JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 4,339,254 $28.5M 0.01% +576,059 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 2,723,363 $17.9M 0.02% 0 13F-HR Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 2,209,615 $14.5M 0.03% -388,121 13F-HR Timeline Group D1 Capital Partners L.P. More: the full row for D1 Capital Partners L.P. 2,203,900 $14.5M 0.24% -302,707 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,821,966 $12M <0.01% +191,679 13F-HR Timeline Group EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 1,234,834 $8.13M 0.15% -621,152 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 1,200,000 $7.9M 0.47% +350,000 13F-HR Timeline Omega Fund Management, LLC More: the full row for Omega Fund Management, LLC 1,184,636 $7.79M 5.06% -1,171,268 13F-HR Timeline Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 1,158,617 $7.62M 0.04% 0 13F-HR Timeline Group NOVO HOLDINGS A/S More: the full row for NOVO HOLDINGS A/S 1,122,581 $7.39M 0.45% 0 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,118,879 $7.36M <0.01% +254,168 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 955,515 $6.29M 0.26% -295,271 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 858,691 $5.65M 0.04% +6,730 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 750,235 $4.94M 0.01% +379,828 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 709,900 $4.67M 0.02% -67,420 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 603,435 $3.97M 0.18% 0 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 567,383 $3.73M <0.01% +14,136 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 546,554 $3.6M 0.05% 0 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 499,301 $3.29M 0.94% +242,085 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 457,403 $3.01M <0.01% +203,457 13F-HR Timeline Group Altium Capital Management LLC More: the full row for Altium Capital Management LLC 405,000 $2.66M 0.83% new 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 393,083 $2.59M 0.66% +142,500 13F-HR Timeline Laurion Capital Management LP More: the full row for Laurion Capital Management LP 260,228 $1.71M 0.11% 0 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 214,284 $1.41M <0.01% +14,185 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 169,505 $1.12M 0.23% +112,339 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 147,807 $973K 0.03% +40,323 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 141,951 $934K <0.01% +104,837 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 139,835 $920K 0.03% 0 13F-HR Timeline Group Privium Fund Management B.V. More: the full row for Privium Fund Management B.V. 138,115 $909K 0.21% new 13F-HR Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 130,000 $855K 0.15% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 90,901 $598K <0.01% +14,150 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 76,981 $507K <0.01% +25,089 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 74,828 $492K <0.01% -167,000 13F-HR/A Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 65,000 $428K 0.01% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 63,874 $420K <0.01% 0 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 61,930 $407K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 55,161 $363K <0.01% +4,951 13F-HR/A Timeline Group SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 52,616 $346K 0.3% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 51,054 $336K <0.01% +39,942 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 50,660 $333K <0.01% +2,677 13F-HR Timeline Group Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 36,050 $237K <0.01% 0 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 34,527 $227K <0.01% +28,986 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 30,376 $200K <0.01% -8,409 13F-HR Timeline Group Aristides Capital LLC More: the full row for Aristides Capital LLC 29,285 $193K 0.06% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 25,197 $166K <0.01% +4,127 13F-HR/A Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 24,924 $164K <0.01% +1,819 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 20,400 $134K <0.01% new 13F-HR Timeline Group CAXTON CORP More: the full row for CAXTON CORP 17,851 $117K 0.71% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 17,794 $117K <0.01% new 13F-HR Timeline Group Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 16,100 $106K 0.02% new 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 15,970 $105K <0.01% 0 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 14,579 $96.2K +1,710 Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 14,512 $95.5K <0.01% -21,165 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 14,223 $93.6K <0.01% 0 13F-HR Timeline Group Corton Capital Inc. More: the full row for Corton Capital Inc. 13,771 $90.6K 0.05% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 13,371 $88K <0.01% +3,093 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 13,226 $87K <0.01% +8,378 13F-HR/A Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 11,715 $77.1K <0.01% -885 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 11,565 $76.1K <0.01% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 11,156 $73.4K <0.01% +3,714 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 11,148 $73.4K <0.01% new 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 10,960 $72K <0.01% new 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 10,710 $70.5K <0.01% new 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 10,425 $69K <0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 7,011 $46.1K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 6,040 $39.7K <0.01% 13F-HR Timeline Allostery Investments LP More: the full row for Allostery Investments LP 5,054 $33.3K 0.07% 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 4,187 $27.6K <0.01% 0 13F-HR/A Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 2,527 $16.6K <0.01% 0 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,387 $15.7K <0.01% 0 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 2,003 $13.2K <0.01% +1,408 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,735 $11.4K <0.01% 0 13F-HR/A Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 1,726 $11.4K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,655 $10.9K <0.01% +238 13F-HR Timeline Group Brooklyn Investment Group More: the full row for Brooklyn Investment Group 1,465 $9.64K <0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 965 $6K <0.01% -2,188 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 785 $5K <0.01% +775 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 694 $4.57K <0.01% 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 623 $4K <0.01% 0 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 416 $2.74K <0.01% new 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 396 $2.61K <0.01% new 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 245 $1.61K <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 197 $1.3K <0.01% 13F-HR Timeline Avior Wealth Management, LLC More: the full row for Avior Wealth Management, LLC 185 $1.22K <0.01% +11 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 100 $658 <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 27 $178 <0.01% 0 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 20 $132 <0.01% new 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 6 $39 <0.01% new 13F-HR Timeline LAZARD ASSET MANAGEMENT LLC in group LAZARD ASSET MANAGEMENT LLC More: the full row for LAZARD ASSET MANAGEMENT LLC 33 $0 0% 0 13F-HR Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.