Skip to content
Disclosery

APLS APELLIS PHARMACEUTICALS INC

Follow

COM (common)

269 managers (273 13F filers) reported a position in APLS shares at 2025-09-30, 122,325,799 shares in all. 59 filers opened a position and 31 filers sold out during the quarter.

Managers
269
13F filers
273
New
59
Added
92
Reduced
91
Sold out
31
Shares held by filers
122,325,799

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
Avoro Capital Advisors LLC12,222,222$277M3.58%013F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC9,987,394$226M<0.01%-167,35713F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY9,643,248$218M0.01%-108,95313F-HR/ATimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…9,290,960$210M0.04%+313,99813F-HRTimelineGroup
Deep Track Capital, LP8,000,382$181M5.05%+1,000,38213F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.6,268,465$142M<0.01%-136,53413F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC4,487,354$102M0.07%-1,489,06013F-HRTimelineGroup
JENNISON ASSOCIATES LLC4,348,055$98.4M0.06%+1,686,23213F-HRTimeline
STATE STREET CORPin group STATE STREET CORP4,037,644$91.4M<0.01%+474,92313F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding3,597,369$81.4M-1,439,881Timeline
EcoR1 Capital, LLC3,447,156$78M3.74%-8,448,65213F-HRTimeline
MONTANOVA CAPITAL, LLC2,878,000$65.1M1.97%013F-HRTimeline
Polar Capital Holdings Plcin group Polar Capital Holdings Plc2,650,230$60M0.29%+1,298,05513F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.2,578,396$58.3M2.28%013F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC2,323,368$52.6M1.26%+841,06813F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC2,072,913$46.9M<0.01%+77,64213F-HRTimelineGroup
Amundiin group Amundi1,493,678$36.4M0.01%-110,42713F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\1,504,457$34M0.01%+8,16113F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/1,477,525$33.4M<0.01%-949,10313F-HR/ATimelineGroup
BANK OF NOVA SCOTIAin group BANK OF NOVA SCOTIA1,456,225$33M0.06%+861,41313F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC1,343,726$30.4M0.02%+1,141,27413F-HRTimelineGroup
ING GROEP NV1,174,500$26.6M0.14%+866,20013F-HRTimeline
VOLORIDGE INVESTMENT MANAGEMENT, LLC992,269$22.5M0.08%+523,55913F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS972,474$22M0.02%-325,98513F-HRTimelineGroup
Octagon Capital Advisors LP903,500$20.4M3.19%013F-HRTimeline
Kynam Capital Management, LP808,607$18.3M1.36%new13F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC722,895$16.4M0.02%+711,90713F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC717,703$16.2M<0.01%-32,45813F-HRTimelineGroup
Nuveen, LLCin group TIAA665,048$15.1M<0.01%+195,79513F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co647,082$14.6M<0.01%-342,06113F-HRTimelineGroup
LOS ANGELES CAPITAL MANAGEMENT LLC620,790$14M0.05%new13F-HRTimeline
Trexquant Investment LP586,939$13.3M0.14%+259,51813F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC586,452$13.3M0.01%+143,89213F-HRTimelineGroup
OSSIAM555,953$12.6M0.16%013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP549,248$12.4M<0.01%+23,36613F-HRTimelineGroup
Woodline Partners LP542,981$12.3M0.06%+12,05813F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.456,791$10.3M0.01%+205,72213F-HRTimelineGroup
Ikarian Capital, LLCin group Ikarian Capital, LLC451,902$10.2M2.07%+376,90213F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC444,972$10.1M0.01%+306,52113F-HRTimelineGroup
Hudson Bay Capital Management LPin group Hudson Bay Capital Management…418,500$9.47M0.06%-56,50013F-HR/ATimelineGroup
SG Americas Securities, LLC417,392$9.45M0.03%+372,28913F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP396,735$8.98M0.01%-2,308,10213F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…363,450$8.23M0.01%+15,10113F-HRTimelineGroup
HRT FINANCIAL LP353,649$8M0.03%+246,44913F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…313,884$7.1M0.01%-14,84213F-HRTimelineGroup
Caption Management, LLC305,000$6.9M0.4%+74,11213F-HRTimeline
Cubist Systematic Strategies, LLC299,783$6.78M0.1%new13F-HRTimeline
IEQ CAPITAL, LLC296,784$6.72M0.02%-50,13913F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC293,199$6.64M0.01%+47,00013F-HRTimelineGroup
683 Capital Management, LLCin group 683 Capital Management, LLC288,000$6.52M0.59%-122,00013F-HRTimelineGroup
J. Goldman & Co LP283,153$6.41M0.24%+189,57913F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC277,648$6.28M0.08%-281,02013F-HR/ATimelineGroup
BARCLAYS PLCin group BARCLAYS PLC269,527$6.1M<0.01%-4,38513F-HR/ATimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding252,068$5.7M-411,645Timeline
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.251,555$5.69M0.05%-326,65013F-HRTimelineGroup
Integral Health Asset Management, LLC250,000$5.66M0.41%new13F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp248,194$5.62M<0.01%+4,86713F-HRTimelineGroup
READYSTATE ASSET MANAGEMENT LP241,977$5.48M0.27%new13F-HRTimeline
Rhenman & Partners Asset Management AB232,250$5.26M0.58%+139,00013F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.217,071$4.91M0.01%new13F-HRTimelineGroup
CANADA PENSION PLAN INVESTMENT BOARD217,000$4.91M<0.01%-119,80013F-HRTimeline
Fiduciary Trust Coin group Fiduciary Trust Co198,179$4.48M0.05%-4,35713F-HRTimelineGroup
ExodusPoint Capital Management, LP194,758$4.41M0.06%new13F-HRTimeline
SILVERCREST ASSET MANAGEMENT GROUP LLC190,526$4.31M0.03%new13F-HRTimeline
Invesco Ltd.in group Invesco Ltd.183,016$4.14M<0.01%+16,88113F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC179,226$4.06M0.1%+156,22913F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP173,087$3.92M<0.01%-312,52813F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC172,934$3.91M<0.01%+22,34113F-HRTimelineGroup
Rafferty Asset Management, LLC168,352$3.81M0.01%+24,50013F-HRTimeline
Y-Intercept (Hong Kong) Ltd163,813$3.71M0.09%-46213F-HRTimeline
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/160,306$3.63M<0.01%+69313F-HRTimelineGroup
EFG Asset Management (North America) Co…155,399$3.52M0.45%+50,37513F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO155,122$3.51M<0.01%+132,76313F-HRTimelineGroup
Walleye Capital LLCgroup of 2 filers holding152,599$3.45M+70,568Timeline
Swiss National Bank146,200$3.31M<0.01%+2,40013F-HRTimeline
California Public Employees Retirement …146,188$3.31M<0.01%+11,55113F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA146,207$3.31M<0.01%-651,37813F-HRTimelineGroup
HighVista Strategies LLC145,729$3.3M0.81%+59,06613F-HRTimeline
Aquatic Capital Management LLC130,828$2.96M0.05%-45,87613F-HRTimeline
Edgestream Partners, L.P.129,751$2.94M0.09%-88,64113F-HRTimeline
Cerity Partners LLCin group Cerity Partners LLC128,110$2.9M<0.01%+13,36513F-HRTimelineGroup
Gotham Asset Management, LLC127,158$2.88M0.01%+7,92913F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC124,373$2.81M<0.01%-91,62613F-HRTimelineGroup
Qube Research & Technologies Ltd120,003$2.72M<0.01%new13F-HRTimeline
RHUMBLINE ADVISERS117,429$2.66M<0.01%-4,57313F-HRTimeline
Steward Partners Investment Advisory, L…114,088$2.58M0.01%-26,88713F-HRTimeline
WORLDQUANT MILLENNIUM ADVISORS LLC111,979$2.53M0.01%new13F-HRTimeline
ALGERT GLOBAL LLC109,733$2.48M0.04%-44,38013F-HR/ATimeline
Simplify Asset Management Inc.106,888$2.42M0.05%new13F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/97,940$2.22M<0.01%+5,78913F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…95,595$2.16M<0.01%+4,18713F-HRTimeline
CWM, LLCin group CWM, LLC94,233$2.13M0.01%-33,35113F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc92,392$2.09M<0.01%-3,65813F-HRTimelineGroup
Rock Springs Capital Management LP92,000$2.08M0.12%+7,70013F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…91,021$2.06M0.03%new13F-HRTimelineGroup
WEALTH ENHANCEMENT ADVISORY SERVICES, L…77,508$1.95M<0.01%-23,15813F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD85,761$1.94M<0.01%-8,64313F-HRTimeline
Arax Advisory Partners82,067$1.86M0.03%new13F-HRTimeline
ALLIANCEBERNSTEIN L.P.80,605$1.82M<0.01%+48,67613F-HRTimeline
Bleakley Financial Group, LLC79,305$1.79M0.04%+2,21713F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC77,678$1.76M<0.01%+3,21213F-HRTimelineGroup
MACKENZIE FINANCIAL CORP76,711$1.74M<0.01%+2,54613F-HRTimeline
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.in group LANDSCAPE CAPITAL MANAGEMENT,…75,000$1.7M0.11%+10,47913F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…73,298$1.66M<0.01%-14,63113F-HRTimeline
J. Safra Sarasin Holding AGin group J. Safra Sarasin Holding AG70,500$1.6M0.03%-45,18413F-HRTimelineGroup
Man Group plcin group Man Group plc67,202$1.52M<0.01%new13F-HRTimelineGroup
Engineers Gate Manager LP66,336$1.5M0.02%+7,61813F-HRTimeline
MACQUARIE GROUP LTDin group MACQUARIE GROUP LTD65,156$1.47M<0.01%new13F-HRTimelineGroup
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.63,660$1.44M0.34%-50,68613F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC62,815$1.42M0.01%-4,94613F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…54,052$1.22M<0.01%-4,80413F-HRTimelineGroup
PDT Partners, LLC53,951$1.22M0.08%-106,10713F-HRTimeline
SIMPLEX TRADING, LLC53,901$1.22M0.03%-2,03313F-HRTimeline
Campbell & CO Investment Adviser LLC53,540$1.21M0.09%new13F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO53,516$1.21M<0.01%-181,28513F-HR/ATimelineGroup
DekaBank Deutsche Girozentrale55,000$1.2M<0.01%013F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC52,834$1.2M<0.01%-276,55813F-HRTimelineGroup
NATIXISin group Natixis Investment Managers52,239$1.18M0.01%-38,42713F-HRTimelineGroup
HIGHLAND CAPITAL MANAGEMENT, LLC50,133$1.13M0.06%new13F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND48,837$1.11M<0.01%-10,04213F-HRTimeline
T. Rowe Price Investment Management, In…48,756$1.1M<0.01%-55213F-HRTimeline
Treasurer of the State of North Carolina48,466$1.1M<0.01%-1,89213F-HRTimeline
Quantinno Capital Management LP48,419$1.1M<0.01%new13F-HRTimeline
Police & Firemen's Retirement System of…48,370$1.09M0.01%+7,41613F-HRTimeline
Hennion & Walsh Asset Management, Inc.48,129$1.09M0.04%-88513F-HRTimeline
Schonfeld Strategic Advisors LLC47,282$1.07M0.01%-36,63413F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …46,113$1.04M<0.01%+20,84013F-HRTimelineGroup
Mariner, LLCin group Mariner, LLC43,239$978K<0.01%+6,90913F-HRTimelineGroup
Focus Partners Wealthgroup of 2 filers holding41,690$902K-12,336Timeline
Handelsbanken Fonder AB39,100$885K<0.01%+8,90013F-HRTimeline
MERCER GLOBAL ADVISORS INC /ADV39,043$884K<0.01%+18,10213F-HRTimeline
Point72 Hong Kong Ltd37,941$859K0.04%new13F-HRTimeline
NOMURA HOLDINGS INCin group NOMURA ASSET MANAGEMENT CO LTD36,600$828K<0.01%new13F-HRTimelineGroup
Creative Planningin group Creative Planning35,645$807K<0.01%+13,80713F-HRTimelineGroup
Vident Advisory, LLCin group Vident Advisory, LLC35,381$801K0.01%new13F-HRTimelineGroup
PROFUND ADVISORS LLC34,712$786K0.03%+6,03613F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson34,412$779K<0.01%013F-HRTimelineGroup
Scientech Research LLC34,182$774K0.27%new13F-HRTimeline
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC33,834$766K0.01%-4,61913F-HRTimelineGroup
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O…33,679$762K<0.01%+20913F-HRTimeline
Pallas Capital Advisors LLC33,077$749K0.03%-21,77213F-HRTimeline
Voleon Capital Management LP32,221$729K0.02%-10,91813F-HRTimeline
GSA CAPITAL PARTNERS LLP31,446$712K0.06%new13F-HRTimeline
FOX RUN MANAGEMENT, L.L.C.27,223$616K0.1%+13,25613F-HRTimeline
Bayesian Capital Management, LP25,500$577K0.12%new13F-HRTimeline
VIRGINIA RETIREMENT SYSTEMS ET Al25,465$576K<0.01%-2,20013F-HRTimeline
Erste Asset Management GmbHin group Erste Asset Management GmbH25,300$573K0.01%-16,70013F-HRTimelineGroup
HAP Trading, LLC24,763$560K0.15%13F-HRTimeline
Entropy Technologies, LP24,603$557K0.04%new13F-HRTimeline
Graham Capital Management, L.P.23,196$525K0.02%-19,89513F-HRTimeline
AlphaQuest LLC23,099$523K0.03%+1,85913F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…23,073$522K0.15%013F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …22,709$514K<0.01%+73613F-HRTimelineGroup
ARIZONA STATE RETIREMENT SYSTEM22,298$505K<0.01%+31513F-HRTimeline
PharVision Advisers, LLC22,291$504K0.28%new13F-HRTimeline
China Universal Asset Management Co., L…22,137$501K0.04%-3,10613F-HRTimeline
CAPSTONE INVESTMENT ADVISORS, LLCin group CAPSTONE INVESTMENT ADVISORS,…21,371$484K<0.01%+9,67113F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…21,317$482K<0.01%+2,18913F-HRTimeline
CAPTRUST FINANCIAL ADVISORS21,111$478K<0.01%-8,42113F-HRTimeline
Bayforest Capital Ltd20,853$472K0.22%-35,78613F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC20,000$453K0.04%+3,00013F-HRTimelineGroup
Merit Financial Group, LLC19,544$442K<0.01%-1,55213F-HR/ATimeline
BRIGHTON JONES LLC19,214$435K0.01%+2,67513F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP18,690$423K<0.01%new13F-HRTimelineGroup
TEACHER RETIREMENT SYSTEM OF TEXAS18,512$419K<0.01%-1,77513F-HRTimeline
FMR LLCin group FMR LLC18,503$419K<0.01%-78913F-HRTimelineGroup
Corton Capital Inc.18,427$417K1.03%-2,58413F-HRTimeline
Concentric Capital Strategies, LP17,979$407K0.02%new13F-HRTimeline
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co17,747$402K<0.01%+11,55813F-HRTimelineGroup
Essential Partners LLC17,759$402K0.13%-6,14313F-HRTimeline
XPONANCE LLC17,483$396K<0.01%-87513F-HRTimeline
SummitTX Capital, L.P.17,232$390K0.02%new13F-HRTimeline
Duncan Williams Asset Management, LLC17,005$385K0.11%013F-HRTimeline
Allianz Asset Management GmbHin group Allianz SE17,000$385K<0.01%new13F-HRTimelineGroup
Ensign Peak Advisors, Inc16,547$374K<0.01%-12,85013F-HR/ATimeline
Quarry LP16,022$363K0.09%+11,02213F-HRTimeline
KLP KAPITALFORVALTNING AS15,600$353K<0.01%013F-HRTimeline
SHERBROOKE PARK ADVISERS LLC15,590$353K0.16%-34913F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC15,272$346K<0.01%-30313F-HRTimeline
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC15,025$345K<0.01%-42,87313F-HRTimelineGroup
GROUP ONE TRADING LLC14,925$338K0.01%-1,85313F-HRTimeline
Point72 (DIFC) Ltd14,591$330K0.02%new13F-HRTimeline
WOLVERINE TRADING, LLC14,480$328K0.01%-1,71813F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd14,407$326K0.02%new13F-HRTimelineGroup
Aigen Investment Management, LP14,181$321K0.05%new13F-HRTimeline
Birchview Capital, LP14,000$317K0.24%013F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding13,491$305K-32,348Timeline
Empowered Funds, LLC13,341$302K<0.01%-14613F-HRTimeline
M&T Bank Corpin group M&T Bank Corp13,025$296K<0.01%new13F-HRTimelineGroup
Wedmont Private Capital11,415$288K0.01%new13F-HRTimeline
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC12,453$280K<0.01%+2,37113F-HRTimelineGroup
Compagnie Lombard Odier SCmA11,000$249K<0.01%013F-HRTimeline
CAXTON ASSOCIATES LLP10,969$248K0.01%new13F-HRTimeline
Summit Trail Advisors, LLC10,276$233K<0.01%new13F-HRTimeline
Integrated Wealth Concepts LLC10,190$231K<0.01%-2,39313F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…9,901$224K<0.01%-2413F-HRTimelineGroup
LECAP ASSET MANAGEMENT LTD9,868$223K0.08%new13F-HRTimeline
Financiere des Professionnels - Fonds d…9,439$214K0.01%new13F-HRTimeline
KEYBANK NATIONAL ASSOCIATION/OHin group KEYBANK NATIONAL ASSOCIATION/…9,084$206K<0.01%new13F-HRTimelineGroup
TWINBEECH CAPITAL LP8,927$202K0.01%new13F-HRTimeline