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5AM Venture Management, LLC

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13F filer, CIK 1799883, SAN FRANCISCO, CA

5AM Venture Management, LLC reported $318,102,880 across 21 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-17. Its ten largest share positions make up 73.5% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001799883-26-000001

Period
2025-12-31
Reported value
$318M
Holdings
21
Top 10 weight
73.5%
New
1
Sold out
5

Largest buys vs the previous quarter

SecurityShares changeApprox. value
MPLTnew+950,011$16.7M
ZNTLadded+3,457,913$4.67M
TARAadded+569,782$3.04M
BHVNadded+260,000$2.94M
TYRAadded+90,000$2.37M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
DNTHexited-365,053-$14.4M
PRAXexited-170,000-$9.01M
ALECexited-995,841-$2.95M
CNTAreduced-100,000-$2.5M
ADVERUM BIOTECHNOLOGIES INCexited-541,666-$2.45M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR 0001799883-26-000001, largest first. % of portfolio is the value over $318,102,880, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
TRDAENTRADA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 4,408,379 shares; 2024Q4: 4,408,379 shares; 2025Q1: 4,408,379 shares; 2025Q2: 4,308,379 shares; 2025Q3: 4,256,379 shares; 2025Q4: 4,056,379 shares 4,056,379$41.7M13.11%-200,000Timeline
CAMPCAMP4 THERAPEUTICS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 2,927,915 shares; 2025Q1: 2,927,915 shares; 2025Q2: 2,927,915 shares; 2025Q3: 5,869,091 shares; 2025Q4: 5,869,091 shares 5,869,091$36M11.31%0Timeline
TYRATYRA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 939,298 shares; 2024Q4: 939,298 shares; 2025Q1: 939,298 shares; 2025Q2: 939,298 shares; 2025Q3: 939,298 shares; 2025Q4: 1,029,298 shares 1,029,298$27.1M8.51%+90,000Timeline
VRDNVIRIDIAN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 736,595 shares; 2024Q4: 736,595 shares; 2025Q1: 736,595 shares; 2025Q2: 736,595 shares; 2025Q3: 736,595 shares; 2025Q4: 736,595 shares 736,595$22.9M7.21%0Timeline
PHVSPHARVARIS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 797,600 shares; 2024Q4: 797,600 shares; 2025Q1: 797,600 shares; 2025Q2: 797,600 shares; 2025Q3: 797,600 shares; 2025Q4: 797,600 shares 797,600$22.1M6.96%0Timeline
ERASERASCA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,405,404 shares; 2024Q4: 5,405,404 shares; 2025Q1: 5,405,404 shares; 2025Q2: 5,405,404 shares; 2025Q3: 5,405,404 shares; 2025Q4: 5,405,404 shares 5,405,404$20.1M6.32%0Timeline
EYPTEYEPOINT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,050,000 shares; 2024Q4: 1,050,000 shares; 2025Q1: 1,050,000 shares; 2025Q2: 1,050,000 shares; 2025Q3: 1,050,000 shares; 2025Q4: 1,050,000 shares 1,050,000$19.2M6.03%0Timeline
MPLTMAPLIGHT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 950,011 shares 950,011$16.7M5.25%newTimeline
CNTACENTESSA PHARMACEUTICALS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,285,000 shares; 2024Q4: 830,945 shares; 2025Q1: 830,945 shares; 2025Q2: 830,945 shares; 2025Q3: 680,945 shares; 2025Q4: 580,945 shares 580,945$14.5M4.57%-100,000Timeline
CLDXCELLDEX THERAPEUTICS INC NEWQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 497,270 shares; 2024Q4: 497,270 shares; 2025Q1: 497,270 shares; 2025Q2: 497,270 shares; 2025Q3: 497,270 shares; 2025Q4: 497,270 shares 497,270$13.5M4.25%0Timeline
TECXTECTONIC THERAPEUTIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 646,524 shares; 2024Q4: 596,660 shares; 2025Q1: 511,660 shares; 2025Q2: 511,660 shares; 2025Q3: 511,660 shares; 2025Q4: 606,660 shares 606,660$12.7M3.98%+95,000Timeline
ELVNENLIVEN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,752,174 shares; 2024Q4: 1,629,765 shares; 2025Q1: 1,322,477 shares; 2025Q2: 772,477 shares; 2025Q3: 772,477 shares; 2025Q4: 772,477 shares 772,477$11.9M3.74%0Timeline
ARTVARTIVA BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,353,304 shares; 2024Q4: 2,353,304 shares; 2025Q1: 2,353,304 shares; 2025Q2: 2,353,304 shares; 2025Q3: 2,353,304 shares; 2025Q4: 2,353,304 shares 2,353,304$10.1M3.17%0Timeline
SRZNSURROZEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 310,000 shares; 2025Q2: 310,000 shares; 2025Q3: 310,000 shares; 2025Q4: 387,500 shares 387,500$8.76M2.75%+77,500Timeline
BHVNBIOHAVEN LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 478,972 shares; 2024Q4: 478,972 shares; 2025Q1: 478,972 shares; 2025Q2: 478,972 shares; 2025Q3: 478,972 shares; 2025Q4: 738,972 shares 738,972$8.34M2.62%+260,000Timeline
TARAPROTARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 800,000 shares; 2025Q1: 800,000 shares; 2025Q2: 800,000 shares; 2025Q3: 800,000 shares; 2025Q4: 1,369,782 shares 1,369,782$7.3M2.3%+569,782Timeline
GHRSGH RESEARCH PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 572,665 shares; 2024Q4: 572,665 shares; 2025Q1: 572,665 shares; 2025Q2: 572,665 shares; 2025Q3: 572,665 shares; 2025Q4: 572,665 shares 572,665$7.27M2.29%0Timeline
SKYESKYE BIOSCIENCE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 9,913,168 shares; 2024Q4: 9,913,168 shares; 2025Q1: 9,913,168 shares; 2025Q2: 9,913,168 shares; 2025Q3: 9,681,763 shares; 2025Q4: 9,681,763 shares 9,681,763$7.26M2.28%0Timeline
ZNTLZENTALIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 490,000 shares; 2024Q4: 490,000 shares; 2025Q1: 490,000 shares; 2025Q2: 490,000 shares; 2025Q3: 490,000 shares; 2025Q4: 3,947,913 shares 3,947,913$5.33M1.68%+3,457,913Timeline
SLNSILENCE THERAPEUTICS PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 476,200 shares; 2024Q4: 476,200 shares; 2025Q1: 476,200 shares; 2025Q2: 476,200 shares; 2025Q3: 476,200 shares; 2025Q4: 476,200 shares 476,200$2.9M0.91%0Timeline
RALLYBIO CORPRALLYBIO CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,630,724 shares; 2024Q4: 3,630,724 shares; 2025Q1: 3,630,724 shares; 2025Q2: 3,630,724 shares; 2025Q3: 3,630,724 shares; 2025Q4: 3,630,724 shares 3,630,724$2.49M0.78%0

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
DNTHDIANTHUS THERAPEUTICS INC365,053$14.4Mshares
PRAXPRAXIS PRECISION MEDICINES I170,000$9.01Mshares
ALECALECTOR INC995,841$2.95Mshares
ADVERUM BIOTECHNOLOGIES INCADVERUM BIOTECHNOLOGIES INC541,666$2.45Mshares
MERSANA THERAPEUTICS INCMERSANA THERAPEUTICS INC52,200$405Kshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001799883-26-000001 base2026-02-17acceptance time not in the bulk data set