TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 3,858,000 $14.6M 1.43% 0 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 3,413,448 $12.9M 0.01% -343,224 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 3,098,987 $11.7M 0.18% new 13F-HR Timeline ARK Investment Management LLC in group ARK Investment Management LLC More: the full row for ARK Investment Management LLC 1,736,202 $6.56M 0.05% -268,923 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 1,608,000 $6.08M 0.68% 0 13F-HR Timeline GMT Capital Corp More: the full row for GMT Capital Corp 1,547,800 $5.85M 0.29% 0 13F-HR Timeline Altium Capital Management LLC More: the full row for Altium Capital Management LLC 1,424,400 $5.38M 1.68% new 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,105,676 $4.18M <0.01% -4,308,900 13F-HR Timeline Group TANG CAPITAL MANAGEMENT LLC in group TANG CAPITAL MANAGEMENT LLC More: the full row for TANG CAPITAL MANAGEMENT LLC 1,000,000 $3.78M 0.25% new 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 1,000,000 $3.78M 0.26% +800,000 13F-HR Timeline Group Aisling Capital Management LP More: the full row for Aisling Capital Management LP 964,500 $3.65M 1.29% 0 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 850,512 $3.21M 0.5% +550,000 13F-HR Timeline Rosalind Advisors, Inc. More: the full row for Rosalind Advisors, Inc. 707,625 $2.67M 1.44% -73,798 13F-HR/A Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 695,669 $2.63M <0.01% -304,820 13F-HR/A Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 650,279 $2.46M 0.01% new 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 461,929 $1.75M 0.01% -52,489 13F-HR Timeline PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 451,267 $1.71M 0.13% 0 13F-HR Timeline Laurion Capital Management LP More: the full row for Laurion Capital Management LP 439,311 $1.66M 0.1% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 419,194 $1.58M <0.01% +8,718 13F-HR/A Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 369,070 $1.4M <0.01% new 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 343,507 $1.3M <0.01% -41,902 13F-HR Timeline Group Founders Fund VII Management, LLC in group Founders Fund Growth II Manag… More: the full row for Founders Fund VII Management, LLC 278,880 $1.05M 100% 0 13F-HR Timeline Group Sumitomo Mitsui Trust Group, Inc. in group Sumitomo Mitsui Trust Group, … More: the full row for Sumitomo Mitsui Trust Group, Inc. 253,345 $958K <0.01% -16,024 13F-HR Timeline Group Amova Asset Management Americas, Inc. in group Amova Asset Management Americ… More: the full row for Amova Asset Management Americas, Inc. 253,345 $955K 0.01% -16,024 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 243,210 $919K 0.23% 0 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 220,883 $835K -47,801 Timeline Brown University More: the full row for Brown University 214,200 $810K 0.35% +141,500 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 212,700 $804K <0.01% +131,300 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 202,894 $767K 0.22% -14 13F-HR Timeline Group Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 200,000 $756K 0.07% new 13F-HR Timeline Hennion & Walsh Asset Management, Inc. More: the full row for Hennion & Walsh Asset Management, Inc. 174,921 $661K 0.03% +26,787 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 171,172 $647K 0.16% -76,904 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 169,479 $638K <0.01% new 13F-HR Timeline Group Blue Owl Capital Holdings LP More: the full row for Blue Owl Capital Holdings LP 161,238 $609K 0.14% new 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 156,748 $593K <0.01% -145,067 13F-HR Timeline Group Saba Capital Management, L.P. in group Saba Capital Management, L.P. More: the full row for Saba Capital Management, L.P. 151,033 $571K 0.01% 0 13F-HR Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 126,636 $479K 0.01% +85,213 13F-HR Timeline BIT Capital GmbH More: the full row for BIT Capital GmbH 115,697 $437K 0.04% new 13F-HR Timeline Oasis Management Co Ltd. in group Oasis Management Co Ltd. More: the full row for Oasis Management Co Ltd. 107,911 $408K 0.13% 0 13F-HR Timeline Group Walleye Capital LLC group of 2 filers holding More: the full row for Walleye Capital LLC 106,013 $401K -231,587 Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 105,286 $398K <0.01% new 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 81,475 $308K -55,786 Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 67,999 $257K <0.01% +9,099 13F-HR Timeline Group AdvisorShares Investments LLC More: the full row for AdvisorShares Investments LLC 66,602 $252K 0.05% +22,720 13F-HR Timeline EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 65,519 $248K 0.1% +23,311 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 62,300 $235K 0.01% -14 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 59,713 $226K <0.01% -59,630 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 55,332 $209K <0.01% +2,927 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 51,815 $196K <0.01% new 13F-HR Timeline Group PEAK6 LLC in group PEAK6 LLC More: the full row for PEAK6 LLC 49,300 $186K 0.01% 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 48,415 $183K <0.01% +34,449 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 42,169 $159K <0.01% 0 13F-HR Timeline Group Green Alpha Advisors, LLC More: the full row for Green Alpha Advisors, LLC 37,614 $142K 0.11% +21,833 13F-HR Timeline TWO SIGMA SECURITIES, LLC More: the full row for TWO SIGMA SECURITIES, LLC 35,604 $135K 0.02% new 13F-HR Timeline Fore Capital, LLC More: the full row for Fore Capital, LLC 35,000 $132K 0.16% 0 13F-HR Timeline KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 33,976 $128K <0.01% +6,297 13F-HR Timeline SVB WEALTH LLC More: the full row for SVB WEALTH LLC 26,607 $101K <0.01% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 25,261 $95.5K <0.01% -256 13F-HR Timeline Group Propel Bio Management, LLC More: the full row for Propel Bio Management, LLC 25,209 $95.3K 0.09% -54,791 13F-HR Timeline Essential Planning, LLC. More: the full row for Essential Planning, LLC. 18,395 $93.6K <0.01% new 13F-HR Timeline STIFEL FINANCIAL CORP in group STIFEL FINANCIAL CORP More: the full row for STIFEL FINANCIAL CORP 22,100 $83.5K <0.01% -12,600 13F-HR Timeline Group Dynamic Technology Lab Private Ltd More: the full row for Dynamic Technology Lab Private Ltd 21,945 $83K 0.01% new 13F-HR Timeline Atom Investors LP More: the full row for Atom Investors LP 17,515 $66.2K 0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 17,489 $66.1K <0.01% +14,511 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 17,114 $64.7K <0.01% -30,169 13F-HR Timeline Group VIRTUS ADVISERS, LLC in group Virtus Investment Advisers, L… More: the full row for VIRTUS ADVISERS, LLC 16,121 $60.9K 0.02% +2,840 13F-HR Timeline Group Simplify Asset Management Inc. More: the full row for Simplify Asset Management Inc. 14,248 $53.9K <0.01% new 13F-HR Timeline Prime Capital Investment Advisors, LLC More: the full row for Prime Capital Investment Advisors, LLC 13,960 $52.8K <0.01% new 13F-HR Timeline Pathstone Holdings, LLC in group Pathstone Holdings, LLC More: the full row for Pathstone Holdings, LLC 13,789 $52.1K <0.01% -2,177 13F-HR Timeline Group Conservest Capital Advisors, Inc. More: the full row for Conservest Capital Advisors, Inc. 13,363 $50.5K 0.01% +3,000 13F-HR Timeline TAP Consulting, LLC More: the full row for TAP Consulting, LLC 11,717 $44.3K 0.01% +1,130 13F-HR Timeline FLAGSHIP HARBOR ADVISORS, LLC More: the full row for FLAGSHIP HARBOR ADVISORS, LLC 11,312 $42.8K <0.01% new 13F-HR Timeline HighTower Advisors, LLC More: the full row for HighTower Advisors, LLC 10,882 $41.1K <0.01% -150 13F-HR Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 10,855 $41K <0.01% +10,000 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 10,782 $40.8K <0.01% new 13F-HR Timeline Intellectus Partners, LLC More: the full row for Intellectus Partners, LLC 10,100 $38.2K 0.01% 0 13F-HR Timeline TrinityBridge Ltd More: the full row for TrinityBridge Ltd 6,400 $24K <0.01% 0 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 5,346 $20.2K <0.01% +2,058 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 4,162 $15.7K <0.01% +4,090 13F-HR Timeline Group North Star Investment Management Corp. More: the full row for North Star Investment Management Corp. 3,372 $12.7K <0.01% -1,425 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 3,224 $12.2K <0.01% +3,161 13F-HR Timeline Group Blue Trust, Inc. More: the full row for Blue Trust, Inc. 2,799 $10.6K <0.01% +2,538 13F-HR/A Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 2,403 $9.08K <0.01% -8,045 13F-HR Timeline Group Colonial Trust Advisors in group Colonial Trust Advisors More: the full row for Colonial Trust Advisors 2,000 $7.56K <0.01% +500 13F-HR Timeline Group Crewe Advisors LLC More: the full row for Crewe Advisors LLC 1,945 $7.35K <0.01% 0 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. in group Mirae Asset Global Investment… More: the full row for Mirae Asset Global Investments Co., Ltd. 1,694 $6.76K <0.01% new 13F-HR Timeline Group TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 1,770 $6.67K <0.01% 0 13F-HR Timeline R Squared Ltd More: the full row for R Squared Ltd 1,570 $5.93K 0.01% 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 1,376 $5.2K <0.01% 0 13F-HR/A Timeline Ancora Advisors LLC in group Ancora Advisors LLC More: the full row for Ancora Advisors LLC 1,330 $5.03K <0.01% 0 13F-HR Timeline Group GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,068 $4.04K <0.01% 13F-HR Timeline Steward Partners Investment Advisory, L… More: the full row for Steward Partners Investment Advisory, LLC 1,000 $3.78K <0.01% 0 13F-HR Timeline Westside Investment Management, Inc. More: the full row for Westside Investment Management, Inc. 900 $3.4K <0.01% 0 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 800 $3.02K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 682 $2.58K <0.01% new 13F-HR Timeline Group NewEdge Advisors, LLC More: the full row for NewEdge Advisors, LLC 550 $2.08K <0.01% 0 13F-HR Timeline Anchor Investment Management, LLC More: the full row for Anchor Investment Management, LLC 550 $2.08K <0.01% 0 13F-HR Timeline ADIRONDACK TRUST CO More: the full row for ADIRONDACK TRUST CO 505 $1.9K <0.01% 0 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 501 $1.89K <0.01% 0 13F-HR Timeline Group NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 500 $1.89K <0.01% +446 13F-HR Timeline Group Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 475 $1.8K <0.01% 0 13F-HR Timeline Pacifica Partners Inc. More: the full row for Pacifica Partners Inc. 420 $1.74K <0.01% 0 13F-HR Timeline New England Capital Financial Advisors … More: the full row for New England Capital Financial Advisors LLC 358 $1.35K <0.01% 0 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 300 $1.13K <0.01% -500 13F-HR Timeline PRINCIPAL SECURITIES, INC. in group PRINCIPAL FINANCIAL GROUP INC More: the full row for PRINCIPAL SECURITIES, INC. 288 $1.09K <0.01% 0 13F-HR Timeline Group GHP Investment Advisors, Inc. More: the full row for GHP Investment Advisors, Inc. 250 $945 <0.01% 0 13F-HR Timeline NVWM, LLC More: the full row for NVWM, LLC 202 $764 <0.01% 0 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 200 $756 <0.01% -54 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 156 $590 <0.01% 13F-HR/A Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 135 $511 <0.01% 0 13F-HR Timeline Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 134 $507 <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 130 $491 <0.01% +26 13F-HR Timeline CENTRAL TRUST Co More: the full row for CENTRAL TRUST Co 100 $378 <0.01% 0 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 100 $378 <0.01% 0 13F-HR Timeline FIFTH THIRD BANCORP in group FIFTH THIRD BANK, NATIONAL AS… More: the full row for FIFTH THIRD BANCORP 60 $227 <0.01% 0 13F-HR Timeline Group TruNorth Capital Management, LLC More: the full row for TruNorth Capital Management, LLC 60 $227 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 56 $212 <0.01% 13F-HR Timeline TFC Financial Management, Inc. More: the full row for TFC Financial Management, Inc. 52 $197 <0.01% 0 13F-HR Timeline Glen Eagle Advisors, LLC More: the full row for Glen Eagle Advisors, LLC 52 $197 <0.01% 0 13F-HR Timeline AdvisorNet Financial, Inc More: the full row for AdvisorNet Financial, Inc 50 $189 <0.01% 0 13F-HR Timeline Anfield Capital Management, LLC in group Anfield Capital Management, L… More: the full row for Anfield Capital Management, LLC 35 $132 <0.01% 0 13F-HR Timeline Group Missouri Trust & Investment Co More: the full row for Missouri Trust & Investment Co 30 $113 <0.01% 0 13F-HR Timeline CROWLEY WEALTH MANAGEMENT, INC. More: the full row for CROWLEY WEALTH MANAGEMENT, INC. 30 $113 <0.01% 13F-HR Timeline CIBC Private Wealth Group LLC in group CIBC Bancorp USA Inc. More: the full row for CIBC Private Wealth Group LLC 23 $95 <0.01% 0 13F-HR Timeline Group Aventura Private Wealth, LLC More: the full row for Aventura Private Wealth, LLC 17 $64 <0.01% 13F-HR Timeline Avior Wealth Management, LLC More: the full row for Avior Wealth Management, LLC 15 $56 <0.01% new 13F-HR Timeline Tradewinds Capital Management, LLC More: the full row for Tradewinds Capital Management, LLC 14 $53 <0.01% 0 13F-HR Timeline SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 1 $4 <0.01% 0 13F-HR Timeline SHELL ASSET MANAGEMENT CO More: the full row for SHELL ASSET MANAGEMENT CO 130 $0 0% -9,315 13F-HR Timeline Value filed as zero, left out of ratios. TSFG, LLC More: the full row for TSFG, LLC 100 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.