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SAMSARA BIOCAPITAL, LLC

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13F filer, CIK 1744967, PALO ALTO, CA

SAMSARA BIOCAPITAL, LLC reported $488,945,395 across 29 holdings for the quarter ended 2025-06-30, in a 13F-HR filed 2025-08-14. Its ten largest share positions make up 88.2% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001415889-25-021908

Period
2025-06-30
Reported value
$489M
Holdings
29
Top 10 weight
88.2%
New
3
Sold out
11

Largest buys vs the previous quarter

SecurityShares changeApprox. value
AURAnew+1,000,000$6.26M
JBIOnew+531,163$5.31M
ALMSadded+1,534,872$4.6M
BOLTnew+52,456$303K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
PVLAreduced-339,743-$7.66M
UPBreduced-623,915-$6.85M
ACELYRIN INCexited-2,523,022-$6.23M
RYTMreduced-87,642-$5.54M
LENZreduced-183,378-$5.37M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q2 2025

Share positions as resolved from 13F-HR 0001415889-25-021908, largest first. % of portfolio is the value over $488,945,395, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
SRRKSCHOLAR ROCK HLDG CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,788,609 shares; 2024Q4: 5,612,896 shares; 2025Q1: 5,612,896 shares; 2025Q2: 5,612,896 shares 5,612,896$199M40.66%0Timeline
MLYSMINERALYS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,074,916 shares; 2024Q4: 5,074,916 shares; 2025Q1: 5,674,916 shares; 2025Q2: 5,674,916 shares 5,674,916$76.8M15.7%0Timeline
SEPNSEPTERNA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,768,520 shares; 2025Q1: 3,149,128 shares; 2025Q2: 3,149,128 shares 3,149,128$33.3M6.81%0Timeline
KLRSKALARIS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 11,448,081 shares; 2025Q2: 11,448,081 shares 11,448,081$30.6M6.25%0Timeline
NGNENEUROGENE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,267,790 shares; 2024Q4: 1,717,127 shares; 2025Q1: 1,717,127 shares; 2025Q2: 1,717,127 shares 1,717,127$25.7M5.25%0Timeline
CARGO THERAPEUTICS INC COMCARGO THERAPEUTICS INC COMQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,415,689 shares; 2024Q4: 4,415,689 shares; 2025Q1: 4,415,689 shares; 2025Q2: 4,415,689 shares 4,415,689$18.2M3.72%0
UPBUPSTREAM BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,217,146 shares; 2025Q1: 2,067,146 shares; 2025Q2: 1,443,231 shares 1,443,231$15.8M3.24%-623,915Timeline
ALMSALUMIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,266,498 shares; 2024Q4: 3,266,498 shares; 2025Q1: 3,266,498 shares; 2025Q2: 4,801,370 shares 4,801,370$14.4M2.95%+1,534,872Timeline
LENZLENZ THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,208,473 shares; 2024Q4: 986,981 shares; 2025Q1: 526,390 shares; 2025Q2: 343,012 shares 343,012$10.1M2.06%-183,378Timeline
PVLAPALVELLA THERAPEUTICS INC NEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 679,486 shares; 2025Q1: 679,486 shares; 2025Q2: 339,743 shares 339,743$7.66M1.57%-339,743Timeline
GOSSGOSSAMER BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,130,268 shares; 2024Q4: 6,130,268 shares; 2025Q1: 6,130,268 shares; 2025Q2: 6,130,268 shares 6,130,268$7.54M1.54%0Timeline
ACLXARCELLX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 353,641 shares; 2024Q4: 253,641 shares; 2025Q1: 135,276 shares; 2025Q2: 101,457 shares 101,457$6.68M1.37%-33,819Timeline
AURAAURA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,000,000 shares 1,000,000$6.26M1.28%newTimeline
NKTXNKARTA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,768,035 shares; 2024Q4: 3,768,035 shares; 2025Q1: 3,768,035 shares; 2025Q2: 3,768,035 shares 3,768,035$6.25M1.28%0Timeline
AVADEL PHARMACEUTICALSAVADEL PHARMACEUTICALSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 967,527 shares; 2024Q4: 967,527 shares; 2025Q1: 967,527 shares; 2025Q2: 675,504 shares 675,504$5.98M1.22%-292,023
JBIOJADE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 531,163 shares 531,163$5.31M1.09%newTimeline
ZYMEZYMEWORKS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,000,000 shares; 2024Q4: 1,000,000 shares; 2025Q1: 666,667 shares; 2025Q2: 310,300 shares 310,300$3.89M0.8%-356,367Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 172,647 shares; 2024Q4: 172,647 shares; 2025Q1: 138,118 shares; 2025Q2: 50,476 shares 50,476$3.19M0.65%-87,642Timeline
VTVTVTV THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 206,784 shares; 2024Q4: 206,784 shares; 2025Q1: 206,784 shares; 2025Q2: 206,784 shares 206,784$3.1M0.63%0Timeline
CTNMCONTINEUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 588,816 shares; 2024Q4: 588,816 shares; 2025Q1: 588,816 shares; 2025Q2: 588,816 shares 588,816$2.34M0.48%0Timeline
SRZNSURROZEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 241,400 shares; 2025Q2: 241,400 shares 241,400$2.16M0.44%0Timeline
SUTRO BIOPHARMA INCSUTRO BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,196,814 shares; 2024Q4: 2,196,814 shares; 2025Q1: 2,196,814 shares; 2025Q2: 2,196,814 shares 2,196,814$1.57M0.32%0
TNGXTANGO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 630,000 shares; 2024Q4: 630,000 shares; 2025Q1: 630,000 shares; 2025Q2: 210,000 shares 210,000$1.08M0.22%-420,000Timeline
HILLEVAX INCHILLEVAX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 799,274 shares; 2024Q4: 399,637 shares; 2025Q1: 399,637 shares; 2025Q2: 399,637 shares 399,637$795K0.16%0
TERNTERNS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 202,348 shares; 2024Q4: 202,348 shares; 2025Q1: 202,348 shares; 2025Q2: 202,348 shares 202,348$755K0.15%0Timeline
ARTVARTIVA BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 291,666 shares; 2024Q4: 291,666 shares; 2025Q1: 291,666 shares; 2025Q2: 291,666 shares 291,666$440K0.09%0Timeline
BOLTBOLT BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 52,456 shares 52,456$303K0.06%newTimeline
NUVATION BIO INCNUVATION BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 133,333 shares; 2024Q4: 133,333 shares; 2025Q1: 133,333 shares; 2025Q2: 133,333 shares 133,333$36K0.01%0
SRZNWSURROZEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q3: restricted; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 99,999 shares; 2024Q4: 99,999 shares; 2025Q1: 99,999 shares; 2025Q2: 99,999 shares 99,999$1.81K<0.01%0Timeline

Sold out in Q2 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
ACELYRIN INCACELYRIN INC2,523,022$6.23Mshares
OKURONKURE THERAPEUTICS INC824,155$3.54Mshares
ABVXABIVAX SA425,000$2.66Mshares
INOZYME PHARMA INCINOZYME PHARMA INC1,562,500$1.42Mshares
PRMEPRIME MEDICINE INC405,228$806Kshares
CYPHCYPHERPUNK TECHNOLOGIES INC2,442,352$745Kshares
BOLT BIOTHERAPEUTICS INCBOLT BIOTHERAPEUTICS INC1,049,153$420Kshares
CRISCURIS INC185,943$390Kshares
LYRA THERAPEUTICS INCLYRA THERAPEUTICS INC1,390,130$176Kshares
KRONOS BIO INCKRONOS BIO INC78,131$64.5Kshares
ALLAKOS INCALLAKOS INC172,089$39.2Kshares

How Q2 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001415889-25-021908 base2025-08-14acceptance time not in the bulk data set