BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 19,751,284 $1.07B 36.25% -2,000,000 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 8,494,151 $460M 25.26% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 6,341,391 $343M 0.02% +1,391,167 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 3,343,643 $181M 0.02% +363,394 13F-HR Timeline Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 2,770,100 $150M 2.12% 0 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 2,186,866 $118M 0.11% -136,105 13F-HR Timeline Group Paradigm Biocapital Advisors LP in group Paradigm Biocapital Advisors … More: the full row for Paradigm Biocapital Advisors LP 1,772,211 $96M 3.34% +840,731 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,674,664 $90.7M 0.02% +178,833 13F-HR Timeline Group Holocene Advisors, LP More: the full row for Holocene Advisors, LP 1,585,167 $85.8M 0.28% 0 13F-HR Timeline WESTFIELD CAPITAL MANAGEMENT CO LP More: the full row for WESTFIELD CAPITAL MANAGEMENT CO LP 1,311,619 $71M 0.31% +144,261 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 1,280,052 $69.3M 0.15% +149,724 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 1,245,299 $67.4M 0.08% +90,914 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 1,100,000 $59.6M 0.33% +600,000 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 1,022,604 $55.4M 0.02% +24,464 13F-HR Timeline FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 673,773 $36.5M 0.17% +7,199 13F-HR Timeline Group Hood River Capital Management LLC More: the full row for Hood River Capital Management LLC 649,590 $35.2M 0.52% +2,928 13F-HR Timeline Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 595,581 $32.3M 0.01% +14,792 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 448,860 $24.3M 0.03% +39,657 13F-HR/A Timeline Group Finepoint Capital LP More: the full row for Finepoint Capital LP 447,935 $24.3M 2.8% +59,100 13F-HR Timeline Camber Capital Management LP More: the full row for Camber Capital Management LP 441,000 $23.9M 0.93% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 368,845 $20M <0.01% -31,940 13F-HR Timeline Group Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 346,617 $18.8M 0.02% -10,219 13F-HR Timeline Group Saturn V Capital Management LP More: the full row for Saturn V Capital Management LP 346,111 $18.7M 7.34% +47,137 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 332,522 $18M 0.72% new 13F-HR Timeline MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 315,230 $17.1M 2.42% -33,833 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 293,535 $15.9M 0.11% +61,105 13F-HR Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 282,313 $15.3M 3.65% 0 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 261,634 $14.2M 0.01% +45,800 13F-HR Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 227,476 $12.3M 0.07% -11,524 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 208,896 $11.3M 0.11% new 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 206,568 $11.2M 0.03% -153,632 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 204,373 $11.1M <0.01% +45,113 13F-HR Timeline Group Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 200,000 $10.8M 0.96% -20,000 13F-HR Timeline VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 178,501 $9.67M 0.01% -39,338 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 155,000 $8.39M 0.01% -350,000 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 142,702 $7.73M 0.01% +24,576 13F-HR Timeline Group Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 136,438 $7.39M 0.31% -36,196 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 115,416 $6.25M <0.01% -2,320 13F-HR Timeline Group RICE HALL JAMES & ASSOCIATES, LLC More: the full row for RICE HALL JAMES & ASSOCIATES, LLC 111,133 $6.02M 0.33% +35,664 13F-HR Timeline AXA S.A. in group AXA S.A. More: the full row for AXA S.A. 104,178 $5.64M 0.02% -164 13F-HR Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 100,000 $5.42M 0.02% 0 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 99,098 $5.37M <0.01% -92,960 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 98,719 $5.35M 0.01% new 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 91,545 $4.96M <0.01% +3,908 13F-HR Timeline Group HARBOR CAPITAL ADVISORS, INC. More: the full row for HARBOR CAPITAL ADVISORS, INC. 79,648 $4.31M 0.19% +2,180 13F-HR Timeline CONGRESS ASSET MANAGEMENT CO More: the full row for CONGRESS ASSET MANAGEMENT CO 72,993 $3.95M 0.03% +6,352 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 70,154 $3.8M +28,000 Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 64,384 $3.49M <0.01% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 58,950 $3.19M <0.01% +540 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 55,890 $3.03M <0.01% -6,140 13F-HR Timeline Group Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 54,294 $2.94M 0.39% -48,519 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 50,995 $2.76M 0.02% +7,167 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 47,144 $2.55M <0.01% -83,454 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 45,540 $2.47M <0.01% -76,559 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 43,541 $2.36M 0.88% 0 13F-HR Timeline Clearbridge Investments, LLC in group Franklin Resources More: the full row for Clearbridge Investments, LLC 43,380 $2.35M <0.01% +9,106 13F-HR Timeline Group Swiss National Bank More: the full row for Swiss National Bank 43,000 $2.33M <0.01% 0 13F-HR Timeline WEXFORD CAPITAL LP More: the full row for WEXFORD CAPITAL LP 24,000 $1.3M 0.33% +10,000 13F-HR Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 23,687 $1.28M 0.86% -3,571 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 22,025 $1.19M <0.01% +1,202 13F-HR Timeline Group BIT Capital GmbH More: the full row for BIT Capital GmbH 20,748 $1.12M 0.1% new 13F-HR Timeline OCONNOR, A Distinct Business Unit of UB… More: the full row for OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 20,740 $1.12M 0.03% +4,740 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 20,141 $1.09M <0.01% 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 19,480 $1.05M <0.01% +1,429 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 18,972 $1.03M <0.01% -241 13F-HR/A Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 17,424 $944K 0.19% -6,033 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 15,895 $861K <0.01% +1,343 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 15,456 $837K <0.01% +1,866 13F-HR Timeline Group Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 15,000 $831K 0.01% 0 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 14,261 $772K <0.01% +8,811 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 12,865 $697K <0.01% -164 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 12,371 $670K 0.03% new 13F-HR Timeline Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 11,100 $601K <0.01% -1,900 13F-HR Timeline JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 11,100 $600K <0.01% 0 13F-HR Timeline Group Cinctive Capital Management LP More: the full row for Cinctive Capital Management LP 10,576 $573K 0.03% new 13F-HR Timeline Allianz Asset Management GmbH in group Allianz SE More: the full row for Allianz Asset Management GmbH 9,900 $536K <0.01% +4,700 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 9,229 $500K 0.03% -11,096 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 9,139 $495K <0.01% -33,174 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 8,971 $486K <0.01% -193 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 8,500 $460K <0.01% +320 13F-HR Timeline Group DNB Asset Management AS in group DNB Asset Management AS More: the full row for DNB Asset Management AS 8,356 $452K <0.01% +847 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 8,146 $441K <0.01% +1,332 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 7,633 $413K <0.01% new 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 7,500 $406K <0.01% new 13F-HR Timeline Group TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 6,532 $354K <0.01% +1,013 13F-HR Timeline ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 6,371 $345K <0.01% +35 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 6,250 $338K <0.01% new 13F-HR/A Timeline Group Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 5,028 $272K <0.01% new 13F-HR Timeline Group PEAK6 LLC in group PEAK6 LLC More: the full row for PEAK6 LLC 5,000 $271K 0.01% 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 4,646 $252K <0.01% -995 13F-HR/A Timeline Group KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 4,500 $244K <0.01% 13F-HR Timeline Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 4,400 $238K <0.01% 0 13F-HR Timeline Group Birchview Capital, LP More: the full row for Birchview Capital, LP 4,000 $217K 0.18% new 13F-HR/A Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 3,911 $212K <0.01% -82,864 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 3,718 $201K <0.01% -4,210 13F-HR Timeline Group Parallax Volatility Advisers, L.P. More: the full row for Parallax Volatility Advisers, L.P. 3,208 $174K <0.01% new 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 2,753 $149K <0.01% 0 13F-HR Timeline Advisors Asset Management, Inc. More: the full row for Advisors Asset Management, Inc. 2,206 $119K <0.01% new 13F-HR/A Timeline VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 1,322 $71.6K 0.03% -840 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 1,250 $67.7K <0.01% +14 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,212 $65.6K <0.01% new 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,030 $55.8K <0.01% +161 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 903 $48.9K <0.01% +338 13F-HR/A Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 325 $17.6K <0.01% +25 13F-HR Timeline Group PRIVATE TRUST CO NA More: the full row for PRIVATE TRUST CO NA 193 $10.5K <0.01% +34 13F-HR Timeline Nationale-Nederlanden Powszechne Towarz… More: the full row for Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. 85 $4.6K <0.01% -228,944 13F-HR Timeline Brooklyn Investment Group More: the full row for Brooklyn Investment Group 78 $4.22K <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 75 $4.06K <0.01% 0 13F-HR/A Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 25 $1K <0.01% +14 13F-HR Timeline Group Geneos Wealth Management Inc. More: the full row for Geneos Wealth Management Inc. 14 $758 <0.01% new 13F-HR Timeline Amundi in group Amundi More: the full row for Amundi 12 $578 <0.01% new 13F-HR Timeline Group J.Safra Asset Management Corp More: the full row for J.Safra Asset Management Corp 8 $424 <0.01% 0 13F-HR Timeline NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 2 $108 <0.01% new 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 0 $54 <0.01% new 13F-HR Timeline Amount filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios. NOMURA ASSET MANAGEMENT CO LTD in group NOMURA ASSET MANAGEMENT CO LTD More: the full row for NOMURA ASSET MANAGEMENT CO LTD 0 $0 0% 0 13F-HR Timeline Group Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.