5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 3,947,913 $5.33M 1.68% +3,457,913 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 2,954,914 $3.99M +130,367 Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 2,883,745 $3.89M 0.01% +558,390 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 2,855,590 $3.86M <0.01% -48,810 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 2,849,294 $3.84M 0.01% +4,142 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,964,255 $2.65M <0.01% -113,035 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 1,660,378 $2.24M <0.01% +251,575 13F-HR Timeline Group Opaleye Management Inc. More: the full row for Opaleye Management Inc. 1,400,906 $1.89M 0.25% +1,084,356 13F-HR/A Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 1,367,254 $1.85M <0.01% -181,527 13F-HR Timeline Group Decheng Capital LLC More: the full row for Decheng Capital LLC 1,323,327 $1.79M 0.24% 0 13F-HR Timeline Ishara Investments LP More: the full row for Ishara Investments LP 1,320,000 $1.78M 2.07% 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,249,968 $1.69M <0.01% +464 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 1,169,573 $1.58M 0.14% +91,917 13F-HR Timeline PRIMECAP MANAGEMENT CO/CA/ More: the full row for PRIMECAP MANAGEMENT CO/CA/ 957,420 $1.29M <0.01% -5,200 13F-HR Timeline Pfizer Inc More: the full row for Pfizer Inc 953,834 $1.29M 0.54% 0 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 803,654 $1.08M <0.01% -604,175 13F-HR/A Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 787,055 $1.06M <0.01% +406,233 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 674,598 $911K <0.01% +141,920 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 673,129 $909K <0.01% -229,392 13F-HR Timeline Group Almitas Capital LLC More: the full row for Almitas Capital LLC 610,073 $824K 0.18% +152,751 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 589,105 $796K <0.01% -117 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 576,707 $779K 0.02% +28,078 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 568,443 $767K <0.01% +406,973 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 530,582 $716K <0.01% 0 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 473,175 $639K <0.01% -172,448 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 463,700 $626K 0.5% +9,900 13F-HR Timeline Peapod Lane Capital LLC More: the full row for Peapod Lane Capital LLC 448,861 $606K 0.52% -116,510 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 419,367 $566K <0.01% +260,432 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 271,790 $367K <0.01% 0 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 260,000 $351K <0.01% 0 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 247,788 $335K <0.01% new 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 243,308 $328K <0.01% +40,003 13F-HR Timeline Group Anfield Capital Management, LLC in group Anfield Capital Management, L… More: the full row for Anfield Capital Management, LLC 242,605 $328K 0.1% +171,228 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 188,582 $255K <0.01% +14,961 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 185,007 $250K <0.01% -538,068 13F-HR Timeline Group WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 130,407 $232K <0.01% -35,883 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 167,100 $226K <0.01% 0 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 137,568 $186K <0.01% +76,917 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 132,000 $178K 0.03% +23,250 13F-HR Timeline OPAL CAPITAL LLC More: the full row for OPAL CAPITAL LLC 72,251 $173K 0.04% 13F-HR Timeline JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 124,525 $168K <0.01% -576,051 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 118,212 $160K <0.01% -226,943 13F-HR/A Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 110,448 $149K <0.01% -10,000 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 107,734 $145K <0.01% +86,412 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 100,290 $135K <0.01% new 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 96,263 $130K <0.01% -88,769 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 92,871 $125K <0.01% -1,248 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 90,910 $123K <0.01% -61,237 13F-HR Timeline PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 86,640 $117K <0.01% -11,258 13F-HR Timeline RBF Capital, LLC More: the full row for RBF Capital, LLC 80,000 $108K <0.01% 0 13F-HR/A Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 80,000 $108K 0.01% +30,000 13F-HR/A Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 77,300 $104K <0.01% 0 13F-HR Timeline 49 WEALTH MANAGEMENT, LLC More: the full row for 49 WEALTH MANAGEMENT, LLC 70,911 $95.7K 0.01% +42,719 13F-HR Timeline COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 61,412 $82.9K <0.01% +425 13F-HR Timeline BARR E S & CO More: the full row for BARR E S & CO 57,500 $77.6K <0.01% +17,500 13F-HR Timeline Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 51,061 $68.9K <0.01% 0 13F-HR Timeline Group ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 48,496 $65.5K <0.01% 0 13F-HR/A Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 45,995 $62.1K <0.01% -60,970 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 34,849 $47K <0.01% 0 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 34,574 $46.7K <0.01% -6,545 13F-HR Timeline Group Regency Capital Management Inc.\DE More: the full row for Regency Capital Management Inc.\DE 29,500 $39.8K 0.02% 0 13F-HR Timeline PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 24,550 $33.1K <0.01% +2,950 13F-HR Timeline Group Carson Advisory Inc. More: the full row for Carson Advisory Inc. 23,470 $31.7K 0.02% -8,600 13F-HR Timeline Acorn Wealth Advisors, LLC More: the full row for Acorn Wealth Advisors, LLC 20,000 $27K 0.01% 0 13F-HR Timeline Sivia Capital Partners, LLC More: the full row for Sivia Capital Partners, LLC 20,000 $27K 0.01% new 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 19,895 $26.9K <0.01% -700 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 17,471 $23.6K <0.01% -39,168 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 17,000 $22.9K 0.01% 0 13F-HR Timeline EVERGREEN CAPITAL MANAGEMENT LLC More: the full row for EVERGREEN CAPITAL MANAGEMENT LLC 16,915 $22.8K <0.01% 0 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 12,880 $17.4K <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 12,740 $17K <0.01% +12,318 13F-HR Timeline Group IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 12,229 $16.5K <0.01% -21,924 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 10,662 $14.4K <0.01% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 10,343 $14K <0.01% -190,766 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 8,564 $12K <0.01% -4,554 13F-HR Timeline Group HIGHLINE WEALTH PARTNERS LLC More: the full row for HIGHLINE WEALTH PARTNERS LLC 5,000 $6.75K <0.01% -7,000 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 1,644 $2.22K <0.01% -949 13F-HR Timeline Group Wilmington Savings Fund Society, FSB More: the full row for Wilmington Savings Fund Society, FSB 1,000 $1.35K <0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 387 $522 <0.01% 0 13F-HR Timeline HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 130 $175 <0.01% 0 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 44 $59 <0.01% 0 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 27 $36 <0.01% -1 13F-HR Timeline Inspire Investing, LLC in group Inspire Investing, LLC More: the full row for Inspire Investing, LLC 16 $22 <0.01% new 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1 $1 <0.01% 0 13F-HR/A Timeline Covestor Ltd More: the full row for Covestor Ltd 51 $0 0% -1 13F-HR Timeline Value filed as zero, left out of ratios.