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Disclosery

DNLI DENALI THERAPEUTICS INC

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Stock (common), issuer CIK 1714899

245 managers (251 13F filers) reported a position in DNLI shares at 2025-12-31, 151,143,774 shares in all. 42 filers opened a position and 34 filers sold out during the quarter.

Managers
245
13F filers
251
New
42
Added
86
Reduced
71
Sold out
34
Shares held by filers
151,143,774

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
VANGUARD GROUP INCgroup of 2 filers holding13,069,626$216M+1,064,182Timeline
BlackRock, Inc.in group BlackRock, Inc.12,715,201$210M<0.01%+425,57513F-HRTimelineGroup
BAILLIE GIFFORD & COin group BAILLIE GIFFORD & CO12,310,889$203M0.17%+719,30413F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding7,388,430$122M-88,960Timeline
T. Rowe Price Investment Management, In…7,254,132$120M0.08%+1,615,56513F-HR/ATimeline
Temasek Holdings (Private) Ltdin group Temasek Holdings (Private) Ltd7,012,974$116M0.37%+1,657,14213F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP6,263,371$103M<0.01%+799,11013F-HRTimelineGroup
FMR LLCin group FMR LLC6,097,211$101M0.01%-243,10513F-HRTimelineGroup
NORGES BANK5,119,622$84.5M0.01%new13F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/3,915,951$64.7M0.01%-652,41713F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC3,835,803$63.3M0.01%+1,672,09813F-HR/ATimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP3,731,695$61.6M0.36%013F-HRTimelineGroup
Capital Research Global Investorsin group Capital Research Global Inves…3,729,244$61.6M0.01%-1,031,61413F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.3,557,935$58.7M0.02%+37,52113F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC3,458,131$57.1M<0.01%-7,92613F-HRTimelineGroup
Holocene Advisors, LP3,152,734$52.1M0.11%+17,02213F-HRTimeline
Crestline Management, L.P.2,810,732$46.4M87.02%-600,00013F-HRTimeline
Fisher Asset Management, LLC2,589,403$42.8M0.01%+957,90713F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP2,374,303$39.2M0.01%+17,08913F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc2,032,967$33.6M0.05%+919,38113F-HRTimelineGroup
Casdin Capital, LLC1,840,000$30.4M1.89%+950,00013F-HRTimeline
Lynx1 Capital Management LPin group Lynx1 Capital Management LP1,738,750$28.7M5.81%+1,477,06313F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.1,700,000$28.1M0.04%-819,53513F-HRTimelineGroup
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC1,524,123$25.2M0.01%+252,93313F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.1,396,513$23.1M0.69%+575,00013F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…1,329,108$22M0.02%+829,94613F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY1,219,854$20.1M<0.01%-469,63813F-HR/ATimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co1,200,475$19.8M<0.01%+49,09113F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP1,199,744$19.8M<0.01%-34,43513F-HRTimelineGroup
Candriam S.C.A.1,166,379$19.3M0.1%+332,79713F-HR/ATimeline
ExodusPoint Capital Management, LP1,023,253$16.9M0.19%new13F-HRTimeline
MASTERS CAPITAL MANAGEMENT LLC1,000,000$16.5M2.28%+250,00013F-HRTimeline
Foresite Capital Management VI LLCin group Foresite Capital Management V…1,000,000$16.5M4.99%013F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/932,144$15.4M<0.01%-28,99413F-HRTimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.859,108$14.2M0.04%new13F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC779,148$12.9M0.01%+90,92413F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP763,892$12.6M0.01%-23,13713F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp762,087$12.6M<0.01%-38,66013F-HRTimelineGroup
Defilade Capital Management, L.P.656,713$10.8M1.47%13F-HRTimeline
Palo Alto Investors LP641,239$10.6M1.47%+233,23313F-HRTimeline
Cercano Management LLC625,000$10.3M0.39%013F-HRTimeline
VOLORIDGE INVESTMENT MANAGEMENT, LLC591,461$9.77M0.03%-344,76913F-HRTimeline
Qube Research & Technologies Ltd590,314$9.75M0.01%+362,32413F-HRTimeline
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding584,977$9.66M+228,685Timeline
SEGALL BRYANT & HAMILL, LLC537,000$8.87M0.12%+24,04213F-HRTimeline
Ensign Peak Advisors, Inc515,721$8.51M0.02%-18,35013F-HR/ATimeline
Vestal Point Capital, LP465,000$7.68M0.28%new13F-HRTimeline
Hudson Bay Capital Management LPin group Hudson Bay Capital Management…450,000$7.43M0.04%+145,00013F-HRTimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP450,985$7.4M0.01%+241,39013F-HRTimeline
STEMPOINT CAPITAL LP419,058$6.92M1.19%-1,315,60113F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC407,359$6.73M<0.01%-29,64213F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC379,051$6.26M<0.01%+21,71013F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC369,767$6.1M<0.01%-937,40413F-HRTimelineGroup
Clarius Group, LLC368,995$6.09M0.35%+9,25013F-HRTimeline
TD Asset Management Inc339,410$5.6M<0.01%-55,19013F-HRTimeline
DAFNA Capital Management LLC318,500$5.26M1.22%+150,00013F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …298,792$4.93M0.01%+297,52113F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.291,936$4.82M<0.01%+42,46913F-HRTimelineGroup
Marex Group Ltdin group Marex Group Ltd287,001$4.74M0.05%-3,99913F-HRTimelineGroup
Nuveen, LLCin group TIAA275,508$4.55M<0.01%-9,26913F-HRTimelineGroup
Swiss National Bank273,800$4.52M<0.01%+6,30013F-HRTimeline
EDMOND DE ROTHSCHILD HOLDING S.A.in group EDMOND DE ROTHSCHILD HOLDING …225,680$3.73M0.05%+20,00013F-HRTimelineGroup
Trexquant Investment LP209,609$3.46M0.03%-220,95713F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding202,481$3.34M+161,495Timeline
Burkehill Global Management, LP200,000$3.3M0.22%new13F-HRTimeline
SCS Capital Management LLC197,998$3.27M0.03%013F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN193,681$3.2M<0.01%+89,50213F-HRTimelineGroup
Rafferty Asset Management, LLC191,567$3.16M0.01%+8,68113F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …184,238$3.03M<0.01%-21,60713F-HRTimelineGroup
RHUMBLINE ADVISERS183,000$3.02M<0.01%-18,56513F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC180,221$2.98M<0.01%+80,66013F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO171,948$2.84M<0.01%-3,07313F-HRTimelineGroup
TEACHERS RETIREMENT SYSTEM OF THE STATE…153,781$2.54M0.02%-17,77213F-HRTimeline
GROUPAMA ASSET MANAGMENT151,591$2.5M0.04%+15,83313F-HRTimeline
SG Americas Securities, LLC149,592$2.47M<0.01%+111,39113F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding135,927$2.24M+387Timeline
Legal & General Group Plcin group Legal & General Group Plc131,223$2.17M<0.01%-12,72913F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…129,409$2.14M<0.01%-11713F-HRTimeline
ALGERT GLOBAL LLC127,030$2.1M0.03%+25,77013F-HR/ATimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC120,718$1.99M0.01%+50,48813F-HRTimelineGroup
Woodline Partners LP114,082$1.88M0.01%+56513F-HRTimeline
B. Metzler seel. Sohn & Co. AGin group B. Metzler seel. Sohn & Co. AG112,300$1.84M0.02%new13F-HRTimelineGroup
NOMURA ASSET MANAGEMENT CO LTDgroup of 2 filers holding107,493$1.77M+107,493Timeline
D.A. DAVIDSON & CO.106,933$1.77M0.01%new13F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\105,086$1.73M<0.01%-102,50813F-HRTimelineGroup
Rhenman & Partners Asset Management AB100,000$1.65M0.15%013F-HRTimeline
Ghisallo Capital Management LLC100,000$1.65M0.07%new13F-HRTimeline
Integrated Wealth Concepts LLC94,582$1.56M0.02%+3,50813F-HRTimeline
Y-Intercept (Hong Kong) Ltd93,587$1.55M0.03%new13F-HRTimeline
Monashee Investment Management LLC91,620$1.51M0.85%new13F-HRTimeline
DekaBank Deutsche Girozentrale59,800$1.35M<0.01%013F-HRTimeline
HRT FINANCIAL LP78,352$1.29M<0.01%new13F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…75,164$1.24M0.01%-3,91113F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD73,581$1.21M<0.01%-6,54513F-HRTimeline
PROFUND ADVISORS LLC71,634$1.18M0.04%+31,47813F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …70,830$1.17M<0.01%+44,60713F-HRTimelineGroup
Ishara Investments LP70,000$1.16M1.35%13F-HRTimeline
PIER 88 INVESTMENT PARTNERS LLC68,200$1.13M0.25%+76013F-HRTimeline
1492 Capital Management LLC67,487$1.11M0.43%new13F-HRTimeline
Capricorn Fund Managers Ltd62,197$1.03M0.25%new13F-HRTimeline
Creative Planningin group Creative Planning60,766$1M<0.01%+5,93213F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources60,270$995K<0.01%-4,36413F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson60,028$991K<0.01%013F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…54,543$901K<0.01%-4,69113F-HRTimelineGroup
TUDOR INVESTMENT CORP ET AL53,683$886K<0.01%-2,68513F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC52,632$869K0.01%+5,83513F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC52,116$860K0.06%+60013F-HR/ATimelineGroup
CLOUGH CAPITAL PARTNERS L Pin group CLOUGH CAPITAL PARTNERS L P51,830$856K0.08%new13F-HRTimelineGroup
Pathstone Holdings, LLCin group Pathstone Holdings, LLC51,424$849K<0.01%+5,59413F-HRTimelineGroup
IRONWOOD INVESTMENT MANAGEMENT LLC50,933$841K0.35%-1,85313F-HRTimeline
Dana Investment Advisors, Inc.50,582$835K0.02%-13413F-HRTimeline
Knights of Columbus Asset Advisors LLC49,007$809K0.05%-1,18313F-HRTimeline
Man Group plcin group Man Group plc48,994$809K<0.01%new13F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…47,459$784K<0.01%013F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…47,410$783K<0.01%-92,25313F-HRTimelineGroup
Employees Retirement System of Texas47,177$779K0.01%+3,40813F-HRTimeline
MAI Capital Management46,526$768K<0.01%013F-HRTimeline
Headlands Technologies LLC46,383$766K0.06%new13F-HRTimeline
Handelsbanken Fonder AB43,800$723K<0.01%+5,50013F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC42,922$709K<0.01%-181,98113F-HRTimelineGroup
AlphaQuest LLC42,909$708K0.04%-31,51313F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC40,608$670K0.01%-125,79113F-HRTimelineGroup
Savvy Advisors, Inc.39,030$644K0.02%-38,06313F-HRTimeline
CAPSTONE INVESTMENT ADVISORS, LLCin group CAPSTONE INVESTMENT ADVISORS,…38,812$641K0.01%new13F-HRTimelineGroup
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC38,669$638K<0.01%+6,25413F-HRTimelineGroup
ARIZONA STATE RETIREMENT SYSTEM38,645$638K<0.01%-2,16813F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND38,478$635K<0.01%013F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC38,438$635K<0.01%+14,29913F-HRTimelineGroup
Police & Firemen's Retirement System of…36,607$604K0.01%-5613F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…34,168$564K<0.01%013F-HRTimeline
Thrivent Financial for Lutheransin group Thrivent Financial for Luther…32,555$538K<0.01%-3,06413F-HRTimelineGroup
PSP Research LLC31,762$524K0.46%13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC30,945$511K<0.01%+16,00913F-HRTimelineGroup
ProShare Advisors LLC30,682$507K<0.01%+2,82713F-HRTimeline
KLP KAPITALFORVALTNING AS29,900$494K<0.01%013F-HRTimeline
Erste Asset Management GmbHin group Erste Asset Management GmbH26,900$446K<0.01%013F-HRTimelineGroup
POLEN CAPITAL MANAGEMENT LLC26,900$444K<0.01%new13F-HRTimeline
Quantinno Capital Management LP26,313$434K<0.01%+1,60613F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC25,592$423K<0.01%+26613F-HRTimelineGroup
China Universal Asset Management Co., L…23,898$395K0.03%-1,73113F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC23,805$393K<0.01%013F-HRTimelineGroup
TT International Asset Management LTD27,000$353K0.07%-38,00013F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS20,540$339K<0.01%-13,28713F-HRTimeline
Bayforest Capital Ltd20,433$337K0.25%new13F-HRTimeline
MARTINGALE ASSET MANAGEMENT L P18,535$306K0.01%new13F-HRTimeline
Graham Capital Management, L.P.18,121$299K0.01%-21,19813F-HRTimeline
SBI Okasan Asset Management Co.Ltd.18,000$298K0.02%13F-HRTimeline
Breakwater Capital Group16,366$270K0.04%+50013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS15,497$256K<0.01%-248,56413F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC15,064$249K<0.01%013F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…14,795$244K0.07%+7,17113F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…13,467$222K<0.01%-33213F-HRTimelineGroup
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co13,434$222K<0.01%013F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…12,941$214K0.01%+5,56513F-HRTimelineGroup
WINTON GROUP Ltdin group WINTON GROUP Ltd12,700$210K0.01%new13F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC12,652$209K<0.01%new13F-HRTimelineGroup
Perbak Capital Partners LLP12,611$208K0.06%new13F-HRTimeline
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC12,468$206K<0.01%-37,05713F-HRTimelineGroup
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…12,238$202K<0.01%013F-HRTimeline
HighTower Advisors, LLC11,757$194K<0.01%-9,56513F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA11,335$187K<0.01%-360,84113F-HRTimelineGroup
Empowered Funds, LLC11,325$187K<0.01%+28813F-HR/ATimeline
INTRUST BANK NA11,164$184K0.02%+58913F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…11,065$183K0.01%013F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC10,700$177K<0.01%-49,10013F-HRTimeline
LPL Financial LLC10,504$173K<0.01%-14413F-HRTimeline
XPONANCE LLC10,497$173K<0.01%+9713F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…8,481$140K<0.01%+19113F-HRTimelineGroup
Sterling Capital Management LLC7,238$119K<0.01%-1,41613F-HRTimeline
Bellevue Group AGin group Bellevue Group AG7,138$118K<0.01%new13F-HRTimelineGroup
Quarry LP7,000$116K0.02%+2,62513F-HRTimeline
LANARK FINANCIAL, INC.6,536$108K0.01%+6,00413F-HRTimeline
KBC Group NVin group KBC Group NV6,268$103K<0.01%+1,77313F-HRTimelineGroup
Persistent Asset Partners Ltd5,670$93.6K0.05%new13F-HRTimeline
ASSETMARK, INCin group ASSETMARK, INC5,187$85.6K<0.01%+1,25013F-HRTimelineGroup
Eurizon Capital SGR S.p.A.5,045$82.7K<0.01%13F-HRTimeline
AMALGAMATED BANK4,161$69K<0.01%-14413F-HRTimeline
Aster Capital Management (DIFC) Ltd3,451$57K0.02%new13F-HRTimeline
Pinnacle Wealth Planning Services, Inc.2,957$48.8K0.01%new13F-HRTimeline
GF FUND MANAGEMENT CO. LTD.2,881$47.6K<0.01%-26513F-HRTimeline
State of Wyoming2,686$44.3K<0.01%+53213F-HRTimeline
CWM, LLCin group CWM, LLC2,606$43K<0.01%+20913F-HRTimelineGroup
BARTLETT & CO. WEALTH MANAGEMENT LLC1,500$24.8K<0.01%013F-HRTimeline
Versant Capital Management, Inc1,476$24.4K<0.01%013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC1,449$23.9K<0.01%-3413F-HRTimeline
Smartleaf Asset Management LLC1,313$21.5K<0.01%+35913F-HRTimeline
COMERICA BANK1,284$21.2K<0.01%013F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…1,265$20.9K<0.01%+18213F-HR/ATimelineGroup
SBI Securities Co., Ltd.1,222$20.2K<0.01%+1,20013F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.1,074$17.7K<0.01%-31413F-HRTimelineGroup
Mitsubishi UFJ Asset Management Co., Lt…in group Mitsubishi UFJ Trust & Bankin…1,001$16.3K<0.01%013F-HRTimelineGroup
GAMMA Investing LLC962$15.9K<0.01%+23313F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\834$13.8K<0.01%+13813F-HRTimelineGroup
QUADRANT CAPITAL GROUP LLC758$12.5K<0.01%-2413F-HRTimeline
Nemes Rush Group LLC700$11.6K<0.01%013F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC627$10.3K<0.01%new13F-HRTimeline
Covestor Ltd579$10K0.01%013F-HRTimeline
HUNTINGTON NATIONAL BANKin group HUNTINGTON NATIONAL BANK491$8.11K<0.01%+18313F-HRTimelineGroup
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.475$8K<0.01%013F-HRTimelineGroup
Optiver Holding B.V.in group Optiver Holding B.V.409$6.75K<0.01%-48713F-HRTimelineGroup