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SPHERA FUNDS MANAGEMENT LTD.

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13F filer, CIK 1496201, TEL AVIV, Israel

SPHERA FUNDS MANAGEMENT LTD. reported $629,683,422 across 96 holdings for the quarter ended 2026-03-31, in a 13F-HR filed 2026-05-15. Its ten largest share positions make up 37.38% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001496201-26-000003

Period
2026-03-31
Reported value
$630M
Holdings
96
Top 10 weight
37.38%
New
22
Sold out
25

Part of the filer group SPHERA FUNDS MANAGEMENT LTD.

How groups are built

Largest buys vs the previous quarter

SecurityShares changeApprox. value
MLYSadded+890,968$24.1M
AZNnew+62,530$12.3M
RAREadded+508,710$10.7M
BBIOadded+137,500$10.2M
CLBTnew+631,521$8.7M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
AZNexited-135,060-$12.4M
SEDGreduced-143,700-$7.34M
ANNXexited-1,316,212-$6.61M
ORICreduced-466,750-$5.91M
ASTRIA THERAPEUTICS INCexited-355,725-$4.66M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2026

Share positions as resolved from 13F-HR 0001496201-26-000003, largest first. % of portfolio is the value over $581,481,527, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
MLYSMINERALYS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 272,472 shares; 2024Q4: 190,672 shares; 2025Q1: 465,526 shares; 2025Q2: 480,974 shares; 2025Q3: 219,910 shares; 2025Q4: 449,003 shares; 2026Q1: 1,339,971 shares 1,339,971$36.3M6.24%+890,968Timeline
TEVATEVA PHARMACEUTICAL INDS LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 2,130,216 shares; 2024Q4: 1,569,181 shares; 2025Q1: 1,572,181 shares; 2025Q2: 1,620,990 shares; 2025Q3: 1,507,025 shares; 2025Q4: 1,123,525 shares; 2026Q1: 1,136,975 shares 1,136,975$34.2M5.89%+13,450Timeline
TSEMTOWER SEMICONDUCTOR LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 209,441 shares; 2024Q4: 166,149 shares; 2025Q1: 61,549 shares; 2025Q2: 264,722 shares; 2025Q3: 311,802 shares; 2025Q4: 122,513 shares; 2026Q1: 145,735 shares 145,735$25.6M4.4%+23,222Timeline
NVMINOVA LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 51,960 shares; 2024Q4: 68,146 shares; 2025Q1: 90,697 shares; 2025Q2: 75,836 shares; 2025Q3: 43,896 shares; 2025Q4: 47,846 shares; 2026Q1: 53,366 shares 53,366$23.2M3.99%+5,520Timeline
BBIOBRIDGEBIO PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 842,644 shares; 2024Q4: 905,279 shares; 2025Q1: 366,608 shares; 2025Q2: 87,108 shares; 2025Q3: 40,746 shares; 2025Q4: 107,746 shares; 2026Q1: 245,246 shares 245,246$18.2M3.13%+137,500Timeline
BIIBBIOGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 24,455 shares; 2024Q4: 22,738 shares; 2025Q1: 22,738 shares; 2025Q2: 82,738 shares; 2025Q3: 82,738 shares; 2025Q4: 94,738 shares; 2026Q1: 92,526 shares 92,526$17M2.92%-2,212Timeline
RAREULTRAGENYX PHARMACEUTICAL INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 195,349 shares; 2024Q4: 228,776 shares; 2025Q1: 267,385 shares; 2025Q2: 100,085 shares; 2025Q3: 352,558 shares; 2025Q4: 300,623 shares; 2026Q1: 809,333 shares 809,333$17M2.92%+508,710Timeline
SNDXSYNDAX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,034,846 shares; 2024Q4: 1,381,241 shares; 2025Q1: 1,663,974 shares; 2025Q2: 1,571,564 shares; 2025Q3: 387,716 shares; 2025Q4: 762,563 shares; 2026Q1: 724,563 shares 724,563$16.9M2.91%-38,000Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 335,024 shares; 2025Q2: 143,693 shares; 2025Q3: 98,526 shares; 2025Q4: 378,500 shares; 2026Q1: 416,340 shares 416,340$16M2.76%+37,840Timeline
SNYSANOFI SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 409,515 shares; 2024Q4: 384,515 shares; 2025Q1: 304,515 shares; 2025Q2: 219,515 shares; 2025Q3: 219,515 shares; 2025Q4: 239,515 shares; 2026Q1: 269,515 shares 269,515$13M2.23%+30,000Timeline
AZNASTRAZENECA PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 62,530 shares 62,530$12.3M2.12%newTimeline
FOLDAMICUS THERAPEUTICQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 990,718 shares; 2025Q3: 991,142 shares; 2025Q4: 658,377 shares; 2026Q1: 603,377 shares 603,377$8.72M1.5%-55,000Timeline
CLBTCELLEBRITE DI LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 298,948 shares; 2025Q4: not reported; 2026Q1: 631,521 shares 631,521$8.7M1.5%newTimeline
APLSAPELLIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 215,873 shares; 2024Q4: 206,251 shares; 2025Q1: 181,346 shares; 2025Q2: 114,346 shares; 2025Q3: 63,660 shares; 2025Q4: 250,961 shares; 2026Q1: 214,914 shares 214,914$8.65M1.49%-36,047Timeline
PANWPALO ALTO NETWORKS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 13,114 shares; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 52,800 shares 52,800$8.46M1.46%newTimeline
LLYELI LILLY & COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 13,190 shares; 2024Q4: 13,190 shares; 2025Q1: 11,690 shares; 2025Q2: 11,540 shares; 2025Q3: 10,040 shares; 2025Q4: 9,040 shares; 2026Q1: 9,040 shares 9,040$8.31M1.43%0Timeline
BCRXBIOCRYST PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 837,889 shares; 2026Q1: 866,464 shares 866,464$8.25M1.42%+28,575Timeline
CAMTCAMTEK LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 36,287 shares; 2024Q4: 36,287 shares; 2025Q1: 23,086 shares; 2025Q2: 31,976 shares; 2025Q3: 29,048 shares; 2025Q4: 39,498 shares; 2026Q1: 53,020 shares 53,020$8.04M1.38%+13,522Timeline
BMRNBIOMARIN PHARMACEUTICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 147,000 shares; 2026Q1: 139,900 shares 139,900$7.9M1.36%-7,100Timeline
CLDXCELLDEX THERAPEUTICS INC NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 419,103 shares; 2024Q4: 474,103 shares; 2025Q1: 507,829 shares; 2025Q2: 419,540 shares; 2025Q3: 207,764 shares; 2025Q4: 239,764 shares; 2026Q1: 243,575 shares 243,575$7.73M1.33%+3,811Timeline
ORAORMAT TECHNOLOGIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 79,000 shares; 2025Q1: 84,000 shares; 2025Q2: 78,000 shares; 2025Q3: 29,000 shares; 2025Q4: not reported; 2026Q1: 68,250 shares 68,250$7.64M1.31%newTimeline
XENEXENON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 52,097 shares; 2025Q1: 26,097 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 127,000 shares 127,000$7.39M1.27%newTimeline
SLNOSOLENO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 41,606 shares; 2025Q4: 136,314 shares; 2026Q1: 216,281 shares 216,281$7.24M1.25%+79,967Timeline
TNGXTANGO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 50,000 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 544,563 shares; 2026Q1: 343,563 shares 343,563$7.19M1.24%-201,000Timeline
JNJJOHNSON & JOHNSONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 69,831 shares; 2024Q4: 69,831 shares; 2025Q1: 52,831 shares; 2025Q2: 40,831 shares; 2025Q3: 40,831 shares; 2025Q4: 35,831 shares; 2026Q1: 28,831 shares 28,831$7.05M1.21%-7,000Timeline
SOLAREDGE TECHNOLOGIES INCSOLAREDGE TECHNOLOGIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 4,000,000 shares; 2025Q4: 4,000,000 shares; 2026Q1: 4,000,000 shares 4,000,000$6.91M1.19%0
IMTXIMMATICS N.VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 721,111 shares; 2024Q4: 921,111 shares; 2025Q1: 921,111 shares; 2025Q2: 583,105 shares; 2025Q3: 583,105 shares; 2025Q4: 861,105 shares; 2026Q1: 696,105 shares 696,105$6.85M1.18%-165,000Timeline
TRVITREVI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 799,957 shares; 2025Q3: 643,957 shares; 2025Q4: 598,534 shares; 2026Q1: 574,029 shares 574,029$6.85M1.18%-24,505Timeline
ORICORIC PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 128,396 shares; 2024Q4: 273,213 shares; 2025Q1: 234,834 shares; 2025Q2: 394,693 shares; 2025Q3: 431,693 shares; 2025Q4: 1,004,378 shares; 2026Q1: 537,628 shares 537,628$6.81M1.17%-466,750Timeline
MAZEMAZE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 355,554 shares; 2025Q2: 356,453 shares; 2025Q3: 154,343 shares; 2025Q4: 71,843 shares; 2026Q1: 227,343 shares 227,343$6.79M1.17%+155,500Timeline
GSKGSK PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 100,000 shares; 2024Q4: 130,000 shares; 2025Q1: 130,000 shares; 2025Q2: 122,000 shares; 2025Q3: 122,000 shares; 2025Q4: 122,000 shares; 2026Q1: 122,000 shares 122,000$6.73M1.16%0Timeline
AMZNAMAZON COM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 105,607 shares; 2024Q4: 62,607 shares; 2025Q1: 36,607 shares; 2025Q2: 32,441 shares; 2025Q3: 13,760 shares; 2025Q4: not reported; 2026Q1: 31,940 shares 31,940$6.65M1.14%newTimeline
ABBVABBVIE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 38,000 shares; 2024Q4: 34,256 shares; 2025Q1: 30,256 shares; 2025Q2: 25,256 shares; 2025Q3: 25,256 shares; 2025Q4: 25,256 shares; 2026Q1: 30,256 shares 30,256$6.58M1.13%+5,000Timeline
AAOIAPPLIED OPTOELECTRONICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 73,400 shares 73,400$6.21M1.07%newTimeline
ELVNENLIVEN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 111,743 shares; 2025Q2: 128,515 shares; 2025Q3: 166,765 shares; 2025Q4: 226,765 shares; 2026Q1: 153,265 shares 153,265$6.01M1.03%-73,500Timeline
MRKMERCK & CO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 59,600 shares; 2024Q4: 59,600 shares; 2025Q1: 59,600 shares; 2025Q2: 48,600 shares; 2025Q3: 48,600 shares; 2025Q4: 48,600 shares; 2026Q1: 48,600 shares 48,600$5.85M1.01%0Timeline
VORVOR BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 410,417 shares; 2026Q1: 321,917 shares 321,917$5.74M0.99%-88,500Timeline
ACADACADIA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 252,539 shares; 2024Q4: 288,539 shares; 2025Q1: not reported; 2025Q2: 174,900 shares; 2025Q3: 148,900 shares; 2025Q4: 212,202 shares; 2026Q1: 256,202 shares 256,202$5.7M0.98%+44,000Timeline
NVSNOVARTIS AGQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 50,000 shares; 2024Q4: 50,000 shares; 2025Q1: 50,000 shares; 2025Q2: 37,000 shares; 2025Q3: 37,000 shares; 2025Q4: 37,000 shares; 2026Q1: 37,000 shares 37,000$5.65M0.97%0Timeline
ELDNELEDON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,297,321 shares; 2024Q4: 2,551,619 shares; 2025Q1: 2,307,119 shares; 2025Q2: 1,959,610 shares; 2025Q3: 1,280,233 shares; 2025Q4: 2,132,131 shares; 2026Q1: 1,772,131 shares 1,772,131$5.46M0.94%-360,000Timeline
ENPHENPHASE ENERGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 64,224 shares; 2024Q4: 50,198 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 26,700 shares; 2025Q4: 186,500 shares; 2026Q1: 142,419 shares 142,419$5.38M0.93%-44,081Timeline
RVMDREVOLUTION MEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 60,000 shares; 2025Q4: 52,500 shares; 2026Q1: 55,110 shares 55,110$5.36M0.92%+2,610Timeline
PFEPFIZER INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 90,000 shares; 2024Q4: 90,000 shares; 2025Q1: 90,000 shares; 2025Q2: 86,000 shares; 2025Q3: 86,000 shares; 2025Q4: 86,000 shares; 2026Q1: 186,000 shares 186,000$5.22M0.9%+100,000Timeline
BHVNBIOHAVEN LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 133,323 shares; 2024Q4: 156,494 shares; 2025Q1: 99,784 shares; 2025Q2: 145,372 shares; 2025Q3: 91,155 shares; 2025Q4: not reported; 2026Q1: 594,000 shares 594,000$5.03M0.86%newTimeline
FBRXFORTE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 495,109 shares; 2025Q3: 474,309 shares; 2025Q4: 185,869 shares; 2026Q1: 184,984 shares 184,984$4.79M0.82%-885Timeline
HELPCYBIN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 933,225 shares; 2024Q4: 538,111 shares; 2025Q1: 527,222 shares; 2025Q2: 398,309 shares; 2025Q3: 370,376 shares; 2025Q4: 825,576 shares; 2026Q1: 987,090 shares 987,090$4.74M0.81%+161,514Timeline
MDGLMADRIGAL PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 3,300 shares; 2026Q1: 9,040 shares 9,040$4.73M0.81%+5,740Timeline
SRRKSCHOLAR ROCK HLDG CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 166,866 shares; 2024Q4: 90,193 shares; 2025Q1: 78,193 shares; 2025Q2: 57,497 shares; 2025Q3: not reported; 2025Q4: 158,265 shares; 2026Q1: 94,265 shares 94,265$4.63M0.8%-64,000Timeline
NVONOVO-NORDISK A SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 78,080 shares; 2024Q4: 98,080 shares; 2025Q1: 118,080 shares; 2025Q2: 105,677 shares; 2025Q3: 105,677 shares; 2025Q4: 115,677 shares; 2026Q1: 120,677 shares 120,677$4.43M0.76%+5,000Timeline
MDWDMEDIWOUND LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 185,270 shares; 2025Q4: 230,347 shares; 2026Q1: 273,192 shares 273,192$4.4M0.76%+42,845Timeline
KODKODIAK SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 175,500 shares; 2026Q1: 114,796 shares 114,796$4.38M0.75%-60,704Timeline
ZBIOZENAS BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 214,334 shares 214,334$4.19M0.72%newTimeline
PMNPROMIS NEUROSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 11,807 shares; 2026Q1: 325,591 shares 325,591$4.14M0.71%+313,784Timeline
RLAYRELAY THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 408,436 shares 408,436$4.06M0.7%newTimeline
SVRASAVARA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 563,107 shares; 2024Q4: 1,211,533 shares; 2025Q1: 1,284,151 shares; 2025Q2: 1,310,233 shares; 2025Q3: 1,350,333 shares; 2025Q4: 1,178,164 shares; 2026Q1: 739,164 shares 739,164$4.04M0.69%-439,000Timeline
WVEWAVE LIFE SCIENCES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 50,000 shares; 2025Q4: 408,166 shares; 2026Q1: 548,272 shares 548,272$3.97M0.68%+140,106Timeline
CRVSCORVUS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 500,491 shares; 2025Q1: 205,859 shares; 2025Q2: 183,094 shares; 2025Q3: 407,709 shares; 2025Q4: 407,709 shares; 2026Q1: 247,961 shares 247,961$3.63M0.62%-159,748Timeline
OVIDOVID THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,622,828 shares 1,622,828$3.6M0.62%newTimeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 53,538 shares 53,538$3.42M0.59%newTimeline
UPBUPSTREAM BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 358,000 shares 358,000$3.22M0.55%newTimeline
ACOGALPHA COGNITION INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 620,000 shares; 2025Q1: 596,992 shares; 2025Q2: 376,649 shares; 2025Q3: 338,752 shares; 2025Q4: 567,616 shares; 2026Q1: 567,616 shares 567,616$3.12M0.54%0Timeline
PALIPALISADE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 184,100 shares; 2026Q1: 1,733,471 shares 1,733,471$3.03M0.52%+1,549,371Timeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 56,504 shares; 2024Q4: 236,262 shares; 2025Q1: 329,262 shares; 2025Q2: 221,416 shares; 2025Q3: 426,518 shares; 2025Q4: 392,894 shares; 2026Q1: 160,594 shares 160,594$2.91M0.5%-232,300Timeline
CLYMCLIMB BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 181,970 shares; 2024Q4: 251,935 shares; 2025Q1: 241,935 shares; 2025Q2: 209,837 shares; 2025Q3: 434,837 shares; 2025Q4: 932,247 shares; 2026Q1: 419,247 shares 419,247$2.87M0.49%-513,000Timeline
ZIMZIM INTEGRATED SHIPPING SERVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 136,005 shares; 2026Q1: 105,950 shares 105,950$2.79M0.48%-30,055Timeline
MSLESATELLOS BIOSCIENCE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 489,207 shares 489,207$2.75M0.47%newTimeline
SEDGSOLAREDGE TECHNOLOGIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 375,000 shares; 2025Q1: 309,216 shares; 2025Q2: 127,966 shares; 2025Q3: 140,966 shares; 2025Q4: 196,536 shares; 2026Q1: 52,836 shares 52,836$2.7M0.46%-143,700Timeline
AMGNAMGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 10,000 shares; 2025Q2: 9,500 shares; 2025Q3: 9,500 shares; 2025Q4: 7,500 shares; 2026Q1: 7,500 shares 7,500$2.64M0.45%0Timeline
CYTKCYTOKINETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 225,021 shares; 2024Q4: 153,021 shares; 2025Q1: 144,961 shares; 2025Q2: 326,718 shares; 2025Q3: 161,517 shares; 2025Q4: 91,717 shares; 2026Q1: 39,817 shares 39,817$2.62M0.45%-51,900Timeline
GPCRSTRUCTURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 84,000 shares; 2025Q2: 95,931 shares; 2025Q3: 173,931 shares; 2025Q4: 41,000 shares; 2026Q1: 50,800 shares 50,800$2.45M0.42%+9,800Timeline
KURAKURA ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 610,087 shares; 2024Q4: 610,087 shares; 2025Q1: 343,522 shares; 2025Q2: 235,522 shares; 2025Q3: 245,522 shares; 2025Q4: 295,522 shares; 2026Q1: 295,522 shares 295,522$2.4M0.41%0Timeline
GENBGENERATE BIOMEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 185,000 shares 185,000$2.31M0.4%newTimeline
IBITISHARES BITCOIN TRUST ETFQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 8,150 shares; 2025Q2: 21,455 shares; 2025Q3: 21,455 shares; 2025Q4: 30,055 shares; 2026Q1: 59,505 shares 59,505$2.29M0.39%+29,450Timeline
CTNMCONTINEUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 173,475 shares; 2026Q1: 173,475 shares 173,475$2.27M0.39%0Timeline
TENXTENAX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 29,166 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 190,111 shares; 2026Q1: 136,015 shares 136,015$2.17M0.37%-54,0962026-09-30, 13G/A: 2,663,296 shares, 7.09% of the class, 13G/A filed 2026-10-13 Timeline
PRLDPRELUDE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 122,752 shares; 2026Q1: 558,339 shares 558,339$1.91M0.33%+435,587Timeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 11,000 shares; 2026Q1: 8,000 shares 8,000$1.83M0.31%-3,000Timeline
VSTMVERASTEM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 163,307 shares; 2025Q3: 78,307 shares; 2025Q4: 343,678 shares; 2026Q1: 343,678 shares 343,678$1.82M0.31%0Timeline
VYGRVOYAGER THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 199,761 shares; 2025Q4: 339,761 shares; 2026Q1: 469,761 shares 469,761$1.81M0.31%+130,000Timeline
STTKSHATTUCK LABS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 195,212 shares; 2026Q1: 280,786 shares 280,786$1.81M0.31%+85,574Timeline
EVMNEVOMMUNE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 166,147 shares; 2026Q1: 78,234 shares 78,234$1.8M0.31%-87,913Timeline
BIOABIOAGE LABS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 243,035 shares; 2026Q1: 86,518 shares 86,518$1.51M0.26%-156,517Timeline
ORGOORGANOGENESIS HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 550,000 shares 550,000$1.3M0.22%newTimeline
CRISCURIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 1,994,937 shares 1,994,937$1.09M0.19%newTimeline
BMYBRISTOL-MYERS SQUIBB COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 20,000 shares; 2025Q1: 20,000 shares; 2025Q2: 17,500 shares; 2025Q3: 17,500 shares; 2025Q4: 17,500 shares; 2026Q1: 17,500 shares 17,500$1.06M0.18%0Timeline
CTMXCYTOMX THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 220,000 shares 220,000$1.03M0.18%newTimeline
NICENICE LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 78,361 shares; 2024Q4: 42,500 shares; 2025Q1: 33,303 shares; 2025Q2: not reported; 2025Q3: 157,400 shares; 2025Q4: not reported; 2026Q1: 5,611 shares 5,611$619K0.11%newTimeline
HOWLWEREWOLF THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 626,810 shares; 2024Q4: 626,810 shares; 2025Q1: 626,810 shares; 2025Q2: 626,810 shares; 2025Q3: 626,810 shares; 2025Q4: 626,810 shares; 2026Q1: 626,810 shares 626,810$522K0.09%0Timeline
SKYESKYE BIOSCIENCE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,563,522 shares; 2024Q4: 1,564,628 shares; 2025Q1: 1,476,353 shares; 2025Q2: 538,434 shares; 2025Q3: 478,928 shares; 2025Q4: 478,928 shares; 2026Q1: 678,928 shares 678,928$417K0.07%+200,000Timeline
DTILPRECISION BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 396,116 shares; 2026Q1: 40,000 shares 40,000$220K0.04%-356,116Timeline
APREAPREA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 270,000 shares; 2024Q4: 270,000 shares; 2025Q1: 270,000 shares; 2025Q2: 270,000 shares; 2025Q3: 270,000 shares; 2025Q4: 270,000 shares; 2026Q1: 270,000 shares 270,000$206K0.04%0Timeline
FHTXFOGHORN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 12,224 shares 12,224$58.4K0.01%newTimeline

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
XBISPDR SERIES TRUST S&P BIOTECHput200,000$25.5M+130,000
CYTKCYTOKINETICS INC COM NEWcall259,300$17.1Mnew
TLTISHARES TR 20 YR TR BD ETFcall47,000$4.07M0
OLMAOLEMA PHARMACEUTICALS INC COMcall100,000$1.49Mnew

Sold out in Q1 2026

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
AZNASTRAZENECA PLC-SPONS ADR135,060$12.4Mshares
PRAXPRAXIS PRECISION MEDICINES I40,000$11.8Mcall
RAREULTRAGENYX PHARMACEUTICAL IN350,000$8.05Mcall
ANNXANNEXON INC1,316,212$6.61Mshares
NICENICE LTD55,700$6.3Mcall
ASTRIA THERAPEUTICS INCASTRIA THERAPEUTICS INC355,725$4.66Mshares
AMDADVANCED MICRO DEVICES INC18,040$3.86Mshares
TARAPROTARA THERAPEUTICS INC650,000$3.46Mshares
AVGOBROADCOM INC9,755$3.38Mshares
ESLTELBIT SYS LTD5,340$3.08Mshares
NRIXNURIX THERAPEUTICS INC124,000$2.35Mshares
JANXJANUX THERAPEUTICS INC157,840$2.18Mshares
TSHATAYSHA GENE THERAPIES INC368,146$2.02Mshares
PHVSPHARVARIS N V63,953$1.77Mshares
VRNSVARONIS SYS INC52,500$1.72Mshares
VTYXVENTYX BIOSCIENCES INC180,114$1.63Mshares
DAWNDAY ONE BIOPHARMACEUTICALS I145,371$1.35Mshares
TRDAENTRADA THERAPEUTICS INC110,942$1.14Mshares
TNYATENAYA THERAPEUTICS INC1,500,000$1.07Mshares
CATXPERSPECTIVE THERAPEUTICS INC349,973$962Kshares
JSPRJASPER THERAPEUTICS INC485,401$888Kshares
PEPGPEPGEN INC121,467$791Kshares
OKURONKURE THERAPEUTICS INC60,454$175Kshares
MREOMEREO BIOPHARMA GROUP PLC255,400$106Kshares
Applied Therapeutics IncApplied Therapeutics Inc50,000$5Kshares

How Q1 2026 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001496201-26-000003 base2026-05-15acceptance time not in the bulk data set