RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 5,404,998 $70.7M 0.72% +3,422,697 13F-HR Timeline Group FCPM III SERVICES B.V. in group FCPM III SERVICES B.V. More: the full row for FCPM III SERVICES B.V. 3,617,354 $47.3M 6.2% +3,237,714 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 2,543,939 $33.3M 0.89% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 2,526,170 $33M <0.01% +2,289,662 13F-HR Timeline Group Venrock Adviser, LLC More: the full row for Venrock Adviser, LLC 1,943,766 $25.4M 1.26% +1,443,800 13F-HR Timeline Paradigm Biocapital Advisors LP in group Paradigm Biocapital Advisors … More: the full row for Paradigm Biocapital Advisors LP 1,750,000 $22.9M 0.61% new 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 1,370,107 $17.9M 5.81% new 13F-HR Timeline NEXTBio Capital Management LP More: the full row for NEXTBio Capital Management LP 999,967 $13.1M 7.67% 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 770,250 $10.1M <0.01% +665,060 13F-HR Timeline Group Caligan Partners LP More: the full row for Caligan Partners LP 925,067 $9.96M 0.91% new 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 465,636 $6.09M <0.01% +431,106 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 433,894 $5.68M <0.01% +428,208 13F-HR Timeline Group SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 410,417 $5.37M 1.12% new 13F-HR Timeline Group Laurion Capital Management LP More: the full row for Laurion Capital Management LP 317,243 $4.15M 0.28% new 13F-HR/A Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 292,118 $3.82M <0.01% +216,209 13F-HR Timeline Group FINDELL CAPITAL MANAGEMENT LLC More: the full row for FINDELL CAPITAL MANAGEMENT LLC 231,000 $3.02M 1% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 224,534 $2.94M <0.01% +199,770 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 185,808 $2.43M <0.01% +158,416 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 167,673 $2.19M 0.01% new 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 163,061 $2.13M <0.01% new 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 145,640 $1.9M <0.01% +129,854 13F-HR/A Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 100,000 $1.31M 0.09% new 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 91,810 $1.2M <0.01% +75,057 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 91,053 $1.19M <0.01% +81,999 13F-HR Timeline Group JOHNSON & JOHNSON in group JOHNSON & JOHNSON More: the full row for JOHNSON & JOHNSON 53,732 $703K 0.13% new 13F-HR/A Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 38,946 $509K <0.01% new 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 28,463 $372K <0.01% +24,007 13F-HR/A Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 28,204 $369K <0.01% new 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 26,791 $350K <0.01% new 13F-HR Timeline Group Sarissa Capital Management LP More: the full row for Sarissa Capital Management LP 25,399 $332K 0.15% 0 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 25,026 $327K new Timeline Bollard Group LLC More: the full row for Bollard Group LLC 23,987 $314K 0.01% +21,210 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 20,700 $271K <0.01% new 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 18,459 $241K <0.01% +13,730 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 17,542 $229K 0.01% new 13F-HR Timeline Group INDEPENDENT FINANCIAL GROUP, LLC More: the full row for INDEPENDENT FINANCIAL GROUP, LLC 17,000 $222K <0.01% new 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 10,798 $141K 0.07% new 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 10,745 $141K 0.02% new 13F-HR Timeline Chung Wu Investment Group, LLC More: the full row for Chung Wu Investment Group, LLC 8,300 $109K 0.09% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 6,340 $82.9K <0.01% new 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 5,110 $66.8K <0.01% new 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 2,746 $35.9K <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 2,312 $30.2K <0.01% +2,234 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,729 $22.6K <0.01% +1,725 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 1,399 $18.3K <0.01% new 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 819 $10.7K <0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 396 $5.18K <0.01% -4,358 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 330 $4.32K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 291 $3.81K <0.01% -5,784 13F-HR Timeline Group MAI Capital Management More: the full row for MAI Capital Management 40 $524 <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 3 $40 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 3 $39 <0.01% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 1 $13 <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 7 $0 0% +5 13F-HR Timeline Group Value filed as zero, left out of ratios.