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SAMSARA BIOCAPITAL, LLC

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13F filer, CIK 1744967, PALO ALTO, CA

SAMSARA BIOCAPITAL, LLC reported $969,256,994 across 21 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-17. Its ten largest share positions make up 91.64% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001744967-26-000002

Period
2025-12-31
Reported value
$969M
Holdings
21
Top 10 weight
91.64%
New
4
Sold out
10

Largest buys vs the previous quarter

SecurityShares changeApprox. value
SRRKadded+1,284,756$56.6M
IVAnew+5,194,805$24.2M
KLRSadded+1,500,000$12.7M
RANInew+8,500,000$11.5M
ALMSadded+955,614$9.33M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
LENZexited-343,012-$16M
MLYSreduced-392,133-$14.2M
PVLAreduced-104,817-$11M
AVADEL PHARMACEUTICALSexited-675,504-$10.3M
UPBreduced-226,107-$6.14M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR 0001744967-26-000002, largest first. % of portfolio is the value over $969,256,994, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
SRRKSCHOLAR ROCK HLDG CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,788,609 shares; 2024Q4: 5,612,896 shares; 2025Q1: 5,612,896 shares; 2025Q2: 5,612,896 shares; 2025Q3: 5,612,896 shares; 2025Q4: 6,897,652 shares 6,897,652$304M31.35%+1,284,756Timeline
MLYSMINERALYS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,074,916 shares; 2024Q4: 5,074,916 shares; 2025Q1: 5,674,916 shares; 2025Q2: 5,674,916 shares; 2025Q3: 6,263,151 shares; 2025Q4: 5,871,018 shares 5,871,018$213M21.98%-392,133Timeline
KLRSKALARIS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 11,448,081 shares; 2025Q2: 11,448,081 shares; 2025Q3: 11,448,081 shares; 2025Q4: 12,948,081 shares 12,948,081$109M11.27%+1,500,000Timeline
SEPNSEPTERNA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,768,520 shares; 2025Q1: 3,149,128 shares; 2025Q2: 3,149,128 shares; 2025Q3: 3,149,128 shares; 2025Q4: 3,149,128 shares 3,149,128$87.8M9.06%0Timeline
ALMSALUMIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,266,498 shares; 2024Q4: 3,266,498 shares; 2025Q1: 3,266,498 shares; 2025Q2: 4,801,370 shares; 2025Q3: 4,801,370 shares; 2025Q4: 5,756,984 shares 5,756,984$56.2M5.8%+955,614Timeline
NGNENEUROGENE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,267,790 shares; 2024Q4: 1,717,127 shares; 2025Q1: 1,717,127 shares; 2025Q2: 1,717,127 shares; 2025Q3: 1,717,127 shares; 2025Q4: 1,717,127 shares 1,717,127$35.4M3.65%0Timeline
IVAINVENTIVA SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 5,194,805 shares 5,194,805$24.2M2.49%newTimeline
GOSSGOSSAMER BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,130,268 shares; 2024Q4: 6,130,268 shares; 2025Q1: 6,130,268 shares; 2025Q2: 6,130,268 shares; 2025Q3: 6,130,268 shares; 2025Q4: 7,222,559 shares 7,222,559$22.4M2.31%+1,092,291Timeline
UPBUPSTREAM BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,217,146 shares; 2025Q1: 2,067,146 shares; 2025Q2: 1,443,231 shares; 2025Q3: 962,154 shares; 2025Q4: 736,047 shares 736,047$20M2.06%-226,107Timeline
AQSTAQUESTIVE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 2,500,000 shares; 2025Q4: 2,500,000 shares 2,500,000$16.1M1.67%0Timeline
JBIOJADE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 531,163 shares; 2025Q3: 531,163 shares; 2025Q4: 968,798 shares 968,798$14.9M1.54%+437,635Timeline
VTVTVTV THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 206,784 shares; 2024Q4: 206,784 shares; 2025Q1: 206,784 shares; 2025Q2: 206,784 shares; 2025Q3: 374,461 shares; 2025Q4: 298,496 shares 298,496$11.9M1.23%-75,965Timeline
RANIRANI THERAPEUTICS HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 8,500,000 shares 8,500,000$11.5M1.18%newTimeline
PVLAPALVELLA THERAPEUTICS INC NEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 679,486 shares; 2025Q1: 679,486 shares; 2025Q2: 339,743 shares; 2025Q3: 209,634 shares; 2025Q4: 104,817 shares 104,817$11M1.13%-104,817Timeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 850,000 shares; 2024Q4: 850,000 shares; 2025Q1: 425,000 shares; 2025Q2: not reported; 2025Q3: 75,442 shares; 2025Q4: 75,442 shares 75,442$10.2M1.05%0Timeline
XFORX4 PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,960,000 shares 1,960,000$7.84M0.81%newTimeline
NKTXNKARTA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,768,035 shares; 2024Q4: 3,768,035 shares; 2025Q1: 3,768,035 shares; 2025Q2: 3,768,035 shares; 2025Q3: 3,768,035 shares; 2025Q4: 3,507,666 shares 3,507,666$6.49M0.67%-260,369Timeline
ACLXARCELLX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 353,641 shares; 2024Q4: 253,641 shares; 2025Q1: 135,276 shares; 2025Q2: 101,457 shares; 2025Q3: 81,165 shares; 2025Q4: 60,873 shares 60,873$3.97M0.41%-20,292Timeline
STROSUTRO BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 204,503 shares 204,503$2.37M0.24%newTimeline
CTNMCONTINEUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 588,816 shares; 2024Q4: 588,816 shares; 2025Q1: 588,816 shares; 2025Q2: 588,816 shares; 2025Q3: 571,142 shares; 2025Q4: 72,245 shares 72,245$826K0.09%-498,897Timeline
NUVATION BIO INCNUVATION BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 133,333 shares; 2024Q4: 133,333 shares; 2025Q1: 133,333 shares; 2025Q2: 133,333 shares; 2025Q3: 133,333 shares; 2025Q4: 124,119 shares 124,119$41K<0.01%-9,214

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
LENZLENZ THERAPEUTICS INC343,012$16Mshares
AVADEL PHARMACEUTICALSAVADEL PHARMACEUTICALS675,504$10.3Mshares
AURAAURA BIOSCIENCES INC584,849$3.61Mshares
ZYMEZYMEWORKS INC207,901$3.55Mshares
SRZNSURROZEN INC241,400$3.11Mshares
RYTMRHYTHM PHARMACEUTICALS INC30,285$3.06Mshares
SUTRO BIOPHARMA INCSUTRO BIOPHARMA INC2,196,814$1.91Mshares
TERNTERNS PHARMACEUTICALS INC135,573$1.02Mshares
BOLTBOLT BIOTHERAPEUTICS INC48,830$260Kshares
SRZNWSURROZEN INC99,999$1.78Kshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001744967-26-000002 base2026-02-17acceptance time not in the bulk data set