5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 3,947,913 $9.24M 2.56% 0 13F-HR Timeline Squadron Capital Management LLC More: the full row for Squadron Capital Management LLC 3,631,000 $8.5M 3.4% new 13F-HR Timeline VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 2,997,503 $7.01M new Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 2,956,526 $6.92M 0.01% +1,485,112 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 2,848,252 $6.66M 0.01% -1,042 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 1,938,145 $4.54M 0.01% -945,600 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,732,083 $4.05M <0.01% -232,172 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 1,484,098 $3.47M <0.01% -176,280 13F-HR Timeline Group Opaleye Management Inc. More: the full row for Opaleye Management Inc. 1,412,656 $3.31M 0.44% +11,750 13F-HR Timeline Decheng Capital LLC More: the full row for Decheng Capital LLC 1,323,327 $3.1M 0.47% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,289,822 $3.02M <0.01% +616,693 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,269,837 $2.97M <0.01% +19,869 13F-HR Timeline Group Ishara Investments LP More: the full row for Ishara Investments LP 1,230,000 $2.88M 2.91% -90,000 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 1,132,294 $2.65M <0.01% -234,960 13F-HR Timeline Group PRIMECAP MANAGEMENT CO/CA/ More: the full row for PRIMECAP MANAGEMENT CO/CA/ 957,420 $2.24M <0.01% 0 13F-HR Timeline Pfizer Inc More: the full row for Pfizer Inc 953,834 $2M 0.84% 0 13F-HR Timeline Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 792,001 $1.85M <0.01% +4,946 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 637,116 $1.49M <0.01% +619,645 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 621,036 $1.45M <0.01% +31,931 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 620,407 $1.45M 0.09% -549,166 13F-HR Timeline Almitas Capital LLC More: the full row for Almitas Capital LLC 610,073 $1.43M 0.32% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 591,217 $1.38M <0.01% +22,774 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 571,257 $1.34M <0.01% +560,914 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 490,339 $1.15M <0.01% +17,164 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 471,438 $1.1M <0.01% +52,071 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 462,678 $1.08M <0.01% +344,466 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 392,643 $919K <0.01% +144,855 13F-HR Timeline Group Peapod Lane Capital LLC More: the full row for Peapod Lane Capital LLC 366,868 $835K 0.68% -81,993 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 350,207 $819K <0.01% -453,447 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 322,507 $755K 0.01% -254,200 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 285,000 $667K <0.01% +25,000 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 283,917 $664K <0.01% +40,609 13F-HR Timeline Group CDC Financial, Inc. More: the full row for CDC Financial, Inc. 283,762 $664K 0.55% new 13F-HR Timeline Anfield Capital Management, LLC in group Anfield Capital Management, L… More: the full row for Anfield Capital Management, LLC 274,516 $642K 0.18% +31,911 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 272,034 $634K <0.01% +175,771 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 269,100 $630K 0.55% -194,600 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 266,032 $623K <0.01% -264,550 13F-HR/A Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 249,690 $584K <0.01% -22,100 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 191,551 $448K <0.01% +24,451 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 155,704 $364K <0.01% -518,894 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 150,000 $351K 0.07% +18,000 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 144,636 $338K 0.02% +64,636 13F-HR Timeline Group PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 139,690 $327K <0.01% +53,050 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 125,767 $294K <0.01% -62,815 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 118,186 $277K <0.01% +25,315 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 117,127 $274K <0.01% new 13F-HR Timeline Group BARR E S & CO More: the full row for BARR E S & CO 110,000 $257K 0.01% +52,500 13F-HR Timeline Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 110,000 $257K 0.08% new 13F-HR/A Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 113,126 $242K <0.01% -71,881 13F-HR/A Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 98,554 $231K 0.01% new 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 94,854 $222K <0.01% -5,436 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 92,427 $216K 0.01% +1,517 13F-HR Timeline WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 78,740 $207K <0.01% -51,667 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 77,300 $181K <0.01% 0 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 77,255 $181K <0.01% new 13F-HR Timeline Group 49 WEALTH MANAGEMENT, LLC More: the full row for 49 WEALTH MANAGEMENT, LLC 66,401 $155K 0.01% -4,510 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 65,520 $153K <0.01% +30,946 13F-HR Timeline Group COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 61,412 $144K <0.01% 0 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 52,185 $122K <0.01% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 51,087 $120K <0.01% new 13F-HR Timeline Group RBF Capital, LLC More: the full row for RBF Capital, LLC 50,000 $117K 0.01% -30,000 13F-HR/A Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 48,572 $114K <0.01% +35,692 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 47,700 $112K <0.01% new 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 47,063 $110K <0.01% new 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 34,849 $81.5K <0.01% 0 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 33,332 $78K <0.01% -104,236 13F-HR Timeline Group Private Advisor Group, LLC More: the full row for Private Advisor Group, LLC 31,472 $73.6K <0.01% new 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 30,691 $71.8K <0.01% -77,043 13F-HR Timeline Group Headlands Technologies LLC More: the full row for Headlands Technologies LLC 29,899 $70K 0.01% new 13F-HR Timeline Regency Capital Management Inc.\DE More: the full row for Regency Capital Management Inc.\DE 29,500 $69K 0.03% 0 13F-HR Timeline State of Wyoming More: the full row for State of Wyoming 28,466 $66.6K 0.01% new 13F-HR Timeline Carson Advisory Inc. More: the full row for Carson Advisory Inc. 23,270 $54.5K 0.03% -200 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 22,895 $53.6K <0.01% +3,000 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 22,675 $53.1K <0.01% -23,320 13F-HR Timeline Group Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 22,447 $52.5K <0.01% -28,614 13F-HR Timeline Group PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 20,850 $48.8K <0.01% -3,700 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 20,600 $48.2K <0.01% new 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 20,400 $47.7K <0.01% new 13F-HR Timeline Sivia Capital Partners, LLC More: the full row for Sivia Capital Partners, LLC 20,000 $46.8K 0.01% 0 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 17,503 $41K 0.02% +503 13F-HR Timeline EVERGREEN CAPITAL MANAGEMENT LLC More: the full row for EVERGREEN CAPITAL MANAGEMENT LLC 16,915 $39.6K <0.01% 0 13F-HR Timeline Catalyst Funds Management Pty Ltd More: the full row for Catalyst Funds Management Pty Ltd 16,700 $39.1K 0.01% new 13F-HR Timeline CTC Alternative Strategies, Ltd. More: the full row for CTC Alternative Strategies, Ltd. 12,500 $29.2K 0.07% new 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 10,662 $24.9K <0.01% 0 13F-HR Timeline Cornerstone Wealth Management, LLC More: the full row for Cornerstone Wealth Management, LLC 10,186 $23.8K <0.01% new 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 5,377 $12.6K <0.01% -3,187 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 1,699 $3.98K <0.01% +55 13F-HR/A Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 1,460 $3.42K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,134 $2.65K <0.01% new 13F-HR Timeline Group Wilmington Savings Fund Society, FSB More: the full row for Wilmington Savings Fund Society, FSB 1,000 $2.34K <0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 387 $906 <0.01% 0 13F-HR Timeline Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 209 $489 <0.01% new 13F-HR Timeline HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 130 $304 <0.01% 0 13F-HR Timeline Silicon Valley Capital Partners More: the full row for Silicon Valley Capital Partners 84 $197 <0.01% new 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 44 $103 <0.01% 0 13F-HR/A Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 27 $63 <0.01% 0 13F-HR Timeline Inspire Investing, LLC in group Inspire Investing, LLC More: the full row for Inspire Investing, LLC 21 $50 <0.01% +5 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 1 $1 <0.01% new 13F-HR/A Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 98 $0 0% -12,642 13F-HR Timeline Group Value filed as zero, left out of ratios.