Paradigm Biocapital Advisors LP in group Paradigm Biocapital Advisors … More: the full row for Paradigm Biocapital Advisors LP 6,184,134 $35.5M 0.73% +1,420,936 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 5,110,871 $29.3M <0.01% +203,308 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 5,050,211 $29M 1.7% +1,850,211 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 5,000,000 $28.7M 0.3% 0 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 4,976,429 $28.5M 0.01% -533,206 13F-HR/A Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 4,475,000 $25.7M 0.72% 0 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 4,424,725 $25.4M 0.65% 0 13F-HR Timeline VANGUARD GROUP INC group of 5 filers holding More: the full row for VANGUARD GROUP INC 4,029,159 $23.1M +4,012,723 Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 3,834,999 $22M 0.02% +60,682 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 3,602,450 $20.7M 0.45% +1,477,450 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 3,568,242 $20.5M <0.01% +380,520 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 2,750,532 $15.8M 0.06% -447,228 13F-HR/A Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,949,885 $11.2M <0.01% +1,168,030 13F-HR Timeline Group Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 1,875,000 $10.8M 0.11% -1,425,000 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 1,680,449 $9.65M 0.02% -214,273 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,612,780 $9.26M 0.01% +704,756 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 1,589,585 $9.12M 0.02% -45,441 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,513,777 $8.69M <0.01% +67,890 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 1,467,350 $8.42M 0.51% +74,189 13F-HR Timeline Group MONTANOVA CAPITAL, LLC More: the full row for MONTANOVA CAPITAL, LLC 1,250,000 $7.17M 0.19% 0 13F-HR Timeline 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 1,200,000 $6.89M 0.64% +80,000 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,200,000 $6.89M 0.43% +200,000 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 1,103,584 $6.33M <0.01% +240,692 13F-HR Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 1,100,000 $6.31M 0.7% -625,000 13F-HR Timeline Spruce Street Capital LP More: the full row for Spruce Street Capital LP 928,593 $5.33M 1.28% +753,593 13F-HR Timeline Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 904,959 $5.19M 0.02% 0 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 513,011 $2.94M 0.42% 0 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 493,666 $2.83M <0.01% +36,614 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 491,532 $2.82M <0.01% +331,244 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 465,515 $2.67M <0.01% +332,258 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 402,924 $2.31M <0.01% +262,743 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 377,059 $2.16M 0.49% +36,200 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 339,623 $1.95M <0.01% +2,237 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 321,793 $1.85M +40,710 Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 319,090 $1.83M <0.01% +226,482 13F-HR Timeline Group Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 245,904 $1.41M <0.01% new 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 228,201 $1.31M <0.01% -29,216 13F-HR Timeline Group Privium Fund Management B.V. More: the full row for Privium Fund Management B.V. 205,000 $1.18M 0.24% +12,450 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 182,975 $1.05M <0.01% -28,554 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 182,069 $1.05M <0.01% -10,141 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 181,676 $1.04M <0.01% -218,891 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 172,703 $991K <0.01% +89,473 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 159,980 $918K +96,766 Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 158,899 $912K <0.01% -7,850 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 142,571 $818K 0.02% -88,592 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 136,377 $783K 0.02% 0 13F-HR Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 125,000 $718K 0.04% 0 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 112,172 $644K 0.01% new 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 61,810 $614K <0.01% 0 13F-HR Timeline Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 100,896 $579K <0.01% -1,263 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 100,607 $577K 0.01% +89,463 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 93,163 $491K <0.01% +63,302 13F-HR/A Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 72,082 $414K <0.01% +2,713 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 67,079 $385K <0.01% +56,721 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 63,518 $365K <0.01% -399,511 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 63,051 $362K <0.01% +5,885 13F-HR Timeline Group DRW Securities, LLC More: the full row for DRW Securities, LLC 47,988 $275K 0.02% new 13F-HR Timeline Bleakley Financial Group, LLC More: the full row for Bleakley Financial Group, LLC 47,964 $275K <0.01% new 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 45,161 $259K 0.01% +7,107 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 43,132 $248K <0.01% +9,260 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 40,878 $231K +2,074 Timeline LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 37,071 $213K <0.01% +25,516 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 35,584 $204K <0.01% -137 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 34,269 $197K 0.01% +22,806 13F-HR Timeline PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 34,297 $197K <0.01% 0 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 30,477 $175K <0.01% -449,728 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 27,910 $160K 0.04% +680 13F-HR Timeline Group AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 26,119 $150K 0.02% new 13F-HR Timeline Mitsubishi UFJ Asset Management Co., Lt… in group Mitsubishi UFJ Trust & Bankin… More: the full row for Mitsubishi UFJ Asset Management Co., Ltd. 25,577 $147K <0.01% -632 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 24,993 $143K <0.01% -45,743 13F-HR/A Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 24,388 $140K <0.01% +11,000 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 24,221 $139K <0.01% new 13F-HR Timeline Cerity Partners LLC in group Cerity Partners LLC More: the full row for Cerity Partners LLC 21,027 $121K <0.01% -1,412 13F-HR Timeline Group Soltis Investment Advisors LLC More: the full row for Soltis Investment Advisors LLC 20,000 $115K 0.01% 0 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 19,887 $114K <0.01% 0 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 18,317 $105K <0.01% -636 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 17,738 $102K <0.01% -1,409 13F-HR Timeline Group EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 16,560 $95.1K 0.03% new 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 16,504 $94.7K <0.01% +2,316 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 16,373 $94K <0.01% 0 13F-HR Timeline WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 15,991 $91.5K <0.01% +1,661 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 15,585 $89.5K <0.01% +3,047 13F-HR Timeline Group CAXTON CORP More: the full row for CAXTON CORP 13,943 $80K 1.99% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 13,620 $78.2K <0.01% +2,386 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 13,400 $76.9K <0.01% 0 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 13,320 $76.5K <0.01% -1,973 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 12,952 $74.3K 0.01% +1,059 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 12,852 $73.8K <0.01% -1,900 13F-HR Timeline E Fund Management Co., Ltd. More: the full row for E Fund Management Co., Ltd. 12,683 $72.8K <0.01% 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 12,165 $69.8K <0.01% -176,589 13F-HR Timeline Group Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 11,901 $68K <0.01% new 13F-HR Timeline Group Ethic Inc. More: the full row for Ethic Inc. 11,132 $63.9K <0.01% -317 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 10,705 $61.4K <0.01% -271 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 9,485 $54.4K <0.01% +8,659 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 6,639 $38.1K <0.01% +767 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 5,631 $32.3K <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 5,300 $30K <0.01% -1,421 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 5,121 $29.4K <0.01% 0 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 4,865 $27.9K <0.01% +2,100 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 3,595 $20.6K <0.01% -289 13F-HR Timeline NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 2,462 $14.1K <0.01% new 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 2,191 $12.6K <0.01% -1,445 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,628 $9.35K <0.01% +194 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 1,456 $8.36K <0.01% +1,216 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 1,355 $7.78K <0.01% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 1,308 $7.51K <0.01% -508 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 1,240 $7.12K <0.01% -11,791 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 1,141 $6.55K <0.01% +441 13F-HR Timeline Group HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 1,000 $5.74K <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 801 $4.6K <0.01% +70 13F-HR/A Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 640 $3.67K <0.01% +85 13F-HR Timeline Group Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 600 $3.44K <0.01% +288 13F-HR/A Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 505 $2.9K <0.01% +18 13F-HR Timeline Group Essential Partners LLC More: the full row for Essential Partners LLC 471 $2.7K <0.01% -5 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 411 $2.36K <0.01% +354 13F-HR Timeline Group Truvestments Capital LLC More: the full row for Truvestments Capital LLC 400 $2.3K <0.01% new 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 379 $2.18K <0.01% -3,007 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 331 $1.9K <0.01% +281 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 226 $1.3K <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 207 $1.19K <0.01% -10 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 205 $1.18K <0.01% +81 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 203 $1.17K <0.01% 0 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 200 $1.15K <0.01% -90 13F-HR Timeline Key Financial Inc More: the full row for Key Financial Inc 200 $1.15K <0.01% new 13F-HR Timeline Torren Management, LLC More: the full row for Torren Management, LLC 178 $1.02K <0.01% -143 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 100 $574 <0.01% 0 13F-HR Timeline Bare Financial Services, Inc More: the full row for Bare Financial Services, Inc 80 $459 <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 60 $344 <0.01% -3,654 13F-HR Timeline Basecamp Wealth Advisors LLC More: the full row for Basecamp Wealth Advisors LLC 29 $166 <0.01% -84 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 16 $92 <0.01% 0 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 11 $64 <0.01% new 13F-HR Timeline Smartleaf Asset Management LLC More: the full row for Smartleaf Asset Management LLC 4 $21 <0.01% 0 13F-HR Timeline