BML Capital Management, LLC More: the full row for BML Capital Management, LLC 14,250,000 $21.8M 17.65% 0 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 9,627,304 $14.7M 0.03% 0 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 8,888,888 $13.6M 1.8% 0 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 5,046,309 $7.72M 0.44% -1,158,000 13F-HR Timeline VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 4,970,254 $7.6M <0.01% +644,991 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 4,666,667 $7.14M 0.12% 0 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 4,134,148 $6.33M 0.01% +2,175,101 13F-HR Timeline Group Decheng Capital LLC More: the full row for Decheng Capital LLC 4,041,736 $6.18M 1.73% +1,775,069 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 2,944,512 $4.51M 0.01% -349,113 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 2,415,584 $3.7M <0.01% +1,343,800 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 2,312,926 $3.54M <0.01% -321,139 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 2,222,222 $3.4M 0.6% 0 13F-HR Timeline ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 2,195,191 $3.35M 0.01% +451,044 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 527,842 $2.77M 2.69% -135,563 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 1,678,664 $2.57M -138,006 Timeline Bollard Group LLC More: the full row for Bollard Group LLC 1,424,176 $2.18M 0.06% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 1,411,057 $2.16M +1,332,010 Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,361,037 $2.08M <0.01% +103,258 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 1,350,820 $2.07M <0.01% +735,737 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,182,737 $1.81M <0.01% +393,140 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,122,081 $1.72M <0.01% +1,066,734 13F-HR Timeline Group Aldebaran Capital, LLC More: the full row for Aldebaran Capital, LLC 1,007,958 $1.54M 1.46% -9,000 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 951,394 $1.46M <0.01% +100,875 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 923,313 $1.41M <0.01% 0 13F-HR Timeline Group Monashee Investment Management LLC More: the full row for Monashee Investment Management LLC 888,888 $1.36M 0.16% 0 13F-HR Timeline Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 865,011 $1.32M 0.01% -43,808 13F-HR Timeline Palo Alto Investors LP More: the full row for Palo Alto Investors LP 776,028 $1.19M 0.23% +206,196 13F-HR Timeline CANTOR FITZGERALD, L. P. in group CANTOR FITZGERALD, L. P. More: the full row for CANTOR FITZGERALD, L. P. 695,573 $1.06M 0.04% +595,573 13F-HR Timeline Group Assenagon Asset Management S.A. More: the full row for Assenagon Asset Management S.A. 681,553 $1.04M <0.01% +284,191 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 555,953 $851K <0.01% +127,366 13F-HR/A Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 498,721 $763K <0.01% +410,401 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 460,842 $705K <0.01% -115,200 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 458,184 $701K <0.01% -865 13F-HR Timeline Group Aisling Capital Management LP More: the full row for Aisling Capital Management LP 434,455 $665K 0.23% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 407,525 $624K <0.01% +88,250 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 390,282 $597K <0.01% -155,282 13F-HR/A Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 354,849 $543K <0.01% +115,254 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 348,917 $534K <0.01% +56,025 13F-HR/A Timeline Group HighTower Advisors, LLC More: the full row for HighTower Advisors, LLC 316,064 $484K <0.01% +53,116 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 311,712 $477K 0.01% -407,185 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 288,719 $442K 0.01% +7,600 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 269,086 $412K <0.01% +93,911 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 250,805 $384K <0.01% +96,454 13F-HR Timeline Group Man Group plc in group Man Group plc More: the full row for Man Group plc 197,748 $303K <0.01% +144,214 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 177,558 $272K 0.01% +163,386 13F-HR Timeline OMERS ADMINISTRATION Corp More: the full row for OMERS ADMINISTRATION Corp 175,900 $269K <0.01% +121,500 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 167,669 $257K <0.01% -37,796 13F-HR Timeline Group Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 150,900 $231K 0.08% -199,100 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 127,592 $195K <0.01% -4,303 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 123,100 $189K <0.01% 0 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 119,001 $182K <0.01% +103,800 13F-HR/A Timeline Group Cubist Systematic Strategies, LLC More: the full row for Cubist Systematic Strategies, LLC 86,348 $132K <0.01% -169,744 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 78,782 $121K <0.01% +21,022 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 73,992 $113K <0.01% +4,529 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 70,502 $108K <0.01% new 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 67,933 $104K <0.01% new 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 65,672 $100K <0.01% +41,212 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 59,865 $92K <0.01% +49,228 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 57,079 $87.3K <0.01% +45,864 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 53,478 $81.8K <0.01% -59,006 13F-HR Timeline Quantessence Capital LLC More: the full row for Quantessence Capital LLC 51,664 $79K 0.02% new 13F-HR Timeline LMR Partners LLP in group LMR Partners LLP More: the full row for LMR Partners LLP 48,360 $74K <0.01% new 13F-HR Timeline Group State of Wyoming More: the full row for State of Wyoming 46,861 $71.7K 0.01% new 13F-HR Timeline Point72 Asia (Singapore) Pte. Ltd. More: the full row for Point72 Asia (Singapore) Pte. Ltd. 45,659 $69.9K 0.02% -2,528 13F-HR Timeline Cambridge Investment Research Advisors,… More: the full row for Cambridge Investment Research Advisors, Inc. 41,873 $64K <0.01% 0 13F-HR Timeline OXFORD ASSET MANAGEMENT LLP More: the full row for OXFORD ASSET MANAGEMENT LLP 41,723 $63.8K 0.03% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 40,242 $61.6K <0.01% -53,305 13F-HR Timeline Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 40,200 $61.5K <0.01% -500 13F-HR Timeline Group ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 39,850 $61K <0.01% new 13F-HR/A Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 39,331 $59.8K <0.01% new 13F-HR Timeline Group Mariner, LLC in group Mariner, LLC More: the full row for Mariner, LLC 37,969 $58.1K <0.01% +195 13F-HR Timeline Group Cannon Global Investment Management, LLC More: the full row for Cannon Global Investment Management, LLC 37,400 $57.2K 0.16% new 13F-HR Timeline Verition Fund Management LLC More: the full row for Verition Fund Management LLC 35,805 $54.8K <0.01% new 13F-HR Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 35,000 $53.5K 0.06% +8,000 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 33,079 $50.6K <0.01% 0 13F-HR/A Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 30,516 $47K <0.01% new 13F-HR Timeline Diametric Capital, LP More: the full row for Diametric Capital, LP 30,137 $46.1K 0.05% new 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 25,189 $38.5K <0.01% new 13F-HR/A Timeline Group CAPSTONE INVESTMENT ADVISORS, LLC in group CAPSTONE INVESTMENT ADVISORS,… More: the full row for CAPSTONE INVESTMENT ADVISORS, LLC 23,564 $36.1K <0.01% new 13F-HR Timeline Group Vontobel Holding Ltd. in group Vontobel Holding Ltd. More: the full row for Vontobel Holding Ltd. 22,000 $33.7K <0.01% +6,000 13F-HR Timeline Group HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 17,286 $26K <0.01% new 13F-HR Timeline Catalyst Funds Management Pty Ltd More: the full row for Catalyst Funds Management Pty Ltd 16,698 $25.5K 0.01% +2,698 13F-HR Timeline Capula Management Ltd in group Capula Management Ltd More: the full row for Capula Management Ltd 15,593 $23.9K <0.01% new 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. Marex Group Ltd in group Marex Group Ltd More: the full row for Marex Group Ltd 14,400 $22K <0.01% 0 13F-HR Timeline Group COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 14,694 $22K <0.01% 0 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 13,573 $20.8K <0.01% new 13F-HR Timeline Group NEUBERGER BERMAN GROUP LLC in group NEUBERGER BERMAN GROUP LLC More: the full row for NEUBERGER BERMAN GROUP LLC 12,656 $19.4K <0.01% 0 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 12,200 $18.7K <0.01% new 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 11,791 $18K <0.01% -94,560 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 11,373 $17.4K <0.01% new 13F-HR Timeline Group VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 11,009 $16.8K <0.01% new 13F-HR Timeline MERCER GLOBAL ADVISORS INC /ADV More: the full row for MERCER GLOBAL ADVISORS INC /ADV 10,220 $15.6K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 7,479 $11.4K <0.01% +6,033 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 6,149 $9.41K <0.01% -53,823 13F-HR Timeline Group Point72 (DIFC) Ltd More: the full row for Point72 (DIFC) Ltd 6,132 $9.38K <0.01% +2,424 13F-HR Timeline WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 4,590 $7.02K <0.01% 0 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 3,413 $5.15K <0.01% -14,506 13F-HR Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 2,942 $4.5K <0.01% -1,350 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 2,094 $3.2K <0.01% -671 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 1,470 $2.25K <0.01% -1,212 13F-HR Timeline Group Capital Advisors, Ltd. LLC More: the full row for Capital Advisors, Ltd. LLC 454 $1K <0.01% 0 13F-HR Timeline NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO in group NORTHWESTERN MUTUAL INVESTMEN… More: the full row for NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 500 $765 <0.01% 0 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 318 $487 <0.01% 0 13F-HR Timeline Truvestments Capital LLC More: the full row for Truvestments Capital LLC 150 $230 <0.01% 0 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 99 $147 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 67 $103 <0.01% +1 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 46 $0 0% -727 13F-HR/A Timeline Group Value filed as zero, left out of ratios. CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.