BML Capital Management, LLC More: the full row for BML Capital Management, LLC 14,250,000 $35.3M 21.95% 0 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 9,627,304 $23.9M 0.04% new 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 8,888,888 $22M 2.47% new 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 6,204,309 $15.4M 0.59% +3,450,814 13F-HR Timeline RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 4,666,667 $11.6M 0.15% new 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 4,325,263 $10.7M <0.01% -360,235 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 3,293,625 $8.17M 0.01% -78,224 13F-HR Timeline Group JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 2,799,759 $6.99M <0.01% new 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 2,634,065 $6.53M 0.01% new 13F-HR Timeline Group SAMSARA BIOCAPITAL, LLC More: the full row for SAMSARA BIOCAPITAL, LLC 2,385,060 $5.91M 0.81% +1,688,889 13F-HR Timeline Decheng Capital LLC More: the full row for Decheng Capital LLC 2,266,667 $5.62M 1.21% new 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 2,222,222 $5.51M 0.64% new 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,959,047 $4.86M <0.01% -1,046,551 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 1,816,670 $4.51M -392,746 Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 1,744,147 $4.32M 0.01% -334,140 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,257,779 $3.12M <0.01% -454,018 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,071,784 $2.66M <0.01% +591,011 13F-HR/A Timeline Group Aldebaran Capital, LLC More: the full row for Aldebaran Capital, LLC 1,016,958 $2.52M 2.4% -26,194 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 923,313 $2.29M <0.01% 0 13F-HR/A Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 908,819 $2.25M 0.01% +576,413 13F-HR Timeline Monashee Investment Management LLC More: the full row for Monashee Investment Management LLC 888,888 $2.2M 0.3% new 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 850,519 $2.11M <0.01% -520,181 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 789,597 $1.96M <0.01% -56,849 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 718,897 $1.78M 0.02% new 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 663,405 $1.65M 1.33% -1,795,468 13F-HR Timeline Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 615,083 $1.53M <0.01% +322,238 13F-HR Timeline JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 576,042 $1.43M 0.01% -339,467 13F-HR Timeline Palo Alto Investors LP More: the full row for Palo Alto Investors LP 569,832 $1.41M 0.22% 0 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 545,564 $1.35M <0.01% +462,837 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 459,049 $1.14M <0.01% -86,923 13F-HR Timeline Group Aisling Capital Management LP More: the full row for Aisling Capital Management LP 434,455 $1.08M 0.38% 0 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 428,587 $1.06M <0.01% +127,031 13F-HR Timeline Group Peapod Lane Capital LLC More: the full row for Peapod Lane Capital LLC 404,452 $1M 0.99% 13F-HR Timeline Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 397,362 $985K <0.01% +211,585 13F-HR Timeline Exome Asset Management LLC More: the full row for Exome Asset Management LLC 389,333 $966K 0.73% new 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 350,000 $868K 0.25% new 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 319,275 $792K <0.01% +130,554 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 292,892 $726K <0.01% +152,312 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 281,119 $697K 0.02% +82,000 13F-HR Timeline HighTower Advisors, LLC More: the full row for HighTower Advisors, LLC 262,948 $652K <0.01% -42,866 13F-HR Timeline Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 256,092 $635K 0.01% +249,121 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 239,595 $594K <0.01% +162,785 13F-HR Timeline Group 683 Capital Management, LLC in group 683 Capital Management, LLC More: the full row for 683 Capital Management, LLC 217,265 $539K 0.05% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 205,465 $510K <0.01% +196,708 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 175,175 $434K <0.01% +47,950 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 154,351 $383K <0.01% 13F-HR/A Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 131,895 $327K <0.01% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 123,100 $306K <0.01% -16,300 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 112,484 $279K 0.01% new 13F-HR Timeline PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 106,351 $264K 0.02% new 13F-HR Timeline CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 100,000 $248K 0.01% new 13F-HR Timeline Group Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 93,547 $232K <0.01% +54,753 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 88,320 $219K <0.01% +79,844 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 79,047 $196K <0.01% +16,639 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 69,463 $172K <0.01% +37,611 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 59,972 $149K <0.01% +57,885 13F-HR Timeline Group Marquette Asset Management, LLC More: the full row for Marquette Asset Management, LLC 57,911 $144K 0.02% -26,068 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 57,760 $143K <0.01% new 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 55,347 $137K <0.01% -309,220 13F-HR Timeline Group OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 54,400 $135K <0.01% new 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 53,534 $133K <0.01% new 13F-HR Timeline Group Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 48,187 $120K 0.03% -3,865 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 44,685 $111K 0.01% new 13F-HR Timeline Group Cambridge Investment Research Advisors,… More: the full row for Cambridge Investment Research Advisors, Inc. 41,873 $104K <0.01% 0 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 40,700 $101K <0.01% +29,200 13F-HR/A Timeline Group Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 37,774 $93.7K <0.01% -10,327 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 33,079 $82K <0.01% new 13F-HR Timeline Group Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 27,000 $67K 0.06% new 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 24,460 $60.7K <0.01% 13F-HR Timeline Caption Management, LLC More: the full row for Caption Management, LLC 17,960 $44.5K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 17,919 $44.4K <0.01% -3,990 13F-HR Timeline Group Vontobel Holding Ltd. in group Vontobel Holding Ltd. More: the full row for Vontobel Holding Ltd. 16,000 $39.7K <0.01% -4,000 13F-HR Timeline Group Alpine Global Management, LLC More: the full row for Alpine Global Management, LLC 15,340 $38K 0.01% new 13F-HR/A Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 15,201 $37.7K <0.01% -5,192 13F-HR/A Timeline Group COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 14,694 $36K <0.01% new 13F-HR Timeline Marex Group Ltd in group Marex Group Ltd More: the full row for Marex Group Ltd 14,400 $35.7K <0.01% 0 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 14,172 $35.1K <0.01% new 13F-HR Timeline Catalyst Funds Management Pty Ltd More: the full row for Catalyst Funds Management Pty Ltd 14,000 $34.7K 0.01% 0 13F-HR Timeline NEUBERGER BERMAN GROUP LLC in group NEUBERGER BERMAN GROUP LLC More: the full row for NEUBERGER BERMAN GROUP LLC 12,656 $31.4K <0.01% 0 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 11,215 $27.8K <0.01% new 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 10,637 $26K <0.01% new 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 6,695 $16K <0.01% +5,610 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 4,590 $11.4K <0.01% 0 13F-HR Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 4,292 $10.6K <0.01% -9,506 13F-HR Timeline Group Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 3,708 $9.2K <0.01% +3,616 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 2,765 $6.86K <0.01% 0 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 2,682 $6.65K <0.01% +950 13F-HR/A Timeline Group MAI Capital Management More: the full row for MAI Capital Management 1,500 $3.72K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,446 $3.59K <0.01% -1,822 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 773 $2K <0.01% +715 13F-HR Timeline Group R Squared Ltd More: the full row for R Squared Ltd 610 $1.51K <0.01% 13F-HR Timeline NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 500 $1.24K <0.01% 0 13F-HR Timeline Group Capital Advisors, Ltd. LLC More: the full row for Capital Advisors, Ltd. LLC 454 $1K <0.01% 0 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 318 $789 <0.01% 0 13F-HR Timeline Truvestments Capital LLC More: the full row for Truvestments Capital LLC 150 $372 <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 99 $246 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 66 $164 <0.01% 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.