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Disclosery

KPTI KARYOPHARM THERAPEUTICS INC

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COMMON STOCK (common), issuer CIK 1503802

92 managers (96 13F filers) reported a position in KPTI shares at 2026-06-30, 21,114,398 shares in all. 34 filers opened a position and 14 filers sold out during the quarter.

Managers
92
13F filers
96
New
34
Added
31
Reduced
13
Sold out
14
Shares held by filers
21,114,398

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

Each filer's latest stake. The shares are the aggregate the reporting persons state, which can include entities that file no 13F.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2026

Filers in the available 13F reports with a share position at 2026-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.1,917,354$18.7M0.16%013F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…1,521,322$14.9M0.02%-285,00013F-HRTimelineGroup
ACORN CAPITAL ADVISORS, LLC1,518,113$14.8M4.05%+1,230,28713F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC1,424,658$13.9M<0.01%+477,07913F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.1,418,799$13.9M<0.01%+1,173,90013F-HRTimelineGroup
VANGUARD GROUP INCgroup of 4 filers holding1,247,405$12.2M+384,519Timeline
Catalio Capital Management, LP940,855$9.19M1.73%+43,14613F-HRTimeline
Avidity Partners Management LP924,487$9.03M1.45%+460,74613F-HRTimeline
T. Rowe Price Investment Management, In…786,309$7.68M0.01%-755,78113F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP695,264$6.79M0.01%+544,03213F-HRTimelineGroup
Kalehua Capital Management LLC685,644$6.7M3.85%new13F-HR/ATimeline
NEA Management Company, LLC576,780$5.64M0.35%new13F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC531,231$5.19M<0.01%+325,09813F-HRTimelineGroup
Ghisallo Capital Management LLC500,000$4.88M0.1%new13F-HRTimeline
Soleus Capital Management, L.P.440,000$4.3M0.15%013F-HRTimeline
UBS Group AGin group UBS Group AG353,545$3.45M<0.01%+159,52813F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP325,991$3.18M<0.01%+245,24913F-HRTimelineGroup
Affinity Asset Advisors, LLC312,500$3.05M0.15%-187,50013F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…309,817$3.03M0.04%+97,45013F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC305,676$2.99M<0.01%-114,89513F-HRTimelineGroup
Boxer Capital Management, LLC302,536$2.96M0.22%013F-HRTimeline
Davidson Kempner Capital Management LP300,000$2.93M0.05%013F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC298,997$2.92M<0.01%+50,04013F-HRTimelineGroup
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…297,460$2.91M0.32%new13F-HRTimelineGroup
Eversept Partners, LP276,174$2.7M0.15%013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO207,609$2.09M<0.01%+207,13813F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY202,506$1.98M<0.01%+183,93613F-HRTimelineGroup
Trexquant Investment LP188,368$1.84M0.01%-69,53513F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS188,038$1.84M<0.01%+187,95413F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC165,904$1.62M<0.01%+158,48013F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP160,006$1.56M<0.01%+121,45013F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP128,451$1.25M<0.01%013F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC108,214$1.06M<0.01%+2,80013F-HRTimeline
C WorldWide Group Holding A/Sin group C WorldWide Group Holding A/S100,000$977K0.02%013F-HRTimelineGroup
Jump Financial, LLCin group Jump Financial, LLC94,000$918K0.01%-168,14613F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.90,304$882K<0.01%+73,56613F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 3 filers holding77,810$760K+28,651Timeline
Connor, Clark & Lunn Investment Managem…76,397$746K<0.01%-2,68413F-HRTimeline
BRIDGEWAY CAPITAL MANAGEMENT, LLC71,873$702K0.01%013F-HRTimeline
J. Goldman & Co LP67,500$659K0.02%new13F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC63,801$623K<0.01%new13F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co61,943$605K<0.01%+48,51413F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA60,430$590K<0.01%+3113F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp57,262$559K<0.01%+45,86313F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd53,272$520K0.01%-111,17113F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC52,069$509K<0.01%new13F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/49,924$488K<0.01%+30,45213F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC37,917$370K<0.01%+32,97613F-HRTimelineGroup
Nuveen, LLCin group TIAA37,868$370K<0.01%new13F-HRTimelineGroup
Engineers Gate Manager LP33,966$332K<0.01%-78,46613F-HRTimeline
NOMURA ASSET MANAGEMENT INTERNATIONAL I…in group NOMURA ASSET MANAGEMENT CO LTD33,333$326K<0.01%new13F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC33,173$324K<0.01%-72,72813F-HRTimelineGroup
TORONTO DOMINION BANKin group TORONTO DOMINION BANK30,930$302K<0.01%new13F-HRTimelineGroup
SILVERBACK ASSET MANAGEMENT LLC30,000$293K0.04%-35,00013F-HRTimeline
Baird Financial Group, Inc.in group Baird Financial Group, Inc.29,791$291K<0.01%013F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/27,225$266K<0.01%+16,33913F-HRTimeline
ExodusPoint Capital Management, LP26,582$260K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…25,000$244K0.01%-5,00013F-HRTimeline
SIMPLEX TRADING, LLC24,086$235K0.01%new13F-HRTimeline
RHUMBLINE ADVISERS23,467$229K<0.01%new13F-HRTimeline
Velan Capital Investment Management LP20,000$195K0.12%+5,00013F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\19,425$190K<0.01%new13F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN16,903$165K<0.01%new13F-HRTimelineGroup
SEI INVESTMENTS COin group SEI INVESTMENTS CO15,083$147K<0.01%new13F-HRTimelineGroup
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC13,750$137K<0.01%+2,25513F-HRTimelineGroup
Headlands Technologies LLC12,113$118K0.01%new13F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…12,017$117K<0.01%new13F-HRTimelineGroup
Virtu Financial LLCin group Virtu Financial LLC10,728$105K<0.01%new13F-HRTimelineGroup
Y-Intercept (Hong Kong) Ltd10,375$101K<0.01%new13F-HRTimeline
Quadrature Capital Ltdin group Quadrature Capital Ltd10,296$101K<0.01%new13F-HRTimelineGroup
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.in group Mirae Asset Global Investment…9,171$89.6K<0.01%new13F-HRTimelineGroup
FMR LLCin group FMR LLC8,936$87.3K<0.01%+8,27113F-HRTimelineGroup
Police & Firemen's Retirement System of…5,874$57.4K<0.01%new13F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND5,600$54.7K<0.01%new13F-HRTimeline
TD Waterhouse Canada Inc.5,707$54.5K<0.01%+2,50413F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc1,935$18.9K<0.01%new13F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…1,808$17.7K<0.01%new13F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…1,592$15.6K<0.01%new13F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…1,259$12.3K<0.01%new13F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.402$3.93K<0.01%013F-HRTimelineGroup
Sterling Capital Management LLC352$3.44K<0.01%new13F-HRTimeline
HARBOUR INVESTMENTS, INC.285$2.78K<0.01%013F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…274$2.68K<0.01%new13F-HR/ATimeline
Quent Capital, LLC166$1.62K<0.01%-6913F-HRTimeline
Integrated Wealth Concepts LLC134$1.32K<0.01%new13F-HRTimeline
MB, LEVIS & ASSOCIATES, LLC100$977<0.01%013F-HRTimeline
SBI Securities Co., Ltd.67$655<0.01%013F-HRTimeline
Activest Wealth Management66$645<0.01%013F-HRTimeline
Allworth Financial LP26$255<0.01%013F-HRTimeline
Caitong International Asset Management …14$137<0.01%new13F-HRTimeline
West Branch Capital LLC3$30<0.01%013F-HRTimeline
PlanVest Financial, Inc1$10<0.01%013F-HRTimeline

Events

  • ACORN BIOVENTURES, L.P. and 4 other reporting persons reported 1,284,221 KPTI shares, 5.7% of the class, as of 2026-09-22, in a 13G/A filed 2026-09-25. 0001636587-26-000084

    Accepted , ingested

  • ACORN BIOVENTURES, L.P. and 4 other reporting persons reported 1,284,221 KPTI shares, 5.7% of the class, as of 2026-09-22, in a 13G/A filed 2026-09-25. 0001636587-26-000083

    Accepted , ingested