BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 19,751,284 $260M 8.76% 0 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 4,610,071 $60.8M 1.39% new 13F-HR Timeline Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 4,355,433 $57.4M 3.25% +2,361,260 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 2,480,767 $32.7M 0.02% new 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 2,095,988 $27.7M 0.01% +2,084,888 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 1,750,000 $23.1M 1.54% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 1,682,148 $22.2M 0.03% +1,660,170 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 1,571,071 $20.7M 0.04% -128,164 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,044,581 $13.8M <0.01% +787,926 13F-HR/A Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 1,000,000 $13.2M 0.85% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 959,553 $12.6M <0.01% +136,596 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 916,511 $12.1M +422,919 Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 837,739 $11M <0.01% +663,578 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 803,210 $10.6M +608,469 Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 802,722 $10.6M 0.01% +713,550 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 772,500 $10.2M 0.02% +762,700 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 637,434 $8.4M <0.01% +1,735 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 635,901 $8.38M 0.03% +492,626 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 500,000 $6.59M 0.05% +475,000 13F-HR Timeline Group Voleon Capital Management LP More: the full row for Voleon Capital Management LP 499,099 $6.58M 0.14% +458,826 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 425,559 $5.61M 0.07% new 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 400,000 $5.27M 0.22% new 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 380,890 $5.02M <0.01% +331,556 13F-HR Timeline Group Rhenman & Partners Asset Management AB More: the full row for Rhenman & Partners Asset Management AB 364,000 $4.8M 0.45% +157,000 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 348,401 $4.59M 0.79% new 13F-HR Timeline Weiss Asset Management LP in group Weiss Asset Management LP More: the full row for Weiss Asset Management LP 332,961 $4.39M 0.06% new 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 322,261 $4.25M 0.02% -643,144 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 286,593 $3.78M <0.01% +161,212 13F-HR Timeline Group Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 275,000 $3.62M 0.79% +25,000 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 270,665 $3.57M <0.01% -92,206 13F-HR/A Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 266,150 $3.51M <0.01% +145,907 13F-HR Timeline Group First Turn Management, LLC More: the full row for First Turn Management, LLC 262,643 $3.46M 0.4% 0 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 239,020 $3.15M <0.01% +154,673 13F-HR Timeline Group ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 221,616 $2.92M 0.05% new 13F-HR/A Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 212,996 $2.81M 0.03% new 13F-HR Timeline Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 198,307 $2.61M 0.11% new 13F-HR Timeline Eagle Health Investments LP More: the full row for Eagle Health Investments LP 187,600 $2.47M 0.54% new 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 184,319 $2.43M 0.02% new 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 183,552 $2.42M <0.01% +172,550 13F-HR Timeline Group Kalehua Capital Management LLC More: the full row for Kalehua Capital Management LLC 175,734 $2.32M 2.29% 13F-HR Timeline Walleye Capital LLC group of 2 filers holding More: the full row for Walleye Capital LLC 163,142 $2.15M +109,442 Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 156,276 $2.06M <0.01% -570,656 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 134,472 $1.77M <0.01% new 13F-HR Timeline Candriam S.C.A. More: the full row for Candriam S.C.A. 134,329 $1.77M 0.01% +687 13F-HR/A Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 130,964 $1.73M <0.01% +129,122 13F-HR Timeline Group RICE HALL JAMES & ASSOCIATES, LLC More: the full row for RICE HALL JAMES & ASSOCIATES, LLC 127,465 $1.68M 0.09% -7,370 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 126,744 $1.67M <0.01% +20,134 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 121,640 $1.6M <0.01% +90,950 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 103,516 $1.36M 0.01% new 13F-HR Timeline J. Goldman & Co LP More: the full row for J. Goldman & Co LP 101,467 $1.34M 0.05% new 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 95,972 $1.26M 0.03% new 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 89,236 $1.18M 0.1% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 85,570 $1.13M <0.01% +20,314 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 78,638 $1.04M 0.02% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 72,606 $956K <0.01% +10,221 13F-HR Timeline Group FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 71,962 $948K 0.15% +60,562 13F-HR Timeline CONGRESS ASSET MANAGEMENT CO More: the full row for CONGRESS ASSET MANAGEMENT CO 71,096 $937K 0.01% -2,269 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 70,611 $931K 0.01% new 13F-HR Timeline Lion Point Capital, LP More: the full row for Lion Point Capital, LP 67,500 $890K 4.6% 0 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 61,948 $817K <0.01% +61,676 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 61,700 $813K 0.04% +33,500 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 61,500 $811K <0.01% +18,500 13F-HR Timeline ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 59,280 $781K 0.53% new 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 58,169 $767K <0.01% +27,413 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 50,973 $672K <0.01% -1,913 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 50,251 $662K <0.01% +50,235 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 50,217 $662K 0.01% new 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 49,168 $648K <0.01% -11,686 13F-HR Timeline Cinctive Capital Management LP More: the full row for Cinctive Capital Management LP 37,194 $490K 0.03% new 13F-HR Timeline IMC-Chicago, LLC More: the full row for IMC-Chicago, LLC 36,468 $481K 0.01% new 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 32,886 $433K <0.01% new 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 30,476 $402K 0.01% +15,007 13F-HR Timeline Entropy Technologies, LP More: the full row for Entropy Technologies, LP 30,300 $399K 0.02% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 29,296 $386K <0.01% +10,324 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 28,972 $382K 0.01% -29,257 13F-HR Timeline AXIOM INVESTORS LLC /DE More: the full row for AXIOM INVESTORS LLC /DE 25,998 $343K <0.01% +818 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 24,292 $320K 0.01% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 22,973 $303K 0.01% -9,272 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 21,888 $288K <0.01% +4,362 13F-HR Timeline Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 20,159 $266K <0.01% new 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 18,479 $244K <0.01% -26,536 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 17,987 $237K 0.06% +15,402 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 16,078 $212K <0.01% -4,827 13F-HR Timeline Group Brooklyn Investment Group More: the full row for Brooklyn Investment Group 14,920 $204K 0.01% new 13F-HR Timeline Vident Advisory, LLC in group Vident Advisory, LLC More: the full row for Vident Advisory, LLC 15,444 $204K <0.01% new 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 13,592 $179K <0.01% +7,673 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 13,533 $178K <0.01% +9,001 13F-HR Timeline Group Campbell & CO Investment Adviser LLC More: the full row for Campbell & CO Investment Adviser LLC 13,448 $177K 0.01% new 13F-HR Timeline Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 12,582 $166K 0.01% new 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 12,438 $164K <0.01% -274 13F-HR Timeline Centiva Capital, LP More: the full row for Centiva Capital, LP 12,291 $162K 0.01% +7,791 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 11,310 $149K <0.01% +4,014 13F-HR Timeline Group HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 11,095 $147K <0.01% new 13F-HR/A Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 10,000 $132K <0.01% +4,792 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 8,985 $118K <0.01% +8,898 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 8,523 $112K 0.05% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 6,950 $91.6K 0.02% -77,603 13F-HR/A Timeline KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 6,800 $89.6K <0.01% +2,300 13F-HR Timeline Quantbot Technologies LP More: the full row for Quantbot Technologies LP 6,266 $82.6K <0.01% new 13F-HR Timeline Delos Wealth Advisors, LLC More: the full row for Delos Wealth Advisors, LLC 6,000 $79.1K 0.05% +4,000 13F-HR Timeline Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 4,489 $59.2K <0.01% -1,050 13F-HR/A Timeline Advisors Asset Management, Inc. More: the full row for Advisors Asset Management, Inc. 3,992 $52.6K <0.01% -2 13F-HR/A Timeline T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 3,557 $47K <0.01% new 13F-HR/A Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 3,426 $45.2K <0.01% +1,069 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 2,052 $27K <0.01% -288 13F-HR Timeline Group Kestra Advisory Services, LLC in group Kestra Advisory Services, LLC More: the full row for Kestra Advisory Services, LLC 2,000 $26.4K <0.01% new 13F-HR Timeline Group ACT CAPITAL MANAGEMENT, LLC More: the full row for ACT CAPITAL MANAGEMENT, LLC 1,500 $19.8K 0.02% 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 1,484 $19.6K <0.01% new 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 1,414 $18.6K <0.01% +1,403 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,328 $17.5K <0.01% +15 13F-HR Timeline Group DecisionPoint Financial, LLC More: the full row for DecisionPoint Financial, LLC 1,219 $16.1K <0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 910 $12K <0.01% -7,111 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 893 $11.8K <0.01% +885 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 771 $10.2K <0.01% +746 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 704 $9.28K <0.01% +703 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 381 $5.02K <0.01% +365 13F-HR Timeline Basecamp Wealth Advisors LLC More: the full row for Basecamp Wealth Advisors LLC 272 $3.58K <0.01% 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 213 $2.81K <0.01% -739 13F-HR Timeline QUADRANT CAPITAL GROUP LLC More: the full row for QUADRANT CAPITAL GROUP LLC 210 $2.77K <0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 103 $2K <0.01% -48,195 13F-HR Timeline Group Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 95 $1.25K <0.01% 0 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 60 $1K <0.01% -82 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 47 $620 <0.01% -12 13F-HR Timeline Group WPG Advisers, LLC More: the full row for WPG Advisers, LLC 3 $40 <0.01% 0 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 1 $13 <0.01% new 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 1 $13 <0.01% -1,100 13F-HR Timeline Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 1 $13 <0.01% new 13F-HR Timeline BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 0 $0 0% -710 13F-HR Timeline Group Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.