Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 15,561,500 $49.6M 2.79% +1,591,618 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 15,396,200 $49.1M <0.01% +6,157,332 13F-HR Timeline Group TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 11,065,662 $35.3M 1.36% 0 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 9,680,185 $30.9M 0.89% +2,686,539 13F-HR Timeline Group VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 8,974,746 $28.6M -434,014 Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 8,461,500 $27M 0.65% 0 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 7,692,300 $24.5M 1.2% 0 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 4,250,826 $13.6M 0.1% +766,600 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 4,068,575 $13M 0.03% -4,016,048 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 4,045,414 $12.9M 1.28% +964,000 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 3,913,081 $12.5M 0.03% +1,047,456 13F-HR Timeline Group Kynam Capital Management, LP More: the full row for Kynam Capital Management, LP 3,646,503 $11.6M 0.87% +1,492,090 13F-HR Timeline RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 3,461,500 $11M 0.14% 0 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 3,372,616 $10.8M 2.18% new 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 2,884,615 $9.2M 0.74% -2,884,615 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 2,661,331 $8.49M 0.1% 0 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 2,545,260 $8.12M 0.01% +683,060 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,381,912 $7.6M <0.01% -6,541 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 2,337,005 $7.46M 0.04% +106 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,800,435 $5.74M <0.01% +1,714,926 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,569,298 $5.01M <0.01% -175,878 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,386,863 $4.42M <0.01% +1,153,524 13F-HR Timeline Group Financial Engines Advisors L.L.C. More: the full row for Financial Engines Advisors L.L.C. 1,381,357 $4.41M 0.01% new 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 1,237,057 $3.95M 0.1% new 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 1,104,993 $3.52M <0.01% -1,248,129 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 1,005,228 $3.21M <0.01% +1,000,457 13F-HR/A Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 769,698 $2.46M +612,017 Timeline Exome Asset Management LLC More: the full row for Exome Asset Management LLC 745,305 $2.38M 1.57% new 13F-HR Timeline Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 729,967 $2.33M <0.01% +9,947 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 653,725 $2.08M <0.01% -903,311 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 644,982 $2.06M <0.01% +5,942 13F-HR Timeline Group Prosight Management, LP More: the full row for Prosight Management, LP 564,800 $1.8M 0.43% -2,952,313 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 535,974 $1.71M 0.14% -94,835 13F-HR Timeline Inspire Investing, LLC in group Inspire Investing, LLC More: the full row for Inspire Investing, LLC 522,482 $1.67M 0.16% new 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 451,128 $1.44M <0.01% +267,962 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 447,753 $1.43M <0.01% +433,075 13F-HR Timeline Group FIRST TRUST ADVISORS LP in group FIRST TRUST ADVISORS LP More: the full row for FIRST TRUST ADVISORS LP 401,891 $1.28M <0.01% new 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 401,367 $1.28M <0.01% +389,399 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 389,685 $1.24M <0.01% -60,422 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 319,288 $1.02M <0.01% -19,918 13F-HR/A Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 315,497 $1.01M -75,809 Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 293,560 $936K <0.01% +10,000 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 257,148 $820K 0.2% new 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 252,659 $806K <0.01% 0 13F-HR Timeline Group Precision Wealth Strategies, LLC More: the full row for Precision Wealth Strategies, LLC 237,081 $756K 0.25% new 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 206,526 $659K 0.05% new 13F-HR Timeline DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 185,286 $591K 0.41% new 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 158,329 $505K <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 152,304 $486K <0.01% -91,243 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 125,035 $399K <0.01% new 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 125,000 $399K 0.32% new 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 122,500 $391K <0.01% new 13F-HR Timeline Formidable Asset Management, LLC More: the full row for Formidable Asset Management, LLC 118,337 $377K 0.06% -194,513 13F-HR Timeline Tidal Investments LLC in group Tidal Investments LLC More: the full row for Tidal Investments LLC 118,337 $377K <0.01% -194,513 13F-HR Timeline Group Congress Park Capital LLC More: the full row for Congress Park Capital LLC 103,922 $332K 0.1% +8,500 13F-HR Timeline Aspire Growth Partners LLC More: the full row for Aspire Growth Partners LLC 102,254 $326K 0.24% 0 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 88,570 $283K <0.01% 0 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 86,653 $276K <0.01% -114,571 13F-HR Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 80,000 $255K 0.24% +5,000 13F-HR Timeline Miller Financial Services LLC More: the full row for Miller Financial Services LLC 67,000 $214K 0.25% +16,000 13F-HR Timeline Merit Financial Group, LLC More: the full row for Merit Financial Group, LLC 53,243 $170K <0.01% new 13F-HR/A Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 52,914 $169K <0.01% new 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 50,773 $162K <0.01% new 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 47,728 $152K <0.01% -1,664 13F-HR Timeline Group Private Advisor Group, LLC More: the full row for Private Advisor Group, LLC 44,002 $140K <0.01% 0 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 42,645 $136K 0.1% new 13F-HR/A Timeline Sanctuary Advisors, LLC More: the full row for Sanctuary Advisors, LLC 34,634 $110K <0.01% new 13F-HR/A Timeline Jain Global LLC More: the full row for Jain Global LLC 33,652 $107K <0.01% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 30,168 $96.2K <0.01% -377,867 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 29,286 $93.4K <0.01% -92,613 13F-HR Timeline Group Ethos Financial Group, LLC More: the full row for Ethos Financial Group, LLC 23,697 $75.6K 0.01% new 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 23,300 $74.3K <0.01% -2,400 13F-HR Timeline Group BlueChip Wealth Advisors LLC More: the full row for BlueChip Wealth Advisors LLC 23,000 $73.4K 0.03% new 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 22,426 $71.5K <0.01% +8,255 13F-HR Timeline Group Forefront Analytics, LLC More: the full row for Forefront Analytics, LLC 18,109 $57.8K 0.06% -9,589 13F-HR Timeline Forefront Wealth Partners, LLC More: the full row for Forefront Wealth Partners, LLC 18,109 $57.8K 0.01% new 13F-HR Timeline Truvestments Capital LLC More: the full row for Truvestments Capital LLC 17,101 $54.6K 0.01% +2,233 13F-HR Timeline WestHill Financial Advisors, Inc. More: the full row for WestHill Financial Advisors, Inc. 17,082 $54.5K 0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 16,710 $52.8K <0.01% +500 13F-HR Timeline Group BIT Capital GmbH More: the full row for BIT Capital GmbH 16,285 $51.9K <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 16,152 $51.5K <0.01% +15,871 13F-HR/A Timeline Group PURSUE WEALTH PARTNERS LLC More: the full row for PURSUE WEALTH PARTNERS LLC 14,492 $46.2K 0.03% 0 13F-HR Timeline VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 14,121 $45K <0.01% +1,686 13F-HR Timeline Nierenberg Investment Management Compan… More: the full row for Nierenberg Investment Management Company, LLC 12,555 $40K 0.02% 0 13F-HR Timeline IPG Investment Advisors LLC More: the full row for IPG Investment Advisors LLC 12,500 $39.9K 0.01% 0 13F-HR Timeline Bay Colony Advisory Group, Inc d/b/a Ba… More: the full row for Bay Colony Advisory Group, Inc d/b/a Bay Colony Advisors 10,747 $34.3K <0.01% new 13F-HR Timeline Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 10,250 $32.7K <0.01% new 13F-HR Timeline Group Peregrine Asset Advisers, Inc. More: the full row for Peregrine Asset Advisers, Inc. 10,000 $31.9K 0.01% 0 13F-HR Timeline Meridian Wealth Management, LLC More: the full row for Meridian Wealth Management, LLC 10,000 $31.9K <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 7,970 $25.4K <0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 7,756 $24.7K <0.01% new 13F-HR Timeline Group Private Wealth Asset Management, LLC More: the full row for Private Wealth Asset Management, LLC 4,000 $12.8K <0.01% 0 13F-HR Timeline TRUIST FINANCIAL CORP in group TRUIST FINANCIAL CORP More: the full row for TRUIST FINANCIAL CORP 12,500 $12.6K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 3,605 $11.5K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 1,490 $4.75K <0.01% +1,488 13F-HR/A Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 689 $2.2K <0.01% -967 13F-HR Timeline Advisory Services Network, LLC More: the full row for Advisory Services Network, LLC 274 $874 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 85 $271 <0.01% +1 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 17 $54 <0.01% 0 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 3 $10 <0.01% -29,658 13F-HR Timeline Group