JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 17,688,592 $48.1M 0.02% -5,046,529 13F-HR Timeline Group Rubric Capital Management LP More: the full row for Rubric Capital Management LP 15,307,347 $41.5M 0.67% 0 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 9,440,112 $25.6M 1.02% +1,620,249 13F-HR Timeline MANGROVE PARTNERS IM, LLC More: the full row for MANGROVE PARTNERS IM, LLC 8,636,485 $23.4M 2.51% 0 13F-HR Timeline DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 6,710,429 $18.2M 0.33% 0 13F-HR Timeline Group ALKEON CAPITAL MANAGEMENT LLC More: the full row for ALKEON CAPITAL MANAGEMENT LLC 4,698,100 $12.7M 0.06% 0 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 4,465,292 $12.1M 0.75% -2,218,955 13F-HR Timeline 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 4,350,000 $11.8M 1.2% -285,000 13F-HR Timeline Group Clearline Capital LP More: the full row for Clearline Capital LP 3,618,163 $9.81M 0.86% +400,269 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 3,090,068 $8.37M <0.01% +964,148 13F-HR Timeline Group Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 3,028,872 $8.21M 0.01% +840,518 13F-HR Timeline Group Tejara Capital Ltd More: the full row for Tejara Capital Ltd 2,430,437 $6.59M 3.05% -90,887 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 1,480,471 $4.01M 0.01% +130,000 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 1,478,500 $4.01M <0.01% +719,400 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 909,640 $2.47M 0.02% -681,416 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 803,758 $2.18M +529,252 Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 785,377 $2.13M <0.01% -1,394,265 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 767,744 $2.08M <0.01% 0 13F-HR Timeline Group Atle Fund Management AB More: the full row for Atle Fund Management AB 764,901 $2.07M 0.89% +374,901 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 760,659 $2.06M <0.01% +417,006 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 599,711 $1.63M 0.11% -87,242 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 595,673 $1.61M <0.01% +201,242 13F-HR Timeline Group Artia Global Partners LP More: the full row for Artia Global Partners LP 475,361 $1.29M 0.33% +54,002 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 455,365 $1.23M <0.01% +181,004 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 450,000 $1.22M 0.01% 0 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 438,661 $1.19M <0.01% -9 13F-HR Timeline Group Monaco Asset Management SAM More: the full row for Monaco Asset Management SAM 395,000 $1.07M 0.41% -21,468 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 373,505 $1.01M -2,127,616 Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 361,542 $980K <0.01% +187,164 13F-HR Timeline Group CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 342,957 $929K 0.02% -12,043 13F-HR Timeline Group Knott David M Jr More: the full row for Knott David M Jr 319,337 $865K 0.39% 0 13F-HR Timeline Paloma Partners Management Co in group Paloma Partners Management Co More: the full row for Paloma Partners Management Co 296,659 $804K 0.18% new 13F-HR Timeline Group Knoll Capital Management, LLC More: the full row for Knoll Capital Management, LLC 260,470 $706K 0.5% 0 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 247,441 $671K <0.01% +102,638 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 201,141 $545K 0.01% +197,024 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 197,599 $535K 0.05% +92,816 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 139,559 $378K 0.01% +105,278 13F-HR Timeline Dauntless Investment Group, LLC More: the full row for Dauntless Investment Group, LLC 134,122 $363K 1.71% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. NOMURA HOLDINGS INC in group NOMURA ASSET MANAGEMENT CO LTD More: the full row for NOMURA HOLDINGS INC 125,000 $339K <0.01% new 13F-HR/A Timeline Group NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 102,583 $278K <0.01% -552,083 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 102,583 $278K 0.07% -552,083 13F-HR Timeline Leonteq Securities AG More: the full row for Leonteq Securities AG 100,000 $271K 0.02% new 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 92,534 $251K <0.01% +378 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 69,341 $188K 0.01% new 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 59,200 $160K <0.01% +23,384 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 52,384 $142K <0.01% -27,003 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 44,942 $122K <0.01% -717 13F-HR Timeline Group Clear Harbor Asset Management, LLC More: the full row for Clear Harbor Asset Management, LLC 42,000 $114K 0.01% 0 13F-HR Timeline Avanza Fonder AB More: the full row for Avanza Fonder AB 38,235 $104K <0.01% +10,114 13F-HR Timeline PFG Investments, LLC More: the full row for PFG Investments, LLC 37,433 $101K 0.01% 0 13F-HR Timeline Three Magnolias Financial Advisors, LLC More: the full row for Three Magnolias Financial Advisors, LLC 37,000 $100K 0.07% new 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 33,825 $91.7K 0.03% -10,182 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 26,930 $73K <0.01% new 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 25,399 $69.1K <0.01% +2,712 13F-HR Timeline Group Centiva Capital, LP More: the full row for Centiva Capital, LP 25,000 $67.8K <0.01% 0 13F-HR Timeline Significant Wealth Partners LLC More: the full row for Significant Wealth Partners LLC 22,261 $60.3K 0.03% +8,490 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 21,176 $57.4K <0.01% -28,242 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 21,099 $57.2K <0.01% new 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 20,668 $56K <0.01% +2,737 13F-HR/A Timeline Group Ascentis Independent Advisors in group Ascentis Wealth Management, L… More: the full row for Ascentis Independent Advisors 19,900 $53.9K 0.01% 0 13F-HR Timeline Group Forefront Analytics, LLC More: the full row for Forefront Analytics, LLC 19,138 $51.9K 0.06% -28,492 13F-HR/A Timeline OneDigital Investment Advisors LLC More: the full row for OneDigital Investment Advisors LLC 18,300 $49.6K <0.01% 0 13F-HR Timeline Sheets Smith Investment Management More: the full row for Sheets Smith Investment Management 16,890 $45.8K 0.04% 0 13F-HR Timeline NFSG Corp More: the full row for NFSG Corp 13,000 $35.2K 0.01% +2,000 13F-HR Timeline LEVEL FOUR ADVISORY SERVICES, LLC in group LEVEL FOUR ADVISORY SERVICES,… More: the full row for LEVEL FOUR ADVISORY SERVICES, LLC 10,000 $27.1K <0.01% 0 13F-HR Timeline Group Marex Group Ltd in group Marex Group Ltd More: the full row for Marex Group Ltd 10,000 $27.1K <0.01% 0 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 9,878 $26.8K <0.01% +3,290 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 9,257 $25.1K <0.01% +877 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 5,377 $14.6K <0.01% +2,314 13F-HR/A Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 4,544 $12.3K 0.01% +3,060 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 4,000 $10.8K <0.01% 0 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 1,637 $4.44K <0.01% +137 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 1,570 $4.25K <0.01% new 13F-HR Timeline Group GPS Wealth Strategies Group, LLC More: the full row for GPS Wealth Strategies Group, LLC 1,500 $4.07K <0.01% 0 13F-HR Timeline SIT INVESTMENT ASSOCIATES INC in group SIT INVESTMENT ASSOCIATES INC More: the full row for SIT INVESTMENT ASSOCIATES INC 970 $3K <0.01% 0 13F-HR Timeline Group Brooklyn Investment Group More: the full row for Brooklyn Investment Group 849 $2.3K <0.01% new 13F-HR/A Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 470 $1.27K <0.01% new 13F-HR Timeline Group MAI Capital Management More: the full row for MAI Capital Management 309 $838 <0.01% 0 13F-HR Timeline New England Capital Financial Advisors … More: the full row for New England Capital Financial Advisors LLC 300 $813 <0.01% 0 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 230 $622 <0.01% -1,000 13F-HR Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 187 $507 <0.01% new 13F-HR Timeline Transce3nd, LLC More: the full row for Transce3nd, LLC 127 $344 <0.01% 0 13F-HR Timeline PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 75 $203 <0.01% +43 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 13 $35 <0.01% 0 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 3 $8 <0.01% 0 13F-HR Timeline Group CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.