JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 17,122,563 $59.8M 0.03% +4,776,697 13F-HR Timeline Group Rubric Capital Management LP More: the full row for Rubric Capital Management LP 15,307,347 $53.6M 0.97% 0 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 9,599,170 $33.6M 1.28% +65,000 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 8,715,013 $30.5M 0.05% -1,000,000 13F-HR Timeline Group MANGROVE PARTNERS IM, LLC More: the full row for MANGROVE PARTNERS IM, LLC 8,636,485 $30.2M 3.6% -93,235 13F-HR Timeline DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 6,710,429 $23.5M 0.45% 0 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 5,097,779 $17.8M 0.74% 0 13F-HR Timeline ALKEON CAPITAL MANAGEMENT LLC More: the full row for ALKEON CAPITAL MANAGEMENT LLC 4,698,100 $16.4M 0.1% 0 13F-HR Timeline 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 4,550,000 $15.9M 1.57% -299,800 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 3,965,432 $13.9M 0.01% -1,429,259 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 3,613,040 $12.6M new Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 3,554,234 $12.4M <0.01% +1,206,409 13F-HR/A Timeline Group Clearline Capital LP More: the full row for Clearline Capital LP 3,217,894 $11.3M 1.49% -26,440 13F-HR Timeline Tejara Capital Ltd More: the full row for Tejara Capital Ltd 2,317,085 $8.11M 5.32% -512,905 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 2,119,852 $7.42M <0.01% +111,471 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 1,189,471 $4.16M 0.01% -115,900 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 1,150,000 $4.03M 1.9% new 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 1,085,512 $3.8M 0.11% +269,790 13F-HR Timeline Group Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 1,000,000 $3.5M 0.31% 0 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 890,548 $3.12M 1.29% 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 866,317 $3.03M <0.01% -162,195 13F-HR Timeline Group NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 824,603 $2.89M 0.07% -10,591 13F-HR Timeline Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 786,953 $2.75M 0.21% -60,000 13F-HR Timeline ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 779,308 $2.73M 2.74% -481,392 13F-HR Timeline Eversept Partners, LP More: the full row for Eversept Partners, LP 777,890 $2.72M 0.28% 0 13F-HR Timeline Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 672,809 $2.35M 0.54% -175,000 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 618,784 $2.17M 0.01% new 13F-HR Timeline Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 493,900 $1.73M 0.01% new 13F-HR Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 421,359 $1.47M 0.59% 0 13F-HR Timeline Atle Fund Management AB More: the full row for Atle Fund Management AB 390,000 $1.37M 0.65% +190,000 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 391,590 $1.37M <0.01% +5,160 13F-HR Timeline Group Monaco Asset Management SAM More: the full row for Monaco Asset Management SAM 381,468 $1.34M 0.59% -3,067 13F-HR Timeline Knott David M Jr More: the full row for Knott David M Jr 331,000 $1.16M 0.42% 0 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 315,000 $1.1M 0.01% +140,000 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 313,950 $1.1M <0.01% +183,692 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 273,019 $956K <0.01% +258,698 13F-HR Timeline Group Knoll Capital Management, LLC More: the full row for Knoll Capital Management, LLC 260,470 $912K 0.59% 0 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 237,777 $832K <0.01% +127,773 13F-HR Timeline CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 225,000 $788K 0.03% new 13F-HR Timeline Group Polar Asset Management Partners Inc. More: the full row for Polar Asset Management Partners Inc. 169,977 $595K 0.01% -28,323 13F-HR/A Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 129,629 $454K <0.01% new 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 120,278 $421K <0.01% -94,357 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 94,456 $331K <0.01% +61,642 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 92,156 $323K <0.01% 0 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 79,387 $278K 0.01% -175,503 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 68,735 $241K <0.01% -65,578 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 55,099 $192K 0.01% +21,244 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 47,085 $165K <0.01% -476 13F-HR Timeline Group Clear Harbor Asset Management, LLC More: the full row for Clear Harbor Asset Management, LLC 42,000 $147K 0.01% -1,500 13F-HR Timeline PFG Investments, LLC More: the full row for PFG Investments, LLC 39,433 $138K 0.01% +22,433 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 37,974 $133K 0.01% new 13F-HR Timeline Group Forefront Analytics, LLC More: the full row for Forefront Analytics, LLC 34,753 $122K 0.06% +953 13F-HR Timeline Centiva Capital, LP More: the full row for Centiva Capital, LP 25,000 $87.5K <0.01% 0 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 23,667 $82.8K <0.01% +2,842 13F-HR Timeline Group Ascentis Independent Advisors in group Ascentis Wealth Management, L… More: the full row for Ascentis Independent Advisors 22,600 $79.1K 0.02% -6,500 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 22,189 $77.7K <0.01% +9,490 13F-HR Timeline Avanza Fonder AB More: the full row for Avanza Fonder AB 19,600 $68.6K <0.01% 13F-HR Timeline VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 19,060 $66.7K 0.03% new 13F-HR Timeline Group OneDigital Investment Advisors LLC More: the full row for OneDigital Investment Advisors LLC 18,300 $64K <0.01% 0 13F-HR Timeline Sheets Smith Investment Management More: the full row for Sheets Smith Investment Management 16,890 $59.1K 0.05% 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 16,435 $57.5K <0.01% +1,666 13F-HR Timeline Group HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 13,577 $47.5K <0.01% -15,000 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 11,116 $38.9K <0.01% new 13F-HR Timeline Group Significant Wealth Partners LLC More: the full row for Significant Wealth Partners LLC 10,805 $37.8K 0.02% new 13F-HR Timeline NFSG Corp More: the full row for NFSG Corp 10,700 $37.5K 0.01% new 13F-HR Timeline LEVEL FOUR ADVISORY SERVICES, LLC in group LEVEL FOUR ADVISORY SERVICES,… More: the full row for LEVEL FOUR ADVISORY SERVICES, LLC 10,000 $35K <0.01% 0 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 10,000 $35K 0.01% 0 13F-HR Timeline Group Marex Group Ltd in group Marex Group Ltd More: the full row for Marex Group Ltd 10,000 $35K <0.01% new 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 9,001 $31.5K <0.01% -1,692 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 7,237 $25.3K <0.01% -36 13F-HR/A Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 4,000 $14K <0.01% 0 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 2,320 $8.12K <0.01% -215,237 13F-HR Timeline Group Lindbrook Capital, LLC More: the full row for Lindbrook Capital, LLC 1,665 $5.83K <0.01% 0 13F-HR Timeline GPS Wealth Strategies Group, LLC More: the full row for GPS Wealth Strategies Group, LLC 1,500 $5.25K <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 1,500 $4.38K <0.01% 0 13F-HR Timeline BFSG, LLC More: the full row for BFSG, LLC 1,000 $3.5K <0.01% 0 13F-HR Timeline SIT INVESTMENT ASSOCIATES INC in group SIT INVESTMENT ASSOCIATES INC More: the full row for SIT INVESTMENT ASSOCIATES INC 970 $3K <0.01% 0 13F-HR Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 679 $2.38K <0.01% 0 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 365 $1.28K <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 320 $1.12K <0.01% 13F-HR/A Timeline MAI Capital Management More: the full row for MAI Capital Management 309 $1.08K <0.01% new 13F-HR Timeline New England Capital Financial Advisors … More: the full row for New England Capital Financial Advisors LLC 300 $1.05K <0.01% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 229 $802 <0.01% -1 13F-HR Timeline Group GeoWealth Management, LLC More: the full row for GeoWealth Management, LLC 158 $554 <0.01% +144 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 129 $452 <0.01% new 13F-HR/A Timeline Group Transce3nd, LLC More: the full row for Transce3nd, LLC 127 $445 <0.01% 13F-HR Timeline Cranbrook Wealth Management, LLC More: the full row for Cranbrook Wealth Management, LLC 60 $210 <0.01% 0 13F-HR Timeline PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 32 $112 <0.01% new 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 13 $46 <0.01% 0 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 3 $10 <0.01% -1,400 13F-HR Timeline Group CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.