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Exome Asset Management LLC

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13F filer, CIK 2011932, NEW YORK, NY

Exome Asset Management LLC reported $193,345,271 across 56 holdings for the quarter ended 2026-03-31, in a 13F-HR filed 2026-05-15. Its ten largest share positions make up 46.47% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001420506-26-001033

Period
2026-03-31
Reported value
$193M
Holdings
56
Top 10 weight
46.47%
New
23
Sold out
27

Largest buys vs the previous quarter

SecurityShares changeApprox. value
INSMnew+26,651$4.36M
MLTXnew+215,376$4.01M
RYTMnew+40,581$3.53M
BSXnew+48,347$3.03M
ALKSnew+84,103$2.97M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
WVEexited-421,488-$7.17M
AZNexited-28,362-$5.26M
JAZZexited-26,494-$4.5M
PRAXreduced-12,653-$4.08M
IMVTexited-158,622-$4.03M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q1 2026

Share positions as resolved from 13F-HR 0001420506-26-001033, largest first. % of portfolio is the value over $169,946,058, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
PRAXPRAXIS PRECISION MEDICINES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 59,002 shares; 2025Q3: 101,996 shares; 2025Q4: 58,122 shares; 2026Q1: 45,469 shares 45,469$14.6M8.62%-12,653Timeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 621,678 shares; 2025Q2: 533,647 shares; 2025Q3: 443,547 shares; 2025Q4: 305,568 shares; 2026Q1: 278,533 shares 278,533$10.7M6.31%-27,035Timeline
ELVNENLIVEN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 222,308 shares; 2026Q1: 220,091 shares 220,091$8.63M5.08%-2,217Timeline
IONSIONIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 61,367 shares; 2025Q1: 135,616 shares; 2025Q2: 121,116 shares; 2025Q3: 131,016 shares; 2025Q4: 116,515 shares; 2026Q1: 110,064 shares 110,064$8.26M4.86%-6,451Timeline
GHGUARDANT HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 89,800 shares; 2024Q4: 147,800 shares; 2025Q1: 127,182 shares; 2025Q2: 98,182 shares; 2025Q3: 98,182 shares; 2025Q4: 98,182 shares; 2026Q1: 82,736 shares 82,736$7.64M4.5%-15,446Timeline
CYTKCYTOKINETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 58,583 shares; 2024Q4: 65,883 shares; 2025Q1: 103,483 shares; 2025Q2: 115,817 shares; 2025Q3: 142,417 shares; 2025Q4: 124,749 shares; 2026Q1: 103,718 shares 103,718$6.84M4.02%-21,031Timeline
LLYELI LILLY & COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 10,447 shares; 2024Q4: 8,247 shares; 2025Q1: 4,673 shares; 2025Q2: 4,673 shares; 2025Q3: 7,852 shares; 2025Q4: 7,852 shares; 2026Q1: 7,012 shares 7,012$6.45M3.79%-840Timeline
ALMSALUMIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 292,770 shares; 2025Q4: 292,250 shares; 2026Q1: 279,176 shares 279,176$6.15M3.62%-13,074Timeline
BBIOBRIDGEBIO PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 211,000 shares; 2024Q4: 246,700 shares; 2025Q1: 165,496 shares; 2025Q2: 155,533 shares; 2025Q3: 133,087 shares; 2025Q4: 80,723 shares; 2026Q1: 67,492 shares 67,492$5.01M2.95%-13,231Timeline
VERAVERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 76,700 shares; 2025Q3: 156,072 shares; 2025Q4: 124,391 shares; 2026Q1: 114,991 shares 114,991$4.63M2.72%-9,400Timeline
INSMINSMED INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 33,600 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 26,651 shares 26,651$4.36M2.56%newTimeline
ELVELEVANCE HEALTH INC FORMERLYQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 17,191 shares; 2026Q1: 14,677 shares 14,677$4.3M2.53%-2,514Timeline
AGIOAGIOS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 66,200 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 136,942 shares; 2026Q1: 125,060 shares 125,060$4.23M2.49%-11,882Timeline
UTHRUNITED THERAPEUTICS CORP DELQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 6,645 shares; 2025Q4: 7,685 shares; 2026Q1: 7,053 shares 7,053$4.18M2.46%-632Timeline
MLTXMOONLAKE IMMUNOTHERAPEUTICSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 178,084 shares; 2025Q4: not reported; 2026Q1: 215,376 shares 215,376$4.01M2.36%newTimeline
NTRANATERA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 22,450 shares; 2024Q4: 22,450 shares; 2025Q1: 18,650 shares; 2025Q2: 18,650 shares; 2025Q3: 18,650 shares; 2025Q4: 18,650 shares; 2026Q1: 18,650 shares 18,650$3.73M2.19%0Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 40,581 shares 40,581$3.53M2.08%newTimeline
UNHUNITEDHEALTH GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 5,835 shares; 2026Q1: 12,862 shares 12,862$3.48M2.05%+7,027Timeline
APLSAPELLIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 100,367 shares; 2024Q4: 119,467 shares; 2025Q1: not reported; 2025Q2: 98,600 shares; 2025Q3: not reported; 2025Q4: 135,849 shares; 2026Q1: 85,517 shares 85,517$3.44M2.02%-50,332Timeline
VSTMVERASTEM INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 599,900 shares; 2025Q3: not reported; 2025Q4: 401,743 shares; 2026Q1: 636,700 shares 636,700$3.37M1.99%+234,957Timeline
TXG10X GENOMICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 163,658 shares; 2025Q3: 163,658 shares; 2025Q4: 163,658 shares; 2026Q1: 154,194 shares 154,194$3.27M1.93%-9,464Timeline
BSXBOSTON SCIENTIFIC CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 40,500 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 48,347 shares 48,347$3.03M1.79%newTimeline
ALKSALKERMES PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 84,103 shares 84,103$2.97M1.75%newTimeline
GLUEMONTE ROSA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 179,484 shares 179,484$2.95M1.74%newTimeline
ISRGINTUITIVE SURGICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 7,427 shares; 2024Q4: 7,427 shares; 2025Q1: 6,358 shares; 2025Q2: 6,358 shares; 2025Q3: 6,358 shares; 2025Q4: 6,358 shares; 2026Q1: 6,358 shares 6,358$2.93M1.72%0Timeline
ADAGADAGENE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 262,625 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,060,221 shares; 2026Q1: 736,845 shares 736,845$2.89M1.7%-323,376Timeline
ARWRARROWHEAD PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 104,507 shares; 2025Q4: 49,758 shares; 2026Q1: 45,721 shares 45,721$2.87M1.69%-4,037Timeline
CBIOCRESCENT BIOPHARMA INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 153,191 shares 153,191$2.81M1.66%newTimeline
RLAYRELAY THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 414,629 shares; 2024Q4: 1,083,487 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 278,302 shares 278,302$2.77M1.63%newTimeline
MAZEMAZE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 88,510 shares 88,510$2.64M1.55%newTimeline
CTMXCYTOMX THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 745,305 shares; 2025Q4: 745,305 shares; 2026Q1: 521,468 shares 521,468$2.45M1.44%-223,837Timeline
AVTXAVALO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 100,036 shares; 2025Q4: not reported; 2026Q1: 159,341 shares 159,341$2.38M1.4%newTimeline
GKOSGLAUKOS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 25,857 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 27,143 shares; 2025Q4: 31,471 shares; 2026Q1: 20,874 shares 20,874$2.25M1.32%-10,597Timeline
CRBPCORBUS PHARMACEUTICALS HLDGSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 289,690 shares; 2025Q2: 277,317 shares; 2025Q3: 229,962 shares; 2025Q4: 139,543 shares; 2026Q1: 234,136 shares 234,136$2.2M1.29%+94,593Timeline
PENPENUMBRA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 9,000 shares; 2025Q1: 9,000 shares; 2025Q2: 9,000 shares; 2025Q3: 9,000 shares; 2025Q4: 9,000 shares; 2026Q1: 6,300 shares 6,300$2.07M1.22%-2,700Timeline
SLNOSOLENO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 77,285 shares; 2025Q1: 43,441 shares; 2025Q2: 41,641 shares; 2025Q3: 48,445 shares; 2025Q4: not reported; 2026Q1: 61,673 shares 61,673$2.06M1.21%newTimeline
LQDALIQUIDIA CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 20,500 shares; 2025Q3: 94,235 shares; 2025Q4: 91,148 shares; 2026Q1: 45,796 shares 45,796$1.73M1.02%-45,352Timeline
ZBIOZENAS BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 80,730 shares 80,730$1.58M0.93%newTimeline
NBPNOVABRIDGE BIOSCIENCESQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,439,604 shares; 2025Q4: 499,587 shares; 2026Q1: 576,960 shares 576,960$1.42M0.84%+77,373Timeline
FDMT4D MOLECULAR THERAPEUTICS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 130,564 shares 130,564$1.22M0.72%newTimeline
NXTCNEXTCURE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 165,000 shares; 2026Q1: 115,500 shares 115,500$1.22M0.71%-49,500Timeline
PALIPALISADE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 758,203 shares; 2026Q1: 600,000 shares 600,000$1.05M0.62%-158,203Timeline
ESTAESTABLISHMENT LABS HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: 21,700 shares; 2024Q4: 13,100 shares; 2025Q1: 13,100 shares; 2025Q2: 13,100 shares; 2025Q3: 13,100 shares; 2025Q4: 13,100 shares; 2026Q1: 13,100 shares 13,100$744K0.44%0Timeline
LPCNLIPOCINE INC NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 60,861 shares 60,861$486K0.29%newTimeline
ABUSARBUTUS BIOPHARMA CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 28,300 shares; 2025Q1: not reported; 2025Q2: 75,484 shares; 2025Q3: 75,484 shares; 2025Q4: 75,484 shares; 2026Q1: 75,484 shares 75,484$340K0.2%0Timeline

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
XBISPDR SERIES TRUST S&P BIOTECHput60,000$7.66Mnew
CYTOKINETICS INCCYTOKINETICS INC PUTput60,000$3.95Mnew
BEONE MEDICINES LTDBEONE MEDICINES LTD SPONSORED ADScall10,000$2.97Mnew
ALUMIS INCALUMIS INC COMput105,000$2.31M+51,800
LIQUIDIA CORPORATIONLIQUIDIA CORPORATION PUTput40,000$1.51Mnew
CENTESSA PHARMACEUTICALS PLCCENTESSA PHARMACEUTICALS PLC PUTput34,700$1.38Mnew
IDEAYA BIOSCIENCES INCIDEAYA BIOSCIENCES INC COMput40,000$1.33Mnew
IDEAYA BIOSCIENCES INCIDEAYA BIOSCIENCES INC COMcall40,000$1.33Mnew
TRAVERE THERAPEUTICS INCTRAVERE THERAPEUTICS INC PUTput20,000$594K-54,700
WAVE LIFE SCIENCES LTDWAVE LIFE SCIENCES LTD PUTput30,000$218Knew
COMPASS THERAPEUTICS INCCOMPASS THERAPEUTICS INC COMcall25,100$133Knew

Sold out in Q1 2026

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
WVEWAVE LIFE SCIENCES LTD421,488$7.17Mshares
AZNASTRAZENECA PLC-SPONS ADR28,362$5.26Mshares
JAZZJAZZ PHARMACEUTICALS PLC26,494$4.5Mshares
IMVTIMMUNOVANT INC158,622$4.03Mshares
UHSUNIVERSAL HLTH SVCS INC17,628$3.84Mshares
IRONDISC MEDICINE INC46,743$3.71Mshares
CELCCELCUITY INC34,289$3.42Mshares
TVTXTRAVERE THERAPEUTICS INC89,052$3.4Mshares
DXCMDEXCOM INC50,147$3.33Mshares
IMCRIMMUNOCORE HLDGS PLC76,750$2.66Mshares
EWTXEDGEWISE THERAPEUTICS INC100,046$2.48Mshares
BLTEBELITE BIO INC14,328$2.29Mshares
WAYWAYSTAR HLDG CORP68,969$2.26Mshares
IRWDIRONWOOD PHARMACEUTICALS INC648,532$2.19Mshares
KPTIKARYOPHARM THERAPEUTICS INC295,541$2.18Mshares
UPBUPSTREAM BIO INC64,845$1.76Mshares
GOSSGOSSAMER BIO INC451,699$1.4Mshares
DISC MEDICINE INCDISC MEDICINE INC16,000$1.27Mput
IKTINHIBIKASE THERAPEUTICS INC600,000$1.23Mshares
IQVIQVIA HLDGS INC5,378$1.21Mshares
THCTENET HEALTHCARE CORP6,084$1.21Mshares
FULCFULCRUM THERAPEUTICS INC92,055$1.04Mshares
ULTRAGENYX PHARMACEUTICAL INULTRAGENYX PHARMACEUTICAL IN35,200$810Kcall
ALDEYRA THERAPEUTICS INCALDEYRA THERAPEUTICS INC100,000$518Kcall
RAPTRAPT THERAPEUTICS INC14,194$481Kshares
PRECIGEN INCPRECIGEN INC100,000$418Kput
SOLENO THERAPEUTICS INCSOLENO THERAPEUTICS INC7,100$328Kput

How Q1 2026 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001420506-26-001033 base2026-05-15acceptance time not in the bulk data set