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Disclosery

AGIO AGIOS PHARMACEUTICALS INC

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COM (common), issuer CIK 1439222

234 managers (238 13F filers) reported a position in AGIO shares at 2025-12-31, 61,258,666 shares in all. 57 filers opened a position and 44 filers sold out during the quarter.

Managers
234
13F filers
238
New
57
Added
79
Reduced
70
Sold out
44
Shares held by filers
61,258,666

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
VANGUARD GROUP INCin group VANGUARD GROUP INC5,594,353$152M<0.01%-10,52313F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.5,235,429$143M<0.01%+689,69113F-HRTimelineGroup
FARALLON CAPITAL MANAGEMENT, L.L.C.5,159,505$140M0.73%-621,56113F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
STATE STREET CORPin group STATE STREET CORP3,108,145$84.6M<0.01%+845,43313F-HRTimelineGroup
ARMISTICE CAPITAL, LLC3,036,000$82.6M2.02%+2,272,00013F-HRTimeline
Erste Asset Management GmbHin group Erste Asset Management GmbH2,804,900$76.3M0.64%+40,00013F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.1,837,186$50M0.04%+1,469,43713F-HRTimelineGroup
NOMURA ASSET MANAGEMENT CO LTDgroup of 2 filers holding1,713,764$46.6MnewTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,413,538$38.5M<0.01%-2,77713F-HRTimelineGroup
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …1,360,730$37M0.04%+373,39113F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC1,348,968$36.7M0.02%+856,98613F-HRTimelineGroup
MPM BIOIMPACT LLC1,303,373$35.5M4.06%new13F-HRTimeline
Frazier Life Sciences Management, L.P.1,279,754$34.8M0.94%013F-HRTimeline
GW&K Investment Management, LLC1,207,301$32.9M0.28%+354,35913F-HRTimeline
TCG Crossover Management, LLC1,181,841$32.2M1.06%-248,20013F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…1,142,432$31.1M0.04%new13F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC1,121,050$30.5M0.04%+725,93013F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC1,033,974$28.1M<0.01%+229,20813F-HR/ATimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP1,004,341$27.3M0.01%-16,86013F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY894,037$24.3M<0.01%+477,03913F-HR/ATimelineGroup
Rock Springs Capital Management LP799,163$21.8M1.12%-159,37913F-HRTimeline
Capital International Investorsin group Capital International Investo…703,865$19.2M<0.01%new13F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/637,886$17.4M<0.01%-1,019,05213F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management635,069$17.3M0.03%+139,57813F-HRTimelineGroup
SCS Capital Management LLC598,765$16.3M0.17%013F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…597,826$16.3M<0.01%-1,873,59013F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…562,642$15.3M0.04%+32,54413F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/539,341$14.7M<0.01%-590,65913F-HRTimelineGroup
Foresite Capital Management VI LLCin group Foresite Capital Management V…530,000$14.4M4.36%new13F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP511,901$13.9M<0.01%-43,50913F-HRTimelineGroup
Artisan Partners Limited Partnership504,485$13.7M0.02%+101,54213F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co482,622$13.1M<0.01%+43613F-HRTimelineGroup
ArrowMark Colorado Holdings LLC466,151$12.7M0.28%-213,77113F-HRTimeline
ALGERT GLOBAL LLC414,218$11.3M0.18%+378,44813F-HR/ATimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC398,267$10.8M0.01%+393,21813F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding385,356$10.5M+312,127Timeline
Qube Research & Technologies Ltd378,373$10.3M0.01%new13F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP353,639$9.63M0.01%+126,81513F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc328,211$8.93M<0.01%+5,27713F-HRTimelineGroup
Vestal Point Capital, LP325,000$8.85M0.32%+198,00013F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC320,352$8.72M<0.01%+104,31213F-HRTimelineGroup
Nuveen, LLCin group TIAA297,908$8.11M<0.01%+178,32813F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO251,777$6.85M<0.01%+68,67713F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS242,670$6.61M<0.01%+227,97213F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding233,661$6.36M-116,027Timeline
Trexquant Investment LP226,600$6.17M0.05%new13F-HRTimeline
Palo Alto Investors LP212,499$5.78M0.81%-52,99813F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…205,019$5.57M0.01%-67,14213F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.200,000$5.44M0.01%+193,49313F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp196,893$5.36M<0.01%-73,20313F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC188,000$5.12M0.38%+151,00013F-HR/ATimelineGroup
Edgestream Partners, L.P.167,998$4.57M0.13%new13F-HRTimeline
GROUP ONE TRADING LLC166,614$4.54M0.13%new13F-HRTimeline
Tetragon Partners GP Ltdin group Tetragon Partners GP Ltd162,018$4.41M0.93%new13F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC151,486$4.12M<0.01%+6,36513F-HRTimelineGroup
MOORE CAPITAL MANAGEMENT, LP150,000$4.08M0.08%+95,00013F-HRTimeline
Allianz Asset Management GmbHin group Allianz SE147,950$4.03M<0.01%+1,30713F-HRTimelineGroup
HighVista Strategies LLC147,662$4.02M1.04%-47,63613F-HRTimeline
HRT FINANCIAL LP146,469$3.99M0.01%new13F-HRTimeline
Invesco Ltd.in group Invesco Ltd.142,580$3.88M<0.01%+15,60413F-HRTimelineGroup
Exome Asset Management LLC136,942$3.73M1.84%new13F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\122,875$3.34M<0.01%-803,85913F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC121,763$3.31M0.01%new13F-HRTimelineGroup
Ikarian Capital, LLCin group Ikarian Capital, LLC115,489$3.14M0.41%-11,49013F-HRTimelineGroup
JACOBS LEVY EQUITY MANAGEMENT, INC111,150$3.03M0.01%new13F-HRTimeline
Assenagon Asset Management S.A.110,440$3.01M<0.01%+43,28713F-HRTimeline
Swiss National Bank108,860$2.96M<0.01%+2,20013F-HRTimeline
Rafferty Asset Management, LLC107,490$2.93M0.01%+39,27013F-HRTimeline
Hudson Bay Capital Management LPin group Hudson Bay Capital Management…100,000$2.72M0.02%-22,50013F-HRTimelineGroup
Parkman Healthcare Partners LLC99,604$2.71M0.26%-77613F-HRTimeline
Caption Management, LLC93,486$2.54M0.11%+75,99213F-HRTimeline
CITIGROUP INCin group CITIGROUP INC88,238$2.4M<0.01%+44,61813F-HRTimelineGroup
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC81,055$2.21M<0.01%-17,18413F-HRTimelineGroup
PANAGORA ASSET MANAGEMENT INC79,840$2.17M0.01%new13F-HRTimeline
Y-Intercept (Hong Kong) Ltd79,831$2.17M0.05%+71,89913F-HRTimeline
Lynx1 Capital Management LPin group Lynx1 Capital Management LP79,624$2.17M0.44%new13F-HRTimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP78,656$2.14M<0.01%+4,22713F-HRTimelineGroup
Woodline Partners LP74,423$2.03M0.01%+42713F-HRTimeline
RHUMBLINE ADVISERS74,153$2.02M<0.01%-13,54913F-HRTimeline
ExodusPoint Capital Management, LP71,146$1.94M0.02%new13F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …70,256$1.92M<0.01%-25,75613F-HRTimelineGroup
KENNEDY CAPITAL MANAGEMENT LLC65,655$1.79M0.04%+41,01413F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN64,772$1.76M<0.01%+20,01813F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.61,494$1.67M<0.01%-913F-HRTimeline
TUDOR INVESTMENT CORP ET AL61,345$1.67M0.01%new13F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …60,560$1.65M<0.01%-10,65313F-HRTimelineGroup
TD Asset Management Inc57,292$1.56M<0.01%-71,00213F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…53,239$1.45M<0.01%-8,05713F-HRTimeline
Headlands Technologies LLC52,739$1.44M0.12%new13F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND51,707$1.41M<0.01%+1,91713F-HRTimeline
Engineers Gate Manager LP49,128$1.34M0.02%new13F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC47,881$1.3M0.01%+20,32713F-HRTimelineGroup
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…47,414$1.29M<0.01%new13F-HRTimelineGroup
DekaBank Deutsche Girozentrale40,000$1.27M<0.01%013F-HRTimeline
SG Americas Securities, LLC46,451$1.26M<0.01%+18,80113F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP46,242$1.26M<0.01%new13F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd46,039$1.25M0.03%new13F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding42,289$1.15M+3,451Timeline
VIRGINIA RETIREMENT SYSTEMS ET Al41,361$1.13M0.01%+30013F-HRTimeline
Freestone Grove Partners LP40,841$1.11M0.01%+25,41713F-HRTimeline
PROFUND ADVISORS LLC39,850$1.08M0.03%+24,74113F-HRTimeline
BOOTHBAY FUND MANAGEMENT, LLC37,291$1.02M0.03%-458,05013F-HRTimeline
HARBOR CAPITAL ADVISORS, INC.37,228$1.01M0.08%+2,39313F-HRTimeline
Aquatic Capital Management LLC36,006$980K0.03%new13F-HRTimeline
Quadrature Capital Ltdin group Quadrature Capital Ltd35,857$976K0.01%new13F-HRTimelineGroup
CAPITAL FUND MANAGEMENT S.A.35,788$974K0.01%new13F-HRTimeline
EDGEWOOD MANAGEMENT LLC35,000$953K<0.01%013F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD34,637$943K<0.01%-93613F-HRTimeline
PRELUDE CAPITAL MANAGEMENT, LLC33,685$917K0.07%new13F-HRTimeline
Hennion & Walsh Asset Management, Inc.33,470$911K0.03%+7,96913F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC33,052$900K0.01%-54,84813F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…32,217$877K<0.01%-1,81513F-HRTimelineGroup
Seven Fleet Capital Management LP31,738$864K0.58%13F-HR/ATimeline
Ishara Investments LP30,000$817K0.95%13F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC27,827$757K0.01%+4,24913F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC27,926$754K<0.01%-63,70913F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC27,697$754K<0.01%-2,53513F-HRTimeline
Quantinno Capital Management LP26,855$731K<0.01%new13F-HRTimeline
Aigen Investment Management, LP25,915$705K0.16%new13F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…25,060$682K0.19%+12,17913F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.25,055$682K<0.01%+25,00213F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…24,679$672K<0.01%+17,82313F-HRTimelineGroup
FMR LLCin group FMR LLC24,334$662K<0.01%+3,62213F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson23,797$648K<0.01%013F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…23,620$643K<0.01%+3,14413F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…21,071$574K<0.01%+5,03313F-HR/ATimelineGroup
OAK RIDGE INVESTMENTS LLC20,004$545K0.03%-5,38113F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…19,336$526K0.01%+7,26513F-HRTimelineGroup
Handelsbanken Fonder AB19,323$526K<0.01%013F-HRTimeline
Entropy Technologies, LP19,163$522K0.03%new13F-HRTimeline
VARCOV Co.19,104$520K0.21%13F-HRTimeline
CANADA PENSION PLAN INVESTMENT BOARD18,200$495K<0.01%new13F-HRTimeline
Knott David M Jr18,000$490K0.23%new13F-HRTimeline
Inspire Investing, LLCin group Inspire Investing, LLC17,115$466K0.04%+5,72013F-HRTimelineGroup
WINTON GROUP Ltdin group WINTON GROUP Ltd16,751$456K0.02%+35113F-HRTimelineGroup
STATE BOARD OF ADMINISTRATION OF FLORID…15,847$431K<0.01%013F-HRTimeline
Police & Firemen's Retirement System of…15,640$426K<0.01%+713F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM15,330$417K<0.01%-92513F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO14,352$391K<0.01%-17,94813F-HRTimelineGroup
Tidal Investments LLCin group Tidal Investments LLC14,247$388K<0.01%-66713F-HRTimelineGroup
Atria Investments, Inc14,053$383K<0.01%+66713F-HRTimeline
AlphaCentric Advisors LLC13,141$358K0.36%13F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA13,055$354K<0.01%-4,47213F-HRTimelineGroup
ProShare Advisors LLC12,897$351K<0.01%+1,16913F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC12,735$347K<0.01%+3,31213F-HRTimelineGroup
COMMERCE BANKin group COMMERCE BANK12,656$344K<0.01%+3,49713F-HRTimelineGroup
Bridgefront Capital, LLC12,649$344K0.09%new13F-HRTimeline
FOX RUN MANAGEMENT, L.L.C.12,567$342K0.05%new13F-HRTimeline
AlphaQuest LLC11,963$326K0.02%+6,55213F-HRTimeline
Pale Fire Capital SEin group Pale Fire Capital11,850$323K0.04%new13F-HRTimelineGroup
KLP KAPITALFORVALTNING AS11,800$321K<0.01%013F-HRTimeline
Gallagher Fiduciary Advisors, LLCin group Gallagher Fiduciary Advisors,…11,245$306K0.01%-1513F-HRTimelineGroup
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co10,437$284K<0.01%-9,88813F-HRTimelineGroup
Creative Planningin group Creative Planning10,370$282K<0.01%-2,74913F-HRTimelineGroup
CAPSTONE INVESTMENT ADVISORS, LLCin group CAPSTONE INVESTMENT ADVISORS,…10,355$282K<0.01%new13F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC10,134$276K<0.01%013F-HRTimelineGroup
STRS OHIO10,000$272K<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…9,502$259K0.02%-68213F-HRTimeline
TWO SIGMA SECURITIES, LLC9,198$250K0.03%new13F-HRTimeline
DIVERSIFIED TRUST CO9,162$249K<0.01%new13F-HRTimeline
Inscription Capital, LLC8,595$234K0.02%new13F-HRTimeline
Fiduciary Trust Coin group Fiduciary Trust Co8,247$224K<0.01%+2,79313F-HRTimelineGroup
Campbell & CO Investment Adviser LLC8,226$224K0.01%new13F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS8,167$222K<0.01%-5,31713F-HRTimeline
GRIFFIN ASSET MANAGEMENT, INC.7,382$201K0.02%new13F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…6,796$185K<0.01%013F-HRTimeline
Caitong International Asset Management …6,740$183K0.04%new13F-HR/ATimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…6,634$181K<0.01%+5,27713F-HRTimelineGroup
Ensign Peak Advisors, Inc6,570$179K<0.01%-6,05013F-HR/ATimeline
SIMPLEX TRADING, LLC6,209$169K<0.01%new13F-HRTimeline
CONTRAVISORY INVESTMENT MANAGEMENT, INC.6,189$168K0.03%new13F-HRTimeline
State of Alaska, Department of Revenue5,000$136K<0.01%new13F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…4,719$128K<0.01%013F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…4,710$128K<0.01%+15613F-HRTimelineGroup
Sterling Capital Management LLC3,283$89.4K<0.01%-62813F-HRTimeline
FIRST HORIZON CORP3,095$84.2K<0.01%+1,97113F-HRTimeline
KBC Group NVin group KBC Group NV3,020$82K<0.01%+1,26913F-HRTimelineGroup
Quarry LP3,000$81.7K0.01%-2,00013F-HRTimeline
Eurizon Capital SGR S.p.A.2,647$72.3K<0.01%13F-HRTimeline
AMALGAMATED BANK1,774$48K<0.01%-18313F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.1,747$47.6K<0.01%+1,41113F-HRTimelineGroup
ASSETMARK, INCin group ASSETMARK, INC1,317$35.8K<0.01%+36213F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.1,145$31.2K<0.01%-10513F-HRTimeline
T. Rowe Price Investment Management, In…892$25K<0.01%new13F-HR/ATimeline
Torren Management, LLC615$16.7K0.01%13F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\509$13.9K<0.01%-6013F-HRTimelineGroup
CITY HOLDING CO500$13.6K<0.01%new13F-HRTimeline
Hurley Capital, LLC486$13.2K0.01%+12013F-HRTimeline
CWM, LLCin group CWM, LLC484$13K<0.01%-4,30713F-HRTimelineGroup
LOS ANGELES CAPITAL MANAGEMENT LLC300$13K<0.01%new13F-HRTimeline
Smartleaf Asset Management LLC460$12.6K<0.01%+6213F-HRTimeline
SIGNATUREFD, LLC399$10.9K<0.01%-11413F-HRTimeline
Quantbot Technologies LP386$10.5K<0.01%-1,59013F-HRTimeline
Aspect Partners, LLC361$9.83K<0.01%013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC295$8.03K<0.01%-48513F-HRTimeline
Bell Investment Advisors, Inc281$7.65K<0.01%-1713F-HRTimeline
THURSTON, SPRINGER, MILLER, HERD & TITA…241$6.56K<0.01%new13F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.204$6K<0.01%013F-HRTimelineGroup
COMERICA BANK209$5.7K<0.01%-16513F-HRTimeline
Hillsdale Investment Management Inc.200$5.44K<0.01%013F-HRTimeline