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SAMSARA BIOCAPITAL, LLC

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13F filer, CIK 1744967, PALO ALTO, CA

SAMSARA BIOCAPITAL, LLC reported $1,029,103,106 across 22 holdings for the quarter ended 2026-03-31, in a 13F-HR filed 2026-05-15. Its ten largest share positions make up 91.97% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001744967-26-000005

Period
2026-03-31
Reported value
$1.03B
Holdings
22
Top 10 weight
91.97%
New
3
Sold out
2

Largest buys vs the previous quarter

SecurityShares changeApprox. value
SGPnew+2,109,953$54.7M
STROadded+858,369$21.4M
ALMSadded+588,235$13M
AGMBnew+600,000$6.29M
CHRSnew+3,428,571$5.79M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
PVLAreduced-66,385-$8.27M
ABVXreduced-18,861-$2.1M
CTNMexited-72,245-$826K
XFORreduced-127,434-$526K
NUVATION BIO INCexited-124,119-$41K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2026

Share positions as resolved from 13F-HR 0001744967-26-000005, largest first. % of portfolio is the value over $1,029,103,106, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
SRRKSCHOLAR ROCK HLDG CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 6,788,609 shares; 2024Q4: 5,612,896 shares; 2025Q1: 5,612,896 shares; 2025Q2: 5,612,896 shares; 2025Q3: 5,612,896 shares; 2025Q4: 6,897,652 shares; 2026Q1: 6,897,652 shares 6,897,652$339M32.95%0Timeline
MLYSMINERALYS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 5,074,916 shares; 2024Q4: 5,074,916 shares; 2025Q1: 5,674,916 shares; 2025Q2: 5,674,916 shares; 2025Q3: 6,263,151 shares; 2025Q4: 5,871,018 shares; 2026Q1: 5,871,018 shares 5,871,018$159M15.45%0Timeline
ALMSALUMIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 3,266,498 shares; 2024Q4: 3,266,498 shares; 2025Q1: 3,266,498 shares; 2025Q2: 4,801,370 shares; 2025Q3: 4,801,370 shares; 2025Q4: 5,756,984 shares; 2026Q1: 6,345,219 shares 6,345,219$140M13.58%+588,235Timeline
SEPNSEPTERNA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,768,520 shares; 2025Q1: 3,149,128 shares; 2025Q2: 3,149,128 shares; 2025Q3: 3,149,128 shares; 2025Q4: 3,149,128 shares; 2026Q1: 3,149,128 shares 3,149,128$75.7M7.35%0Timeline
KLRSKALARIS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 11,448,081 shares; 2025Q2: 11,448,081 shares; 2025Q3: 11,448,081 shares; 2025Q4: 12,948,081 shares; 2026Q1: 12,948,081 shares 12,948,081$74.7M7.26%0Timeline
SGPSPYGLASS PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 2,109,953 shares 2,109,953$54.7M5.31%newTimeline
NGNENEUROGENE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 1,267,790 shares; 2024Q4: 1,717,127 shares; 2025Q1: 1,717,127 shares; 2025Q2: 1,717,127 shares; 2025Q3: 1,717,127 shares; 2025Q4: 1,717,127 shares; 2026Q1: 1,717,127 shares 1,717,127$34.6M3.36%0Timeline
IVAINVENTIVA SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 5,194,805 shares; 2026Q1: 5,194,805 shares 5,194,805$28.8M2.8%0Timeline
STROSUTRO BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 204,503 shares; 2026Q1: 1,062,872 shares 1,062,872$26.5M2.57%+858,369Timeline
JBIOJADE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 531,163 shares; 2025Q3: 531,163 shares; 2025Q4: 968,798 shares; 2026Q1: 968,798 shares 968,798$13.6M1.32%0Timeline
VTVTVTV THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 206,784 shares; 2024Q4: 206,784 shares; 2025Q1: 206,784 shares; 2025Q2: 206,784 shares; 2025Q3: 374,461 shares; 2025Q4: 298,496 shares; 2026Q1: 298,496 shares 298,496$11.8M1.15%0Timeline
AQSTAQUESTIVE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 2,500,000 shares; 2025Q4: 2,500,000 shares; 2026Q1: 2,500,000 shares 2,500,000$10.4M1.01%0Timeline
XFORX4 PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,960,000 shares; 2026Q1: 1,832,566 shares 1,832,566$7.57M0.74%-127,434Timeline
NKTXNKARTA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 3,768,035 shares; 2024Q4: 3,768,035 shares; 2025Q1: 3,768,035 shares; 2025Q2: 3,768,035 shares; 2025Q3: 3,768,035 shares; 2025Q4: 3,507,666 shares; 2026Q1: 3,507,666 shares 3,507,666$7.4M0.72%0Timeline
ACLXARCELLX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 353,641 shares; 2024Q4: 253,641 shares; 2025Q1: 135,276 shares; 2025Q2: 101,457 shares; 2025Q3: 81,165 shares; 2025Q4: 60,873 shares; 2026Q1: 60,873 shares 60,873$6.99M0.68%0Timeline
UPBUPSTREAM BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,217,146 shares; 2025Q1: 2,067,146 shares; 2025Q2: 1,443,231 shares; 2025Q3: 962,154 shares; 2025Q4: 736,047 shares; 2026Q1: 736,047 shares 736,047$6.62M0.64%0Timeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 850,000 shares; 2024Q4: 850,000 shares; 2025Q1: 425,000 shares; 2025Q2: not reported; 2025Q3: 75,442 shares; 2025Q4: 75,442 shares; 2026Q1: 56,581 shares 56,581$6.3M0.61%-18,861Timeline
AGMBAGOMAB THERAPEUTICS NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 600,000 shares 600,000$6.29M0.61%newTimeline
RANIRANI THERAPEUTICS HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 8,500,000 shares; 2026Q1: 8,500,000 shares 8,500,000$6.25M0.61%0Timeline
CHRSCOHERUS ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 3,428,571 shares 3,428,571$5.79M0.56%newTimeline
PVLAPALVELLA THERAPEUTICS INC NEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 679,486 shares; 2025Q1: 679,486 shares; 2025Q2: 339,743 shares; 2025Q3: 209,634 shares; 2025Q4: 104,817 shares; 2026Q1: 38,432 shares 38,432$4.79M0.47%-66,385Timeline
GOSSGOSSAMER BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 6,130,268 shares; 2024Q4: 6,130,268 shares; 2025Q1: 6,130,268 shares; 2025Q2: 6,130,268 shares; 2025Q3: 6,130,268 shares; 2025Q4: 7,222,559 shares; 2026Q1: 7,222,559 shares 7,222,559$2.37M0.23%0Timeline

Sold out in Q1 2026

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
CTNMCONTINEUM THERAPEUTICS INC72,245$826Kshares
NUVATION BIO INCNUVATION BIO INC124,119$41Kshares

How Q1 2026 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001744967-26-000005 base2026-05-15acceptance time not in the bulk data set