SR One Capital Management, LP More: the full row for SR One Capital Management, LP 4,911,539 $40.2M 9.81% 0 13F-HR Timeline ENAVATE SCIENCES GP, LLC More: the full row for ENAVATE SCIENCES GP, LLC 3,761,359 $30.8M 22.12% 13F-HR Timeline NEA Management Company, LLC More: the full row for NEA Management Company, LLC 2,613,948 $21.4M 1.21% 0 13F-HR Timeline Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 1,892,806 $15.5M 1.54% 0 13F-HR Timeline Group NVP ASSOCIATES, LLC More: the full row for NVP ASSOCIATES, LLC 1,838,482 $15.1M 8.05% 0 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 1,781,715 $14.6M <0.01% -218,285 13F-HR Timeline Group NOVO HOLDINGS A/S More: the full row for NOVO HOLDINGS A/S 1,600,000 $13.1M 0.79% +450,000 13F-HR Timeline DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 1,562,942 $12.8M 0.24% 0 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 1,183,260 $9.69M 1.09% 0 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 1,158,000 $9.48M 0.02% 0 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 1,135,289 $9.17M <0.01% -366,139 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 1,006,558 $8.24M <0.01% new 13F-HR Timeline Group VANGUARD GROUP INC in group VANGUARD GROUP INC More: the full row for VANGUARD GROUP INC 979,323 $8.02M <0.01% +829,323 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 878,667 $7.2M 0.27% 0 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 744,035 $6.09M 0.17% -400,000 13F-HR Timeline Group Pivotal bioVenture Partners Investment … in group Pivotal bioVenture Partners I… More: the full row for Pivotal bioVenture Partners Investment Advisor LLC 736,645 $6.03M 4.07% +85,950 13F-HR Timeline Group ArrowMark Colorado Holdings LLC More: the full row for ArrowMark Colorado Holdings LLC 627,669 $5.14M 0.07% +327,669 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 511,220 $4.19M <0.01% +24,366 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 358,212 $2.93M <0.01% +307,162 13F-HR/A Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 348,760 $2.86M <0.01% +323,903 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 211,506 $1.73M <0.01% new 13F-HR Timeline Group SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 171,940 $1.55M <0.01% new 13F-HR Timeline Catalio Capital Management, LP in group Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 187,184 $1.53M 0.34% 13F-HR Timeline Group Eversept Partners, LP More: the full row for Eversept Partners, LP 172,103 $1.41M 0.15% -18,428 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 134,896 $1.1M <0.01% +17,515 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 131,665 $1.08M <0.01% +131,606 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 124,246 $1.02M <0.01% new 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 118,660 $972K <0.01% new 13F-HR Timeline Group SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 111,605 $914K 0.8% 0 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 82,624 $677K <0.01% -11,698 13F-HR Timeline Group NORGES BANK More: the full row for NORGES BANK 66,202 $542K <0.01% -8,798 13F-HR Timeline M&T Bank Corp in group M&T Bank Corp More: the full row for M&T Bank Corp 62,622 $512K <0.01% +37,738 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 56,039 $459K 0.03% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 42,174 $345K <0.01% -90,226 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 38,942 $319K <0.01% new 13F-HR/A Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 38,400 $314K <0.01% new 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 35,944 $294K <0.01% new 13F-HR Timeline Group ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 33,790 $277K <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 29,839 $244K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 23,939 $196K <0.01% +8,439 13F-HR/A Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 22,990 $188K <0.01% new 13F-HR/A Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 21,575 $177K <0.01% new 13F-HR Timeline Group Nuveen Asset Management, LLC in group TIAA More: the full row for Nuveen Asset Management, LLC 19,909 $163K <0.01% new 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 18,245 $149K <0.01% new 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 17,045 $140K <0.01% +4,045 13F-HR Timeline Group Birchview Capital, LP More: the full row for Birchview Capital, LP 16,500 $135K 0.11% new 13F-HR/A Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 12,104 $99.1K <0.01% new 13F-HR Timeline Group STONERIDGE INVESTMENT PARTNERS LLC More: the full row for STONERIDGE INVESTMENT PARTNERS LLC 10,955 $90K 0.03% new 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 10,225 $83.7K <0.01% new 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 8,596 $70.4K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 7,982 $65.4K <0.01% new 13F-HR Timeline Group Corebridge Financial, Inc. in group Corebridge Financial, Inc. More: the full row for Corebridge Financial, Inc. 7,640 $62.6K <0.01% new 13F-HR Timeline Group PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 6,417 $52.6K <0.01% +2,568 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 4,499 $36.8K <0.01% 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 2,800 $22.9K <0.01% new 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,608 $13.2K <0.01% new 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 1,519 $12.4K <0.01% new 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,144 $9.37K <0.01% new 13F-HR/A Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,117 $9.15K <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,140 $9K <0.01% new 13F-HR Timeline Group AMALGAMATED BANK More: the full row for AMALGAMATED BANK 524 $4K <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 226 $1.85K <0.01% new 13F-HR Timeline R Squared Ltd More: the full row for R Squared Ltd 210 $1.72K <0.01% 13F-HR Timeline MRP Capital Investments, LLC More: the full row for MRP Capital Investments, LLC 35 $287 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 2 $16 <0.01% 13F-HR Timeline CONCOURSE FINANCIAL GROUP SECURITIES, I… More: the full row for CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0 $0 0% 0 13F-HR Timeline Value filed as zero, left out of ratios. Amount filed as zero, left out of ratios.