NOVO HOLDINGS A/S More: the full row for NOVO HOLDINGS A/S 3,686,622 $64.8M 5.03% new 13F-HR Timeline FCPM III SERVICES B.V. in group FCPM III SERVICES B.V. More: the full row for FCPM III SERVICES B.V. 3,226,400 $56.7M 7.43% new 13F-HR Timeline Group T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 2,799,180 $49.2M 0.03% new 13F-HR/A Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,937,168 $34M <0.01% new 13F-HR/A Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,095,514 $19.2M <0.01% new 13F-HR Timeline Group Nan Fung Group Holdings Ltd More: the full row for Nan Fung Group Holdings Ltd 971,253 $17.1M 15.27% new 13F-HR Timeline 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 950,011 $16.7M 5.25% new 13F-HR Timeline Sanofi More: the full row for Sanofi 912,041 $16M 5.16% new 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 869,668 $15.3M <0.01% new 13F-HR Timeline Group Pivotal bioVenture Partners Investment … in group Pivotal bioVenture Partners I… More: the full row for Pivotal bioVenture Partners Investment Advisor LLC 611,447 $10.7M 4.15% new 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 550,000 $9.66M 0.18% new 13F-HR Timeline Group Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 522,305 $9.17M 5.34% new 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 450,000 $7.9M 0.24% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 389,026 $6.83M <0.01% new 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 385,000 $6.76M 0.25% new 13F-HR Timeline BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 364,705 $6.41M 0.04% new 13F-HR Timeline Group Jain Global LLC More: the full row for Jain Global LLC 327,693 $5.76M 0.06% new 13F-HR Timeline Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 327,058 $5.74M 1.77% new 13F-HR/A Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 229,484 $4.03M <0.01% new 13F-HR Timeline Group LAZARD ASSET MANAGEMENT LLC in group LAZARD ASSET MANAGEMENT LLC More: the full row for LAZARD ASSET MANAGEMENT LLC 207,494 $3.64M 0.01% new 13F-HR Timeline Group Board of Trustees of The Leland Stanfor… More: the full row for Board of Trustees of The Leland Stanford Junior University 199,233 $3.5M 0.71% new 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 190,139 $3.34M <0.01% new 13F-HR Timeline Group Freestone Grove Partners LP More: the full row for Freestone Grove Partners LP 183,771 $3.23M 0.02% new 13F-HR Timeline Tetragon Partners GP Ltd in group Tetragon Partners GP Ltd More: the full row for Tetragon Partners GP Ltd 164,525 $2.89M 0.61% new 13F-HR Timeline Group BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 147,930 $2.6M <0.01% new 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 143,764 $2.53M 0.59% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 138,427 $2.43M <0.01% new 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 119,557 $2.1M <0.01% new 13F-HR Timeline Group SEVEN GRAND MANAGERS, LLC More: the full row for SEVEN GRAND MANAGERS, LLC 100,000 $1.76M 0.13% new 13F-HR Timeline STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 100,000 $1.76M 0.3% new 13F-HR Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 75,000 $1.32M 0.09% new 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 66,872 $1.17M <0.01% new 13F-HR Timeline Group DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 63,791 $1.12M 0.67% new 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 56,000 $952K 0.02% new 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 47,840 $840K <0.01% new 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 39,659 $697K <0.01% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 37,820 $664K <0.01% new 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 36,960 $649K <0.01% new 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 35,857 $630K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 26,415 $464K <0.01% new 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 23,222 $408K <0.01% new 13F-HR/A Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 21,766 $382K 0.18% new 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 20,197 $355K <0.01% new 13F-HR Timeline Group Ghisallo Capital Management LLC More: the full row for Ghisallo Capital Management LLC 20,000 $351K 0.02% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 18,687 $328K <0.01% new 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 18,290 $321K <0.01% new 13F-HR Timeline Group OXFORD ASSET MANAGEMENT LLP More: the full row for OXFORD ASSET MANAGEMENT LLP 17,763 $312K 0.11% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 13,945 $245K <0.01% new 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 13,642 $240K <0.01% new 13F-HR Timeline Lynx1 Capital Management LP in group Lynx1 Capital Management LP More: the full row for Lynx1 Capital Management LP 13,477 $237K 0.05% new 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 12,970 $228K <0.01% new 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 11,928 $210K <0.01% new 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 11,686 $205K <0.01% new 13F-HR Timeline Group LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 10,000 $176K <0.01% new 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 9,798 $172K <0.01% new 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 7,815 $137K <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 6,743 $118K <0.01% new 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 5,300 $93.1K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 3,986 $70K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 3,455 $60.7K <0.01% new 13F-HR Timeline Group STRS OHIO More: the full row for STRS OHIO 3,000 $52.7K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,870 $50.4K <0.01% new 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 1,649 $29K <0.01% new 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,371 $24.1K <0.01% new 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 1,337 $23.5K <0.01% new 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,040 $18.3K <0.01% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 904 $15.9K <0.01% new 13F-HR Timeline Group SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 607 $10.7K <0.01% new 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 582 $10K <0.01% new 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 519 $9.12K <0.01% new 13F-HR Timeline AMALGAMATED BANK More: the full row for AMALGAMATED BANK 530 $9K <0.01% new 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 500 $8.78K <0.01% new 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 383 $6.73K <0.01% new 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 120 $2.11K <0.01% new 13F-HR Timeline