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Boxer Capital Management, LLC

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13F filer, CIK 2018299, San Diego, CA

Boxer Capital Management, LLC reported $332,470,540 across 28 holdings for the quarter ended 2025-03-31, in a 13F-HR/A filed 2026-02-17. Its ten largest share positions make up 72.35% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR/A 0002018299-26-000003

Period
2025-03-31
Reported value
$332M
Holdings
28
Top 10 weight
72.35%
New
2
Sold out
34

Part of the filer group Boxer Capital Management, LLC

  • Aaron Davis
  • Boxer Holdings GP, LLC
  • Boxer Holdings, LP
How groups are built

Stakes and trades reported after 2025-03-31

13D, 13G and Form 4 filings by this filer's group, dated after the 13F period, on securities the quarter does not hold as shares.

  • SRZN SURROZEN INC: 13G/A 1,360,683 shares, 11.6% of the class, 13G/A filed 2026-10-07, 0001213900-26-107661Timeline
    Accepted , ingested

Largest buys vs the previous quarter

SecurityShares changeApprox. value
SLDBnew+1,240,700$4.59M
DNLInew+250,000$3.4M
PRLDadded+399,827$308K
KODadded+35,000$98.3K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
SPRINGWORKS THERAPEUTICS INCexited-3,421,541-$124M
RVMDreduced-2,961,487-$105M
MERUS N Vreduced-1,200,000-$50.5M
NUVLreduced-670,192-$47.5M
AXSMexited-470,000-$39.8M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2025

Share positions as resolved from 13F-HR/A 0002018299-26-000003, largest first. % of portfolio is the value over $332,470,540, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
RVMDREVOLUTION MEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 4,279,464 shares; 2025Q1: 1,317,977 shares 1,317,977$46.6M14.02%-2,961,487Timeline
NUVLNUVALENT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,120,192 shares; 2025Q1: 450,000 shares 450,000$31.9M9.6%-670,192Timeline
MERUS N VMERUS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,900,000 shares; 2025Q1: 700,000 shares 700,000$29.5M8.86%-1,200,000
RNAMAVIDITY BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,727,388 shares; 2025Q1: 865,000 shares 865,000$25.5M7.68%-862,388Timeline
ANABANAPTYSBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,300,000 shares; 2025Q1: 1,300,000 shares 1,300,000$24.2M7.27%0Timeline
XENEXENON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 600,000 shares; 2025Q1: 600,000 shares 600,000$20.1M6.05%0Timeline
REPLREPLIMUNE GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,796,341 shares; 2025Q1: 1,796,341 shares 1,796,341$17.5M5.27%0Timeline
APLSAPELLIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,426,000 shares; 2025Q1: 713,000 shares 713,000$15.6M4.69%-713,000Timeline
CHIMERIX INC COMCHIMERIX INC COMQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 2,060,000 shares; 2025Q1: 1,810,000 shares 1,810,000$15.4M4.63%-250,000
TNGXTANGO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 10,380,999 shares; 2025Q1: 10,380,999 shares 10,380,999$14.2M4.28%0Timeline
ELVNENLIVEN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 671,358 shares; 2025Q1: 671,358 shares 671,358$13.2M3.97%0Timeline
ORICORIC PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,732,571 shares; 2025Q1: 1,732,571 shares 1,732,571$9.67M2.91%0Timeline
DAWNDAY ONE BIOPHARMACEUTICALS IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,189,943 shares; 2025Q1: 1,189,943 shares 1,189,943$9.44M2.84%0Timeline
KYMRKYMERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 425,000 shares; 2025Q1: 325,000 shares 325,000$8.9M2.68%-100,000Timeline
PRTAPROTHENA CORP PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 690,000 shares; 2025Q1: 690,000 shares 690,000$8.54M2.57%0Timeline
QUREUNIQURE NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 750,000 shares; 2025Q1: 750,000 shares 750,000$7.95M2.39%0Timeline
LEGNLEGEND BIOTECH CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 700,000 shares; 2025Q1: 200,000 shares 200,000$6.79M2.04%-500,000Timeline
NRIXNURIX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 563,067 shares; 2025Q1: 563,067 shares 563,067$6.69M2.01%0Timeline
AMLXAMYLYX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,750,000 shares; 2025Q1: 1,750,000 shares 1,750,000$6.2M1.86%0Timeline
SLDBSOLID BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 1,240,700 shares 1,240,700$4.59M1.38%newTimeline
DNLIDENALI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: not reported; 2025Q1: 250,000 shares 250,000$3.4M1.02%newTimeline
KODKODIAK SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,000,000 shares; 2025Q1: 1,035,000 shares 1,035,000$2.91M0.87%+35,000Timeline
PRLDPRELUDE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 1,708,187 shares; 2025Q1: 2,108,014 shares 2,108,014$1.62M0.49%+399,827Timeline
TILINSTIL BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 355,500 shares; 2025Q1: 80,125 shares 80,125$1.39M0.42%-275,375Timeline
BOLDBOUNDLESS BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 250,000 shares; 2025Q1: 250,000 shares 250,000$378K0.11%0Timeline
CLYMCLIMB BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 2,603,190 shares; 2025Q1: 145,000 shares 145,000$177K0.05%-2,458,190Timeline
NUVATION BIO INCNUVATION BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 266,666 shares; 2025Q1: 266,666 shares 266,666$85.3K0.03%0
SRZNWSURROZEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q2: restricted; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not loaded; 2024Q4: 66,666 shares; 2025Q1: 66,666 shares 66,666$2K<0.01%0Timeline

Sold out in Q1 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
SPRINGWORKS THERAPEUTICS INCSPRINGWORKS THERAPEUTICS INC3,421,541$124Mshares
AXSMAXSOME THERAPEUTICS INC.470,000$39.8Mshares
SRRKSCHOLAR ROCK HLDG CORP750,000$32.4Mshares
TYRATYRA BIOSCIENCES INC2,027,678$28.2Mshares
RCUSARCUS BIOSCIENCES INC1,602,200$23.9Mshares
GERNGERON CORP6,000,000$21.2Mshares
THRDTHIRD HARMONIC BIO INC2,000,000$20.6Mshares
IMVTIMMUNOVANT INC825,000$20.4Mshares
ARVNARVINAS INC1,058,614$20.3Mshares
POSEIDA THERAPEUTICS INCPOSEIDA THERAPEUTICS INC2,000,000$19.2Mshares
RCKTROCKET PHARMACEUTICALS INC1,466,051$18.4Mshares
GPCRSTRUCTURE THERAPEUTICS INC500,000$13.6Mshares
KALVKALVISTA PHARMACEUTICALS INC1,590,000$13.5Mshares
CGEMCULLINAN THERAPEUTICS INC907,895$11.1Mshares
SYRESPYRE THERAPEUTICS INC466,680$10.9Mshares
JSPRJASPER THERAPEUTICS INC350,000$7.48Mshares
ITEOS THERAPEUTICS INCITEOS THERAPEUTICS INC946,915$7.27Mshares
IOVAIOVANCE BIOTHERAPEUTICS INC750,000$5.55Mshares
SMMTSUMMIT THERAPEUTICS INC250,000$4.46Mshares
TERNTERNS PHARMACEUTICALS INC752,000$4.17Mshares
KROSKEROS THERAPEUTICS INC250,000$3.96Mshares
APGEAPOGEE THERAPEUTICS INC86,000$3.9Mshares
OLMAOLEMA PHARMACEUTICALS INC650,000$3.79Mshares
Mersana Therapeutics IncMersana Therapeutics Inc2,635,000$3.77Mshares
SANASANA BIOTECHNOLOGY INC1,545,000$2.52Mshares
BCAXBICARA THERAPEUTICS INC135,000$2.35Mshares
RLAYRELAY THERAPEUTICS INC536,132$2.21Mshares
ZNTLZENTALIS PHARMACEUTICALS INC450,000$1.36Mshares
BDTXBLACK DIAMOND THERAPEUTICS I506,000$1.08Mshares
OBIOORCHESTRA BIOMED HLDGS INC238,193$953Kshares
ZURAZURA BIO LTD300,000$750Kshares
MISTMILESTONE PHARMACEUTICALS IN309,007$729Kshares
BCABBIOATLA INC686,347$406Kshares
DBVTDBV TECHNOLOGIES S A50,000$154Kshares

How Q1 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0002018299-25-000002 superseded2025-05-15acceptance time not in the bulk data set
13F-HR/A 0002018299-26-000003 baserestatement2026-02-17acceptance time not in the bulk data set