RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 6,576,306 $50.8M 0.51% +1,150,000 13F-HR Timeline Deep Track Capital, LP More: the full row for Deep Track Capital, LP 5,740,850 $44.3M 1.01% new 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 4,752,842 $36.7M <0.01% +1,035,660 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 4,152,706 $32.1M <0.01% +673,695 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 3,925,126 $30.3M 0.14% +2,866,350 13F-HR Timeline Group ARMISTICE CAPITAL, LLC More: the full row for ARMISTICE CAPITAL, LLC 3,536,000 $27.3M 0.67% +1,440,000 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 3,219,295 $24.9M <0.01% +990,655 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 3,195,726 $24.7M 0.05% -951,036 13F-HR Timeline Group Foresite Capital Management VI LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management VI LLC 3,135,120 $24.2M 7.32% +520,000 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 2,732,079 $21.1M 16.68% +62,047 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 2,353,465 $18.2M 0.01% +2,168,625 13F-HR Timeline Group FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 2,000,000 $15.4M 0.08% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. SymBiosis Capital Partners, LLC More: the full row for SymBiosis Capital Partners, LLC 2,000,000 $15.4M 14.1% 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,871,562 $14.4M <0.01% +292,076 13F-HR/A Timeline Group Rosalind Advisors, Inc. More: the full row for Rosalind Advisors, Inc. 1,788,475 $13.8M 5.03% -141,088 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 1,700,000 $13.1M 0.87% -2,350,000 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,495,424 $11.5M <0.01% +1,248,011 13F-HR/A Timeline Group ACORN CAPITAL ADVISORS, LLC More: the full row for ACORN CAPITAL ADVISORS, LLC 1,469,153 $11.3M 3.84% +689,655 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,392,822 $10.8M <0.01% +148,241 13F-HR Timeline Group NEXTBio Capital Management LP More: the full row for NEXTBio Capital Management LP 1,307,330 $10.1M 5.92% 13F-HR Timeline Vivo Capital, LLC More: the full row for Vivo Capital, LLC 1,106,524 $8.54M 0.55% -1,538,461 13F-HR Timeline TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 1,069,810 $8.26M 0.41% +280,000 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 995,026 $7.68M 0.01% -2,884,338 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 947,303 $7.31M 0.28% +533,431 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 926,011 $7.15M <0.01% new 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 875,884 $6.76M +364,540 Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 557,016 $4.3M 0.04% -33,168 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 555,129 $4.29M <0.01% -604,469 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 502,094 $3.88M +217,692 Timeline Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 462,140 $3.57M 0.21% -830,763 13F-HR Timeline Group TORONTO DOMINION BANK in group TORONTO DOMINION BANK More: the full row for TORONTO DOMINION BANK 460,413 $3.55M 0.01% 0 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 401,743 $3.1M 1.53% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 398,546 $3.08M <0.01% +78,290 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 393,097 $3.03M <0.01% +15,806 13F-HR Timeline Group Pinnacle Financial Partners, Inc. in group Pinnacle Financial Partners, … More: the full row for Pinnacle Financial Partners, Inc. 390,524 $3.01M 0.02% 13F-HR/A Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 390,325 $3.01M <0.01% +378,958 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 364,436 $2.81M <0.01% +362,421 13F-HR Timeline Group Y-Intercept (Hong Kong) Ltd More: the full row for Y-Intercept (Hong Kong) Ltd 364,283 $2.81M 0.06% +349,985 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 343,678 $2.65M 0.55% +265,371 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 338,853 $2.62M <0.01% -23,744 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 320,806 $2.48M <0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 316,862 $2.45M <0.01% +167,080 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 275,913 $2.13M <0.01% +131,558 13F-HR Timeline Group Ishara Investments LP More: the full row for Ishara Investments LP 270,000 $2.08M 2.43% 13F-HR Timeline Polymer Capital Management (HK) LTD More: the full row for Polymer Capital Management (HK) LTD 266,812 $2.06M 0.32% -42,968 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 254,900 $1.97M <0.01% new 13F-HR Timeline PANAGORA ASSET MANAGEMENT INC More: the full row for PANAGORA ASSET MANAGEMENT INC 244,067 $1.88M 0.01% +17,824 13F-HR Timeline Torray Investment Partners LLC More: the full row for Torray Investment Partners LLC 216,387 $1.67M 0.24% new 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 213,865 $1.65M 0.21% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 201,845 $1.56M <0.01% +33,470 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 199,344 $1.54M <0.01% +78 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 188,653 $1.46M <0.01% +7,457 13F-HR Timeline Group Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 174,384 $1.35M 0.05% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 161,165 $1.24M <0.01% +17,772 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 154,768 $1.19M 0.01% -36,770 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 150,000 $1.16M 0.68% new 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 145,512 $1.12M <0.01% -9,497 13F-HR Timeline Group ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 143,446 $1.11M 0.75% 0 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 143,318 $1.11M -117,779 Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 131,121 $1.01M 0.03% +82,210 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 129,333 $998K <0.01% +37,481 13F-HR Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 125,000 $965K 0.06% new 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 122,689 $947K <0.01% +8,370 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 104,947 $810K 0.01% +69,047 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 104,093 $804K <0.01% -46,376 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 96,046 $741K <0.01% -316,495 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 88,851 $686K <0.01% new 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 74,221 $573K 0.04% new 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 70,405 $544K 0.02% new 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 68,541 $529K 0.01% new 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 67,270 $519K <0.01% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 62,597 $483K <0.01% +28,134 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 60,504 $467K <0.01% +2,510 13F-HR Timeline FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 57,137 $441K 0.07% new 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 49,002 $378K <0.01% -8,309 13F-HR Timeline Group PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 47,665 $368K 0.01% +27,887 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 45,570 $352K <0.01% +7,213 13F-HR Timeline Group Cetera Investment Advisers More: the full row for Cetera Investment Advisers 43,378 $335K <0.01% new 13F-HR Timeline ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 42,469 $328K <0.01% new 13F-HR Timeline Group CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 42,251 $326K 0.01% new 13F-HR Timeline Group STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 39,772 $307K <0.01% -2,326 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 39,107 $302K <0.01% new 13F-HR Timeline VARCOV Co. More: the full row for VARCOV Co. 33,775 $261K 0.1% 13F-HR Timeline MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 32,351 $248K <0.01% +6,795 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 30,930 $239K 0.01% new 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 28,929 $223K <0.01% +2,784 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 27,682 $214K 0.06% new 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 27,236 $211K <0.01% -550,796 13F-HR Timeline Quarry LP More: the full row for Quarry LP 27,000 $208K 0.03% new 13F-HR Timeline Aries Wealth Management More: the full row for Aries Wealth Management 26,249 $203K 0.04% 0 13F-HR Timeline NewEdge Wealth, LLC More: the full row for NewEdge Wealth, LLC 25,885 $200K <0.01% 0 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 25,172 $194K <0.01% new 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 23,438 $181K 0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 22,361 $173K <0.01% +1,064 13F-HR Timeline Group Entropy Technologies, LP More: the full row for Entropy Technologies, LP 20,793 $161K 0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 20,476 $158K <0.01% +4,366 13F-HR Timeline Group INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 19,224 $148K <0.01% -576 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 17,887 $138K <0.01% -25,043 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 16,410 $127K <0.01% -35,967 13F-HR Timeline Group Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 15,140 $117K 0.08% 13F-HR/A Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 15,021 $116K <0.01% new 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 12,611 $97.4K <0.01% 0 13F-HR Timeline CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 12,500 $96.5K <0.01% new 13F-HR Timeline DRW Securities, LLC More: the full row for DRW Securities, LLC 11,989 $92.6K 0.01% new 13F-HR Timeline ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 11,000 $84.9K <0.01% new 13F-HR/A Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 7,491 $57.8K <0.01% -13,213 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 5,287 $40.8K <0.01% +670 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 5,200 $39.9K <0.01% 0 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 4,629 $35.7K <0.01% +51 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,889 $30K <0.01% 0 13F-HR Timeline Group LORING WOLCOTT & COOLIDGE FIDUCIARY ADV… More: the full row for LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA 4,500 $29.2K <0.01% -1,449 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 3,507 $27.1K <0.01% -5,043 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 3,406 $26.3K <0.01% -1,461 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 3,289 $25.4K <0.01% +372 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 2,173 $16.8K <0.01% -80 13F-HR/A Timeline Group Cygnus Capital Advisors, LLC More: the full row for Cygnus Capital Advisors, LLC 1,894 $15K 0.01% 13F-HR Timeline FLAGSHIP HARBOR ADVISORS, LLC More: the full row for FLAGSHIP HARBOR ADVISORS, LLC 1,800 $13.9K <0.01% new 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 1,763 $13.6K <0.01% +1,762 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 1,679 $13K <0.01% +340 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 1,540 $11.9K <0.01% +103 13F-HR Timeline NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 850 $6.56K <0.01% new 13F-HR/A Timeline Group CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 570 $4K <0.01% +13 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 426 $3.29K <0.01% 0 13F-HR Timeline Group Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 416 $3.21K <0.01% 0 13F-HR Timeline INTERNATIONAL ASSETS INVESTMENT MANAGEM… More: the full row for INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC 400 $3.09K <0.01% new 13F-HR Timeline Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 368 $2.84K <0.01% 0 13F-HR Timeline Group Arax Advisory Partners More: the full row for Arax Advisory Partners 298 $2.3K <0.01% -144 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 154 $1.19K <0.01% -35 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 143 $1.1K <0.01% 0 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 107 $826 <0.01% +45 13F-HR Timeline Torren Management, LLC More: the full row for Torren Management, LLC 107 $826 <0.01% 13F-HR Timeline PENSION & WEALTH MANAGEMENT ADVISORS, I… More: the full row for PENSION & WEALTH MANAGEMENT ADVISORS, INC. 73 $564 <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 55 $425 <0.01% -71 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 46 $355 <0.01% new 13F-HR Timeline Group IFP Advisors, Inc More: the full row for IFP Advisors, Inc 41 $317 <0.01% 0 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 27 $208 <0.01% new 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 27 $208 <0.01% 0 13F-HR Timeline HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 14 $108 <0.01% 0 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 11 $85 <0.01% -300 13F-HR Timeline Group Global Retirement Partners, LLC More: the full row for Global Retirement Partners, LLC 8 $62 <0.01% 0 13F-HR Timeline Inspire Investing, LLC in group Inspire Investing, LLC More: the full row for Inspire Investing, LLC 3 $22 <0.01% new 13F-HR Timeline Group