TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 7,311,760 $7.53M 0.5% -500,000 13F-HR Timeline Group BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 5,228,461 $5.39M 0.18% 0 13F-HR Timeline Group VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 5,199,294 $5.36M +36,992 Timeline Prosight Management, LP More: the full row for Prosight Management, LP 3,905,000 $4.02M 1.13% +882,891 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 3,221,012 $3.32M <0.01% +660,756 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 3,137,046 $3.23M 0.01% +36,052 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 2,650,000 $2.73M 0.01% new 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 1,547,215 $1.59M 0.01% +23,139 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 1,380,800 $1.42M 0.01% +169,000 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 1,346,800 $1.39M <0.01% +331,800 13F-HR Timeline Laurion Capital Management LP More: the full row for Laurion Capital Management LP 1,248,364 $1.29M 0.08% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,239,778 $1.28M <0.01% +71,212 13F-HR Timeline Group Congress Park Capital LLC More: the full row for Congress Park Capital LLC 964,590 $994K 0.36% -251,418 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 815,643 $840K <0.01% +12,112 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 811,630 $836K <0.01% +811,349 13F-HR Timeline Group Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 599,850 $618K <0.01% -1,044,318 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 508,556 $524K <0.01% +439,421 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 487,902 $503K <0.01% 0 13F-HR Timeline Group Altium Capital Management LLC More: the full row for Altium Capital Management LLC 467,491 $482K 0.15% -447,509 13F-HR Timeline Formidable Asset Management, LLC More: the full row for Formidable Asset Management, LLC 382,529 $394K 0.06% +136,528 13F-HR Timeline Tidal Investments LLC in group Tidal Investments LLC More: the full row for Tidal Investments LLC 382,529 $394K <0.01% +136,528 13F-HR Timeline Group MONIMUS CAPITAL MANAGEMENT, LP More: the full row for MONIMUS CAPITAL MANAGEMENT, LP 364,306 $375K 0.35% 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 331,624 $342K 0.01% -25,000 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 322,311 $332K <0.01% +5,192 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 320,767 $330K <0.01% -150,701 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 320,043 $330K <0.01% +56,400 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 306,783 $316K <0.01% +22,476 13F-HR Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 286,480 $295K <0.01% +5,887 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 241,980 $249K <0.01% -2 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 150,632 $155K <0.01% +20,746 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 145,036 $149K 0.03% -758,923 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 110,242 $113K <0.01% +83,402 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 98,383 $101K <0.01% +73,923 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 64,300 $66.2K <0.01% +27,800 13F-HR Timeline Group Forefront Analytics, LLC More: the full row for Forefront Analytics, LLC 64,259 $66.2K 0.03% +4,499 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 59,778 $61.6K <0.01% +49,474 13F-HR Timeline Group Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 57,012 $59K <0.01% -31,506 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 55,108 $56.8K <0.01% 0 13F-HR Timeline COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 53,243 $55K <0.01% -1,000 13F-HR Timeline Private Advisor Group, LLC More: the full row for Private Advisor Group, LLC 44,002 $45.3K <0.01% -8,177 13F-HR Timeline LPL Financial LLC More: the full row for LPL Financial LLC 42,315 $43.6K <0.01% +4,000 13F-HR Timeline Aspire Growth Partners LLC More: the full row for Aspire Growth Partners LLC 40,780 $42K 0.04% 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 38,885 $40K <0.01% new 13F-HR Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 35,000 $36K 0.03% new 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 34,054 $35.1K <0.01% -13,595 13F-HR Timeline Group ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 33,570 $34.6K <0.01% new 13F-HR/A Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 32,922 $33.9K <0.01% -10,742 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 30,792 $31.7K <0.01% -3,000 13F-HR Timeline Group TRAPHAGEN INVESTMENT ADVISORS LLC More: the full row for TRAPHAGEN INVESTMENT ADVISORS LLC 30,500 $31.4K <0.01% new 13F-HR Timeline Miller Financial Services LLC More: the full row for Miller Financial Services LLC 25,000 $25.8K 0.02% 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 24,817 $25.6K <0.01% 0 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 21,653 $22.3K <0.01% -5,578 13F-HR Timeline Group WestHill Financial Advisors, Inc. More: the full row for WestHill Financial Advisors, Inc. 17,082 $17.6K <0.01% 0 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 13,201 $13.6K <0.01% -37,167 13F-HR/A Timeline Group Nierenberg Investment Management Compan… More: the full row for Nierenberg Investment Management Company, LLC 12,555 $12.9K 0.01% 0 13F-HR Timeline IPG Investment Advisors LLC More: the full row for IPG Investment Advisors LLC 12,500 $12.9K <0.01% 0 13F-HR Timeline Peregrine Asset Advisers, Inc. More: the full row for Peregrine Asset Advisers, Inc. 10,000 $10.3K <0.01% 0 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 8,924 $9.19K <0.01% 0 13F-HR Timeline Group LAZARD ASSET MANAGEMENT LLC in group LAZARD ASSET MANAGEMENT LLC More: the full row for LAZARD ASSET MANAGEMENT LLC 5,505 $5K <0.01% -3,323 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 4,224 $4.35K <0.01% -687 13F-HR/A Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 3,273 $3.37K <0.01% +3,035 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 2,021 $2.08K <0.01% -18,540 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 1,107 $1.14K <0.01% 13F-HR Timeline Bollard Group LLC More: the full row for Bollard Group LLC 712 $1K <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 870 $896 <0.01% -30 13F-HR/A Timeline Group Bell Investment Advisors, Inc More: the full row for Bell Investment Advisors, Inc 388 $400 <0.01% new 13F-HR Timeline Raleigh Capital Management Inc. More: the full row for Raleigh Capital Management Inc. 250 $258 <0.01% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 78 $80 <0.01% -116 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 507 $0 0% new 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.