 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 20,000 $143K <0.01% -85,000 13F-HR/A Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 19,059 $137K 0.03% -1,894 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 18,972 $136K <0.01% 0 13F-HR Timeline VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 18,790 $135K <0.01% -119,578 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 17,526 $126K <0.01% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 15,469 $111K <0.01% new 13F-HR Timeline Rangeley Capital, LLC More: the full row for Rangeley Capital, LLC 15,000 $108K 0.1% new 13F-HR Timeline MYDA Advisors LLC More: the full row for MYDA Advisors LLC 15,000 $108K 0.03% new 13F-HR Timeline HARBOR CAPITAL ADVISORS, INC. More: the full row for HARBOR CAPITAL ADVISORS, INC. 13,706 $98K 0.01% -37,703 13F-HR Timeline Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 15,000 $93.7K <0.01% 0 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 12,712 $91.1K <0.01% -237 13F-HR Timeline MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 11,954 $85.7K <0.01% -3,798 13F-HR Timeline Group FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 11,400 $81.7K 0.01% new 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 11,100 $79.5K <0.01% 0 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 11,002 $78.9K <0.01% -41,717 13F-HR Timeline Group Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 10,600 $76K <0.01% 0 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 9,800 $70.3K <0.01% -176,768 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 9,001 $64.5K 0.02% +7,201 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 8,021 $57.5K <0.01% +5,050 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 7,890 $56.6K <0.01% -9,436 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 7,296 $52.3K <0.01% +1,158 13F-HR Timeline Group Covestor Ltd More: the full row for Covestor Ltd 6,437 $46K 0.03% new 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 5,919 $42.4K <0.01% +3,166 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 5,539 $39.7K <0.01% -3,600 13F-HR/A Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 5,208 $37.3K <0.01% +4,483 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 4,532 $32.5K <0.01% +1,781 13F-HR/A Timeline Group Centiva Capital, LP More: the full row for Centiva Capital, LP 4,500 $32.3K <0.01% new 13F-HR Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 4,500 $32.3K <0.01% 0 13F-HR Timeline Advisors Asset Management, Inc. More: the full row for Advisors Asset Management, Inc. 3,994 $28.6K <0.01% -15 13F-HR/A Timeline FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 4,000 $28K 0.01% new 13F-HR Timeline Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 3,535 $25.3K <0.01% new 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 2,585 $18.5K 0.01% +449 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 2,357 $16.9K <0.01% -3,103 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 2,340 $16.8K <0.01% +785 13F-HR Timeline Group Delos Wealth Advisors, LLC More: the full row for Delos Wealth Advisors, LLC 2,000 $14.3K 0.01% new 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 1,842 $13.2K <0.01% -198,479 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,313 $9.41K <0.01% -1,436 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 1,101 $7.89K <0.01% +1,084 13F-HR/A Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 956 $6.86K <0.01% -14,152 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 952 $6.83K <0.01% new 13F-HR Timeline ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 888 $6.37K <0.01% new 13F-HR Timeline Group BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 710 $6K <0.01% +610 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 87 $3.05K <0.01% +37 13F-HR Timeline Group BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 272 $2K <0.01% +15 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 142 $1K <0.01% +22 13F-HR Timeline Group Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 95 $681 <0.01% new 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 82 $588 <0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 59 $424 <0.01% -4,281 13F-HR Timeline Group PRIVATE TRUST CO NA More: the full row for PRIVATE TRUST CO NA 52 $373 <0.01% -68 13F-HR Timeline J.Safra Asset Management Corp More: the full row for J.Safra Asset Management Corp 51 $366 <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 25 $179 <0.01% new 13F-HR Timeline TD PRIVATE CLIENT WEALTH LLC More: the full row for TD PRIVATE CLIENT WEALTH LLC 17 $122 <0.01% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 16 $115 <0.01% -4,537 13F-HR/A Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 16 $115 <0.01% -34 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 11 $79 <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 8 $57 <0.01% new 13F-HR Timeline Group MONTAG A & ASSOCIATES INC More: the full row for MONTAG A & ASSOCIATES INC 7 $51 <0.01% new 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 6 $43 <0.01% new 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 5 $36 <0.01% 0 13F-HR Timeline WPG Advisers, LLC More: the full row for WPG Advisers, LLC 3 $22 <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1 $7 <0.01% -273 13F-HR Timeline Group NOMURA ASSET MANAGEMENT CO LTD in group NOMURA ASSET MANAGEMENT CO LTD More: the full row for NOMURA ASSET MANAGEMENT CO LTD 0 $0 0% 0 13F-HR Timeline Group Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.