JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 22,735,121 $52.4M 0.03% +5,612,558 13F-HR Timeline Group Rubric Capital Management LP More: the full row for Rubric Capital Management LP 15,307,347 $34.4M 0.62% 0 13F-HR Timeline MANGROVE PARTNERS IM, LLC More: the full row for MANGROVE PARTNERS IM, LLC 8,636,485 $19.4M 2.17% 0 13F-HR Timeline Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 7,819,863 $17.6M 0.8% +2,722,084 13F-HR Timeline DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 6,710,429 $15.1M 0.3% 0 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 6,684,247 $15M 0.86% -2,914,923 13F-HR Timeline ALKEON CAPITAL MANAGEMENT LLC More: the full row for ALKEON CAPITAL MANAGEMENT LLC 4,698,100 $10.6M 0.06% 0 13F-HR Timeline 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 4,635,000 $10.4M 1.06% +85,000 13F-HR Timeline Group Clearline Capital LP More: the full row for Clearline Capital LP 3,217,894 $7.24M 0.73% 0 13F-HR Timeline Tejara Capital Ltd More: the full row for Tejara Capital Ltd 2,521,324 $5.67M 2.8% +204,239 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 2,501,121 $5.63M -1,111,919 Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 2,188,354 $4.92M 0.01% new 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 2,179,642 $4.9M <0.01% -1,374,592 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 2,125,920 $4.78M <0.01% +6,068 13F-HR/A Timeline Group ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 1,700,756 $3.83M 0.01% -7,014,257 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 1,591,056 $3.58M 0.02% +1,097,156 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 1,350,471 $3.04M <0.01% +161,000 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 1,275,000 $2.87M 1.56% +125,000 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 947,986 $2.13M 0.01% +329,202 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 876,961 $1.97M 0.07% -208,551 13F-HR/A Timeline Group Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 800,000 $1.8M 0.2% -200,000 13F-HR Timeline ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 791,815 $1.78M 2.07% +12,507 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 767,744 $1.73M <0.01% -98,573 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 759,100 $1.71M <0.01% new 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 686,953 $1.55M 0.12% -100,000 13F-HR Timeline NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 654,666 $1.47M 0.03% -169,937 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 654,666 $1.47M 0.44% -235,882 13F-HR Timeline Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 450,000 $1.01M 0.01% +135,000 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 438,670 $987K <0.01% +436,350 13F-HR Timeline Group Artia Global Partners LP More: the full row for Artia Global Partners LP 421,359 $948K 0.28% 0 13F-HR Timeline Monaco Asset Management SAM More: the full row for Monaco Asset Management SAM 416,468 $937K 0.47% +35,000 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 394,431 $887K <0.01% -3,571,001 13F-HR Timeline Group Atle Fund Management AB More: the full row for Atle Fund Management AB 390,000 $878K 0.39% 0 13F-HR Timeline CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 355,000 $799K 0.03% +130,000 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 343,653 $773K <0.01% +29,703 13F-HR Timeline Group Knott David M Jr More: the full row for Knott David M Jr 319,337 $719K 0.34% -11,663 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 274,506 $618K +205,771 Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 274,361 $617K <0.01% +1,342 13F-HR Timeline Group Knoll Capital Management, LLC More: the full row for Knoll Capital Management, LLC 260,470 $586K 0.38% 0 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 174,378 $392K <0.01% -217,212 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 144,803 $326K <0.01% +24,525 13F-HR/A Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 113,247 $255K 0.22% new 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 104,783 $236K 0.01% new 13F-HR Timeline BIT Capital GmbH More: the full row for BIT Capital GmbH 101,070 $227K 0.03% new 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 92,156 $207K <0.01% 0 13F-HR Timeline Group J. Goldman & Co LP More: the full row for J. Goldman & Co LP 79,387 $179K 0.01% 0 13F-HR Timeline DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 492,215 $169K 0.13% new 13F-HR Timeline Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 49,418 $111K <0.01% +27,229 13F-HR Timeline Forefront Analytics, LLC More: the full row for Forefront Analytics, LLC 47,630 $107K 0.12% +12,877 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 45,659 $103K <0.01% -1,426 13F-HR Timeline Group Virtus Investment Advisers, LLC group of 2 filers holding More: the full row for Virtus Investment Advisers, LLC 44,007 $99K +24,947 Timeline Clear Harbor Asset Management, LLC More: the full row for Clear Harbor Asset Management, LLC 42,000 $94.5K 0.01% 0 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 39,030 $87.8K <0.01% -55,426 13F-HR Timeline Group PFG Investments, LLC More: the full row for PFG Investments, LLC 37,433 $84.2K 0.01% -2,000 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 35,816 $80.6K <0.01% new 13F-HR/A Timeline Group GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 34,281 $77.1K <0.01% new 13F-HR Timeline Avanza Fonder AB More: the full row for Avanza Fonder AB 28,121 $66.6K <0.01% +8,521 13F-HR Timeline Centiva Capital, LP More: the full row for Centiva Capital, LP 25,000 $56.2K <0.01% 0 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 22,687 $51.2K <0.01% new 13F-HR Timeline Group Ascentis Independent Advisors in group Ascentis Wealth Management, L… More: the full row for Ascentis Independent Advisors 19,900 $44.8K 0.01% -2,700 13F-HR Timeline Group OneDigital Investment Advisors LLC More: the full row for OneDigital Investment Advisors LLC 18,300 $41.2K <0.01% 0 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 17,931 $40.3K <0.01% -5,736 13F-HR/A Timeline Group Sheets Smith Investment Management More: the full row for Sheets Smith Investment Management 16,890 $38K 0.04% 0 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 15,713 $35K <0.01% new 13F-HR Timeline Significant Wealth Partners LLC More: the full row for Significant Wealth Partners LLC 13,771 $31K 0.02% +2,966 13F-HR Timeline HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 13,577 $29.8K <0.01% 0 13F-HR Timeline Group NFSG Corp More: the full row for NFSG Corp 11,000 $24.8K 0.01% +300 13F-HR Timeline LEVEL FOUR ADVISORY SERVICES, LLC in group LEVEL FOUR ADVISORY SERVICES,… More: the full row for LEVEL FOUR ADVISORY SERVICES, LLC 10,000 $22.5K <0.01% 0 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 10,000 $22.5K <0.01% 0 13F-HR Timeline Group Marex Group Ltd in group Marex Group Ltd More: the full row for Marex Group Ltd 10,000 $22.5K <0.01% 0 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 8,380 $18.9K <0.01% -621 13F-HR/A Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 6,588 $14.8K <0.01% -649 13F-HR/A Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 4,117 $9K <0.01% -50,982 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 4,000 $9K <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 3,063 $6.89K <0.01% +2,934 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 1,500 $3.81K <0.01% 0 13F-HR Timeline GPS Wealth Strategies Group, LLC More: the full row for GPS Wealth Strategies Group, LLC 1,500 $3.38K <0.01% 0 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 1,484 $3.34K <0.01% +1,164 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 1,230 $2.77K <0.01% +1,001 13F-HR Timeline Group SIT INVESTMENT ASSOCIATES INC in group SIT INVESTMENT ASSOCIATES INC More: the full row for SIT INVESTMENT ASSOCIATES INC 970 $2K <0.01% 0 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 365 $821 <0.01% 0 13F-HR Timeline Group MAI Capital Management More: the full row for MAI Capital Management 309 $696 <0.01% 0 13F-HR Timeline New England Capital Financial Advisors … More: the full row for New England Capital Financial Advisors LLC 300 $675 <0.01% 0 13F-HR Timeline Transce3nd, LLC More: the full row for Transce3nd, LLC 127 $286 <0.01% 0 13F-HR Timeline PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 32 $112 <0.01% 0 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 13 $29 <0.01% 0 13F-HR Timeline Group Grove Bank & Trust More: the full row for Grove Bank & Trust 12 $27 <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 3 $7 <0.01% 0 13F-HR Timeline Group CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.