Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 4,424,725 $17.8M 0.71% +3,469,210 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 4,009,137 $16.1M 0.04% new 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 3,684,383 $14.8M 0.01% -873,537 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 3,607,967 $14.5M 0.01% +884,604 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 3,589,355 $14.4M 2.13% +2,108,474 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 3,228,161 $13M 0.68% +2,091,912 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 2,836,292 $11.4M 0.01% +1,764,803 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 2,572,162 $10.3M 0.05% +1,735,148 13F-HR Timeline VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 2,017,866 $8.11M +918,581 Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,827,964 $7.35M <0.01% -14,268 13F-HR Timeline Group Omega Fund Management, LLC More: the full row for Omega Fund Management, LLC 1,184,636 $4.76M 3.08% 0 13F-HR Timeline Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 1,124,922 $4.52M 0.02% -33,695 13F-HR Timeline Group D1 Capital Partners L.P. More: the full row for D1 Capital Partners L.P. 978,652 $3.93M 0.05% 0 13F-HR Timeline Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 867,302 $3.49M 2.9% new 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 647,880 $2.6M 0.01% -450,263 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 603,435 $2.43M 0.13% 0 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 578,081 $2.32M <0.01% -8,435 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 550,029 $2.21M 0.73% 0 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 513,026 $2.06M <0.01% +43,298 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 414,863 $1.67M 0.01% 0 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 378,083 $1.52M 0.42% 0 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 271,904 $1.09M <0.01% +239,822 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 200,786 $807K <0.01% -5,307 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 188,635 $758K <0.01% +138,298 13F-HR Timeline Group Privium Fund Management B.V. More: the full row for Privium Fund Management B.V. 178,356 $753K 0.16% +18,158 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 163,172 $656K 0.02% 0 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 145,109 $583K 0.09% -25,339 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 139,835 $562K 0.02% 0 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 116,142 $467K <0.01% +69,475 13F-HR/A Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 106,200 $427K <0.01% +85,900 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 84,781 $341K <0.01% +465 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 70,270 $282K +20,123 Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 69,242 $278K -63,482 Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 65,152 $262K <0.01% +14,508 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 64,220 $258K <0.01% +8,046 13F-HR Timeline Group Palumbo Wealth Management LLC More: the full row for Palumbo Wealth Management LLC 56,303 $226K 0.07% new 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 53,400 $215K 0.01% +15,000 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 48,434 $195K <0.01% +8,223 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 47,023 $189K <0.01% new 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 36,368 $146K <0.01% -42,740 13F-HR Timeline Group PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 34,741 $140K <0.01% 0 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 33,102 $133K <0.01% -2,948 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 31,990 $129K <0.01% +1,798 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 29,779 $120K <0.01% new 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 29,370 $118K <0.01% +13,400 13F-HR Timeline Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 27,650 $111K 0.01% +8,750 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 26,653 $107K <0.01% +4,883 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 23,922 $96.2K <0.01% +12,552 13F-HR Timeline Group Soltis Investment Advisors LLC More: the full row for Soltis Investment Advisors LLC 20,000 $80.4K 0.01% 0 13F-HR Timeline CAXTON CORP More: the full row for CAXTON CORP 17,332 $69.7K 0.71% -519 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 15,325 $61.6K <0.01% +3,916 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 14,759 $59.3K -321 Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 14,748 $59.3K <0.01% -8,579 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 14,528 $58K <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 13,750 $55.3K <0.01% -30 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 13,682 $55K <0.01% +2,342 13F-HR Timeline AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 12,475 $50.1K 0.02% new 13F-HR Timeline Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 12,447 $50K <0.01% new 13F-HR Timeline Group IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 11,851 $47.6K <0.01% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 11,753 $47.2K <0.01% +1,889 13F-HR Timeline Group Ethic Inc. More: the full row for Ethic Inc. 10,726 $44.2K <0.01% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 10,425 $42K <0.01% 0 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 10,351 $42K <0.01% +6,216 13F-HR Timeline Group COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 10,190 $41K <0.01% new 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 6,667 $26.8K <0.01% +35 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 6,040 $24.3K <0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 5,094 $20.5K <0.01% -771 13F-HR Timeline Group FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 5,000 $20K 0.01% 0 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 4,187 $16.8K <0.01% 0 13F-HR/A Timeline Brooklyn Investment Group More: the full row for Brooklyn Investment Group 3,852 $15.5K <0.01% new 13F-HR/A Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 3,138 $12K <0.01% +1,305 13F-HR/A Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 2,765 $11.1K <0.01% +2,426 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 2,387 $9.6K <0.01% 0 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 2,032 $8.17K <0.01% -495 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,735 $6.97K <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 1,197 $4.81K <0.01% +1,000 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 820 $3.3K <0.01% 0 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 623 $3K <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 657 $2.64K <0.01% +281 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 645 $2.59K <0.01% +618 13F-HR/A Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 219 $880 <0.01% new 13F-HR Timeline Group Essential Partners LLC More: the full row for Essential Partners LLC 174 $699 <0.01% 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 107 $430 <0.01% +101 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 100 $402 <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 105 $364 <0.01% new 13F-HR/A Timeline Group True Wealth Design, LLC More: the full row for True Wealth Design, LLC 3 $13 <0.01% -16 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1 $4 <0.01% 0 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.