FMR LLC in group FMR LLC More: the full row for FMR LLC 9,082,000 $178M 0.01% +1,377,745 13F-HR Timeline Group SR One Capital Management, LP More: the full row for SR One Capital Management, LP 5,037,854 $98.5M 10.76% 0 13F-HR Timeline NEA Management Company, LLC More: the full row for NEA Management Company, LLC 4,023,219 $78.7M 4.47% +500,000 13F-HR Timeline ENAVATE SCIENCES GP, LLC More: the full row for ENAVATE SCIENCES GP, LLC 3,919,159 $76.6M 21.8% 0 13F-HR Timeline FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 3,127,031 $61.1M 0.1% +411,453 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 2,548,444 $49.8M 0.22% +1,490,835 13F-HR Timeline Group Capital International Investors in group Capital International Investo… More: the full row for Capital International Investors 2,434,000 $47.6M 0.01% new 13F-HR Timeline Group Royalty Pharma Sub-Manager, LLC in group Royalty Pharma Sub-Manager, L… More: the full row for Royalty Pharma Sub-Manager, LLC 2,388,150 $46.7M 27.02% +1,125,000 13F-HR/A Timeline Group Fairmount Funds Management LLC in group Fairmount Funds Management LLC More: the full row for Fairmount Funds Management LLC 2,359,025 $46.1M 3.33% +150,000 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 2,037,548 $39.8M <0.01% +270,030 13F-HR Timeline Group NVP ASSOCIATES, LLC More: the full row for NVP ASSOCIATES, LLC 1,838,482 $35.9M 20.4% 0 13F-HR Timeline VANGUARD GROUP INC group of 6 filers holding More: the full row for VANGUARD GROUP INC 1,711,870 $33.5M new Timeline VANGUARD CAPITAL MANAGEMENT LLC : 1,245,391 (<0.01%) 13F-HR/A VANGUARD PORTFOLIO MANAGEMENT LLC : 251,410 (<0.01%) 13F-HR VANGUARD FIDUCIARY TRUST CO : 179,388 (<0.01%) 13F-HR Vanguard Global Advisers, LLC : 20,840 (<0.01%) 13F-HR VANGUARD ASSET MANAGEMENT, Ltd : 10,642 (<0.01%) 13F-HR Vanguard Investments Australia, L… : 4,199 (<0.01%) 13F-HR ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 897,321 $32.6M 0.01% +878,971 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,470,923 $28.8M <0.01% +1,032,629 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 1,246,053 $24.4M <0.01% +390,719 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 1,135,935 $22.2M 2.62% new 13F-HR Timeline Group EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 789,500 $15.4M 0.66% 0 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 667,070 $13M 0.03% +473,917 13F-HR Timeline Group ArrowMark Colorado Holdings LLC More: the full row for ArrowMark Colorado Holdings LLC 658,909 $12.9M 0.34% -92,252 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 655,785 $12.8M <0.01% +67,392 13F-HR Timeline Group Pivotal bioVenture Partners Investment … in group Pivotal bioVenture Partners I… More: the full row for Pivotal bioVenture Partners Investment Advisor LLC 591,991 $11.6M 4.14% 0 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 590,525 $11.5M 0.04% new 13F-HR/A Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 524,066 $10.2M 2.51% new 13F-HR Timeline Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 502,077 $9.82M 0.58% 0 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 501,928 $9.81M 0.01% +494,828 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 476,818 $9.32M 0.01% +427,658 13F-HR Timeline Group NEXTBio Capital Management LP More: the full row for NEXTBio Capital Management LP 426,736 $8.34M 3.87% +104,753 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 388,347 $7.59M <0.01% +341,187 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 382,928 $7.49M +305,033 Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 381,461 $7.46M <0.01% +250,763 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 357,266 $6.99M <0.01% -11,982 13F-HR Timeline Sio Capital Management, LLC More: the full row for Sio Capital Management, LLC 331,730 $6.49M 0.93% new 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 275,056 $5.38M <0.01% +259,956 13F-HR Timeline Group JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 250,000 $4.89M <0.01% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 224,402 $4.39M <0.01% +11,209 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 219,947 $4.3M 0.05% new 13F-HR Timeline Group iA Global Asset Management Inc. More: the full row for iA Global Asset Management Inc. 215,830 $4.22M 0.06% new 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 214,334 $4.19M 0.72% new 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 200,000 $3.91M 0.11% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 194,640 $3.81M <0.01% +39,274 13F-HR Timeline Group SEB Asset Management AB More: the full row for SEB Asset Management AB 163,860 $3.2M 0.01% 13F-HR Timeline Monashee Investment Management LLC More: the full row for Monashee Investment Management LLC 150,000 $2.93M 1.6% new 13F-HR Timeline Maven Securities LTD in group Maven Securities LTD More: the full row for Maven Securities LTD 150,000 $2.93M 0.17% new 13F-HR Timeline Group Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 125,232 $2.45M 0.02% new 13F-HR/A Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 113,479 $2.22M <0.01% -74,489 13F-HR Timeline Group Atom Investors LP More: the full row for Atom Investors LP 107,016 $2.09M 0.15% new 13F-HR Timeline SEVEN GRAND MANAGERS, LLC More: the full row for SEVEN GRAND MANAGERS, LLC 100,000 $1.96M 0.13% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 93,396 $1.83M <0.01% -34,939 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 85,005 $1.66M <0.01% +71,327 13F-HR Timeline Group Exome Asset Management LLC More: the full row for Exome Asset Management LLC 80,730 $1.58M 0.93% new 13F-HR Timeline VOLORIDGE INVESTMENT MANAGEMENT, LLC More: the full row for VOLORIDGE INVESTMENT MANAGEMENT, LLC 77,493 $1.51M 0.01% -55,946 13F-HR Timeline Birchview Capital, LP More: the full row for Birchview Capital, LP 70,000 $1.37M 0.78% new 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 67,770 $1.32M <0.01% +16,920 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 66,870 $1.31M <0.01% +42,411 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 60,864 $1.19M <0.01% +9,062 13F-HR Timeline Group Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 60,001 $1.17M 0.02% new 13F-HR Timeline Group AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 50,971 $996K <0.01% -27,249 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 48,169 $942K <0.01% new 13F-HR Timeline ALPS ADVISORS INC in group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 43,694 $854K <0.01% -383 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 42,874 $838K <0.01% +27,333 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 42,500 $831K 0.19% new 13F-HR Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 40,000 $782K 0.04% new 13F-HR Timeline J. Goldman & Co LP More: the full row for J. Goldman & Co LP 36,797 $719K 0.03% new 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 31,600 $618K <0.01% 0 13F-HR Timeline SCHRODER INVESTMENT MANAGEMENT GROUP More: the full row for SCHRODER INVESTMENT MANAGEMENT GROUP 33,697 $614K <0.01% -16,939 13F-HR Timeline Voleon Capital Management LP More: the full row for Voleon Capital Management LP 29,612 $579K 0.01% +19,425 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 29,610 $579K <0.01% -4,767 13F-HR Timeline Group JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 27,532 $538K <0.01% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 26,813 $524K <0.01% +4,867 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 25,749 $503K <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 25,109 $458K <0.01% +3,383 13F-HR/A Timeline Group PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 21,416 $419K 0.02% new 13F-HR Timeline Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 21,126 $413K <0.01% new 13F-HR Timeline STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 20,814 $407K <0.01% +10,593 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 19,311 $378K 0.01% +7,128 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 19,266 $377K <0.01% +6,485 13F-HR Timeline Group Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 18,640 $364K 0.01% new 13F-HR Timeline ALLSTATE CORP in group ALLSTATE CORP More: the full row for ALLSTATE CORP 18,223 $356K <0.01% new 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 17,638 $345K <0.01% +8,511 13F-HR Timeline Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 17,186 $332K +5,798 Timeline Corient Private Wealth LP in group Corient Private Wealth LP More: the full row for Corient Private Wealth LP 16,845 $329K <0.01% new 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 16,645 $325K 0.02% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 15,819 $309K <0.01% +118 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 13,526 $264K 0.02% +212 13F-HR Timeline Scientech Research LLC More: the full row for Scientech Research LLC 12,952 $253K 0.21% new 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 12,909 $252K <0.01% +2,809 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 12,658 $247K <0.01% +385 13F-HR Timeline Group FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 13,331 $243K 0.04% new 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 12,386 $242K <0.01% new 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 10,432 $204K <0.01% -2,595 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 9,999 $195K <0.01% +2,861 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 9,888 $193K <0.01% +7,537 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 8,885 $174K <0.01% -12,266 13F-HR/A Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 7,235 $141K <0.01% +6,440 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 6,777 $132K <0.01% new 13F-HR Timeline Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 6,717 $131K 0.04% +163 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 6,363 $124K <0.01% +1,864 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 6,200 $121K <0.01% 0 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 4,767 $93.2K <0.01% -1,057 13F-HR Timeline Group KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 3,400 $66.5K <0.01% 0 13F-HR Timeline STRS OHIO More: the full row for STRS OHIO 2,800 $54.7K <0.01% 0 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 2,721 $53.2K <0.01% +1,376 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 2,415 $47.2K <0.01% +2,300 13F-HR Timeline Ameritas Investment Partners, Inc. group of 2 filers holding More: the full row for Ameritas Investment Partners, Inc. 1,930 $37.7K +562 Timeline CWM, LLC in group CWM, LLC More: the full row for CWM, LLC 1,472 $28.8K <0.01% -706 13F-HR Timeline Group HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 1,370 $26.8K <0.01% new 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 1,205 $23.6K <0.01% +151 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 994 $19.4K <0.01% +110 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 779 $15.2K <0.01% -308 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 677 $13.2K <0.01% +674 13F-HR Timeline Group SIGNATUREFD, LLC More: the full row for SIGNATUREFD, LLC 370 $7.23K <0.01% -19 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 300 $5.87K <0.01% new 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 293 $5.73K <0.01% +274 13F-HR Timeline J.Safra Asset Management Corp More: the full row for J.Safra Asset Management Corp 270 $5.28K <0.01% +178 13F-HR Timeline Quantbot Technologies LP More: the full row for Quantbot Technologies LP 256 $5K <0.01% new 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 245 $4.79K <0.01% +66 13F-HR Timeline FIFTH THIRD BANCORP in group FIFTH THIRD BANK, NATIONAL AS… More: the full row for FIFTH THIRD BANCORP 107 $2.09K <0.01% new 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 98 $1.92K <0.01% +25 13F-HR/A Timeline Group Torren Management, LLC More: the full row for Torren Management, LLC 95 $1.86K <0.01% 0 13F-HR Timeline Physician Wealth Advisors, Inc. More: the full row for Physician Wealth Advisors, Inc. 92 $1.8K <0.01% +25 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 60 $1.17K <0.01% new 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 26 $509 <0.01% -21 13F-HR Timeline Cornerstone Financial Management LLC More: the full row for Cornerstone Financial Management LLC 26 $508 <0.01% 0 13F-HR/A Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 21 $411 <0.01% +20 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 20 $391 <0.01% new 13F-HR Timeline Bare Financial Services, Inc More: the full row for Bare Financial Services, Inc 14 $274 <0.01% new 13F-HR Timeline MAI Capital Management More: the full row for MAI Capital Management 12 $235 <0.01% +5 13F-HR Timeline Sunbelt Securities, Inc. More: the full row for Sunbelt Securities, Inc. 11 $215 <0.01% 0 13F-HR Timeline Stone House Investment Management, LLC More: the full row for Stone House Investment Management, LLC 5 $98 <0.01% new 13F-HR Timeline True Wealth Design, LLC More: the full row for True Wealth Design, LLC 3 $59 <0.01% 0 13F-HR Timeline Essential Partners LLC More: the full row for Essential Partners LLC 2 $39 <0.01% -1 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 6 $0 0% new 13F-HR Timeline Value filed as zero, left out of ratios.