Matrix Capital Management Company, LP More: the full row for Matrix Capital Management Company, LP 13,959,973 $16.2M 7.27% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 3,476,808 $4.03M <0.01% +407,294 13F-HR Timeline Group VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 2,884,632 $3.35M -392,946 Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 2,799,020 $3.24M 0.01% +124,985 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 2,368,967 $2.75M +977,033 Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 1,924,300 $2.23M 0.45% -60,700 13F-HR/A Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,741,747 $2.02M <0.01% -2,487,750 13F-HR Timeline Group Almitas Capital LLC More: the full row for Almitas Capital LLC 1,599,266 $1.86M 0.47% -111,655 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 1,550,000 $1.8M 0.09% +50,000 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 1,529,553 $1.77M <0.01% +703,512 13F-HR Timeline TYBOURNE CAPITAL MANAGEMENT (HK) LTD More: the full row for TYBOURNE CAPITAL MANAGEMENT (HK) LTD 1,478,152 $1.71M 4.96% +516,666 13F-HR Timeline Decheng Capital LLC More: the full row for Decheng Capital LLC 1,323,327 $1.54M 0.39% -696,435 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 1,197,624 $1.39M <0.01% +79,847 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 1,133,375 $1.31M 0.09% +591,400 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,097,651 $1.27M <0.01% +3,693 13F-HR Timeline Group PRIMECAP MANAGEMENT CO/CA/ More: the full row for PRIMECAP MANAGEMENT CO/CA/ 1,027,620 $1.19M <0.01% -237,000 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 970,862 $1.13M <0.01% new 13F-HR Timeline Group Pfizer Inc More: the full row for Pfizer Inc 953,834 $1.11M 0.19% 0 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 861,767 $1000K <0.01% +405,374 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 857,582 $995K <0.01% +508,617 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 713,315 $827K <0.01% -416,777 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 664,061 $770K <0.01% +515,257 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 618,167 $717K <0.01% -737,502 13F-HR Timeline Group Peapod Lane Capital LLC More: the full row for Peapod Lane Capital LLC 559,213 $649K 0.65% +795 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 550,447 $639K <0.01% -196,029 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 530,582 $615K <0.01% 0 13F-HR Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 490,000 $568K 0.22% 0 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 462,340 $536K <0.01% +391,282 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 434,958 $505K <0.01% -184,372 13F-HR Timeline Group Man Group plc in group Man Group plc More: the full row for Man Group plc 406,344 $471K <0.01% +305,328 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 335,966 $390K <0.01% -111,434 13F-HR Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 320,318 $372K <0.01% +242,106 13F-HR Timeline Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 314,845 $365K <0.01% -46,391 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 299,097 $347K <0.01% -187,402 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 271,790 $315K <0.01% -1,047,995 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 264,829 $307K 0.01% +140,433 13F-HR Timeline Group WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 174,006 $219K <0.01% -60,065 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 184,677 $214K <0.01% +2,487 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 173,484 $201K <0.01% +102,661 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 167,100 $194K <0.01% -35,320 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 155,714 $181K <0.01% +6,230 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 150,990 $175K <0.01% -1,265 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 145,769 $169K -119,754 Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 129,867 $151K <0.01% -211,521 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 129,468 $150K <0.01% -12,468 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 123,444 $143K <0.01% -338,859 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 113,863 $132K <0.01% new 13F-HR Timeline Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 109,010 $126K 0.12% +49,010 13F-HR Timeline Quarry LP More: the full row for Quarry LP 105,000 $122K 0.03% -15,000 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 91,195 $106K <0.01% +78,578 13F-HR Timeline Group IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 86,300 $100K <0.01% -7,620 13F-HR Timeline RBF Capital, LLC More: the full row for RBF Capital, LLC 80,000 $92.8K <0.01% new 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 77,300 $89.7K <0.01% -75,000 13F-HR Timeline State of Wyoming More: the full row for State of Wyoming 73,797 $85.6K 0.01% +28,621 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 72,261 $83.8K <0.01% new 13F-HR Timeline Anfield Capital Management, LLC in group Anfield Capital Management, L… More: the full row for Anfield Capital Management, LLC 71,377 $82.8K 0.03% 0 13F-HR Timeline Group Thrivent Financial for Lutherans in group Thrivent Financial for Luther… More: the full row for Thrivent Financial for Lutherans 70,641 $82K <0.01% 0 13F-HR/A Timeline Group COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 60,987 $71K <0.01% +300 13F-HR Timeline Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 59,453 $69K 0.01% +41,348 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 52,456 $60.6K <0.01% new 13F-HR Timeline Group Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 51,061 $59.2K <0.01% 0 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 50,000 $58K 0.01% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 46,461 $53.9K <0.01% -2,641 13F-HR/A Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 41,454 $49K <0.01% -28,231 13F-HR Timeline BARR E S & CO More: the full row for BARR E S & CO 40,000 $46.4K <0.01% 0 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 39,736 $46.1K <0.01% -712,781 13F-HR Timeline Group PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O… More: the full row for PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 36,700 $42.6K <0.01% +28,576 13F-HR Timeline Corient Private Wealth LP in group Corient Private Wealth LP More: the full row for Corient Private Wealth LP 35,760 $41.5K <0.01% new 13F-HR/A Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 35,475 $41.2K <0.01% -89,326 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 34,849 $40.4K <0.01% 0 13F-HR Timeline Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 32,740 $38K <0.01% new 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 32,113 $37.3K <0.01% new 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 30,340 $35.2K <0.01% -206,183 13F-HR Timeline Group Carson Advisory Inc. More: the full row for Carson Advisory Inc. 29,570 $34.3K 0.02% 0 13F-HR Timeline Regency Capital Management Inc.\DE More: the full row for Regency Capital Management Inc.\DE 29,500 $34.2K 0.02% 0 13F-HR Timeline HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 27,877 $33.3K <0.01% new 13F-HR Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 28,646 $33K <0.01% -11,053 13F-HR Timeline Group Catalyst Funds Management Pty Ltd More: the full row for Catalyst Funds Management Pty Ltd 26,800 $31.1K 0.01% new 13F-HR Timeline Harvest Investment Services, LLC More: the full row for Harvest Investment Services, LLC 25,472 $29.5K 0.01% +705 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 23,343 $27K <0.01% -761 13F-HR Timeline 49 WEALTH MANAGEMENT, LLC More: the full row for 49 WEALTH MANAGEMENT, LLC 21,546 $25K <0.01% -23,967 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 20,595 $23.9K <0.01% -1,670 13F-HR Timeline Group Acorn Wealth Advisors, LLC More: the full row for Acorn Wealth Advisors, LLC 20,000 $23.2K 0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 19,447 $22.6K <0.01% -21,199 13F-HR Timeline Group PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 18,900 $21.9K <0.01% -13,070 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 17,114 $19.9K <0.01% +11,873 13F-HR Timeline Group Birchview Capital, LP More: the full row for Birchview Capital, LP 17,000 $19.7K 0.02% 0 13F-HR Timeline EVERGREEN CAPITAL MANAGEMENT LLC More: the full row for EVERGREEN CAPITAL MANAGEMENT LLC 16,915 $19.6K <0.01% 0 13F-HR Timeline DRW Securities, LLC More: the full row for DRW Securities, LLC 16,830 $19.5K <0.01% new 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 16,638 $19.3K <0.01% new 13F-HR/A Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 13,021 $15.1K <0.01% new 13F-HR Timeline CAPTRUST FINANCIAL ADVISORS More: the full row for CAPTRUST FINANCIAL ADVISORS 11,842 $13.7K <0.01% -4,103 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 11,692 $13.6K <0.01% new 13F-HR/A Timeline Group R Squared Ltd More: the full row for R Squared Ltd 10,808 $12.5K 0.01% new 13F-HR Timeline Dynamic Technology Lab Private Ltd More: the full row for Dynamic Technology Lab Private Ltd 10,546 $12K <0.01% -9,210 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 9,699 $11K <0.01% +8,154 13F-HR Timeline HIGHLINE WEALTH PARTNERS LLC More: the full row for HIGHLINE WEALTH PARTNERS LLC 7,000 $8.12K <0.01% new 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 2,713 $3.15K <0.01% +2,704 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 2,350 $2.73K <0.01% -127 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 2,278 $2.64K <0.01% -33,089 13F-HR Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 2,271 $2.63K <0.01% -22,602 13F-HR Timeline Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 2,061 $2.39K <0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 2,441 $2K <0.01% -3,864 13F-HR/A Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,164 $1.35K <0.01% -8,135 13F-HR Timeline Group Wilmington Savings Fund Society, FSB More: the full row for Wilmington Savings Fund Society, FSB 1,000 $1.16K <0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 387 $449 <0.01% +60 13F-HR Timeline HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 130 $151 <0.01% 0 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 58 $67 <0.01% 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 42 $49 <0.01% new 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 35 $40 <0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 28 $32 <0.01% -588 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 27 $31 <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 10 $12 <0.01% 0 13F-HR/A Timeline Group True Wealth Design, LLC More: the full row for True Wealth Design, LLC 9 $11 <0.01% -71 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 1 $1 <0.01% -59,615 13F-HR/A Timeline Group Covestor Ltd More: the full row for Covestor Ltd 52 $0 0% +29 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.