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SAMSARA BIOCAPITAL, LLC

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13F filer, CIK 1744967, PALO ALTO, CA

SAMSARA BIOCAPITAL, LLC reported $765,928,969 across 27 holdings for the quarter ended 2025-09-30, in a 13F-HR filed 2025-11-14. Its ten largest share positions make up 89.44% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001744967-25-000004

Period
2025-09-30
Reported value
$766M
Holdings
27
Top 10 weight
89.44%
New
2
Sold out
4

Largest buys vs the previous quarter

SecurityShares changeApprox. value
MLYSadded+588,235$22.3M
AQSTnew+2,500,000$14M
ABVXnew+75,442$6.41M
VTVTadded+167,677$3.92M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
CARGO THERAPEUTICS INC COMexited-4,415,689-$18.2M
UPBreduced-481,077-$9.05M
PVLAreduced-130,109-$8.16M
AURAreduced-415,151-$2.57M
RYTMreduced-20,191-$2.04M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q3 2025

Share positions as resolved from 13F-HR 0001744967-25-000004, largest first. % of portfolio is the value over $765,928,969, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
MLYSMINERALYS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,074,916 shares; 2024Q4: 5,074,916 shares; 2025Q1: 5,674,916 shares; 2025Q2: 5,674,916 shares; 2025Q3: 6,263,151 shares 6,263,151$237M31.01%+588,235Timeline
SRRKSCHOLAR ROCK HLDG CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,788,609 shares; 2024Q4: 5,612,896 shares; 2025Q1: 5,612,896 shares; 2025Q2: 5,612,896 shares; 2025Q3: 5,612,896 shares 5,612,896$209M27.29%0Timeline
KLRSKALARIS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 11,448,081 shares; 2025Q2: 11,448,081 shares; 2025Q3: 11,448,081 shares 11,448,081$66.2M8.64%0Timeline
SEPNSEPTERNA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,768,520 shares; 2025Q1: 3,149,128 shares; 2025Q2: 3,149,128 shares; 2025Q3: 3,149,128 shares 3,149,128$59.2M7.73%0Timeline
NGNENEUROGENE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,267,790 shares; 2024Q4: 1,717,127 shares; 2025Q1: 1,717,127 shares; 2025Q2: 1,717,127 shares; 2025Q3: 1,717,127 shares 1,717,127$29.8M3.89%0Timeline
ALMSALUMIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,266,498 shares; 2024Q4: 3,266,498 shares; 2025Q1: 3,266,498 shares; 2025Q2: 4,801,370 shares; 2025Q3: 4,801,370 shares 4,801,370$19.2M2.5%0Timeline
UPBUPSTREAM BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,217,146 shares; 2025Q1: 2,067,146 shares; 2025Q2: 1,443,231 shares; 2025Q3: 962,154 shares 962,154$18.1M2.36%-481,077Timeline
GOSSGOSSAMER BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 6,130,268 shares; 2024Q4: 6,130,268 shares; 2025Q1: 6,130,268 shares; 2025Q2: 6,130,268 shares; 2025Q3: 6,130,268 shares 6,130,268$16.1M2.1%0Timeline
LENZLENZ THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,208,473 shares; 2024Q4: 986,981 shares; 2025Q1: 526,390 shares; 2025Q2: 343,012 shares; 2025Q3: 343,012 shares 343,012$16M2.09%0Timeline
AQSTAQUESTIVE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 2,500,000 shares 2,500,000$14M1.82%newTimeline
PVLAPALVELLA THERAPEUTICS INC NEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 679,486 shares; 2025Q1: 679,486 shares; 2025Q2: 339,743 shares; 2025Q3: 209,634 shares 209,634$13.1M1.72%-130,109Timeline
AVADEL PHARMACEUTICALSAVADEL PHARMACEUTICALSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 967,527 shares; 2024Q4: 967,527 shares; 2025Q1: 967,527 shares; 2025Q2: 675,504 shares; 2025Q3: 675,504 shares 675,504$10.3M1.35%0
VTVTVTV THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 206,784 shares; 2024Q4: 206,784 shares; 2025Q1: 206,784 shares; 2025Q2: 206,784 shares; 2025Q3: 374,461 shares 374,461$8.74M1.14%+167,677Timeline
NKTXNKARTA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,768,035 shares; 2024Q4: 3,768,035 shares; 2025Q1: 3,768,035 shares; 2025Q2: 3,768,035 shares; 2025Q3: 3,768,035 shares 3,768,035$7.8M1.02%0Timeline
CTNMCONTINEUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 588,816 shares; 2024Q4: 588,816 shares; 2025Q1: 588,816 shares; 2025Q2: 588,816 shares; 2025Q3: 571,142 shares 571,142$6.71M0.88%-17,674Timeline
ACLXARCELLX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 353,641 shares; 2024Q4: 253,641 shares; 2025Q1: 135,276 shares; 2025Q2: 101,457 shares; 2025Q3: 81,165 shares 81,165$6.66M0.87%-20,292Timeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 850,000 shares; 2024Q4: 850,000 shares; 2025Q1: 425,000 shares; 2025Q2: not reported; 2025Q3: 75,442 shares 75,442$6.41M0.84%newTimeline
JBIOJADE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 531,163 shares; 2025Q3: 531,163 shares 531,163$4.58M0.6%0Timeline
AURAAURA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,000,000 shares; 2025Q3: 584,849 shares 584,849$3.61M0.47%-415,151Timeline
ZYMEZYMEWORKS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,000,000 shares; 2024Q4: 1,000,000 shares; 2025Q1: 666,667 shares; 2025Q2: 310,300 shares; 2025Q3: 207,901 shares 207,901$3.55M0.46%-102,399Timeline
SRZNSURROZEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 241,400 shares; 2025Q2: 241,400 shares; 2025Q3: 241,400 shares 241,400$3.11M0.41%0Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 172,647 shares; 2024Q4: 172,647 shares; 2025Q1: 138,118 shares; 2025Q2: 50,476 shares; 2025Q3: 30,285 shares 30,285$3.06M0.4%-20,191Timeline
SUTRO BIOPHARMA INCSUTRO BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,196,814 shares; 2024Q4: 2,196,814 shares; 2025Q1: 2,196,814 shares; 2025Q2: 2,196,814 shares; 2025Q3: 2,196,814 shares 2,196,814$1.91M0.25%0
TERNTERNS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 202,348 shares; 2024Q4: 202,348 shares; 2025Q1: 202,348 shares; 2025Q2: 202,348 shares; 2025Q3: 135,573 shares 135,573$1.02M0.13%-66,775Timeline
BOLTBOLT BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 52,456 shares; 2025Q3: 48,830 shares 48,830$260K0.03%-3,626Timeline
NUVATION BIO INCNUVATION BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 133,333 shares; 2024Q4: 133,333 shares; 2025Q1: 133,333 shares; 2025Q2: 133,333 shares; 2025Q3: 133,333 shares 133,333$26.9K<0.01%0
SRZNWSURROZEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 99,999 shares; 2024Q4: 99,999 shares; 2025Q1: 99,999 shares; 2025Q2: 99,999 shares; 2025Q3: 99,999 shares 99,999$1.78K<0.01%0Timeline

Sold out in Q3 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
CARGO THERAPEUTICS INC COMCARGO THERAPEUTICS INC COM4,415,689$18.2Mshares
TNGXTANGO THERAPEUTICS INC210,000$1.08Mshares
HILLEVAX INCHILLEVAX INC399,637$795Kshares
ARTVARTIVA BIOTHERAPEUTICS INC291,666$440Kshares

How Q3 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001744967-25-000004 base2025-11-14acceptance time not in the bulk data set