FMR LLC in group FMR LLC More: the full row for FMR LLC 4,888,781 $42.2M <0.01% +53,398 13F-HR Timeline Group Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 3,220,368 $27.8M 2.5% 0 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 3,220,364 $27.8M 1.56% 0 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 2,279,892 $19.7M 0.55% -229,409 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,150,203 $18.6M <0.01% +435,855 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 1,726,744 $14.9M <0.01% -80,838 13F-HR Timeline Group Versant Venture Management, LLC More: the full row for Versant Venture Management, LLC 1,525,820 $13.2M 6.2% 0 13F-HR Timeline RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 1,449,273 $12.5M 0.15% 0 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 1,413,280 $12.2M 0.37% -358,836 13F-HR Timeline Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 1,255,798 $10.8M 0.08% 0 13F-HR Timeline Avidity Partners Management LP More: the full row for Avidity Partners Management LP 1,127,186 $9.73M 2.21% 0 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 1,062,326 $9.17M 0.11% 0 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 796,744 $6.88M 0.37% 0 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 665,915 $5.75M <0.01% -10,516 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 632,599 $5.46M 2.28% +134,545 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 625,000 $5.39M 0.53% 0 13F-HR Timeline DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 531,163 $4.58M 0.07% 0 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 531,163 $4.58M 0.11% 0 13F-HR Timeline Group SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 531,163 $4.58M 0.6% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 499,287 $4.31M <0.01% +180,516 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 229,581 $1.98M <0.01% +1,489 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 162,711 $1.4M <0.01% new 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 107,553 $928K <0.01% new 13F-HR Timeline Group Sofinnova Investments, Inc. More: the full row for Sofinnova Investments, Inc. 107,391 $927K 0.06% 0 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 93,250 $805K <0.01% -10,005 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 82,351 $711K <0.01% +3,958 13F-HR Timeline Group Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 65,317 $564K 0.05% 0 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 54,241 $468K <0.01% +4,468 13F-HR/A Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 45,767 $395K <0.01% -229,063 13F-HR/A Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 42,784 $369K <0.01% -1,786 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 42,748 $369K <0.01% -17,380 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 40,297 $348K 0.02% +14,545 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 38,080 $329K <0.01% new 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 34,576 $298K <0.01% new 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 29,596 $255K <0.01% +3,982 13F-HR Timeline Group Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 26,975 $233K <0.01% +4,989 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 24,870 $215K <0.01% +4,037 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 24,610 $212K <0.01% new 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 19,831 $171K <0.01% -1,207 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 17,653 $152K <0.01% -21,576 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 16,256 $141K <0.01% 0 13F-HR Timeline DELTEC ASSET MANAGEMENT LLC More: the full row for DELTEC ASSET MANAGEMENT LLC 15,756 $136K 0.02% 0 13F-HR Timeline MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 15,222 $131K <0.01% -2,535 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 14,931 $129K <0.01% +11,709 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 14,580 $126K <0.01% +230 13F-HR/A Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 14,122 $122K <0.01% -8,873 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 13,284 $115K <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 13,198 $114K <0.01% -2,169 13F-HR/A Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 12,054 $104K <0.01% 0 13F-HR Timeline Corient Private Wealth LP in group Corient Private Wealth LP More: the full row for Corient Private Wealth LP 11,741 $101K <0.01% +1,608 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 11,072 $95.6K <0.01% -348 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 10,388 $89.6K <0.01% +3,275 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 5,268 $45.5K <0.01% 0 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 5,222 $45.1K <0.01% +5,100 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 4,422 $38.2K <0.01% +1,279 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,312 $28.6K <0.01% 0 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 2,954 $25.5K <0.01% 0 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 2,238 $19.3K <0.01% +1,362 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,031 $17.5K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,905 $16.4K <0.01% -1,184 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 1,592 $13.7K <0.01% -10,551 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,020 $9K <0.01% -2,671 13F-HR Timeline Group STRS OHIO More: the full row for STRS OHIO 900 $7.77K <0.01% -4,000 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 182 $1.57K <0.01% +55 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 155 $1.34K <0.01% +152 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 83 $716 <0.01% -256 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 77 $665 <0.01% +61 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 43 $371 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 27 $233 <0.01% +23 13F-HR Timeline PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 5 $43 <0.01% -8 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 5 $43 <0.01% -25 13F-HR Timeline JONES FINANCIAL COMPANIES LLLP in group JONES FINANCIAL COMPANIES LLLP More: the full row for JONES FINANCIAL COMPANIES LLLP 2 $17 <0.01% 0 13F-HR Timeline Group ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 1 $9 <0.01% 0 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 1 $9 <0.01% -6 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 57 $0 0% -63 13F-HR Timeline Group Value filed as zero, left out of ratios. AMALGAMATED BANK More: the full row for AMALGAMATED BANK 9 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Avion Wealth More: the full row for Avion Wealth 7 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Capital Advisors, Ltd. LLC More: the full row for Capital Advisors, Ltd. LLC 6 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios.